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IL145952A0 - Polymorphs of crystalline (2-benzhydryl-1-azabicyclo [2.2.2.] oct-3-yl) - (5-iso-propyl-2-methoxybenzyl) - amine citrate as nk-1 receptor antagonists - Google Patents

Polymorphs of crystalline (2-benzhydryl-1-azabicyclo [2.2.2.] oct-3-yl) - (5-iso-propyl-2-methoxybenzyl) - amine citrate as nk-1 receptor antagonists

Info

Publication number
IL145952A0
IL145952A0 IL14595200A IL14595200A IL145952A0 IL 145952 A0 IL145952 A0 IL 145952A0 IL 14595200 A IL14595200 A IL 14595200A IL 14595200 A IL14595200 A IL 14595200A IL 145952 A0 IL145952 A0 IL 145952A0
Authority
IL
Israel
Prior art keywords
benzhydryl
azabicyclo
polymorphs
methoxybenzyl
iso
Prior art date
Application number
IL14595200A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of IL145952A0 publication Critical patent/IL145952A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL14595200A 1999-06-01 2000-05-17 Polymorphs of crystalline (2-benzhydryl-1-azabicyclo [2.2.2.] oct-3-yl) - (5-iso-propyl-2-methoxybenzyl) - amine citrate as nk-1 receptor antagonists IL145952A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13699599P 1999-06-01 1999-06-01
PCT/IB2000/000663 WO2000073303A1 (en) 1999-06-01 2000-05-17 Polymorphs of crystalline (2-benzhydryl-1-azabicyclo[2.2.2]oct-3-yl)-(5-isopropyl-2-methoxybenzyl)-amine citrate as nk-1 receptor antagonists

Publications (1)

Publication Number Publication Date
IL145952A0 true IL145952A0 (en) 2002-07-25

Family

ID=22475353

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14595200A IL145952A0 (en) 1999-06-01 2000-05-17 Polymorphs of crystalline (2-benzhydryl-1-azabicyclo [2.2.2.] oct-3-yl) - (5-iso-propyl-2-methoxybenzyl) - amine citrate as nk-1 receptor antagonists

Country Status (38)

Country Link
US (1) US6387925B1 (es)
EP (1) EP1181289A1 (es)
JP (1) JP2003501353A (es)
KR (1) KR20020005055A (es)
CN (1) CN1353712A (es)
AP (1) AP2001002350A0 (es)
AR (1) AR029753A1 (es)
AU (1) AU767331B2 (es)
BG (1) BG106139A (es)
BR (1) BR0011125A (es)
CA (1) CA2372236A1 (es)
CO (1) CO5170468A1 (es)
CR (1) CR6513A (es)
CZ (1) CZ20014270A3 (es)
DZ (1) DZ3051A1 (es)
EA (1) EA004206B1 (es)
EE (1) EE200100655A (es)
GT (1) GT200000086A (es)
HK (1) HK1046407A1 (es)
HN (1) HN2000000076A (es)
HR (1) HRP20010884A2 (es)
HU (1) HUP0201798A3 (es)
IL (1) IL145952A0 (es)
IS (1) IS6129A (es)
MX (1) MXPA01012328A (es)
NO (1) NO20015845L (es)
NZ (1) NZ514762A (es)
OA (1) OA11955A (es)
PA (1) PA8496001A1 (es)
PE (1) PE20010155A1 (es)
PL (1) PL352715A1 (es)
SK (1) SK17342001A3 (es)
SV (1) SV2002000092A (es)
TN (1) TNSN00119A1 (es)
TR (1) TR200103472T2 (es)
UY (1) UY26177A1 (es)
WO (1) WO2000073303A1 (es)
ZA (1) ZA200109839B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004031191A1 (en) * 2002-10-04 2004-04-15 Merck Sharp & Dohme Limited Azabicyclic spiroether derivatives as receptor antagonists
CA2529820A1 (en) * 2003-06-18 2004-12-29 Teva Pharmaceutical Industries Ltd Fluvastatin sodium crystal forms, processes for preparing them, compositions containing them and methods of using them
US7371906B2 (en) 2004-08-24 2008-05-13 Eastman Kodak Company Process for photo-oxidative stability improvements
US9446029B2 (en) 2010-07-27 2016-09-20 Colorado State University Research Foundation Use of NK-1 receptor antagonists in management of visceral pain
CN110577522B (zh) * 2018-06-07 2022-12-27 东莞市东阳光动物保健药品有限公司 马罗匹坦柠檬酸盐新晶型及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005525A1 (en) * 1988-11-23 1990-05-31 Pfizer Inc. Quinuclidine derivatives as substance p antagonists
JPH0733386B2 (ja) * 1991-05-31 1995-04-12 フアイザー・インコーポレイテツド キヌクリジン誘導体
AU676489B2 (en) * 1992-11-12 1997-03-13 Pfizer Inc. Quinuclidine derivative as substance P antagonist
US5393762A (en) * 1993-06-04 1995-02-28 Pfizer Inc. Pharmaceutical agents for treatment of emesis
US6262067B1 (en) * 1999-06-22 2001-07-17 Pfizer Inc. Polymorphs of a crystalline azo-bicyclo 2,2,2 OCT-3-yl amine dihydrochloride and their pharmaceutical compositions

Also Published As

Publication number Publication date
EA200100982A1 (ru) 2002-06-27
AU767331B2 (en) 2003-11-06
NO20015845D0 (no) 2001-11-30
ZA200109839B (en) 2003-01-29
NO20015845L (no) 2002-01-30
KR20020005055A (ko) 2002-01-16
BG106139A (bg) 2002-05-31
UY26177A1 (es) 2000-12-29
IS6129A (is) 2001-10-26
JP2003501353A (ja) 2003-01-14
HK1046407A1 (zh) 2003-01-10
HN2000000076A (es) 2001-02-02
TNSN00119A1 (fr) 2005-11-10
CA2372236A1 (en) 2000-12-07
WO2000073303A1 (en) 2000-12-07
US6387925B1 (en) 2002-05-14
AR029753A1 (es) 2003-07-16
SV2002000092A (es) 2002-02-05
PA8496001A1 (es) 2002-07-30
EE200100655A (et) 2003-02-17
MXPA01012328A (es) 2002-07-30
BR0011125A (pt) 2002-02-19
HUP0201798A3 (en) 2002-10-28
TR200103472T2 (tr) 2002-05-21
OA11955A (en) 2006-04-13
EP1181289A1 (en) 2002-02-27
CO5170468A1 (es) 2002-06-27
CZ20014270A3 (cs) 2002-08-14
PE20010155A1 (es) 2001-02-08
SK17342001A3 (sk) 2002-10-08
NZ514762A (en) 2002-12-20
HUP0201798A2 (en) 2002-09-28
AU4424600A (en) 2000-12-18
DZ3051A1 (fr) 2004-03-27
CN1353712A (zh) 2002-06-12
EA004206B1 (ru) 2004-02-26
AP2001002350A0 (en) 2001-12-31
CR6513A (es) 2003-11-25
PL352715A1 (en) 2003-09-08
HRP20010884A2 (en) 2003-04-30
GT200000086A (es) 2001-11-21

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