IL134816A - Substituted diarylether sulfonic acids and their preparation - Google Patents

Substituted diarylether sulfonic acids and their preparation

Info

Publication number: IL134816A
Authority: IL; Israel
Prior art keywords: diarylether; substituted; preparation; sulfonic acids; sulfonic
Prior art date: 1995-12-08

Application number

IL13481696A

Other languages

English (en)

Other versions

IL134816A0 (en

Original Assignee

Agouron Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-08

Filing date

1996-12-05

Publication date

2003-02-12

1996-12-05 Application filed by Agouron Pharma filed Critical Agouron Pharma

2001-05-20 Publication of IL134816A0 publication Critical patent/IL134816A0/xx

2003-02-12 Publication of IL134816A publication Critical patent/IL134816A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/04—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

IL13481696A 1995-12-08 1996-12-05 Substituted diarylether sulfonic acids and their preparation IL134816A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US56976695A	1995-12-08	1995-12-08
PCT/US1996/019328 WO1997020824A1 (en)	1995-12-08	1996-12-05	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation
IL12455996A IL124559A (en)	1995-12-08	1996-12-05	Inhibitors of metalloproteinases, pharmaceutical preparations containing them and their use

Publications (2)

Publication Number	Publication Date
IL134816A0 IL134816A0 (en)	2001-05-20
IL134816A true IL134816A (en)	2003-02-12

Family

ID=24276764

Family Applications (6)

Application Number	Title	Priority Date	Filing Date
IL12455996A IL124559A (en)	1995-12-08	1996-12-05	Inhibitors of metalloproteinases, pharmaceutical preparations containing them and their use
IL13481696A IL134816A (en)	1995-12-08	1996-12-05	Substituted diarylether sulfonic acids and their preparation
IL13802796A IL138027A (en)	1995-12-08	1996-12-05	Intermediates for the preparation and preparation of metalloproteinase inhibitors
IL13802700A IL138027A0 (en)	1995-12-08	2000-08-23	Intermediates of metalloproteinase inhibitors and a method for their preparation
IL13802800A IL138028A0 (en)	1995-12-08	2000-08-23	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical use
IL14367401A IL143674A0 (en)	1995-12-08	2001-06-11	Metalloproteinase inhibitors, and the methods for making these

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
IL12455996A IL124559A (en)	1995-12-08	1996-12-05	Inhibitors of metalloproteinases, pharmaceutical preparations containing them and their use

Family Applications After (4)

Application Number	Title	Priority Date	Filing Date
IL13802796A IL138027A (en)	1995-12-08	1996-12-05	Intermediates for the preparation and preparation of metalloproteinase inhibitors
IL13802700A IL138027A0 (en)	1995-12-08	2000-08-23	Intermediates of metalloproteinase inhibitors and a method for their preparation
IL13802800A IL138028A0 (en)	1995-12-08	2000-08-23	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical use
IL14367401A IL143674A0 (en)	1995-12-08	2001-06-11	Metalloproteinase inhibitors, and the methods for making these

Country Status (39)

Country	Link
US (1)	US6153757A (xx)
EP (2)	EP1095936B1 (xx)
JP (1)	JP2000502330A (xx)
KR (1)	KR19990072009A (xx)
CN (2)	CN1542002A (xx)
AP (2)	AP1288A (xx)
AT (2)	ATE283264T1 (xx)
AU (1)	AU725831C (xx)
BG (1)	BG64279B1 (xx)
BR (1)	BR9611929A (xx)
CA (1)	CA2238306A1 (xx)
CO (1)	CO4790150A1 (xx)
CZ (1)	CZ292942B6 (xx)
DE (2)	DE69626684T2 (xx)
DK (1)	DK0874830T3 (xx)
EA (1)	EA003294B1 (xx)
ES (2)	ES2195034T3 (xx)
GE (1)	GEP20012388B (xx)
GT (2)	GT199700015A (xx)
HR (1)	HRP970031A2 (xx)
HU (1)	HUP9902092A3 (xx)
ID (1)	ID17624A (xx)
IL (6)	IL124559A (xx)
MX (1)	MX9804457A (xx)
MY (1)	MY117290A (xx)
NO (1)	NO311360B1 (xx)
NZ (1)	NZ325559A (xx)
OA (1)	OA10794A (xx)
PA (1)	PA8431301A1 (xx)
PE (1)	PE69298A1 (xx)
PL (1)	PL327275A1 (xx)
PT (1)	PT874830E (xx)
SI (1)	SI0874830T1 (xx)
SK (1)	SK73898A3 (xx)
SV (1)	SV1997000008A (xx)
TR (1)	TR199800990T2 (xx)
TW (1)	TW546293B (xx)
WO (1)	WO1997020824A1 (xx)
YU (1)	YU21597A (xx)

Families Citing this family (114)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR19990072009A (ko) *	1995-08-12	1999-09-27	게리 이. 프리드만	메탈로프로티나제 방해제, 그를 포함하는 약제 조성물 및 약제로서의 용도, 그리고 그의 제조방법 및 제조에 유용한 중간체
US6500948B1 (en)	1995-12-08	2002-12-31	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
CN1230884A (zh) *	1996-07-22	1999-10-06	孟山都公司	硫羟砜金属蛋白酶抑制剂
US6747027B1 (en)	1996-07-22	2004-06-08	Pharmacia Corporation	Thiol sulfonamide metalloprotease inhibitors
TR199900400T2 (xx) *	1996-08-28	1999-05-21	The Procter & Gamble Company	Heterosiklik metaloproteaz inhibit�rleri.
AU727820B2 (en) *	1996-08-28	2000-12-21	Procter & Gamble Company, The	1,3-diheterocyclic metalloprotease inhibitors
BR9712792A (pt) *	1996-08-28	1999-12-14	Procter & Gamble	Inibidores de metaloprotease bidentada.
NZ334256A (en) *	1996-08-28	2000-11-24	Procter & Gamble	1-substituted sulphonyl-pyrrolidine derivatives useful as metalloprotease inhibitors
US6872742B2 (en)	1996-08-28	2005-03-29	The Procter & Gamble Company	Substituted cyclic amine metalloprotease inhibitors
TR199900382T2 (xx) *	1996-08-28	1999-05-21	The Procter & Gamble Company	Heterosiklik metaloproteaz inhibit�rleri.
US6228869B1 (en)	1996-10-16	2001-05-08	American Cyanamid Company	Ortho-sulfonamido bicyclic hydroxamic acids as matrix metalloproteinase and TACE inhibitors
US5929097A (en) *	1996-10-16	1999-07-27	American Cyanamid Company	Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
US5962481A (en)	1996-10-16	1999-10-05	American Cyanamid Company	Preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
US5977408A (en) *	1996-10-16	1999-11-02	American Cyanamid Company	Preparation and use of β-sulfonamido hydroxamic acids as matrix metalloproteinase and TACE inhibitors
US6548524B2 (en)	1996-10-16	2003-04-15	American Cyanamid Company	Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors
JP2001503037A (ja) *	1996-10-16	2001-03-06	アメリカン・サイアナミド・カンパニー	マトリクス金属プロテナイーゼおよびｔａｃｅに対する阻害薬としてのオルト―スルホンアミドヘテロアリールヒドロキサム酸の製造および使用
US6008243A (en) *	1996-10-24	1999-12-28	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US6174915B1 (en)	1997-03-25	2001-01-16	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
EP0948489A1 (en) *	1996-12-17	1999-10-13	Fujisawa Pharmaceutical Co., Ltd.	Piperazine compounds as inhibitors of mmp or tnf
US6794511B2 (en)	1997-03-04	2004-09-21	G. D. Searle	Sulfonyl aryl or heteroaryl hydroxamic acid compounds
US6696449B2 (en)	1997-03-04	2004-02-24	Pharmacia Corporation	Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors
US6362183B1 (en)	1997-03-04	2002-03-26	G. D. Searle & Company	Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds
ATE283848T1 (de) *	1997-03-04	2004-12-15	Pharmacia Corp	Thiarylsulfonamid-hydroxamsäurederivate
US6087359A (en) *	1997-03-04	2000-07-11	Getman; Daniel P.	Thioaryl sulfonamide hydroxamic acid compounds
US6380258B2 (en)	1997-03-04	2002-04-30	G. D. Searle, L.L.C.	Sulfonyl divalent aryl or heteroaryl hydroxamic acid compounds
WO1998039316A1 (en)	1997-03-04	1998-09-11	Monsanto Company	N-hydroxy 4-sulfonyl butanamide compounds
US7115632B1 (en)	1999-05-12	2006-10-03	G. D. Searle & Co.	Sulfonyl aryl or heteroaryl hydroxamic acid compounds
WO1998039315A1 (en)	1997-03-04	1998-09-11	Monsanto Company	Aromatic sulfonyl alpha-cycloamino hydroxamic acid compounds
US5985900A (en) *	1997-04-01	1999-11-16	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
AU747280B2 (en) *	1997-04-01	2002-05-09	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
WO1998050348A1 (en) *	1997-05-09	1998-11-12	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
JP2004137284A (ja) *	1997-06-17	2004-05-13	Kaken Pharmaceut Co Ltd	２−スルファモイル安息香酸誘導体
EP1009737A2 (en)	1997-07-31	2000-06-21	The Procter & Gamble Company	Sulfonylamino substituted hydroxamic acid derivatives as metalloprotease inhibitors
US6403632B1 (en) *	2000-03-01	2002-06-11	Bristol Myers Squibb Pharma Co	Lactam metalloprotease inhibitors
JPH11199512A (ja) *	1997-10-24	1999-07-27	Pfizer Prod Inc	変形性関節症および他のｍｍｐ媒介疾患の治療のためのｍｍｐ−１３選択的阻害剤の使用
BR9814643A (pt)	1997-11-14	2000-10-03	Searle & Co	Inibidor de metaloprotease de ácido sulfona hidroxâmico aromático
US6750228B1 (en)	1997-11-14	2004-06-15	Pharmacia Corporation	Aromatic sulfone hydroxamic acid metalloprotease inhibitor
US20010039287A1 (en)	1997-11-14	2001-11-08	Thomas E Barta	Aromatic sulfone hydroxamic acid metalloprotease inhibitor
HUP0100277A3 (en) *	1998-01-27	2002-03-28	American Cyanamid Company Madi	2,3,4,5-tetrahydro-1h-[1,4]-benzodiazepine-3-hydroxamic acids as metalloproteinase inhibitors, process for their preparation and pharmaceutical compositions containing them
US6071903A (en) *	1998-01-27	2000-06-06	American Cyanamid Company	2,3,4,5-tetrahydro-1H-[1,4]-benzodiazepine-3-hydroxyamic acids
EP1053226A1 (en)	1998-02-04	2000-11-22	Novartis AG	Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases
US6410580B1 (en)	1998-02-04	2002-06-25	Novartis Ag	Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases
US6329418B1 (en) *	1998-04-14	2001-12-11	The Procter & Gamble Company	Substituted pyrrolidine hydroxamate metalloprotease inhibitors
AU3982599A (en) *	1998-05-14	1999-11-29	Du Pont Pharmaceuticals Company	Novel substituted aryl hydroxamic acids as metalloproteinase inhibitors
CA2333554A1 (en) *	1998-06-17	1999-12-23	Chu-Baio Xue	Cyclic hydroxamic acids as metalloproteinase inhibitors
DE69939190D1 (de)	1998-06-18	2008-09-04	Hoffmann La Roche	Verfahren für Arylalkylsulfid
FR2780402B1 (fr) *	1998-06-30	2001-04-27	Adir	Nouveaux composes acides carboxyliques et hydroxamiques inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2000009492A1 (en) *	1998-08-12	2000-02-24	Pfizer Products Inc.	Tace inhibitors
UA59453C2 (uk) *	1998-08-12	2003-09-15	Пфайзер Продактс Інк.	Похідні гідроксипіпеколат гідроксамової кислоти як інгібітори матричних металопротеїназ
US6509337B1 (en) *	1998-09-17	2003-01-21	Pfizer Inc.	Arylsulfonyl Hydroxamic Acid derivatives as MMP and TNF inhibitors
US6307049B1 (en)	1998-09-30	2001-10-23	The Procter & Gamble Co.	Heterocyclic 2-substituted ketoamides
JP2002525305A (ja) *	1998-09-30	2002-08-13	ザ、プロクター、エンド、ギャンブル、カンパニー	スルホンアミドを用いた脱毛治療の方法
US6300341B1 (en)	1998-09-30	2001-10-09	The Procter & Gamble Co.	2-substituted heterocyclic sulfonamides
US6288261B1 (en) *	1998-12-18	2001-09-11	Abbott Laboratories	Inhibitors of matrix metalloproteinases
US6858598B1 (en) *	1998-12-23	2005-02-22	G. D. Searle & Co.	Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
IL143901A0 (en) *	1998-12-23	2002-04-21	Searle & Co	Use of cyclooxygenase-2- inhibitor, a matrix metallaproteinase inhibitor, an antineoplastic agent and optionally radiation as a combination treatment of neoplasia
US6277885B1 (en)	1999-01-27	2001-08-21	American Cyanamid Company	Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors
US6762178B2 (en)	1999-01-27	2004-07-13	Wyeth Holdings Corporation	Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors
US6753337B2 (en)	1999-01-27	2004-06-22	Wyeth Holdings Corporation	Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors
US6946473B2 (en)	1999-01-27	2005-09-20	Wyeth Holdings Corporation	Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors
US6200996B1 (en)	1999-01-27	2001-03-13	American Cyanamid Company	Heteroaryl acetylenic sulfonamide and phosphinic acid amide hydroxamic acid tace inhibitors
US6544984B1 (en)	1999-01-27	2003-04-08	American Cyanamid Company	2,3,4,5-tetrahydro-1H-(1,4)benzodiazepine-3-hydroxamic acids
US6340691B1 (en)	1999-01-27	2002-01-22	American Cyanamid Company	Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors
US6326516B1 (en)	1999-01-27	2001-12-04	American Cyanamid Company	Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors
US6225311B1 (en)	1999-01-27	2001-05-01	American Cyanamid Company	Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors
US6313123B1 (en)	1999-01-27	2001-11-06	American Cyanamid Company	Acetylenic sulfonamide thiol tace inhibitors
AR022423A1 (es) *	1999-01-27	2002-09-04	American Cyanamid Co	Compuestos derivados de acidos 2,3,4,5-tetrahidro-1h-[1,4]benzodiazepina-3-hidroxamicos, composicion farmaceutica que los comprenden, y el uso de losmismos para la manufactura de un medicamento
US6358980B1 (en)	1999-01-27	2002-03-19	American Cyanamid Company	Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors
US6800646B1 (en)	1999-02-08	2004-10-05	Pharmacia Corporation	Sulfamato hydroxamic acid metalloprotease inhibitor
AU775701B2 (en)	1999-02-08	2004-08-12	G.D. Searle & Co.	Sulfamato hydroxamic acid metalloprotease inhibitor
IL145089A0 (en)	1999-03-03	2002-06-30	Procter & Gamble	Alkenyl-and alkynyl-containing metalloprotease inhibitors
MXPA01008857A (es)	1999-03-03	2002-07-02	Procter & Gamble	Inhibidores de metaloproteasa dihetero sustituidos.
AUPP982399A0 (en) *	1999-04-19	1999-05-13	Fujisawa Pharmaceutical Co., Ltd.	Mmp inhibitor
US6583299B1 (en)	1999-05-20	2003-06-24	G.D. Searle & Co.	α-amino-β-sulfonyl hydroxamic acid compounds
US6869951B1 (en)	1999-07-16	2005-03-22	Pharmacia Corporation	Method of changing conformation of a matrix metalloproteinase
AR033651A1 (es)	1999-10-01	2004-01-07	Hoffmann La Roche	Derivados de pirimidina-2,4,6-triona, composiciones farmaceuticas que contienen dichos compuestos y el empleo de los mismos para la manufactura de un medicamento
HK1049334B (en)	2000-03-17	2004-07-16	Bristol-Myers Squibb Pharma Company	Beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha
CZ20023033A3 (cs)	2000-03-17	2003-01-15	Bristol-Myers Squibb Pharma Company	Deriváty cyklických beta-aminokyselin jako inhibitory matrixových metaloproteáz a TNF-alfa
EP1138680A1 (en) *	2000-03-29	2001-10-04	Pfizer Products Inc.	Gem substituted sulfonyl hydroxamic acids as MMP inhibitors
CN1366524A (zh) *	2000-04-07	2002-08-28	三星电子株式会社	磺胺衍生物作为基质金属蛋白酶抑制剂
US6683093B2 (en)	2000-05-12	2004-01-27	Pharmacia Corporation	Aromatic sulfone hydroxamic acids and their use as protease inhibitors
US6927216B2 (en)	2000-10-03	2005-08-09	Bristol-Myers Squibb Pharma Company	Cyclic sulfonyl compounds as inhibitors of metalloproteases
WO2002055491A2 (en)	2001-01-11	2002-07-18	Bristol Myers Squibb Company P	1,2-DISUBSTITUTED CYCLIC INHIBITORS OF MATRIX METALLORPROTEASES AND TNF-$g(a)
FR2819252A1 (fr) *	2001-01-11	2002-07-12	Servier Lab	Nouveaux derives d'acide hydroxamique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2002055516A2 (en)	2001-01-11	2002-07-18	Bristol Myers Squibb Co	1,1-DISUBSTITUTED CYCLIC INHIBITORS OF MATRIX METALLOPROTEASE AND TNF-$g(a)
MXPA01013326A (es)	2001-02-14	2002-08-26	Warner Lambert Co	Bifenil sulfonamidas utiles como inhibisdores de metaloproteinasa de matriz.
EP1373199A4 (en)	2001-03-15	2004-04-07	Bristol Myers Squibb Pharma Co	SPIROCYCLIC BETA-AMINOACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND THE CONVERSION ENZYME OF TNF-ALPHA (TAGE)
US6716845B2 (en)	2001-03-30	2004-04-06	Hoffmann-La Roche Inc.	Barbituric acid derivatives
CZ20032913A3 (cs)	2001-05-11	2004-05-12	Pharmaciaácorporation	Aromatické sulfonhydroxamáty a jejich použití jako inhibitorů proteázy
CA2449019A1 (en) *	2001-05-29	2002-12-05	Guilford Pharmaceuticals Inc.	Method for treating nerve injury caused by surgery
US6683078B2 (en)	2001-07-19	2004-01-27	Pharmacia Corporation	Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors
AUPR726201A0 (en) *	2001-08-24	2001-09-20	Fujisawa Pharmaceutical Co., Ltd.	New use of a cyclic compound
JP2003081937A (ja) *	2001-09-07	2003-03-19	Bayer Ag	ベンゼンスルホンアミド誘導体
MXPA04004010A (es)	2001-11-01	2004-07-23	Wyeth Corp	Acidos hidroxamicos de aril sulfonamida alenicos como inhibidores de tace y metaloproteinasa de matriz.
WO2003048119A2 (en) *	2001-11-30	2003-06-12	Bristol-Myers Squibb Company	Method of producing n-[(2s)-sulfanyl-4-(1,5,5-trimethylhydantoinyl)butanoyl]-l-leucyl-l-tert-leucine n-methylamide and intermediate thereof
PE20030701A1 (es) *	2001-12-20	2003-08-21	Schering Corp	Compuestos para el tratamiento de trastornos inflamatorios
EP1501827A2 (en)	2002-04-25	2005-02-02	Pharmacia Corporation	Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acid and their use as protease inhibitors
AU2003233154A1 (en)	2002-06-10	2003-12-22	Pfizer Inc.	Metabolites of prinomastat and their sythesis
ES2425013T3 (es) *	2002-06-12	2013-10-10	Symphony Evolution, Inc.	Inhibidores de ADAM-10 humana
CA2490646A1 (en) *	2002-06-25	2003-12-31	Pharmacia Corporation	Arylsulfonylhydroxamic acid and amide derivatives and their use as protease inhibitors
AU2003304456A1 (en)	2002-12-23	2005-03-16	Wyeth Holdings Corporation	Acetylenic aryl sulfonate hydroxamic acid tace and matrix metalloproteinase inhibitors
EP1592389B1 (en) *	2003-02-14	2009-04-22	Laboratoires Serono SA	Piperazine-2-carboxamide derivatives
CA2516328A1 (en) *	2003-02-18	2004-09-02	Pfizer Inc.	Inhibitors of hepatitis c virus, compositions and treatments using the same
ES2401911T3 (es)	2003-03-24	2013-04-25	Axikin Pharmaceuticals, Inc.	Derivados de 2-fenoxi- y 2-fenilsulfanil-bencenosulfonamida con actividad antagonista de CCR3 para el tratamiento de asma y otras alteraciones inflamatorias o inmunológicas
GT200500139A (es)	2004-06-08	2005-07-25		Metodo para la preparacion de acidos hidroxamicos
ATE509956T1 (de) *	2006-06-08	2011-06-15	Helmholtz Zentrum Muenchen	Spezifische proteaseinhibitoren und ihre verwendung in der krebstherapie
US8426415B2 (en)	2007-10-16	2013-04-23	Symphony Evolution, Inc.	Human ADAM-10 inhibitors
EP2147684A1 (en) *	2008-07-22	2010-01-27	Bracco Imaging S.p.A	Diagnostic Agents Selective Against Metalloproteases
WO2011081884A1 (en)	2009-12-14	2011-07-07	Massachusetts Institute Of Technology	Systems and methods related to optical nanosensors including photoluminescent nanostructures
IT1401253B1 (it)	2010-04-23	2013-07-18	Uni Degli Studi Carlo Bo Urbino	Uso del sulodexide per la riduzione delle metalloproteinasi di matrice.
US9193699B2 (en) *	2011-10-04	2015-11-24	Institut National De La Sante Et De La Recherche Medicale (Inserm	Apoptosis inducing compounds
BR112021006407A8 (pt)	2018-10-04	2022-12-06	Inst Nat Sante Rech Med	uso de inibidores do egfr para ceratodermas
WO2020218316A1 (ja) *	2019-04-26	2020-10-29	日産化学株式会社	アリールスルホン酸エステル化合物の製造方法
US20220227792A1 (en) *	2019-06-14	2022-07-21	Loyola University Of Chicago	Carborane hydroxamic acid matrix metalloproteinase agents for boron neutron capture therapy

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4032639A (en) *	1976-03-22	1977-06-28	American Home Products Corporation	2,3,4,4A-Tetrahydro-1H-pyrazino[1,2-a,]quinoxalin-5(6H)-ones and derivatives thereof for relieving hypertension
ZW23187A1 (en) *	1986-12-15	1988-06-29	Hoffmann La Roche	Phosphinic acid derivatives
GB9000846D0 (en) *	1990-01-15	1990-03-14	Beecham Group Plc	Novel compounds
GB9022117D0 (en) *	1990-10-11	1990-11-21	Beecham Group Plc	Novel compounds
US5183900A (en) *	1990-11-21	1993-02-02	Galardy Richard E	Matrix metalloprotease inhibitors
US5239078A (en) *	1990-11-21	1993-08-24	Glycomed Incorporated	Matrix metalloprotease inhibitors
US5189178A (en) *	1990-11-21	1993-02-23	Galardy Richard E	Matrix metalloprotease inhibitors
EP0489579B1 (en) *	1990-12-03	1995-03-29	Celltech Therapeutics Limited	Peptidyl derivatives
WO1992021360A1 (en) *	1991-05-28	1992-12-10	Merck & Co., Inc.	Substituted n-carboxyalkylpeptidyl derivatives as antidegenerative active agents
US5256657A (en) *	1991-08-19	1993-10-26	Sterling Winthrop, Inc.	Succinamide derivative matrix-metalloprotease inhibitors
GB9211706D0 (en) *	1992-06-03	1992-07-15	Celltech Ltd	Peptidyl derivatives
GB9211707D0 (en) *	1992-06-03	1992-07-15	Celltech Ltd	Peptidyl derivatives
US5376664A (en) *	1992-07-27	1994-12-27	The Du Pont Merck Pharmaceutical Company	Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents
JPH08503475A (ja) *	1992-11-25	1996-04-16	メルクエンドカンパニーインコーポレーテッド	抗変性活性剤としてのカルボキシ−ペプチジル誘導体
US5552419A (en) *	1993-01-06	1996-09-03	Ciba-Geigy Corporation	Arylsulfonamido-substituted hydroxamic acids
US5455258A (en) *	1993-01-06	1995-10-03	Ciba-Geigy Corporation	Arylsulfonamido-substituted hydroxamic acids
US5506242A (en) *	1993-01-06	1996-04-09	Ciba-Geigy Corporation	Arylsufonamido-substituted hydroxamic acids
GB9307956D0 (en) *	1993-04-17	1993-06-02	Walls Alan J	Hydroxamic acid derivatives
GB9308695D0 (en) *	1993-04-27	1993-06-09	Celltech Ltd	Peptidyl derivatives
DK0712403T3 (da) *	1993-08-05	1998-01-26	Syntex Inc	Matrix-metalloproteaseinhibitorer
US6013792A (en) *	1993-08-05	2000-01-11	Syntex (U.S.A.), Inc.	Matrix metalloprotease inhibitors
UA48121C2 (uk) *	1993-11-04	2002-08-15	Сінтекс (С.Ш.А.) Інк.	Інгібітори матричних металопротеаз і фармацетична композиція на їх основі
US6037472A (en) *	1993-11-04	2000-03-14	Syntex (U.S.A.) Inc.	Matrix metalloprotease inhibitors
JP3827324B2 (ja) *	1994-01-22	2006-09-27	ブリテッシュバイオテックファーマシューティカルズリミテッド	金属タンパク質分解酵素阻害剤
US5514716A (en) *	1994-02-25	1996-05-07	Sterling Winthrop, Inc.	Hydroxamic acid and carboxylic acid derivatives, process for their preparation and use thereof
EP0763012B1 (en) *	1994-05-28	1999-06-09	British Biotech Pharmaceuticals Limited	Succinyl hydroxamic acid, n-formyl-n-hydroxy amino carboxylic acid and succinic acid amide derivatives as metalloprotease inhibitors
CA2193691A1 (en) *	1994-06-22	1995-12-28	Andrew Miller	Metalloproteinase inhibitors
GB9416897D0 (en) *	1994-08-20	1994-10-12	British Biotech Pharm	Metalloproteinase inhibitors
GB9423914D0 (en) *	1994-11-26	1995-01-11	British Biotech Pharm	Polyether derivatives as metalloproteinase inhibitors
US5863949A (en) *	1995-03-08	1999-01-26	Pfizer Inc	Arylsulfonylamino hydroxamic acid derivatives
US5861510A (en) *	1995-04-20	1999-01-19	Pfizer Inc	Arylsulfonyl hydroxamic acid derivatives as MMP and TNF inhibitors
KR980009238A (ko) *	1995-07-28	1998-04-30	우에노 도시오	설포닐아미노산 유도체
EP0757984B1 (en) *	1995-08-08	2002-10-30	Ono Pharmaceutical Co., Ltd.	Hydroxamic acid derivatives useful for inhibiting gelatinase
KR19990072009A (ko) *	1995-08-12	1999-09-27	게리 이. 프리드만	메탈로프로티나제 방해제, 그를 포함하는 약제 조성물 및 약제로서의 용도, 그리고 그의 제조방법 및 제조에 유용한 중간체
DE19542189A1 (de) *	1995-11-13	1997-05-15	Hoechst Ag	Cyclische N-substituierte alpha-Iminohydroxamsäuren
CN1131215C (zh) *	1995-11-13	2003-12-17	赫彻斯特股份公司	环和杂环N－取代的α－亚氨基异羟肟酸和羧酸
PT874836E (pt) *	1995-11-17	2003-02-28	Warner Lambert Co	Inibidores com sulfonamida de metaloproteinases de matriz
US5753653A (en) *	1995-12-08	1998-05-19	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
TW453995B (en) *	1995-12-15	2001-09-11	Novartis Ag	Certain alpha-substituted arylsulfonamido acetohydroxamic acids
ATE225343T1 (de) *	1995-12-20	2002-10-15	Hoffmann La Roche	Matrix-metalloprotease inhibitoren
ATE214368T1 (de) *	1995-12-22	2002-03-15	Warner Lambert Co	Aromatische keto-säure und ihre derivate als inhibitoren der matrix metalloproteinase
US5837224A (en) *	1996-01-19	1998-11-17	The Regents Of The University Of Michigan	Method of inhibiting photoaging of skin
KR100338857B1 (ko) *	1996-01-23	2002-05-30	시오노 요시히코	술폰화 아미노산 유도체 및 이를 함유한메탈로프로테이나제 저해제
CN1228083A (zh) *	1996-08-23	1999-09-08	美国辉瑞有限公司	芳基磺酰氨基异羟肟酸衍生物
NZ334256A (en) *	1996-08-28	2000-11-24	Procter & Gamble	1-substituted sulphonyl-pyrrolidine derivatives useful as metalloprotease inhibitors
TR199900400T2 (xx) *	1996-08-28	1999-05-21	The Procter & Gamble Company	Heterosiklik metaloproteaz inhibit�rleri.
US5929097A (en) *	1996-10-16	1999-07-27	American Cyanamid Company	Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
US5985900A (en) *	1997-04-01	1999-11-16	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses

1996
- 1996-12-05 KR KR1019980704301A patent/KR19990072009A/ko not_active Ceased
- 1996-12-05 NZ NZ325559A patent/NZ325559A/xx unknown
- 1996-12-05 IL IL12455996A patent/IL124559A/en not_active IP Right Cessation
- 1996-12-05 EP EP00128719A patent/EP1095936B1/en not_active Expired - Lifetime
- 1996-12-05 DK DK96944229T patent/DK0874830T3/da active
- 1996-12-05 BR BR9611929A patent/BR9611929A/pt active Search and Examination
- 1996-12-05 HU HU9902092A patent/HUP9902092A3/hu unknown
- 1996-12-05 AU AU14091/97A patent/AU725831C/en not_active Ceased
- 1996-12-05 DE DE69626684T patent/DE69626684T2/de not_active Expired - Fee Related
- 1996-12-05 PT PT96944229T patent/PT874830E/pt unknown
- 1996-12-05 WO PCT/US1996/019328 patent/WO1997020824A1/en not_active Ceased
- 1996-12-05 AP APAP/P/2001/002270A patent/AP1288A/en active
- 1996-12-05 CN CNA2004100335232A patent/CN1542002A/zh active Pending
- 1996-12-05 IL IL13481696A patent/IL134816A/xx not_active IP Right Cessation
- 1996-12-05 AP APAP/P/1998/001284A patent/AP1368A/en active
- 1996-12-05 IL IL13802796A patent/IL138027A/en not_active IP Right Cessation
- 1996-12-05 PL PL96327275A patent/PL327275A1/xx unknown
- 1996-12-05 SK SK738-98A patent/SK73898A3/sk unknown
- 1996-12-05 ES ES96944229T patent/ES2195034T3/es not_active Expired - Lifetime
- 1996-12-05 CA CA002238306A patent/CA2238306A1/en not_active Abandoned
- 1996-12-05 EP EP96944229A patent/EP0874830B1/en not_active Expired - Lifetime
- 1996-12-05 GE GEAP19964389A patent/GEP20012388B/en unknown
- 1996-12-05 EA EA199800541A patent/EA003294B1/ru not_active IP Right Cessation
- 1996-12-05 AT AT00128719T patent/ATE283264T1/de not_active IP Right Cessation
- 1996-12-05 ES ES00128719T patent/ES2233275T3/es not_active Expired - Lifetime
- 1996-12-05 TR TR1998/00990T patent/TR199800990T2/xx unknown
- 1996-12-05 CN CNB961995831A patent/CN1207289C/zh not_active Expired - Fee Related
- 1996-12-05 DE DE69633947T patent/DE69633947T2/de not_active Expired - Fee Related
- 1996-12-05 AT AT96944229T patent/ATE234291T1/de not_active IP Right Cessation
- 1996-12-05 US US09/011,971 patent/US6153757A/en not_active Expired - Fee Related
- 1996-12-05 SI SI9630588T patent/SI0874830T1/xx unknown
- 1996-12-05 JP JP9521405A patent/JP2000502330A/ja not_active Ceased
- 1996-12-05 CZ CZ19981733A patent/CZ292942B6/cs not_active IP Right Cessation
1997
- 1997-01-18 MY MYPI97000193A patent/MY117290A/en unknown
- 1997-01-22 HR HR96/019,328A patent/HRP970031A2/hr not_active Application Discontinuation
- 1997-01-23 TW TW086100726A patent/TW546293B/zh not_active IP Right Cessation
- 1997-01-29 GT GT199700015A patent/GT199700015A/es unknown
- 1997-01-29 GT GT199700015AK patent/GT199700015AA/es unknown
- 1997-02-06 SV SV1997000008A patent/SV1997000008A/es not_active Application Discontinuation
- 1997-02-12 CO CO97007169A patent/CO4790150A1/es unknown
- 1997-05-26 YU YU21597A patent/YU21597A/sr unknown
- 1997-05-27 PE PE1997000427A patent/PE69298A1/es not_active Application Discontinuation
- 1997-05-30 PA PA19978431301A patent/PA8431301A1/es unknown
- 1997-06-02 ID IDP971874A patent/ID17624A/id unknown
1998
- 1998-06-03 OA OA9800074A patent/OA10794A/en unknown
- 1998-06-04 MX MX9804457A patent/MX9804457A/es not_active IP Right Cessation
- 1998-06-05 NO NO19982590A patent/NO311360B1/no unknown
- 1998-06-05 BG BG102510A patent/BG64279B1/bg unknown
2000
- 2000-08-23 IL IL13802700A patent/IL138027A0/xx unknown
- 2000-08-23 IL IL13802800A patent/IL138028A0/xx unknown
2001
- 2001-06-11 IL IL14367401A patent/IL143674A0/xx unknown

Also Published As

Publication number	Publication date
DE69633947T2 (de)	2005-12-01
IL124559A (en)	2004-07-25
ATE234291T1 (de)	2003-03-15
PL327275A1 (en)	1998-12-07
PE69298A1 (es)	1998-11-13
IL143674A0 (en)	2002-04-21
GT199700015AA (es)	1998-07-23
DE69633947D1 (de)	2004-12-30
ES2195034T3 (es)	2003-12-01
AP1368A (en)	2005-04-21
SK73898A3 (en)	1999-01-11
ID17624A (id)	1998-01-15
YU21597A (en)	1999-11-22
AU725831B2 (en)	2000-10-19
EP1095936A1 (en)	2001-05-02
NZ325559A (en)	2000-01-28
SI0874830T1 (en)	2003-08-31
DE69626684T2 (de)	2004-04-29
DE69626684D1 (de)	2003-04-17
KR19990072009A (ko)	1999-09-27
EA003294B1 (ru)	2003-04-24
CN1207289C (zh)	2005-06-22
TR199800990T2 (xx)	1998-07-21
IL134816A0 (en)	2001-05-20
CA2238306A1 (en)	1997-06-12
EP1095936B1 (en)	2004-11-24
TW546293B (en)	2003-08-11
CN1542002A (zh)	2004-11-03
PT874830E (pt)	2003-06-30
HRP970031A2 (en)	1998-08-31
IL138028A0 (en)	2001-10-31
WO1997020824A1 (en)	1997-06-12
HUP9902092A3 (en)	2000-12-28
PA8431301A1 (es)	2000-05-24
OA10794A (en)	2001-07-05
BG102510A (en)	1999-08-31
CN1207734A (zh)	1999-02-10
ES2233275T3 (es)	2005-06-16
IL138027A (en)	2004-08-31
AU1409197A (en)	1997-06-27
NO982590D0 (no)	1998-06-05
MY117290A (en)	2004-06-30
EA199800541A1 (ru)	1998-12-24
HUP9902092A2 (hu)	1999-09-28
ATE283264T1 (de)	2004-12-15
GEP20012388B (en)	2001-03-25
CZ292942B6 (cs)	2004-01-14
US6153757A (en)	2000-11-28
IL124559A0 (en)	1998-12-06
JP2000502330A (ja)	2000-02-29
GT199700015A (es)	1998-07-23
BG64279B1 (bg)	2004-08-31
MX9804457A (es)	1998-09-30
EP0874830B1 (en)	2003-03-12
EP0874830A1 (en)	1998-11-04
IL138027A0 (en)	2001-10-31
NO311360B1 (no)	2001-11-19
SV1997000008A (es)	1999-02-15
AP9801284A0 (en)	1998-09-30
NO982590L (no)	1998-08-05
AP2001002270A0 (en)	2001-09-30
BR9611929A (pt)	1999-05-18
CZ173398A3 (cs)	1998-11-11
AP1288A (en)	2004-07-21
CO4790150A1 (es)	1999-05-31
DK0874830T3 (da)	2003-04-22
AU725831C (en)	2002-10-17

Publication	Publication Date	Title
IL134816A (en)	2003-02-12	Substituted diarylether sulfonic acids and their preparation
IL118825A0 (en)	1996-10-31	6-dimethylaminomethyl -1- phenyl-cyclohexane compounds their preparation and use
IL119864A0 (en)	1997-03-18	1-phenyl-2-dimethylaminomethyl-cyclohexan-1-OL compounds their preparation and use
IL116325A0 (en)	1996-03-31	Substituted 1h-imidazoles their preparation and use
PL338357A1 (en)	2000-10-23	Some 5-alkyl-2-arylaminophenyloacetic acids and their derivatives
IL116851A0 (en)	1996-07-23	3-arylidene-2-oxindole derivatives their preparation and use
GB9503240D0 (en)	1995-04-12	Preparation
IL118442A0 (en)	1996-09-12	Triazolymethyl-cyclopentanols their preparation and use
ZA979175B (en)	1999-04-14	Novel piperidineketocarboxylic acid derivatives their preparation and use
IL118441A0 (en)	1996-09-12	Triazolymethyl-oxiranes their preparation and use
PL321686A1 (en)	1997-12-22	Trensdermal preparation
ZA973097B (en)	1998-10-12	Novel aspire-hydroxy acid derivatives their preparation and use
IL116710A0 (en)	1996-05-14	Substituted 2-phenylpyridines their preparation and use
IL123421A0 (en)	1998-09-24	Phenylacetic acids their preparation and compositions comprising them
IL116712A0 (en)	1996-05-14	Substituted 2-phenylpyridines their preparation and use
NZ236731A (en)	1992-10-28	#b#-substituted sulphonic acids and sulphonates and their preparation
GB9416149D0 (en)	1994-09-28	Vesicle formulation
AU4459196A (en)	1996-08-14	Sustained-release preparation and use
IL116711A0 (en)	1996-05-14	Substituted 2-phenylpyridines their preparation and use
IL116658A0 (en)	1996-05-14	Peptides their preparation and use
AU4526396A (en)	1996-07-19	Preparation of anhydropolyamino acids
IL120903A0 (en)	1997-09-30	Fluoroalkylglycosiduronic acids and corresponding 6(3)-lactones their preparation and their uses
IL122686A0 (en)	1998-08-16	Benzylhydroxylamines their preparation and use
IL118444A0 (en)	1996-09-12	Mercapto-triazolyl-silanes their preparation and use
IL115183A0 (en)	1995-12-31	Imidic acid derivatives their preparation and use

Legal Events

Date	Code	Title
2003-07-31	FF	Patent granted
2003-07-31	KB	Patent renewed
2007-08-19	MM9K	Patent not in force due to non-payment of renewal fees