[go: up one dir, main page]

IL164319A0 - Confocal microscopy imaging system - Google Patents

Confocal microscopy imaging system

Info

Publication number
IL164319A0
IL164319A0 IL16431904A IL16431904A IL164319A0 IL 164319 A0 IL164319 A0 IL 164319A0 IL 16431904 A IL16431904 A IL 16431904A IL 16431904 A IL16431904 A IL 16431904A IL 164319 A0 IL164319 A0 IL 164319A0
Authority
IL
Israel
Prior art keywords
imaging system
confocal microscopy
microscopy imaging
confocal
microscopy
Prior art date
Application number
IL16431904A
Other languages
English (en)
Original Assignee
Amersham Biosciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Biosciences Corp filed Critical Amersham Biosciences Corp
Publication of IL164319A0 publication Critical patent/IL164319A0/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5002—Partitioning blood components
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0028—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders specially adapted for specific applications, e.g. for endoscopes, ophthalmoscopes, attachments to conventional microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/006—Optical details of the image generation focusing arrangements; selection of the plane to be imaged
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0064—Optical details of the image generation multi-spectral or wavelength-selective arrangements, e.g. wavelength fan-out, chromatic profiling
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0072—Optical details of the image generation details concerning resolution or correction, including general design of CSOM objectives
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/008—Details of detection or image processing, including general computer control
    • G02B21/0084—Details of detection or image processing, including general computer control time-scale detection, e.g. strobed, ultra-fast, heterodyne detection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IL16431904A 1998-03-16 2004-09-28 Confocal microscopy imaging system IL164319A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4252798A 1998-03-16 1998-03-16
PCT/US1999/005589 WO1999047963A1 (en) 1998-03-16 1999-03-16 Confocal microscopy imaging system

Publications (1)

Publication Number Publication Date
IL164319A0 true IL164319A0 (en) 2005-12-18

Family

ID=21922413

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13849699A IL138496A0 (en) 1998-03-16 1999-03-16 Confocal microscopy imaging system
IL16431904A IL164319A0 (en) 1998-03-16 2004-09-28 Confocal microscopy imaging system

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL13849699A IL138496A0 (en) 1998-03-16 1999-03-16 Confocal microscopy imaging system

Country Status (10)

Country Link
EP (1) EP1064579A4 (xx)
JP (1) JP4812937B2 (xx)
KR (2) KR100618502B1 (xx)
CN (1) CN100380160C (xx)
AU (1) AU758571B2 (xx)
BR (1) BR9908767B1 (xx)
CA (1) CA2324262C (xx)
IL (2) IL138496A0 (xx)
NO (1) NO20004601L (xx)
WO (1) WO1999047963A1 (xx)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5876946A (en) * 1997-06-03 1999-03-02 Pharmacopeia, Inc. High-throughput assay
US20030036855A1 (en) 1998-03-16 2003-02-20 Praelux Incorporated, A Corporation Of New Jersey Method and apparatus for screening chemical compounds
DE19927724A1 (de) * 1998-06-19 2000-01-20 Optiscan Pty Ltd Verfahren und Vorrichtung mit Zweiphotonen-Endoskop oder Mikroskop
US6690463B2 (en) * 2000-02-10 2004-02-10 Evotec Biosystems Ag Fluorescence intensity and lifetime distribution analysis
ATE277386T1 (de) * 2000-10-27 2004-10-15 Amersham Biosciences Corp Verfahren zum screening von chemischen verbindungen
FR2820828B1 (fr) * 2001-02-09 2003-05-02 Commissariat Energie Atomique Dispositif d'observation d'echantillons par fluorescence, notamment de facon sequentielle
DE10117723A1 (de) * 2001-04-09 2002-10-17 Evotec Ag Probenträger, insbesondere für biochemische Reaktionen
US7219016B2 (en) 2001-04-20 2007-05-15 Yale University Systems and methods for automated analysis of cells and tissues
DE10122607B4 (de) * 2001-05-10 2006-11-30 Leica Microsystems Cms Gmbh Verfahren und Anordnung zur direkten Fourierabbildung von Proben
DE10157511A1 (de) 2001-11-23 2003-06-12 Evotec Ag Verfahren und Vorrichtung zur Korrektur der Größe und/oder Form eines Messvolumens in einer chemischen und/oder biologischen Probe
JP2003177131A (ja) * 2001-12-11 2003-06-27 Olympus Optical Co Ltd 生物学的な結合親和性を検出する方法
GB0211068D0 (en) * 2002-05-14 2002-06-26 Amersham Biosciences Uk Ltd Method for assessing biofilms
GB0211072D0 (en) * 2002-05-15 2002-06-26 Amersham Biosciences Uk Ltd Reagent and method for the determination of changes in a cellular morphological parameter
US9157860B2 (en) 2002-05-16 2015-10-13 Applied Biosystems, Llc Achromatic lens array
US6982166B2 (en) * 2002-05-16 2006-01-03 Applera Corporation Lens assembly for biological testing
DE102004014048B4 (de) * 2004-03-19 2008-10-30 Sirona Dental Systems Gmbh Vermessungseinrichtung und Verfahren nach dem Grundprinzip der konfokalen Mikroskopie
US7170675B2 (en) 2004-05-19 2007-01-30 Celloptic, Inc. Method and system for wide-field multi-photon microscopy having a confocal excitation plane
DE102004034970A1 (de) * 2004-07-16 2006-02-02 Carl Zeiss Jena Gmbh Lichtrastermikroskop und Verwendung
CN101031837B (zh) * 2004-07-23 2011-06-15 通用电气医疗集团尼亚加拉有限公司 用于荧光共焦显微镜检查的方法和设备
CN1310023C (zh) * 2004-11-10 2007-04-11 哈尔滨工业大学 三差动共焦显微三维超分辨成像方法
GB0427050D0 (en) * 2004-12-10 2005-01-12 Amersham Biosciences Uk Ltd Method of,and apparatus and computer software for,imaging biological objects
DE202005010588U1 (de) * 2005-07-04 2005-10-13 Weiss Umwelttechnik Gmbh Simulationsanlagen-Messtechnik Anordnung zum Prüfen von pharmazeutischen Substanzen
US7329860B2 (en) 2005-11-23 2008-02-12 Illumina, Inc. Confocal imaging methods and apparatus
KR100737170B1 (ko) * 2006-01-20 2007-07-10 경북대학교 산학협력단 양자점 형광체를 이용한 이동식 형광 측정장치
US7567346B2 (en) * 2006-03-01 2009-07-28 General Electric Company System and method for multimode imaging
AU2007248424B2 (en) 2006-05-05 2013-04-18 Historx, Inc. Immunohistochemical methods for determining signal transduction activity in tumors
JP2009544007A (ja) 2006-07-13 2009-12-10 イェール・ユニバーシティー バイオマーカーの細胞内局在性に基づいて癌予後を行う方法
US7838302B2 (en) 2006-08-07 2010-11-23 President And Fellows Of Harvard College Sub-diffraction limit image resolution and other imaging techniques
GB0625775D0 (en) * 2006-12-22 2007-02-07 Isis Innovation Focusing apparatus and method
JP4957458B2 (ja) * 2007-08-27 2012-06-20 株式会社Ｊｖｃケンウッド ボイスコイル及びスピーカ
WO2009048142A1 (ja) * 2007-10-11 2009-04-16 Nikon Corporation 観察装置
CN105403545B (zh) 2007-12-21 2019-05-28 哈佛大学 三维中的亚衍射极限图像分辨率
WO2009115108A1 (en) * 2008-03-19 2009-09-24 Ruprecht-Karls-Universität Heidelberg A method and an apparatus for localization of single dye molecules in the fluorescent microscopy
KR101532611B1 (ko) * 2009-04-28 2015-07-01 삼성전자주식회사 주밍샷 효과를 나타내는 디지털 영상 처리 장치 및 방법
CN102869982B (zh) * 2010-03-01 2014-04-30 奥林巴斯株式会社 光学分析装置、光学分析方法
US8692708B2 (en) * 2010-03-30 2014-04-08 Sony Corporation Radiometric imaging device and corresponding method
US8767069B2 (en) * 2010-06-30 2014-07-01 Luminex Corporation Apparatus, system, and method for increasing measurement accuracy in a particle imaging device using light distribution
CN103026205B (zh) 2010-07-26 2016-03-23 奥林巴斯株式会社 使用发光探针检测溶液中稀疏颗粒的方法
EP2602613B1 (en) 2010-09-10 2017-02-22 Olympus Corporation Optical analysis method using optical intensity of single light-emitting particle
CN103221806B (zh) 2010-09-10 2015-11-25 奥林巴斯株式会社 使用两个以上的波长带的光的测量的光学分析方法
WO2012039352A1 (ja) * 2010-09-21 2012-03-29 オリンパス株式会社 単一発光粒子検出を用いた光分析方法
JP5737704B2 (ja) * 2010-09-27 2015-06-17 株式会社ライフテック 蛍光一粒子検出方法および検出システム
EP2615445B1 (en) * 2010-10-13 2014-05-21 Olympus Corporation Method of measuring a diffusion characteristic value of a particle
WO2012053355A1 (ja) 2010-10-19 2012-04-26 オリンパス株式会社 単一発光粒子の偏光特性を観測する光分析装置、光分析方法及びそのための光分析用コンピュータプログラム
WO2012070414A1 (ja) 2010-11-25 2012-05-31 オリンパス株式会社 単一発光粒子の光の波長特性を用いた光分析装置及び光分析方法
JP5856983B2 (ja) 2011-01-20 2016-02-10 オリンパス株式会社 単一発光粒子からの光の検出を用いた光分析方法及び光分析装置
JP6009944B2 (ja) 2011-01-26 2016-10-19 オリンパス株式会社 核酸分子の多型識別方法
WO2012102260A1 (ja) 2011-01-26 2012-08-02 オリンパス株式会社 核酸分子の多型識別方法
JP6033798B2 (ja) * 2011-03-01 2016-11-30 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション 蛍光顕微鏡検査法における照明位相制御のためのシステムおよび方法
CN103460026B (zh) 2011-03-29 2015-06-10 奥林巴斯株式会社 利用单个发光粒子检测的光分析装置、光分析方法以及光分析用计算机程序
WO2012141019A1 (ja) 2011-04-13 2012-10-18 オリンパス株式会社 単一発光粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム
CN103620389B (zh) 2011-04-18 2016-08-17 奥林巴斯株式会社 目标粒子的定量方法、光分析装置以及光分析用计算机程序
CN103733047B (zh) 2011-08-11 2016-03-30 奥林巴斯株式会社 目标粒子的检测方法
WO2013024650A1 (ja) 2011-08-15 2013-02-21 オリンパス株式会社 単一発光粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム
JP6010033B2 (ja) 2011-08-26 2016-10-19 オリンパス株式会社 光分析を用いた単一粒子検出装置、単一粒子検出方法及び単一粒子検出用コンピュータプログラム
WO2013031439A1 (ja) 2011-08-26 2013-03-07 オリンパス株式会社 単一発光粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム
CN103765194B (zh) 2011-08-30 2016-02-17 奥林巴斯株式会社 目标粒子的检测方法
CN103765197B (zh) 2011-08-30 2016-03-02 奥林巴斯株式会社 利用单个发光粒子检测的光分析装置、光分析方法以及光分析用计算机程序
JP2014528060A (ja) * 2011-09-06 2014-10-23 コーニンクレッカ フィリップス エヌ ヴェ 複数のセンサ領域を持つ光学バイオセンサ
EP2778658A4 (en) 2011-11-10 2015-12-02 Olympus Corp SPECTROSCOPY DEVICE, SPECTROSCOPY PROCESS AND SPECTROSCOPY COMPUTER PROGRAM DETECTING SINGLE LIGHT-EMITTING PARTICLES
DE102011087196A1 (de) * 2011-11-28 2013-05-29 Leica Microsystems Cms Gmbh Mikroskopbeleuchtungssystem und -verfahren
WO2013121905A1 (ja) 2012-02-17 2013-08-22 オリンパス株式会社 単一粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム
JP5940644B2 (ja) 2012-02-22 2016-06-29 オリンパス株式会社 標的粒子の検出方法
CH706326A2 (de) * 2012-03-14 2013-09-30 Tecan Trading Ag Verfahren und Mikroplatten-Reader zum Untersuchung von biologischen Zellen oder Zellkulturen.
JP6095645B2 (ja) 2012-03-21 2017-03-15 オリンパス株式会社 標的核酸分子の検出方法
EP2840381B1 (en) 2012-04-18 2017-08-09 Olympus Corporation Method for detecting target particles
WO2013157319A1 (ja) 2012-04-18 2013-10-24 オリンパス株式会社 光分析を用いた単一粒子検出装置、単一粒子検出方法及び単一粒子検出用コンピュータプログラム
CN102841083B (zh) * 2012-06-11 2014-08-20 北京大学 一种激光扫描位相显微成像方法及系统
US8654352B1 (en) * 2012-08-08 2014-02-18 Asm Technology Singapore Pte Ltd Chromatic confocal scanning apparatus
CN104155279B (zh) * 2013-05-13 2017-04-26 中国科学院大连化学物理研究所 一种线形共聚焦紫外拉曼光谱仪
WO2015015951A1 (ja) 2013-07-31 2015-02-05 オリンパス株式会社 単一発光粒子検出技術を用いた光学顕微鏡装置、顕微鏡観察法及び顕微鏡観察のためのコンピュータプログラム
CN105593667A (zh) 2013-10-07 2016-05-18 奥林巴斯株式会社 利用单个发光粒子检测的光分析装置、光分析方法以及光分析用计算机程序
US10677734B2 (en) 2014-09-05 2020-06-09 Thermo Fisher Scientific Oy Method and apparatus for optical measurement of liquid sample
CN104296684B (zh) * 2014-11-05 2016-11-30 哈尔滨工业大学 基于表面镀膜共焦显微形貌测量装置的膜厚误差校正方法
GB2534402A (en) * 2015-01-22 2016-07-27 Idea Biomedical Ltd Auto-focussing method and device
CN104677884B (zh) * 2015-03-17 2017-07-11 北京理工大学 高空间分辨激光分光瞳差动共焦质谱显微成像方法与装置
CN104697452A (zh) * 2015-03-24 2015-06-10 宁波高新区零零七工业设计有限公司 激光成像系统
US9599807B2 (en) * 2015-06-30 2017-03-21 General Electric Company Optical microscope and method for detecting lens immersion
JPWO2017098597A1 (ja) 2015-12-09 2018-10-11 オリンパス株式会社 単一発光粒子検出を用いた光分析方法及び光分析装置
LU93022B1 (de) * 2016-04-08 2017-11-08 Leica Microsystems Verfahren und Mikroskop zum Untersuchen einer Probe
CN108061964B (zh) * 2017-10-25 2020-03-27 中国科学技术大学 一种可用于大样品的高速三维显微成像装置和方法
CN108319008B (zh) * 2018-02-02 2019-11-12 华中科技大学 一种光学显微成像方法及装置
CN108680542B (zh) * 2018-03-26 2020-01-10 华中科技大学 一种阵列式线扫描荧光显微成像装置
CN108445619A (zh) * 2018-05-11 2018-08-24 中国工程物理研究院流体物理研究所 光学扫描系统及方法
CN111722389B (zh) * 2019-03-18 2025-07-29 重庆旺隆仁供应链管理有限公司 一种高荧光收集率的微型内窥镜
EP4097634A1 (en) * 2020-01-31 2022-12-07 Stellenbosch University Method for determining mitochondrial events
CN111239047B (zh) * 2020-03-09 2023-10-27 深圳中科飞测科技股份有限公司 一种光学设备及实现自动聚焦的方法
GB2593194B (en) * 2020-03-18 2022-09-07 Refeyn Ltd Methods and apparatus for optimised interferometric scattering microscopy
WO2022056385A1 (en) 2020-09-14 2022-03-17 Singular Genomics Systems, Inc. Methods and systems for multidimensional imaging
KR102447224B1 (ko) * 2020-10-26 2022-09-27 한국생산기술연구원 미세 입자의 정성 및 정량 분석 장치
KR102766494B1 (ko) * 2021-12-30 2025-02-12 한국광기술원 홀로그래픽 이미지 센서를 포함한 홀로그래픽 현미경
CN114813706B (zh) * 2022-06-29 2022-12-13 国科大杭州高等研究院 一种血细胞高光谱光镊捕获能量共振转移分析仪

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63306413A (ja) * 1987-06-09 1988-12-14 Olympus Optical Co Ltd 走査型光学顕微鏡
US4844617A (en) * 1988-01-20 1989-07-04 Tencor Instruments Confocal measuring microscope with automatic focusing
US5020891A (en) * 1988-09-14 1991-06-04 Washington University Single aperture confocal scanning biomicroscope and kit for converting single lamp biomicroscope thereto
US5034613A (en) * 1989-11-14 1991-07-23 Cornell Research Foundation, Inc. Two-photon laser microscopy
US5274240A (en) * 1990-01-12 1993-12-28 The Regents Of The University Of California Capillary array confocal fluorescence scanner and method
GB9015793D0 (en) * 1990-07-18 1990-09-05 Medical Res Council Confocal scanning optical microscope
JPH04221917A (ja) * 1990-12-25 1992-08-12 Tamron Co Ltd 顕微鏡の自動焦点調節方法およびその装置
US5162641A (en) * 1991-02-19 1992-11-10 Phoenix Laser Systems, Inc. System and method for detecting, correcting and measuring depth movement of target tissue in a laser surgical system
US5784162A (en) * 1993-08-18 1998-07-21 Applied Spectral Imaging Ltd. Spectral bio-imaging methods for biological research, medical diagnostics and therapy
US5465147A (en) * 1991-04-29 1995-11-07 Massachusetts Institute Of Technology Method and apparatus for acquiring images using a ccd detector array and no transverse scanner
JPH05188301A (ja) * 1991-09-09 1993-07-30 Sumitomo Electric Ind Ltd レーザ顕微鏡
JPH05332733A (ja) * 1992-05-27 1993-12-14 Hitachi Ltd 検出光学系並びに立体形状検出方法
JPH07128596A (ja) * 1993-09-08 1995-05-19 Nikon Corp コンフォーカル顕微鏡
US5587832A (en) * 1993-10-20 1996-12-24 Biophysica Technologies, Inc. Spatially light modulated confocal microscope and method
JP3450406B2 (ja) * 1994-03-10 2003-09-22 オリンパス光学工業株式会社 観察画像の位置調整装置及び走査型光学顕微鏡
JPH07281100A (ja) * 1994-04-05 1995-10-27 Nikon Corp オートフォーカス顕微鏡用の挟持標本体
US5515864A (en) * 1994-04-21 1996-05-14 Zuckerman; Ralph Method and apparatus for the in vivo measurement of oxygen concentration levels by the indirect determination of fluoescence lifetime
WO1997043611A1 (en) * 1996-05-16 1997-11-20 Affymetrix, Inc. Systems and methods for detection of labeled materials
US5900949A (en) * 1996-05-23 1999-05-04 Hewlett-Packard Company CCD imager for confocal scanning microscopy
US5880465A (en) * 1996-05-31 1999-03-09 Kovex Corporation Scanning confocal microscope with oscillating objective lens
US5915048A (en) * 1996-06-05 1999-06-22 Zetetic Institute Method and apparatus for discriminating in-focus images from out-of-focus light signals from background and foreground light sources
JPH09329749A (ja) * 1996-06-11 1997-12-22 Nikon Corp 光走査型顕微鏡
DE19627568A1 (de) * 1996-07-09 1998-01-15 Zeiss Carl Jena Gmbh Anordnung und Verfahren zur konfokalen Mikroskopie
DE19632594A1 (de) * 1996-08-13 1998-02-19 Johannes Prof Dr Schwider Konfokales Mikroskop unter Anwendung von refraktiven Mikrolinsen-Feldern
US5760901A (en) * 1997-01-28 1998-06-02 Zetetic Institute Method and apparatus for confocal interference microscopy with background amplitude reduction and compensation
JP3816632B2 (ja) * 1997-05-14 2006-08-30 オリンパス株式会社 走査型顕微鏡

Also Published As

Publication number Publication date
JP4812937B2 (ja) 2011-11-09
NO20004601L (no) 2000-11-10
CN1301357A (zh) 2001-06-27
WO1999047963A8 (en) 1999-11-18
AU758571B2 (en) 2003-03-27
WO1999047963A9 (en) 1999-12-23
KR100560588B1 (ko) 2006-03-16
JP2002507762A (ja) 2002-03-12
NO20004601D0 (no) 2000-09-15
BR9908767A (pt) 2001-10-16
CN100380160C (zh) 2008-04-09
KR20050088500A (ko) 2005-09-06
EP1064579A1 (en) 2001-01-03
CA2324262C (en) 2010-05-25
CA2324262A1 (en) 1999-09-23
AU3354799A (en) 1999-10-11
IL138496A0 (en) 2001-10-31
WO1999047963A1 (en) 1999-09-23
KR20010041945A (ko) 2001-05-25
KR100618502B1 (ko) 2006-09-01
BR9908767B1 (pt) 2011-09-06
EP1064579A4 (en) 2007-11-07

Similar Documents

Publication Publication Date Title
IL138496A0 (en) Confocal microscopy imaging system
AU2421101A (en) Confocal imaging
GB2321517B (en) Confocal microscopic equipment
GB2367905B (en) Imaging optical system
GB2299235B (en) Arrangement for confocal fluorescence microscopy
EP1240535A4 (en) COMPOSITION OF MICROSCOPE
GB2352827B (en) Laser-scanning microscope
AU4099799A (en) Heterodyne confocal microscopy
AU8275798A (en) Fluorescence imaging system
GB2349033B (en) Signal enhancement for fluorescence microscopy
AU6184196A (en) Confocal ultrasonic imaging system
GB2322206B (en) Confocal microspectrometer system
GB9815702D0 (en) Improved imaging system for fluorescence assays
IL133052A0 (en) Imaging system
GB2353859B (en) Imaging system
GB9815701D0 (en) Improved imaging system for fluorescence assays
GB9809736D0 (en) Objective lens system
AU2003204937A1 (en) Confocal microscopy imaging system
GB9810341D0 (en) Optical imaging system
GB9803355D0 (en) Confocal imaging
CA84377S (en) Microscope case
GB2339923B (en) Optical imaging system
GB9703342D0 (en) Confocal imaging
GB9602051D0 (en) Confocal imaging
CA83967S (en) Microscope