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IL138160A0 - Quinoline derivatives - Google Patents

Quinoline derivatives

Info

Publication number
IL138160A0
IL138160A0 IL13816099A IL13816099A IL138160A0 IL 138160 A0 IL138160 A0 IL 138160A0 IL 13816099 A IL13816099 A IL 13816099A IL 13816099 A IL13816099 A IL 13816099A IL 138160 A0 IL138160 A0 IL 138160A0
Authority
IL
Israel
Prior art keywords
quinoline derivatives
quinoline
derivatives
Prior art date
Application number
IL13816099A
Other languages
English (en)
Original Assignee
Active Biotech Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Active Biotech Ab filed Critical Active Biotech Ab
Publication of IL138160A0 publication Critical patent/IL138160A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL13816099A 1998-04-27 1999-04-26 Quinoline derivatives IL138160A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9801474A SE9801474D0 (sv) 1998-04-27 1998-04-27 Quinoline Derivatives
PCT/SE1999/000676 WO1999055678A1 (fr) 1998-04-27 1999-04-26 Derives de quinoline

Publications (1)

Publication Number Publication Date
IL138160A0 true IL138160A0 (en) 2001-10-31

Family

ID=20411103

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13816099A IL138160A0 (en) 1998-04-27 1999-04-26 Quinoline derivatives
IL138160A IL138160A (en) 1998-04-27 2000-08-30 Quinoline derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL138160A IL138160A (en) 1998-04-27 2000-08-30 Quinoline derivatives

Country Status (32)

Country Link
EP (1) EP1073639B1 (fr)
JP (1) JP4045069B2 (fr)
KR (1) KR100571534B1 (fr)
CN (1) CN1113057C (fr)
AP (1) AP1293A (fr)
AT (1) ATE228505T1 (fr)
AU (1) AU747550B2 (fr)
BR (1) BR9909925B1 (fr)
CA (1) CA2329788C (fr)
CZ (1) CZ297439B6 (fr)
DE (1) DE69904162T2 (fr)
DK (1) DK1073639T3 (fr)
EE (1) EE04275B1 (fr)
ES (1) ES2188242T3 (fr)
HR (1) HRP20000726B1 (fr)
HU (1) HU227709B1 (fr)
ID (1) ID26277A (fr)
IL (2) IL138160A0 (fr)
IS (1) IS2082B (fr)
ME (1) ME00870B (fr)
NO (1) NO315606B1 (fr)
NZ (1) NZ506641A (fr)
OA (1) OA11547A (fr)
PL (1) PL190441B1 (fr)
PT (1) PT1073639E (fr)
RS (1) RS50029B (fr)
RU (1) RU2197481C2 (fr)
SE (1) SE9801474D0 (fr)
TR (1) TR200003061T2 (fr)
UA (1) UA60354C2 (fr)
WO (1) WO1999055678A1 (fr)
ZA (1) ZA200004601B (fr)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0002320D0 (sv) * 1999-10-25 2000-06-21 Active Biotech Ab Malignant tumors
SE0201778D0 (sv) * 2002-06-12 2002-06-12 Active Biotech Ab Process for the manufacture of quinoline derivatives
KR100908655B1 (ko) 2002-11-27 2009-07-21 엘지디스플레이 주식회사 데이터 공급시간의 변조방법과 이를 이용한액정표시장치의 구동방법 및 장치
SE0400235D0 (sv) * 2004-02-06 2004-02-06 Active Biotech Ab New composition containing quinoline compounds
SE0401578D0 (sv) * 2004-06-18 2004-06-18 Active Biotech Ab Novel compounds
US7838522B2 (en) 2004-11-17 2010-11-23 Ares Trading S.A. Benzothiazole formulations and use thereof
RS52193B (sr) 2004-12-21 2012-10-31 Merck Serono Sa. Ciklični derivati sulfonil amina i njihova upotreba
DK1844032T3 (da) 2005-01-31 2011-10-24 Merck Serono Sa N-hydroxyamid-derivater og deres anvendelse
BRPI0613042A2 (pt) 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 jnk 억제제
AU2006286489B2 (en) 2005-09-01 2012-08-09 Ares Trading S.A. Treatment of optic neuritis
SI1937642T1 (sl) * 2005-10-19 2015-01-30 Teva Pharmaceutical Industries Ltd. Kristali natrijevega lakvinimoda in postopek za njihovo pripravo
CN101466379B (zh) * 2006-06-12 2012-10-31 泰华制药工业有限公司 稳定的拉喹莫德的制剂
EP2234485B1 (fr) 2007-12-20 2013-11-13 Teva Pharmaceutical Industries, Ltd. Préparations de laquinimod stables
KR20110048571A (ko) 2008-09-03 2011-05-11 테바 파마슈티컬 인더스트리즈 리미티드 면역 기능을 지닌 2―옥소―1,2―다이하이드로―퀴놀린 조절제
RS54707B1 (sr) * 2009-07-30 2016-08-31 Teva Pharmaceutical Industries Ltd. Tretman kronove bolesti lakvinimodom
PL2467372T3 (pl) * 2009-08-10 2017-04-28 Teva Pharmaceutical Industries Ltd. Leczenie zaburzeń związanych z BDNF z zastosowaniem lakwinimodu
US8889661B2 (en) * 2010-03-03 2014-11-18 Teva Pharmaceutical Industries, Ltd. Treatment of lupus nephritis using laquinimod
PH12012501741A1 (en) * 2010-03-03 2012-11-12 Teva Pharma Treatment of lupus arthritis using laquinimod
KR20130014523A (ko) 2010-03-03 2013-02-07 테바 파마슈티컬 인더스트리즈 리미티드 라퀴니모드 및 메토트렉세이트의 병용에 의한 류마티스 관절염의 치료
WO2011116091A1 (fr) 2010-03-17 2011-09-22 Novartis Ag Distributeur
AU2011275720B2 (en) * 2010-07-09 2015-05-14 Active Biotech Ab Method for manufacturing of quinoline-3-carboxamides
SG186948A1 (en) 2010-07-09 2013-02-28 Teva Pharma Deuterated n-ethyl-n-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof
KR20130041193A (ko) * 2010-07-09 2013-04-24 테바 파마슈티컬 인더스트리즈 리미티드 5-클로로-4-하이드록시-1-메틸-2-옥소-n-페닐-1,2-다이하이드로퀴놀린-3-카복스아마이드, 염 및 그의 용도
EP2444086A1 (fr) 2010-10-22 2012-04-25 Almirall, S.A. Combinaisons comportant des inhibiteurs de DHODH et de COX
US8889627B2 (en) 2011-10-12 2014-11-18 Teva Pharmaceutical Industries, Ltd. Treatment of multiple sclerosis with combination of laquinimod and fingolimod
US9161935B2 (en) * 2012-02-03 2015-10-20 Teva Pharmaceutical Industries, Ltd. Use of laquinimod for treating Crohn's disease patients who failed first-line anti-TNF therapy
EA201491517A1 (ru) 2012-02-16 2015-03-31 Тева Фармасьютикал Индастриз Лтд. N-этил-n-фенил-1,2-дигидро-4,5-дигидрокси-1-метил-2-оксо-3-хинолинкарбоксамид, его получение и применения
TW201350467A (zh) 2012-05-08 2013-12-16 Teva Pharma N-乙基-4-羥基-1-甲基-5-(甲基(2,3,4,5,6-五羥基己基)胺基)-2-側氧-n-苯基-1,2-二氫喹啉-3-甲醯胺
TW201400117A (zh) 2012-06-05 2014-01-01 Teva Pharma 使用拉喹莫德治療眼發炎疾病
TW201410244A (zh) 2012-08-13 2014-03-16 Teva Pharma 用於治療gaba媒介之疾病之拉喹莫德(laquinimod)
CN104955522A (zh) 2012-11-07 2015-09-30 梯瓦制药工业有限公司 拉喹莫德胺盐
RU2545056C2 (ru) * 2012-12-10 2015-03-27 Государственное бюджетное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия" Министерства здавоохранения и социального развития Российской Федерации (ГБОУ ВПО ПГФА Минздравсоцразвития России) Противовоспалительное и анальгетическое средство на основе изопропиламида 1,2-дигидро-1н-2-оксоцинхониновой кислоты
CA2900503A1 (fr) * 2013-02-15 2014-08-21 Teva Pharmaceutical Industries Ltd. Traitement de la sclerose en plaques a l'aide de laquinimod
WO2014153145A2 (fr) 2013-03-14 2014-09-25 Teva Pharmaceutical Industries Ltd. Cristaux de sodium de laquinimod et procédé amélioré pour leur fabrication
WO2015168103A1 (fr) 2014-04-29 2015-11-05 Teva Pharmaceutical Industries Ltd. Laquinimod pour le traitement de patients atteints de sclérose en plaques récurrente rémittente (sep-rr) chez ayant un degré d'incapacité élevé
WO2016042112A1 (fr) 2014-09-23 2016-03-24 Active Biotech Ab Quinoléine carboxamides destinées à être utilisées dans le traitement du myélome multiple
ES2663836T3 (es) 2014-11-19 2018-04-17 Active Biotech Ab Carboxamidas de quinolina para su uso en el tratamiento de leucemia
DK3886858T3 (da) * 2019-12-19 2022-08-22 Active Biotech Ab Forbindelser til behandling af øjensygdomme forbundet med for megen vaskularisering
WO2021175924A1 (fr) 2020-03-03 2021-09-10 Active Biotech Ab Tasquinimod ou sel pharmaceutiquement acceptable de celui-ci destiné à être utilisé en polythérapie
CA3179303A1 (fr) * 2020-05-21 2021-11-25 Darren Orton Inhibiteurs de notch et leurs utilisations
US20230293512A1 (en) 2020-07-23 2023-09-21 Erasmus University Medical Center Rotterdam S100 proteins as novel therapeutic targets in myeloproliferative neoplasms
JP2024503372A (ja) 2021-01-18 2024-01-25 アクティブ バイオテック エイビー 骨髄異形成症候群の処置における使用のためのタスキニモドまたはその薬学的に許容される塩
WO2022248401A1 (fr) 2021-05-25 2022-12-01 Active Biotech Ab Pluralité de particules de tasquinimod et utilisation de celles-ci
IL309486A (en) 2021-07-02 2024-02-01 Active Biotech Ab A pharmacy product containing tesquinimod and a method for evaluating the cleanliness of this product
AU2022421214A1 (en) * 2021-12-20 2024-07-04 The Johns Hopkins University Compounds for treatment of cancer
WO2025083549A1 (fr) 2023-10-16 2025-04-24 Sun Pharma Advanced Research Company Limited Méthodes et combinaisons d'inhibiteurs de la voie il-23 et de modulateurs de la voie de signalisation s1p pour le traitement de maladies auto-immunes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE52670B1 (en) * 1981-03-03 1988-01-20 Leo Ab Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation
SU1735288A1 (ru) * 1990-03-05 1992-05-23 Харьковский государственный фармацевтический институт Способ получени N-R-замещенных амидов 4-гидроксихинолон-2 карбоновой -3-кислоты
GB9108547D0 (en) * 1991-04-22 1991-06-05 Fujisawa Pharmaceutical Co Quinoline derivatives
DE4120646A1 (de) * 1991-06-22 1992-12-24 Bayer Ag 7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate
US5428040A (en) * 1993-08-31 1995-06-27 The Du Pont Merck Pharmaceutical Company Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents
SE9400810D0 (sv) * 1994-03-10 1994-03-10 Pharmacia Ab New use of Quinoline-3-carboxamide compounds

Also Published As

Publication number Publication date
PT1073639E (pt) 2003-04-30
DE69904162D1 (de) 2003-01-09
CN1298393A (zh) 2001-06-06
HRP20000726B1 (hr) 2009-04-30
ATE228505T1 (de) 2002-12-15
CN1113057C (zh) 2003-07-02
JP2002513006A (ja) 2002-05-08
AP2000001933A0 (en) 2000-12-31
JP4045069B2 (ja) 2008-02-13
ES2188242T3 (es) 2003-06-16
HK1036618A1 (en) 2002-01-11
BR9909925B1 (pt) 2010-09-21
WO1999055678A1 (fr) 1999-11-04
AU4301399A (en) 1999-11-16
ZA200004601B (en) 2002-02-27
HUP0102084A3 (en) 2002-12-28
TR200003061T2 (tr) 2001-01-22
OA11547A (en) 2004-05-24
RS50029B (sr) 2008-11-28
NO20005254D0 (no) 2000-10-19
AU747550B2 (en) 2002-05-16
CZ297439B6 (cs) 2006-12-13
AP1293A (en) 2004-08-30
EP1073639A1 (fr) 2001-02-07
HU227709B1 (en) 2011-12-28
YU61200A (sh) 2003-07-07
RU2197481C2 (ru) 2003-01-27
IS5615A (is) 2000-08-31
IL138160A (en) 2006-04-10
HRP20000726A2 (en) 2001-04-30
PL343420A1 (en) 2001-08-13
ID26277A (id) 2000-12-14
CA2329788C (fr) 2004-11-23
PL190441B1 (pl) 2005-12-30
UA60354C2 (uk) 2003-10-15
EP1073639B1 (fr) 2002-11-27
NO20005254L (no) 2000-12-27
DK1073639T3 (da) 2003-03-24
IS2082B (is) 2006-02-15
ME00870B (fr) 2008-11-28
CA2329788A1 (fr) 1999-11-04
DE69904162T2 (de) 2003-08-21
EE200000613A (et) 2002-04-15
BR9909925A (pt) 2001-01-09
NZ506641A (en) 2002-03-28
NO315606B1 (no) 2003-09-29
KR100571534B1 (ko) 2006-04-14
EE04275B1 (et) 2004-04-15
HUP0102084A2 (hu) 2001-11-28
CZ20003849A3 (cs) 2001-03-14
SE9801474D0 (sv) 1998-04-27

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