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IL135723A - 1'-Ä4-Ä1-4-Fluorophenyl)-1H-indole-3-ylÜ-1-butylÜ-spiroÄisobenzofuran-1-(3H),4'-piperidineÜhydrohal ogenides and pharmaceutical compositions containing them - Google Patents

1'-Ä4-Ä1-4-Fluorophenyl)-1H-indole-3-ylÜ-1-butylÜ-spiroÄisobenzofuran-1-(3H),4'-piperidineÜhydrohal ogenides and pharmaceutical compositions containing them

Info

Publication number
IL135723A
IL135723A IL13572398A IL13572398A IL135723A IL 135723 A IL135723 A IL 135723A IL 13572398 A IL13572398 A IL 13572398A IL 13572398 A IL13572398 A IL 13572398A IL 135723 A IL135723 A IL 135723A
Authority
IL
Israel
Prior art keywords
ylü
spiroäisobenzofuran
piperidineühydrohal
ogenides
butylü
Prior art date
Application number
IL13572398A
Other languages
English (en)
Other versions
IL135723A0 (en
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of IL135723A0 publication Critical patent/IL135723A0/xx
Publication of IL135723A publication Critical patent/IL135723A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL13572398A 1997-11-07 1998-11-06 1'-Ä4-Ä1-4-Fluorophenyl)-1H-indole-3-ylÜ-1-butylÜ-spiroÄisobenzofuran-1-(3H),4'-piperidineÜhydrohal ogenides and pharmaceutical compositions containing them IL135723A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK126797 1997-11-07
PCT/DK1998/000480 WO1999024436A1 (fr) 1997-11-07 1998-11-06 Hydrohalogenures de 1'-[4- [1-(4-fluorophenyl)- 1h-indole-3-yl]-1-butyl] -spiro-[isobenzofuran- 1(3h),4'- piperidine]

Publications (2)

Publication Number Publication Date
IL135723A0 IL135723A0 (en) 2001-05-20
IL135723A true IL135723A (en) 2005-11-20

Family

ID=8102935

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13572398A IL135723A (en) 1997-11-07 1998-11-06 1'-Ä4-Ä1-4-Fluorophenyl)-1H-indole-3-ylÜ-1-butylÜ-spiroÄisobenzofuran-1-(3H),4'-piperidineÜhydrohal ogenides and pharmaceutical compositions containing them

Country Status (38)

Country Link
US (2) US6844352B2 (fr)
EP (1) EP1044202B1 (fr)
JP (1) JP3605358B2 (fr)
KR (1) KR100399274B1 (fr)
CN (1) CN1105115C (fr)
AR (1) AR023010A1 (fr)
AT (1) ATE288918T1 (fr)
AU (1) AU749094B2 (fr)
BG (1) BG64906B1 (fr)
BR (1) BR9813949A (fr)
CA (1) CA2308745C (fr)
CZ (1) CZ288666B6 (fr)
DE (1) DE69828999T2 (fr)
DZ (1) DZ2642A1 (fr)
EA (1) EA002092B1 (fr)
EG (1) EG23791A (fr)
ES (1) ES2234162T3 (fr)
HR (1) HRP20000261B1 (fr)
HU (1) HUP0100991A3 (fr)
ID (1) ID25776A (fr)
IL (1) IL135723A (fr)
IS (1) IS2342B (fr)
JO (1) JO2052B1 (fr)
MA (1) MA25585A1 (fr)
NO (1) NO325920B1 (fr)
NZ (1) NZ504065A (fr)
PE (1) PE130299A1 (fr)
PL (1) PL190538B1 (fr)
PT (1) PT1044202E (fr)
RS (1) RS49777B (fr)
SK (1) SK285245B6 (fr)
TN (1) TNSN98201A1 (fr)
TR (1) TR200001267T2 (fr)
TW (1) TW483894B (fr)
UA (1) UA64769C2 (fr)
UY (1) UY25236A1 (fr)
WO (1) WO1999024436A1 (fr)
ZA (1) ZA9810116B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR030453A1 (es) * 2000-08-15 2003-08-20 Lundbeck & Co As H Composicion farmaceutica con contenido de 1' [4-[1-(4-fluorofenil)-1h-indol-3-il]-1-butil] espiro [isobenzofuran-1 (3h), 4'-piperidina]
AU2003263155A1 (en) * 2002-09-20 2004-04-08 H. Lundbeck A/S Method for manufacture of dihydroisobenzofuran derivatives
WO2004110388A2 (fr) 2003-06-12 2004-12-23 Agy Therapeutics, Inc. Ligands des recepteurs sigma pour regeneration neuronale et retablissement fonctionnel
WO2007012319A1 (fr) * 2005-07-29 2007-02-01 Sigma-Aldrich Production Gmbh Melanges lc/ms contenant des additifs ionisants
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
WO2007053596A1 (fr) 2005-10-31 2007-05-10 Braincells, Inc. Modulation de la neurogenese dont la mediation est assuree par recepteur gaba
EP1991212A1 (fr) * 2006-03-08 2008-11-19 Braincells, Inc. Modulation de neurogenèse par des agents nootropes
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
WO2007134136A2 (fr) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenèse par modulation de l'angiotensine
EP2026813A2 (fr) 2006-05-09 2009-02-25 Braincells, Inc. Neurogenèse induite par le récepteur 5ht
WO2008030651A1 (fr) * 2006-09-08 2008-03-13 Braincells, Inc. Combinaisons contenant un dérivé de 4-acylaminopyridine
US20080103165A1 (en) * 2006-09-19 2008-05-01 Braincells, Inc. Ppar mediated modulation of neurogenesis
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2010099217A1 (fr) 2009-02-25 2010-09-02 Braincells, Inc. Modulation de neurogenèse à l'aide de combinaisons de d-cyclosérine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5109002A (en) * 1989-09-08 1992-04-28 Du Pont Merck Pharmaceutical Company Antipsychotic 1-cycloalkylpiperidines
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
IL135723A0 (en) 2001-05-20
NZ504065A (en) 2002-05-31
MA25585A1 (fr) 2002-12-31
CZ20001663A3 (cs) 2000-10-11
CN1278823A (zh) 2001-01-03
AU1022699A (en) 1999-05-31
HRP20000261A2 (en) 2001-04-30
CZ288666B6 (cs) 2001-08-15
BG64906B1 (bg) 2006-08-31
JP3605358B2 (ja) 2004-12-22
PT1044202E (pt) 2005-04-29
US20030055074A1 (en) 2003-03-20
NO20002188D0 (no) 2000-04-27
BR9813949A (pt) 2000-09-26
ZA9810116B (en) 1999-05-07
CN1105115C (zh) 2003-04-09
AU749094B2 (en) 2002-06-20
TR200001267T2 (tr) 2000-09-21
PE130299A1 (es) 1999-12-16
KR20010031791A (ko) 2001-04-16
UA64769C2 (uk) 2004-03-15
UY25236A1 (es) 2000-12-29
HK1034075A1 (en) 2001-10-12
RS49777B (sr) 2008-06-05
EP1044202B1 (fr) 2005-02-09
ES2234162T3 (es) 2005-06-16
ATE288918T1 (de) 2005-02-15
ID25776A (id) 2000-11-02
HUP0100991A2 (hu) 2001-09-28
US6844352B2 (en) 2005-01-18
YU23500A (sh) 2003-12-31
DZ2642A1 (fr) 2004-12-28
JO2052B1 (en) 1999-05-15
EA002092B1 (ru) 2001-12-24
KR100399274B1 (ko) 2003-09-26
PL190538B1 (pl) 2005-12-30
HUP0100991A3 (en) 2003-03-28
SK285245B6 (sk) 2006-09-07
IS2342B (is) 2008-02-15
AR023010A1 (es) 2002-09-04
EA200000502A1 (ru) 2000-10-30
CA2308745C (fr) 2004-01-20
EG23791A (en) 2007-08-13
JP2001522852A (ja) 2001-11-20
NO325920B1 (no) 2008-08-18
IS5460A (is) 2000-04-18
WO1999024436A1 (fr) 1999-05-20
US20050171135A1 (en) 2005-08-04
TW483894B (en) 2002-04-21
TNSN98201A1 (fr) 2005-03-15
SK6462000A3 (en) 2000-10-09
BG104485A (en) 2001-01-31
DE69828999D1 (de) 2005-03-17
DE69828999T2 (de) 2005-07-21
CA2308745A1 (fr) 1999-05-20
HRP20000261B1 (en) 2009-04-30
PL340220A1 (en) 2001-01-15
NO20002188L (no) 2000-06-14
EP1044202A1 (fr) 2000-10-18

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees