IL160642A0 - Pyrrolidinone derivatives - Google Patents

Pyrrolidinone derivatives

Info

Publication number: IL160642A0
Authority: IL; Israel
Prior art keywords: pyrrolidinone derivatives; pyrrolidinone; derivatives
Prior art date: 2001-10-03

Application number

IL16064202A

Other languages

English (en)

Original Assignee

Ucb Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-03

Filing date

2002-09-26

Publication date

2004-07-25

2002-09-26 Application filed by Ucb Sa filed Critical Ucb Sa

2004-07-25 Publication of IL160642A0 publication Critical patent/IL160642A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Dermatology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Virology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Gastroenterology & Hepatology (AREA)
Hematology (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
Ophthalmology & Optometry (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)

IL16064202A 2001-10-03 2002-09-26 Pyrrolidinone derivatives IL160642A0 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US97014001A	2001-10-03	2001-10-03
US40080702P	2002-08-01	2002-08-01
PCT/EP2002/010810 WO2003030897A1 (fr)	2001-10-03	2002-09-26	Derives pyrrolidinone

Publications (1)

Publication Number	Publication Date
IL160642A0 true IL160642A0 (en)	2004-07-25

Family

ID=27017198

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL16064202A IL160642A0 (en)	2001-10-03	2002-09-26	Pyrrolidinone derivatives

Country Status (19)

Country	Link
US (3)	US6727275B2 (fr)
EP (1)	EP1434577A1 (fr)
JP (1)	JP2005523238A (fr)
KR (1)	KR20040048936A (fr)
CN (1)	CN1564685A (fr)
AR (1)	AR036672A1 (fr)
BG (1)	BG108660A (fr)
BR (1)	BR0212968A (fr)
CA (1)	CA2463198A1 (fr)
CO (1)	CO5390075A1 (fr)
CZ (1)	CZ2004442A3 (fr)
HU (1)	HUP0402503A2 (fr)
IL (1)	IL160642A0 (fr)
MX (1)	MXPA04002982A (fr)
NO (1)	NO20041767L (fr)
NZ (1)	NZ532018A (fr)
PL (1)	PL370355A1 (fr)
RU (1)	RU2004109818A (fr)
WO (1)	WO2003030897A1 (fr)

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KR20100087209A (ko) *	2001-08-10	2010-08-03	시오노기세이야쿠가부시키가이샤	항바이러스제
US7109186B2 (en)	2002-07-09	2006-09-19	Bristol-Myers Squibb Company	HIV integrase inhibitors
NZ563078A (en) *	2002-09-13	2009-07-31	Biogen Idec Inc	Method of purifying polypeptides by simulated moving bed chromatography
US20070249691A1 (en) *	2004-05-26	2007-10-25	Boeckx Gustaaf M	Mercaptoimidazoles as Ccr2 Receptor Antagonists
EP1756089B1 (fr) *	2004-05-26	2008-10-22	Janssen Pharmaceutica N.V.	Mercaptoimidazoles utilises comme antagonistes du recepteur ccr2
EP1778646A1 (fr) *	2004-08-11	2007-05-02	Janssen Pharmaceutica N.V.	Mercaptoimidazoles servant d'antagonistes du récepteur ccr2
WO2006029173A2 (fr) *	2004-09-08	2006-03-16	Boys Town National Research Hospital	Traitement d'une maladie de la membrane basale glomerulaire dans laquelle intervient la metalloprotease matricielle 12
US20090012148A1 (en) *	2005-11-01	2009-01-08	Maxfield Frederick R	Reducing cellular cholesterol levels and/or treating or preventing phospholipidosis
US20080076120A1 (en) *	2006-09-14	2008-03-27	Millennium Pharmaceuticals, Inc.	Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
WO2008127275A2 (fr) *	2006-09-22	2008-10-23	Ptc Therapeutics, Inc.	Composés pyrrolidone en tant qu'inhibiteurs d'hydrolase d'arnt peptidyle bactérienne et utilisations de ceux-ci
US8278345B2 (en) *	2006-11-09	2012-10-02	Probiodrug Ag	Inhibitors of glutaminyl cyclase
PE20081785A1 (es)	2007-02-19	2009-01-12	Novartis Ag	Derivados de ciclohexil-amida del acido aril carboxilico
WO2008103382A1 (fr) *	2007-02-20	2008-08-28	Sergey Kozmin	Procédé permettant d'assembler des bibliothèques chimiques de grande pureté, composés supprimant les activités de l'acétyl coenzyme a carboxylase découverts grâce à ce procédé
WO2008120725A1 (fr)	2007-03-30	2008-10-09	Shionogi & Co., Ltd.	Nouveau dérivé de pyrrolinone et composition médicale le contenant
FR2929851B1 (fr)	2008-04-09	2012-11-30	Centre Nat Rech Scient	Molecules inhibant une voie metabolique impliquant la proteine tyrosine kinase syk et procede d'identification de ces molecules
US8575197B2 (en) *	2008-09-25	2013-11-05	Shionogi & Co., Ltd.	Pyrolinone derivative and pharmaceutical composition comprising the same
JP2012532849A (ja) *	2009-07-10	2012-12-20	ビバリス	Ｃ型肝炎ｎｓ５ｂポリメラーゼの阻害剤としての１−（６員アゾ複素環式）−ピロリン−２−オン化合物、その医薬組成物、およびそれらの治療上の使用
US20120189579A1 (en) *	2009-07-10	2012-07-26	Vivalis	Substituted pyrrolidinone as inhibitors of hepatitis c ns5b polymerase, the pharmaceutical composition thereof and their therapeutic use
CN102791704B (zh)	2010-03-10	2015-11-25	前体生物药物股份公司	谷氨酰胺酰环化酶(qc, ec 2.3.2.5)的杂环抑制剂
WO2012093174A1 (fr)	2011-01-07	2012-07-12	Vivalis	Dérivés de 1-(azo-hétérocyclique à 6 chaînons)-2,5-dihydro-1h-pyrrol-2-one à titre d'anti-virus de l'hépatite c, composition pharmaceutique les contenant et leur utilisation thérapeutique
WO2013048928A1 (fr) *	2011-09-27	2013-04-04	Bristol-Myers Squibb Company	Composés pyrrolinone carboxamide utiles comme inhibiteurs de lipase endothéliale
WO2013048982A1 (fr)	2011-09-27	2013-04-04	Bristol-Myers Squibb Company	Composés de pyrrolinone-carboxamide utiles en tant qu'inhibiteurs de lipase endothéliale
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2002
- 2002-09-26 CA CA002463198A patent/CA2463198A1/fr not_active Abandoned
- 2002-09-26 KR KR10-2004-7004999A patent/KR20040048936A/ko not_active Withdrawn
- 2002-09-26 BR BR0212968-0A patent/BR0212968A/pt not_active Application Discontinuation
- 2002-09-26 US US10/255,494 patent/US6727275B2/en not_active Expired - Fee Related
- 2002-09-26 CZ CZ2004442A patent/CZ2004442A3/cs unknown
- 2002-09-26 CN CNA028195639A patent/CN1564685A/zh active Pending
- 2002-09-26 PL PL02370355A patent/PL370355A1/xx not_active Application Discontinuation
- 2002-09-26 RU RU2004109818/15A patent/RU2004109818A/ru not_active Application Discontinuation
- 2002-09-26 WO PCT/EP2002/010810 patent/WO2003030897A1/fr not_active Ceased
- 2002-09-26 EP EP02800576A patent/EP1434577A1/fr not_active Withdrawn
- 2002-09-26 US US10/489,661 patent/US20050004180A1/en not_active Abandoned
- 2002-09-26 IL IL16064202A patent/IL160642A0/xx unknown
- 2002-09-26 NZ NZ532018A patent/NZ532018A/xx unknown
- 2002-09-26 JP JP2003533929A patent/JP2005523238A/ja active Pending
- 2002-09-26 HU HU0402503A patent/HUP0402503A2/hu unknown
- 2002-10-03 CO CO02089166A patent/CO5390075A1/es not_active Application Discontinuation
- 2002-10-03 AR ARP020103733A patent/AR036672A1/es not_active Application Discontinuation
2003
- 2003-12-31 US US10/750,247 patent/US6936633B2/en not_active Expired - Fee Related
2004
- 2004-03-30 MX MXPA04002982A patent/MXPA04002982A/es unknown
- 2004-04-01 BG BG108660A patent/BG108660A/xx unknown
- 2004-04-30 NO NO20041767A patent/NO20041767L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CO5390075A1 (es)	2004-04-30
MXPA04002982A (es)	2004-07-15
JP2005523238A (ja)	2005-08-04
BR0212968A (pt)	2004-10-13
EP1434577A1 (fr)	2004-07-07
HUP0402503A2 (hu)	2005-03-29
US20030149081A1 (en)	2003-08-07
PL370355A1 (en)	2005-05-16
WO2003030897A1 (fr)	2003-04-17
AR036672A1 (es)	2004-09-22
NO20041767L (no)	2004-04-30
US6727275B2 (en)	2004-04-27
CA2463198A1 (fr)	2003-04-17
NZ532018A (en)	2004-12-24
KR20040048936A (ko)	2004-06-10
CN1564685A (zh)	2005-01-12
US6936633B2 (en)	2005-08-30
CZ2004442A3 (cs)	2005-03-16
BG108660A (en)	2005-03-31
RU2004109818A (ru)	2005-05-10
US20040157914A1 (en)	2004-08-12
US20050004180A1 (en)	2005-01-06

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