IL142011A0 - Stable concentrated insulin preparations for pulmonary delivery - Google Patents

Stable concentrated insulin preparations for pulmonary delivery

Info

Publication number: IL142011A0
Authority: IL; Israel
Prior art keywords: pulmonary delivery; insulin preparations; stable concentrated; concentrated insulin; formulations
Prior art date: 1998-10-16

Application number

IL14201199A

Other languages

English (en)

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-16

Filing date

1999-10-15

Publication date

2002-03-10

1999-10-15 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2002-03-10 Publication of IL142011A0 publication Critical patent/IL142011A0/xx

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
102000004877 Insulin Human genes 0.000 title abstract 2
108090001061 Insulin Proteins 0.000 title abstract 2
229940125396 insulin Drugs 0.000 title abstract 2
230000002685 pulmonary effect Effects 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title 1
238000009472 formulation Methods 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
239000000126 substance Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Inorganic Chemistry (AREA)
Immunology (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Pulmonology (AREA)
Obesity (AREA)
Organic Chemistry (AREA)
Dispersion Chemistry (AREA)
Otolaryngology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

IL14201199A 1998-10-16 1999-10-15 Stable concentrated insulin preparations for pulmonary delivery IL142011A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DKPA199801327		1998-10-16
PCT/DK1999/000556 WO2000023098A1 (en)	1998-10-16	1999-10-15	Stable concentrated insulin preparations for pulmonary delivery

Publications (1)

Publication Number	Publication Date
IL142011A0 true IL142011A0 (en)	2002-03-10

Family

ID=8103620

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL14201199A IL142011A0 (en)	1998-10-16	1999-10-15	Stable concentrated insulin preparations for pulmonary delivery
IL142011A IL142011A (en)	1998-10-16	2001-03-14	Stable concentrated insulin preparations for pulmonary delivery

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL142011A IL142011A (en)	1998-10-16	2001-03-14	Stable concentrated insulin preparations for pulmonary delivery

Country Status (22)

Country	Link
EP (2)	EP1172114B1 (pt)
JP (1)	JP4212240B2 (pt)
KR (1)	KR100617286B1 (pt)
CN (1)	CN1210058C (pt)
AT (2)	ATE277630T1 (pt)
AU (1)	AU758146B2 (pt)
BR (1)	BR9914585A (pt)
CA (1)	CA2346969A1 (pt)
CZ (1)	CZ20011134A3 (pt)
DE (2)	DE69920767T2 (pt)
DK (2)	DK1172114T3 (pt)
ES (2)	ES2177323T3 (pt)
HU (1)	HUP0104111A3 (pt)
IL (2)	IL142011A0 (pt)
NO (1)	NO323365B1 (pt)
PL (1)	PL197504B1 (pt)
PT (2)	PT1121144E (pt)
RU (1)	RU2218935C2 (pt)
TW (1)	TWI223597B (pt)
UA (1)	UA65636C2 (pt)
WO (1)	WO2000023098A1 (pt)
ZA (1)	ZA200102105B (pt)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5783556A (en) *	1996-08-13	1998-07-21	Genentech, Inc.	Formulated insulin-containing composition
DE10114178A1 (de)	2001-03-23	2002-10-10	Aventis Pharma Gmbh	Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
EP1270012A1 (en) *	2001-06-21	2003-01-02	Pfizer Products Inc.	Use of pulmonary administration of insulin for treatment of diabetes
EP1506230B1 (en) *	2002-05-07	2011-01-19	Novo Nordisk A/S	Soluble formulations comprising monomeric insulin and acylated insulin
DE10227232A1 (de)	2002-06-18	2004-01-15	Aventis Pharma Deutschland Gmbh	Saure Insulinzubereitungen mit verbesserter Stabilität
KR101235507B1 (ko) *	2003-02-28	2013-02-20	추가이 세이야쿠 가부시키가이샤	단백질을 함유하는 안정화 제제
AU2004218808A1 (en) *	2003-03-11	2004-09-23	Novo Nordisk A/S	Pharmaceutical preparations comprising acid-stabilised insulin
EP2107069B1 (en)	2003-08-05	2013-01-16	Novo Nordisk A/S	Novel insulin derivatives
PL1969004T3 (pl) *	2005-12-28	2012-01-31	Novo Nordisk As	Kompozycje zawierające acylowaną insulinę i cynk oraz sposób wytwarzania tych kompozycji
WO2008015099A2 (en)	2006-07-31	2008-02-07	Novo Nordisk A/S	Pegylated, extended insulins
JP5864834B2 (ja)	2006-09-22	2016-02-17	ノボ・ノルデイスク・エー／エス	プロテアーゼ耐性のインスリンアナログ
WO2008132229A2 (en) *	2007-04-30	2008-11-06	Novo Nordisk A/S	Highly concentrated insulin solutions and compositions
ES2563038T3 (es)	2007-04-30	2016-03-10	Novo Nordisk A/S	Método para secar una composición proteica, una composición proteica seca y una composición farmacéutica que comprende la proteína seca
WO2008152106A1 (en)	2007-06-13	2008-12-18	Novo Nordisk A/S	Pharmaceutical formulation comprising an insulin derivative
CN101970477B (zh)	2008-03-14	2014-12-31	诺沃-诺迪斯克有限公司	蛋白酶稳定的胰岛素类似物
JP5749155B2 (ja)	2008-03-18	2015-07-15	ノボ・ノルデイスク・エー／エス	プロテアーゼ安定化アシル化インスリンアナログ
AU2011235959C1 (en) *	2008-06-13	2013-10-10	Eli Lilly And Company	PEGylated insulin lispro compounds
TWI451876B (zh) *	2008-06-13	2014-09-11	Lilly Co Eli	聚乙二醇化之離脯胰島素化合物
PT2349324T (pt)	2008-10-17	2017-12-06	Sanofi Aventis Deutschland	Combinação de uma insulina e de um agonista do glp-1
KR20110085985A (ko)	2008-10-30	2011-07-27	노보 노르디스크 에이/에스	하루 한번 주사 빈도보다 적은 인슐린 주사를 사용한 진성 당뇨병의 치료
SG10201500871TA (en)	2009-11-13	2015-04-29	Sanofi Aventis Deutschland	Pharmaceutical composition comprising a glp-1 agonist and methionine
WO2011058083A1 (de)	2009-11-13	2011-05-19	Sanofi-Aventis Deutschland Gmbh	Pharmazeutische zusammensetzung umfassend einen glp-1-agonisten, ein insulin und methionin
RS55378B1 (sr)	2010-08-30	2017-03-31	Sanofi Aventis Deutschland	Upotreba ave0010 za proizvodnju leka za tretman diabetes mellitus tipa 2
DK2632478T3 (da)	2010-10-27	2019-10-07	Novo Nordisk As	Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
HRP20151068T1 (hr)	2011-08-29	2016-01-01	Sanofi-Aventis Deutschland Gmbh	Farmaceutska kombinacija za upotrebu za glikemijsku kontrolu kod pacijenata s dijabetesom tipa 2
AR087744A1 (es)	2011-09-01	2014-04-16	Sanofi Aventis Deutschland	Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
BR112014025132A2 (pt)	2012-04-11	2017-07-11	Novo Nordisk As	formulações de insulina
WO2014102623A1 (en) *	2012-12-26	2014-07-03	Wockhardt Limited	Pharmaceutical composition
AU2014247167B2 (en)	2013-04-03	2018-11-22	Sanofi	Treatment of diabetes mellitus by long–acting formulations of insulins
EP2991672A1 (en)	2013-04-30	2016-03-09	Novo Nordisk A/S	Novel administration regime
ES2676065T3 (es)	2013-10-07	2018-07-16	Novo Nordisk A/S	Nuevo derivado de un análogo de la insulina
TWI758239B (zh)	2014-12-12	2022-03-21	德商賽諾菲阿凡提斯德意志有限公司	甘精胰島素/利司那肽固定比率配製劑
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
GB201607918D0 (en)	2016-05-06	2016-06-22	Arecor Ltd	Novel formulations
HUE060149T2 (hu)	2016-12-16	2023-02-28	Novo Nordisk As	Inzulint tartalmazó gyógyászati készítmények
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
US12343383B2 (en)	2019-07-12	2025-07-01	Novo Nordisk A/S	High concentration insulin formulation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI78616C (fi) *	1982-02-05	1989-09-11	Novo Industri As	Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt.
US5506203C1 (en) *	1993-06-24	2001-02-06	Astra Ab	Systemic administration of a therapeutic preparation
US5474978A (en) *	1994-06-16	1995-12-12	Eli Lilly And Company	Insulin analog formulations
US5504188A (en) *	1994-06-16	1996-04-02	Eli Lilly And Company	Preparation of stable zinc insulin analog crystals
ES2292189T3 (es) *	1996-06-20	2008-03-01	Novo Nordisk A/S	Preparaciones a base de insulina conteniendo manitol.
ATE219942T1 (de) *	1997-03-20	2002-07-15	Novo Nordisk As	Therapeutische pulverformulierung zur pulmonaren anwendung, welche kristallines insulin enthält
AU6611898A (en) *	1997-03-20	1998-10-20	Novo Nordisk A/S	Method for preparation of a therapeutic powder through coprecipitation of insulin and absorption enhancer

1999
- 1999-10-15 PT PT99948725T patent/PT1121144E/pt unknown
- 1999-10-15 AT AT01126054T patent/ATE277630T1/de not_active IP Right Cessation
- 1999-10-15 DE DE69920767T patent/DE69920767T2/de not_active Expired - Lifetime
- 1999-10-15 ES ES99948725T patent/ES2177323T3/es not_active Expired - Lifetime
- 1999-10-15 AU AU61889/99A patent/AU758146B2/en not_active Ceased
- 1999-10-15 UA UA2001042148A patent/UA65636C2/uk unknown
- 1999-10-15 CN CNB998122084A patent/CN1210058C/zh not_active Expired - Fee Related
- 1999-10-15 PT PT01126054T patent/PT1172114E/pt unknown
- 1999-10-15 BR BR9914585-5A patent/BR9914585A/pt not_active Application Discontinuation
- 1999-10-15 CA CA002346969A patent/CA2346969A1/en not_active Abandoned
- 1999-10-15 KR KR1020017004702A patent/KR100617286B1/ko not_active Expired - Fee Related
- 1999-10-15 HU HU0104111A patent/HUP0104111A3/hu unknown
- 1999-10-15 PL PL347210A patent/PL197504B1/pl not_active IP Right Cessation
- 1999-10-15 IL IL14201199A patent/IL142011A0/xx active IP Right Grant
- 1999-10-15 DK DK01126054T patent/DK1172114T3/da active
- 1999-10-15 DE DE69901726T patent/DE69901726T2/de not_active Expired - Lifetime
- 1999-10-15 EP EP01126054A patent/EP1172114B1/en not_active Expired - Lifetime
- 1999-10-15 CZ CZ20011134A patent/CZ20011134A3/cs unknown
- 1999-10-15 WO PCT/DK1999/000556 patent/WO2000023098A1/en not_active Ceased
- 1999-10-15 JP JP2000576871A patent/JP4212240B2/ja not_active Expired - Fee Related
- 1999-10-15 DK DK99948725T patent/DK1121144T3/da active
- 1999-10-15 RU RU2001113271/14A patent/RU2218935C2/ru not_active IP Right Cessation
- 1999-10-15 AT AT99948725T patent/ATE218364T1/de not_active IP Right Cessation
- 1999-10-15 EP EP99948725A patent/EP1121144B1/en not_active Expired - Lifetime
- 1999-10-15 ES ES01126054T patent/ES2228728T3/es not_active Expired - Lifetime
- 1999-10-20 TW TW088118264A patent/TWI223597B/zh not_active IP Right Cessation
2001
- 2001-03-14 ZA ZA200102105A patent/ZA200102105B/xx unknown
- 2001-03-14 IL IL142011A patent/IL142011A/en not_active IP Right Cessation
- 2001-04-10 NO NO20011842A patent/NO323365B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP1121144B1 (en)	2002-06-05
TWI223597B (en)	2004-11-11
ES2228728T3 (es)	2005-04-16
HUP0104111A3 (en)	2002-05-28
DK1121144T3 (da)	2002-09-23
EP1172114B1 (en)	2004-09-29
AU6188999A (en)	2000-05-08
BR9914585A (pt)	2001-07-03
EP1172114A2 (en)	2002-01-16
ATE218364T1 (de)	2002-06-15
JP4212240B2 (ja)	2009-01-21
CZ20011134A3 (cs)	2001-08-15
KR20010075631A (ko)	2001-08-09
PL347210A1 (en)	2002-03-25
AU758146B2 (en)	2003-03-13
JP2002527487A (ja)	2002-08-27
NO20011842D0 (no)	2001-04-10
PL197504B1 (pl)	2008-04-30
HUP0104111A2 (hu)	2002-04-29
CN1323219A (zh)	2001-11-21
DE69920767D1 (de)	2004-11-04
ES2177323T3 (es)	2002-12-01
EP1121144A1 (en)	2001-08-08
NO20011842L (no)	2001-06-15
PT1172114E (pt)	2005-02-28
DE69901726D1 (de)	2002-07-11
DE69901726T2 (de)	2002-12-19
EP1172114A3 (en)	2003-07-23
PT1121144E (pt)	2002-11-29
IL142011A (en)	2007-07-04
ZA200102105B (en)	2001-10-12
CN1210058C (zh)	2005-07-13
WO2000023098A1 (en)	2000-04-27
KR100617286B1 (ko)	2006-08-30
CA2346969A1 (en)	2000-04-27
ATE277630T1 (de)	2004-10-15
DE69920767T2 (de)	2006-02-02
RU2218935C2 (ru)	2003-12-20
NO323365B1 (no)	2007-04-10
UA65636C2 (uk)	2004-04-15
DK1172114T3 (da)	2005-01-24

Publication	Publication Date	Title
PL347210A1 (en)	2002-03-25	Stable concentrated insulin preparations for pulmonary delivery
NO20010013L (no)	2001-03-01	Svovelsubstituerte sulfonylaminokarboksylsyre N-arylamider, deres fremstilling og anvendelse samt farmasöytiske preparater inneholdende forbindelsene
ZA975470B (en)	1997-12-22	Insulin preparations containing naci.
PH30982A (en)	1997-12-23	Optically active 5H-pyrrolo Ä3,4-bÜ pyrazine derivative, its preparation and pharmaceutical compositions containing it.
DE69914934D1 (de)	2004-03-25	Stabile wässrige insulinzubereitungen ohne phenol und kresol
GR3030529T3 (en)	1999-10-29	Stabilized medicinal aerosol solution formulations.
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