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IL166021A0 - Trabsolant acceptance inducing cells of monocytic origin and their preparation and use - Google Patents

Trabsolant acceptance inducing cells of monocytic origin and their preparation and use

Info

Publication number
IL166021A0
IL166021A0 IL16602103A IL16602103A IL166021A0 IL 166021 A0 IL166021 A0 IL 166021A0 IL 16602103 A IL16602103 A IL 16602103A IL 16602103 A IL16602103 A IL 16602103A IL 166021 A0 IL166021 A0 IL 166021A0
Authority
IL
Israel
Prior art keywords
inducing cells
trabsolant
preparation
acceptance
monocytic origin
Prior art date
Application number
IL16602103A
Other languages
English (en)
Original Assignee
Blasticon Biotech Forschung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Blasticon Biotech Forschung filed Critical Blasticon Biotech Forschung
Publication of IL166021A0 publication Critical patent/IL166021A0/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/001Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/17Monocytes; Macrophages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/20Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22Immunosuppressive or immunotolerising
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/20Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24Antigen-presenting cells [APC]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/418Antigens related to induction of tolerance to non-self
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0645Macrophages, e.g. Kuepfer cells in the liver; Monocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/22Colony stimulating factors (G-CSF, GM-CSF)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/24Interferons [IFN]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/11Coculture with; Conditioned medium produced by blood or immune system cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL16602103A 2002-07-12 2003-07-11 Trabsolant acceptance inducing cells of monocytic origin and their preparation and use IL166021A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10231655A DE10231655A1 (de) 2002-07-12 2002-07-12 Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung
PCT/EP2003/007551 WO2004007701A1 (en) 2002-07-12 2003-07-11 Transplant acceptance inducing cells of monocytic origin and their preparation and use

Publications (1)

Publication Number Publication Date
IL166021A0 true IL166021A0 (en) 2006-01-15

Family

ID=30009939

Family Applications (3)

Application Number Title Priority Date Filing Date
IL16602103A IL166021A0 (en) 2002-07-12 2003-07-11 Trabsolant acceptance inducing cells of monocytic origin and their preparation and use
IL166021A IL166021A (en) 2002-07-12 2004-12-28 Transplant acceptance inducing cells of monocytic origin and their preparation and use
IL172854A IL172854A0 (en) 2002-07-12 2005-12-27 Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical preparations

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL166021A IL166021A (en) 2002-07-12 2004-12-28 Transplant acceptance inducing cells of monocytic origin and their preparation and use
IL172854A IL172854A0 (en) 2002-07-12 2005-12-27 Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical preparations

Country Status (18)

Country Link
US (1) US20060286670A1 (de)
EP (2) EP1557462B1 (de)
JP (1) JP2005532803A (de)
CN (1) CN100523176C (de)
AT (2) ATE390480T1 (de)
AU (1) AU2003250939B2 (de)
BR (1) BR0312693A (de)
CA (1) CA2492383A1 (de)
DE (3) DE10231655A1 (de)
DK (2) DK1557462T3 (de)
ES (3) ES2304647T3 (de)
IL (3) IL166021A0 (de)
NO (1) NO20050719L (de)
PT (2) PT1557462E (de)
RU (1) RU2370535C2 (de)
SI (3) SI1492869T1 (de)
WO (1) WO2004007701A1 (de)
ZA (2) ZA200501054B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
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DE10362002B4 (de) 2003-06-23 2006-10-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Adulte pluripotente Stammzellen
AU2004256154A1 (en) * 2003-07-11 2005-01-20 Blasticon Biotechnologische Forschung Gmbh Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical proparations
EP1928479B1 (de) * 2005-08-24 2016-06-08 Yeda Research And Development Co., Ltd. Universale von spendern stammende tolerogene zellen zur induktion von nicht-syngener transplantationstoleranz
US8470316B2 (en) 2005-10-14 2013-06-25 Chugai Seiyaku Kabushiki Kaisha Agents for suppressing damage to transplanted islets after islet transplantation
CA2626688C (en) 2005-10-21 2017-10-03 Chugai Seiyaku Kabushiki Kaisha Agents for treating cardiopathy
AR057582A1 (es) 2005-11-15 2007-12-05 Nat Hospital Organization Agentes para suprimir la induccion de linfocitos t citotoxicos
US9260516B2 (en) 2006-04-07 2016-02-16 Osaka University Method for promoting muscle regeneration by administering an antibody to the IL-6 receptor
WO2008090901A1 (ja) * 2007-01-23 2008-07-31 Shinshu University 慢性拒絶反応抑制剤
CN104906581A (zh) 2008-06-05 2015-09-16 国立研究开发法人国立癌症研究中心 神经浸润抑制剂
EP2365823B1 (de) * 2008-10-30 2016-11-30 Yeda Research And Development Company Ltd. Zentrale anti-dritte-t-gedächtniszellen, verfahren zur herstellung davon und verwendung davon in der transplantation und bei der krankheitsbehandlung
JP5436905B2 (ja) * 2009-03-26 2014-03-05 テルモ株式会社 シート状細胞培養物の製造方法
JP5667357B2 (ja) * 2009-11-30 2015-02-12 テルモ株式会社 シート状細胞培養物の製造方法
CN101812428A (zh) * 2010-04-26 2010-08-25 西北农林科技大学 一种乳腺上皮细胞的组织块种植方法
US9539322B2 (en) 2010-05-28 2017-01-10 National University Corporation Hokkaido University Method of enhancing an antitumor T cell response by administering an anti-IL-6 receptor antibody
DE102011004335A1 (de) 2011-02-17 2012-08-23 Thomas Grammel Verfahren zur Herstellung eines Vakzins
RU2508924C1 (ru) * 2013-02-21 2014-03-10 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" Способ профилактики и лечения отторжения почечного трансплантата
JP5727665B2 (ja) * 2014-12-11 2015-06-03 テルモ株式会社 シート状細胞培養物の製造方法
JP5893786B2 (ja) * 2015-04-02 2016-03-23 テルモ株式会社 シート状細胞培養物の製造方法
CA2991077A1 (en) * 2015-07-03 2017-01-12 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for obtaining regulatory t cells and uses thereof
JP6903866B2 (ja) * 2016-01-27 2021-07-14 国立大学法人 熊本大学 血液由来単球の増殖誘導方法
JP6140322B2 (ja) * 2016-02-24 2017-05-31 テルモ株式会社 シート状細胞培養物の製造方法
JP6490738B2 (ja) * 2017-04-28 2019-03-27 テルモ株式会社 シート状細胞培養物の製造方法
US11851486B2 (en) 2017-05-02 2023-12-26 National Center Of Neurology And Psychiatry Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils
EP3698808B1 (de) 2017-10-20 2025-01-01 Hyogo College Of Medicine Anti-il-6 rezeptorantikörper enthaltende medizinische zusammensetzung zur verhinderung von postoperativer adhäsion
JP6657452B2 (ja) * 2019-02-27 2020-03-04 テルモ株式会社 シート状細胞培養物の製造方法
JP7002497B2 (ja) * 2019-06-20 2022-01-20 テルモ株式会社 シート状細胞培養物の製造方法
JP6872051B2 (ja) * 2020-02-05 2021-05-19 テルモ株式会社 シート状細胞培養物の製造方法

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US5766920A (en) * 1982-08-11 1998-06-16 Cellcor, Inc. Ex vivo activation of immune cells
US5683693A (en) * 1994-04-25 1997-11-04 Trustees Of Dartmouth College Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40
US7410773B2 (en) * 1995-02-02 2008-08-12 Ghazi Jaswinder Dhoot Method of preparing an undifferentiated cell
US9068164B1 (en) * 1995-02-02 2015-06-30 Tristem Trading (Cyprus) Limited Method of preparing an undifferentiated cell
GB9502022D0 (en) * 1995-02-02 1995-03-22 Abuljadayel Ilham M S A method for preparing lymphohaematopoietic progenitor cells
US7112440B2 (en) * 1995-02-02 2006-09-26 Ghazi Jaswinder Dhoot Method of increasing the relative number of CD45 low cells in a cell population
ATE240119T1 (de) * 1995-03-08 2003-05-15 Scripps Research Inst Antigen präsentierendes system und aktivierung von t-zellen
AU7499498A (en) * 1997-05-21 1998-12-11 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Methods and compositions for making dendritic cells from expanded populations ofmonocytes and for activating t cells
NL1017973C2 (nl) * 2000-05-10 2002-11-08 Tristem Trading Cyprus Ltd Inrichting.
US7405076B2 (en) * 2000-11-14 2008-07-29 Universite Libre De Bruxelles Generation and use of dendritic cells
TWI288779B (en) * 2002-03-28 2007-10-21 Blasticon Biotech Forschung Dedifferentiated, programmable stem cells of monocytic origin, and their production and use

Also Published As

Publication number Publication date
SI1557462T1 (sl) 2008-08-31
EP1492869A1 (de) 2005-01-05
AU2003250939B2 (en) 2008-05-22
CN100523176C (zh) 2009-08-05
JP2005532803A (ja) 2005-11-04
WO2004007701A1 (en) 2004-01-22
EP1492869B1 (de) 2005-11-09
ES2304647T3 (es) 2008-10-16
PT1557462E (pt) 2008-06-18
DK1492869T3 (da) 2006-03-06
DK1557462T3 (da) 2008-06-23
ATE309331T1 (de) 2005-11-15
PT1644484E (pt) 2008-10-21
CN1681918A (zh) 2005-10-12
BR0312693A (pt) 2005-04-26
DE60320009D1 (de) 2008-05-08
DE60320009T2 (de) 2009-05-20
DE60302231T2 (de) 2006-07-20
US20060286670A1 (en) 2006-12-21
SI1644484T1 (sl) 2009-02-28
EP1557462A3 (de) 2006-02-01
SI1492869T1 (sl) 2006-04-30
DE10231655A1 (de) 2004-02-26
NO20050719L (no) 2005-04-04
ES2252696T3 (es) 2006-05-16
IL166021A (en) 2010-05-17
EP1557462A2 (de) 2005-07-27
ATE390480T1 (de) 2008-04-15
ZA200501054B (en) 2005-08-30
CA2492383A1 (en) 2004-01-22
ZA200601074B (en) 2007-11-28
EP1492869B9 (de) 2006-05-24
ES2310711T3 (es) 2009-01-16
AU2003250939A1 (en) 2004-02-02
EP1557462B1 (de) 2008-03-26
DE60302231D1 (de) 2005-12-15
RU2370535C2 (ru) 2009-10-20
RU2005103627A (ru) 2005-08-27
HK1071586A1 (en) 2005-07-22
IL172854A0 (en) 2006-06-11

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