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IL129851A0 - Purification of neurotrophins - Google Patents

Purification of neurotrophins

Info

Publication number
IL129851A0
IL129851A0 IL12985197A IL12985197A IL129851A0 IL 129851 A0 IL129851 A0 IL 129851A0 IL 12985197 A IL12985197 A IL 12985197A IL 12985197 A IL12985197 A IL 12985197A IL 129851 A0 IL129851 A0 IL 129851A0
Authority
IL
Israel
Prior art keywords
neurotrophins
purification
including mature
mature ngf
methods
Prior art date
Application number
IL12985197A
Other languages
English (en)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of IL129851A0 publication Critical patent/IL129851A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Epoxy Compounds (AREA)
IL12985197A 1996-11-15 1997-11-14 Purification of neurotrophins IL129851A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3083896P 1996-11-15 1996-11-15
US4785597P 1997-05-29 1997-05-29
PCT/US1997/021068 WO1998021234A2 (en) 1996-11-15 1997-11-14 Purification of neurotrophins

Publications (1)

Publication Number Publication Date
IL129851A0 true IL129851A0 (en) 2000-02-29

Family

ID=26706516

Family Applications (2)

Application Number Title Priority Date Filing Date
IL12985197A IL129851A0 (en) 1996-11-15 1997-11-14 Purification of neurotrophins
IL129851A IL129851A (en) 1996-11-15 1999-05-09 A process for isolating recombinant human neurotropin and a recombinant human neurotropin preparation prepared by such a process

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL129851A IL129851A (en) 1996-11-15 1999-05-09 A process for isolating recombinant human neurotropin and a recombinant human neurotropin preparation prepared by such a process

Country Status (21)

Country Link
US (5) US6005081A (xx)
EP (1) EP0942930B1 (xx)
JP (3) JP4671372B2 (xx)
KR (1) KR100554332B1 (xx)
CN (1) CN1268639C (xx)
AT (1) ATE371670T1 (xx)
AU (1) AU729459B2 (xx)
BR (1) BR9713055A (xx)
CA (1) CA2268747A1 (xx)
CZ (1) CZ300296B6 (xx)
DE (1) DE69738074T2 (xx)
EA (1) EA002349B1 (xx)
ES (1) ES2293662T3 (xx)
HU (1) HU222666B1 (xx)
ID (1) ID26697A (xx)
IL (2) IL129851A0 (xx)
NO (1) NO327149B1 (xx)
NZ (1) NZ335207A (xx)
PL (1) PL191400B1 (xx)
TR (1) TR199901734T2 (xx)
WO (1) WO1998021234A2 (xx)

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CN1268639C (zh) * 1996-11-15 2006-08-09 基因技术股份有限公司 神经营养蛋白的纯化
JP2001524670A (ja) * 1997-11-20 2001-12-04 イーエスエー・インコーポレーテッド 電気化学的分析システム
KR101036414B1 (ko) * 1998-05-06 2011-05-23 제넨테크, 인크. 이온 교환 크로마토그래피에 의한 단백질 정제 방법
AU2001249515B2 (en) 2000-03-27 2006-10-05 Genetics Institute, Llc Methods for purifying highly anionic proteins
DK1404428T3 (da) * 2001-06-05 2006-10-30 Genetics Inst Llc Fremgangsmåder til oprensning af stærkt anioniske proteiner
WO2002102844A1 (en) * 2001-06-15 2002-12-27 Queensland Bioprocessing Technology Pty Ltd Haemocyanin from abalone and process of purification thereof
CA2490409A1 (en) 2002-06-28 2004-01-08 Centocor, Inc. Mammalian ch1 deleted mimetibodies, compositions, methods and uses
US7998705B2 (en) * 2002-08-06 2011-08-16 FUJIFILM Diosynth Biotechnologies U.S.A., Inc Increased dynamic binding capacity in ion exchange chromatography by addition of polyethylene glycol
AU2003902066A0 (en) * 2003-05-01 2003-05-15 Norika Holdings Extraction process for a pharmaceutical product
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EP1538201A1 (en) * 2003-12-02 2005-06-08 F.Hoffmann-La Roche Ag Method for the recombinant production and purification of protein kinases
WO2005082401A1 (en) * 2004-02-20 2005-09-09 Rinat Neuroscience Corp. Methods of treating obesity or diabetes using nt-4/5
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US8097584B2 (en) 2005-05-25 2012-01-17 Novo Nordisk A/S Stabilized formulations of insulin that comprise ethylenediamine
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EP1960419B1 (en) * 2005-12-09 2016-03-16 Ares Trading S.A. Method for purifying fsh or a fsh mutant
CN100419422C (zh) * 2005-12-12 2008-09-17 北京三诺佳邑生物技术有限责任公司 测定神经生长因子含量的方法
KR101398713B1 (ko) 2005-12-20 2014-06-12 브리스톨-마이어스 스큅 컴퍼니 조성물 및 조성물의 제조 방법
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US7935342B2 (en) * 2006-02-02 2011-05-03 Rinat Neuroscience Corp. Methods for treating obesity by administering a trkB antagonist
US10741034B2 (en) 2006-05-19 2020-08-11 Apdn (B.V.I.) Inc. Security system and method of marking an inventory item and/or person in the vicinity
US9790538B2 (en) * 2013-03-07 2017-10-17 Apdn (B.V.I.) Inc. Alkaline activation for immobilization of DNA taggants
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EP2188302B1 (en) 2007-07-09 2017-11-01 Genentech, Inc. Prevention of disulfide bond reduction during recombinant production of polypeptides
PL2840090T3 (pl) 2007-10-30 2018-07-31 Genentech, Inc. Oczyszczanie przeciwciał za pomocą chromatografii kationowymiennej
US8447409B2 (en) * 2008-10-15 2013-05-21 Cochlear Limited Electroneural interface for a medical implant
US20120269815A1 (en) * 2008-12-23 2012-10-25 Regents Of The University Of Minnesota Neurotrophins and uses thereof
JP5695384B2 (ja) 2009-10-05 2015-04-01 花王株式会社 毛髪形状感受性遺伝子
SG181496A1 (en) 2009-12-18 2012-07-30 Csl Ltd Method of purifying polypeptides
JP5699429B2 (ja) * 2009-12-18 2015-04-08 東ソー株式会社 Ｆｃレセプターの精製方法
JP5903044B2 (ja) 2010-06-25 2016-04-13 日本臓器製薬株式会社 被検物質の判定又は評価方法
CN102898514B (zh) * 2011-07-28 2015-04-29 中国人民解放军军事医学科学院生物工程研究所 重组人神经生长因子缺失突变体及其制备方法和用途
EP2594295A1 (en) 2011-11-16 2013-05-22 Servicio Andaluz De Salud Nerve implants based on a compacted biomaterial containing cells
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CN103880943A (zh) * 2014-01-20 2014-06-25 厦门北大之路生物工程有限公司 一种rhNGF成熟肽的制备方法
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CN104195160A (zh) * 2014-08-08 2014-12-10 厦门北大之路生物工程有限公司 一种以Pro-BDNF的形式制备人脑源性神经营养因子的方法
US10760182B2 (en) 2014-12-16 2020-09-01 Apdn (B.V.I.) Inc. Method and device for marking fibrous materials
CN106279397A (zh) * 2015-06-09 2017-01-04 舒泰神（北京）生物制药股份有限公司 一种神经生长因子的提取方法
CN109070130B (zh) 2016-04-11 2022-03-22 亚普蒂恩（B V I）公司 用于标记纤维素产品的方法
CN106478801A (zh) * 2016-10-10 2017-03-08 未名生物医药有限公司 一种从哺乳动物细胞培养物中分离重组人神经生长因子的方法
US10995371B2 (en) 2016-10-13 2021-05-04 Apdn (B.V.I.) Inc. Composition and method of DNA marking elastomeric material
WO2018156352A1 (en) 2017-02-21 2018-08-30 Apdn (B.V.I) Inc. Nucleic acid coated submicron particles for authentication
GB201705955D0 (en) * 2017-04-13 2017-05-31 Cell Guidance Systems Ltd Delivery method
CN107973848B (zh) * 2017-12-28 2020-10-16 未名生物医药有限公司 一种从混合物中分离天然序列神经生长因子的方法
CN108239146A (zh) * 2018-03-26 2018-07-03 江苏中新医药有限公司 一种高纯度rhNGF的制备方法
CN108467428A (zh) * 2018-03-26 2018-08-31 江苏中新医药有限公司 一种清除rhNGF中N端截短及异常变异体的方法
CN108467429A (zh) * 2018-03-26 2018-08-31 江苏中新医药有限公司 疏水层析动态清除重组人神经生长因子前体的方法
EP3784691A1 (en) * 2018-04-27 2021-03-03 Chiesi Farmaceutici S.p.A. Production of nerve growth factor (ngf) and of muteins thereof
CN114252519B (zh) * 2020-09-23 2023-11-24 舒泰神（北京）生物制药股份有限公司 一种测定神经生长因子纯度的方法
CN114380901A (zh) * 2021-12-31 2022-04-22 华东理工大学 蛋白纳米粒子的制备方法、所得蛋白纳米粒子及其应用

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Also Published As

Publication number Publication date
US20040138431A1 (en) 2004-07-15
NO327149B1 (no) 2009-05-04
EP0942930A2 (en) 1999-09-22
EP0942930B1 (en) 2007-08-29
NO992353D0 (no) 1999-05-14
WO1998021234A2 (en) 1998-05-22
PL333460A1 (en) 1999-12-20
US6812330B2 (en) 2004-11-02
DE69738074T2 (de) 2008-05-21
CN1268639C (zh) 2006-08-09
EA002349B1 (ru) 2002-04-25
DE69738074D1 (de) 2007-10-11
WO1998021234A3 (en) 1998-07-23
HU222666B1 (hu) 2003-09-29
US6953844B2 (en) 2005-10-11
HUP9903947A3 (en) 2001-03-28
CN1237184A (zh) 1999-12-01
US20020137893A1 (en) 2002-09-26
PL191400B1 (pl) 2006-05-31
JP2007302679A (ja) 2007-11-22
CZ300296B6 (cs) 2009-04-15
AU729459B2 (en) 2001-02-01
JP4881234B2 (ja) 2012-02-22
IL129851A (en) 2006-12-10
NO992353L (no) 1999-07-09
BR9713055A (pt) 2000-04-04
JP4671372B2 (ja) 2011-04-13
KR100554332B1 (ko) 2006-02-24
NZ335207A (en) 2000-09-29
US6184360B1 (en) 2001-02-06
US6423831B1 (en) 2002-07-23
ES2293662T3 (es) 2008-03-16
EA199900436A1 (ru) 2000-02-28
US6005081A (en) 1999-12-21
JP2009040786A (ja) 2009-02-26
JP2001503779A (ja) 2001-03-21
KR20000053297A (ko) 2000-08-25
CA2268747A1 (en) 1998-05-22
ATE371670T1 (de) 2007-09-15
AU5444898A (en) 1998-06-03
HUP9903947A2 (hu) 2000-03-28
TR199901734T2 (xx) 2000-01-21
ID26697A (id) 2001-02-01
CZ166699A3 (cs) 1999-10-13

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