IL155712A0 - Aminothiazoles and their use as adenosine receptor antagonists - Google Patents
Aminothiazoles and their use as adenosine receptor antagonistsInfo
- Publication number
- IL155712A0 IL155712A0 IL15571201A IL15571201A IL155712A0 IL 155712 A0 IL155712 A0 IL 155712A0 IL 15571201 A IL15571201 A IL 15571201A IL 15571201 A IL15571201 A IL 15571201A IL 155712 A0 IL155712 A0 IL 155712A0
- Authority
- IL
- Israel
- Prior art keywords
- aminothiazoles
- receptor antagonists
- adenosine receptor
- adenosine
- antagonists
- Prior art date
Links
- RAIPHJJURHTUIC-UHFFFAOYSA-N 1,3-thiazol-2-amine Chemical class NC1=NC=CS1 RAIPHJJURHTUIC-UHFFFAOYSA-N 0.000 title 1
- 229940121359 adenosine receptor antagonist Drugs 0.000 title 1
- 239000000296 purinergic P1 receptor antagonist Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0028383.8A GB0028383D0 (en) | 2000-11-21 | 2000-11-21 | Organic compounds |
| PCT/EP2001/013378 WO2002042298A1 (en) | 2000-11-21 | 2001-11-19 | Aminothiazoles and their use as adenosine receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL155712A0 true IL155712A0 (en) | 2003-11-23 |
Family
ID=9903594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15571201A IL155712A0 (en) | 2000-11-21 | 2001-11-19 | Aminothiazoles and their use as adenosine receptor antagonists |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7109202B2 (sk) |
| EP (1) | EP1339711B1 (sk) |
| JP (1) | JP3973556B2 (sk) |
| KR (1) | KR20040007412A (sk) |
| CN (1) | CN1244580C (sk) |
| AR (1) | AR035371A1 (sk) |
| AT (1) | ATE300536T1 (sk) |
| AU (1) | AU2002237221A1 (sk) |
| BR (1) | BR0115478A (sk) |
| CA (1) | CA2429442A1 (sk) |
| CZ (1) | CZ20031393A3 (sk) |
| DE (1) | DE60112322T2 (sk) |
| EC (1) | ECSP034611A (sk) |
| ES (1) | ES2246346T3 (sk) |
| GB (1) | GB0028383D0 (sk) |
| HU (1) | HUP0302079A2 (sk) |
| IL (1) | IL155712A0 (sk) |
| MX (1) | MXPA03004439A (sk) |
| NO (1) | NO20032277L (sk) |
| NZ (1) | NZ525875A (sk) |
| PE (1) | PE20020580A1 (sk) |
| PL (1) | PL361842A1 (sk) |
| RU (1) | RU2003117476A (sk) |
| SK (1) | SK6032003A3 (sk) |
| WO (1) | WO2002042298A1 (sk) |
| ZA (1) | ZA200303721B (sk) |
Families Citing this family (121)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020115635A1 (en) * | 2001-02-21 | 2002-08-22 | Pnina Fishman | Modulation of GSK-3beta activity and its different uses |
| EP1452530A4 (en) * | 2001-12-03 | 2005-11-30 | Japan Tobacco Inc | AZOL CONNECTION AND THEIR MEDICAL USE |
| DK1466912T3 (da) * | 2002-01-18 | 2013-07-01 | Astellas Pharma Inc | 2-acylaminothiazolderivat eller salt deraf |
| AR044519A1 (es) | 2003-05-02 | 2005-09-14 | Novartis Ag | Derivados de piridin-tiazol amina y de pirimidin-tiazol amina |
| TW200524887A (en) * | 2003-10-27 | 2005-08-01 | Lundbeck & Co As H | N-thiazol-2-yl-benzamide derivatives |
| AU2004309279B2 (en) * | 2003-12-26 | 2010-07-15 | Kyowa Kirin Co., Ltd. | Thiazole derivative |
| GB0401336D0 (en) * | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
| GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
| GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
| PE20060272A1 (es) * | 2004-05-24 | 2006-05-22 | Glaxo Group Ltd | (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a |
| GB0417910D0 (en) * | 2004-08-11 | 2004-09-15 | Novartis Ag | Organic compounds |
| EA200700707A1 (ru) * | 2004-09-22 | 2007-08-31 | Х. Лундбекк А/С | Производные 2-ациламинотиазола |
| SG155924A1 (en) * | 2004-09-22 | 2009-10-29 | Lundbeck & Co As H | 2-acylaminothiazole derivatives |
| GT200500281A (es) | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
| GB0424284D0 (en) | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
| GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
| GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
| US7674912B2 (en) | 2005-04-25 | 2010-03-09 | H. Lundbeck A/S | Pro-drugs of N-thiazol-2-yl-benzamide derivatives |
| CN101247807A (zh) * | 2005-05-09 | 2008-08-20 | 艾其林医药公司 | 噻唑化合物及使用方法 |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| JP2008543754A (ja) * | 2005-06-09 | 2008-12-04 | メルク エンド カムパニー インコーポレーテッド | チェックポイントキナーゼの阻害剤 |
| US20100280023A1 (en) * | 2005-06-23 | 2010-11-04 | Kyowa Hakko Kogyo Co., Ltd. | Thiazole derivatives |
| GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| ES2270715B1 (es) | 2005-07-29 | 2008-04-01 | Laboratorios Almirall S.A. | Nuevos derivados de pirazina. |
| HUE034666T2 (hu) * | 2005-08-02 | 2018-02-28 | Kyowa Hakko Kirin Co Ltd | Szer alvászavar kezelésére és/vagy megelõzésére |
| GB0516313D0 (en) | 2005-08-08 | 2005-09-14 | Argenta Discovery Ltd | Azole derivatives and their uses |
| US7994211B2 (en) | 2005-08-08 | 2011-08-09 | Argenta Discovery Limited | Bicyclo[2.2.1]hept-7-ylamine derivatives and their uses |
| JP5341516B2 (ja) * | 2005-09-13 | 2013-11-13 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ２−アニリン−４−アリール置換チアゾール誘導体 |
| ES2274712B1 (es) | 2005-10-06 | 2008-03-01 | Laboratorios Almirall S.A. | Nuevos derivados imidazopiridina. |
| MY144906A (en) | 2005-10-21 | 2011-11-30 | Novartis Ag | Human antibodies against il13 and therapeutic uses |
| US20070203153A1 (en) * | 2005-11-08 | 2007-08-30 | Astellas Pharma Inc. | Compositions and methods for treating thrombocytopenia |
| GB0526244D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
| RU2457842C2 (ru) * | 2006-03-17 | 2012-08-10 | Гайлид Пало Альто, Инк. | Способ предотвращения и лечения болезни печени с использованием антагонистов рецептора аденозина a2b |
| WO2007118149A2 (en) * | 2006-04-07 | 2007-10-18 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical Lollege | Thiazole and thiophene analogues, and their use in treating autoimmune diseases and cancers |
| RU2457209C2 (ru) | 2006-04-21 | 2012-07-27 | Новартис Аг | Производные пурина, предназначенные для применения в качестве агонистов аденозинового рецептора а2а |
| JP2010500361A (ja) * | 2006-08-08 | 2010-01-07 | アカークス，インコーポレーテッド | ヒトの血小板レベルを増加させるための組成物および方法 |
| MX2009003185A (es) | 2006-09-29 | 2009-04-03 | Novartis Ag | Pirazolopirimidinas como inhibidores de lipido cinasa pi3k. |
| AU2007315234A1 (en) | 2006-10-30 | 2008-05-08 | Novartis Ag | Heterocyclic compounds as antiinflammatory agents |
| HRP20110201T1 (hr) | 2007-01-10 | 2011-08-31 | Irm Llc | Spojevi i sastavi kao inhibitori proteaze kanalizirane aktivacije |
| DE602008005140D1 (de) | 2007-05-07 | 2011-04-07 | Novartis Ag | Organische verbindungen |
| MX2010004177A (es) | 2007-10-18 | 2010-05-03 | Janssen Pharmaceutica Nv | 1,2,4-triazoles trisustituidos. |
| JO2784B1 (en) | 2007-10-18 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | 5,3,1 - Triazole substitute derivative |
| AR069637A1 (es) | 2007-12-10 | 2010-02-10 | Novartis Ag | Derivados de pirazinas |
| CN101970405A (zh) | 2007-12-14 | 2011-02-09 | 普尔马金医疗(哮喘)有限公司 | 吲哚及其治疗用途 |
| CN101910153B (zh) | 2008-01-11 | 2014-01-22 | 诺华股份有限公司 | 作为激酶抑制剂的嘧啶类 |
| EP2244706B1 (en) * | 2008-02-25 | 2016-04-06 | Merck Patent GmbH | Glucokinase activators |
| ES2442932T3 (es) | 2008-03-19 | 2014-02-14 | Janssen Pharmaceutica N.V. | 1,2,4-Triazoles trisustituidos como moduladores de receptores nicotínicos de acetilcolina |
| CL2009001125A1 (es) | 2008-05-09 | 2011-02-11 | Janssen Pharmaceutica Nv | Compuestos derivados de pirazol trisustituido, moduladores alostericos positivos de los receptores ach nicotinicos; composicion farmaceutica que los comprende; proceso de preparacion de la composicion; y su uso en el tratamiento de enfermedades de snc o inflamatorias. |
| WO2009150137A2 (en) | 2008-06-10 | 2009-12-17 | Novartis Ag | Organic compounds |
| CN101747327B (zh) * | 2008-12-02 | 2013-03-27 | 中国人民解放军军事医学科学院毒物药物研究所 | 芳酰胺基噻唑类衍生物及其制备方法和用途 |
| PT2391366E (pt) | 2009-01-29 | 2013-02-05 | Novartis Ag | Benzimidazoles substituídos para o tratamento de astrocitomas |
| GB0902648D0 (en) | 2009-02-17 | 2009-04-01 | Argenta Discovery Ltd | Pharmaceutical compounds and compositions |
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2000
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2001
- 2001-11-19 IL IL15571201A patent/IL155712A0/xx unknown
- 2001-11-19 MX MXPA03004439A patent/MXPA03004439A/es unknown
- 2001-11-19 CZ CZ20031393A patent/CZ20031393A3/cs unknown
- 2001-11-19 EP EP01986395A patent/EP1339711B1/en not_active Expired - Lifetime
- 2001-11-19 US US10/432,302 patent/US7109202B2/en not_active Expired - Fee Related
- 2001-11-19 BR BR0115478-8A patent/BR0115478A/pt not_active Application Discontinuation
- 2001-11-19 NZ NZ525875A patent/NZ525875A/en unknown
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- 2001-11-19 HU HU0302079A patent/HUP0302079A2/hu unknown
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- 2001-11-19 RU RU2003117476/04A patent/RU2003117476A/ru not_active Application Discontinuation
- 2001-11-19 PL PL01361842A patent/PL361842A1/xx not_active Application Discontinuation
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- 2001-11-19 SK SK603-2003A patent/SK6032003A3/sk unknown
- 2001-11-19 CA CA002429442A patent/CA2429442A1/en not_active Abandoned
- 2001-11-19 KR KR10-2003-7006156A patent/KR20040007412A/ko not_active Ceased
- 2001-11-19 AT AT01986395T patent/ATE300536T1/de not_active IP Right Cessation
- 2001-11-19 AU AU2002237221A patent/AU2002237221A1/en not_active Abandoned
- 2001-11-19 DE DE60112322T patent/DE60112322T2/de not_active Expired - Lifetime
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| JP3973556B2 (ja) | 2007-09-12 |
| DE60112322D1 (de) | 2005-09-01 |
| CN1476447A (zh) | 2004-02-18 |
| NZ525875A (en) | 2004-11-26 |
| ES2246346T3 (es) | 2006-02-16 |
| AR035371A1 (es) | 2004-05-12 |
| PL361842A1 (en) | 2004-10-04 |
| CA2429442A1 (en) | 2002-05-30 |
| KR20040007412A (ko) | 2004-01-24 |
| HUP0302079A2 (hu) | 2003-09-29 |
| SK6032003A3 (en) | 2004-01-08 |
| CN1244580C (zh) | 2006-03-08 |
| NO20032277D0 (no) | 2003-05-20 |
| ATE300536T1 (de) | 2005-08-15 |
| MXPA03004439A (es) | 2003-08-19 |
| US7109202B2 (en) | 2006-09-19 |
| US20040053982A1 (en) | 2004-03-18 |
| GB0028383D0 (en) | 2001-01-03 |
| ECSP034611A (es) | 2003-06-25 |
| AU2002237221A1 (en) | 2002-06-03 |
| NO20032277L (no) | 2003-07-21 |
| EP1339711A1 (en) | 2003-09-03 |
| DE60112322T2 (de) | 2006-05-24 |
| EP1339711B1 (en) | 2005-07-27 |
| BR0115478A (pt) | 2004-02-17 |
| JP2004521871A (ja) | 2004-07-22 |
| ZA200303721B (en) | 2004-05-10 |
| CZ20031393A3 (cs) | 2003-08-13 |
| PE20020580A1 (es) | 2002-08-13 |
| RU2003117476A (ru) | 2005-02-10 |
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