IL129477A0 - N-(aryl/heteroaryl)amino acid derivatives pharmaceutical compositions comprising same and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds - Google Patents

N-(aryl/heteroaryl)amino acid derivatives pharmaceutical compositions comprising same and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

Info

Publication number: IL129477A0
Authority: IL; Israel
Prior art keywords: heteroaryl; aryl; synthesis; compounds; amino acid
Prior art date: 1996-11-22

Application number

IL12947797A

Original Assignee

Elan Pharm Inc

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-22

Filing date

1997-11-20

Publication date

2000-02-29

1997-11-20 Application filed by Elan Pharm Inc, Lilly Co Eli filed Critical Elan Pharm Inc

2000-02-29 Publication of IL129477A0 publication Critical patent/IL129477A0/en

Links

150000003862 amino acid derivatives Chemical class 0.000 title 1
DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
125000001072 heteroaryl group Chemical group 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)

IL12947797A 1996-11-22 1997-11-20 N-(aryl/heteroaryl)amino acid derivatives pharmaceutical compositions comprising same and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds IL129477A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US75533496A	1996-11-22	1996-11-22
PCT/US1997/018704 WO1998022493A2 (en)	1996-11-22	1997-11-20	N-(ARYL/HETEROARYL) AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS

Publications (1)

Publication Number	Publication Date
IL129477A0 true IL129477A0 (en)	2000-02-29

Family

ID=25038718

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12947797A IL129477A0 (en)	1996-11-22	1997-11-20	N-(aryl/heteroaryl)amino acid derivatives pharmaceutical compositions comprising same and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

Country Status (13)

Country	Link
EP (1)	EP0942923A2 (en)
JP (1)	JP2001519769A (en)
CN (1)	CN1237978A (en)
AU (1)	AU5354398A (en)
BR (1)	BR9714358A (en)
CA (1)	CA2270876A1 (en)
HU (1)	HUP0001383A3 (en)
ID (1)	ID22275A (en)
IL (1)	IL129477A0 (en)
NO (1)	NO992426L (en)
NZ (1)	NZ335157A (en)
TR (1)	TR199901132T2 (en)
WO (1)	WO1998022493A2 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ509241A (en)	1998-08-07	2003-08-29	Du Pont Pharm Co	Succinoylamino lactams as inhibitors of alpha-beta protein production
HRP990246A2 (en)	1998-08-07	2000-06-30	Du Pont Pharm Co	Succinoylamino benzodiazepines as inhibitors of a beta protein production
AU6278099A (en)	1998-09-30	2000-04-17	Elan Pharmaceuticals, Inc.	Biological reagents and methods for determining the mechanism in the generation of beta-amyloid peptide
US6737038B1 (en)	1998-11-12	2004-05-18	Bristol-Myers Squibb Company	Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
IL142816A0 (en)	1998-12-24	2002-03-10	Du Pont Pharm Co	SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
US6960576B2 (en)	1999-09-13	2005-11-01	Bristol-Myers Squibb Pharma Company	Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
US6503902B2 (en)	1999-09-13	2003-01-07	Bristol-Myers Squibb Pharma Company	Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production
WO2001027108A1 (en)	1999-10-08	2001-04-19	Bristol-Myers Squibb Pharma Company	AMINO LACTAM SULFONAMIDES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
US6525044B2 (en)	2000-02-17	2003-02-25	Bristol-Myers Squibb Company	Succinoylamino carbocycles and heterocycles as inhibitors of a-β protein production
BR0110051A (en)	2000-04-03	2004-12-07	Bristol Myers Squibb Pharma Co	Compound, Compound Use, Pharmaceutical Composition and Method of Treatment of Alzheimer's Disease
EP1268433A1 (en)	2000-04-03	2003-01-02	Bristol-Myers Squibb Pharma Company	Cyclic lactams as inhibitors of a-beta-protein production
US6632812B2 (en)	2000-04-11	2003-10-14	Dupont Pharmaceuticals Company	Substituted lactams as inhibitors of Aβ protein production
AU2001261728A1 (en)	2000-05-17	2001-11-26	Bristol-Myers Squibb Pharma Company	Use of small molecule radioligands for diagnostic imaging
WO2001092235A1 (en)	2000-06-01	2001-12-06	Bristol-Myers Squibb Pharma Company	LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
US6432944B1 (en)	2000-07-06	2002-08-13	Bristol-Myers Squibb Company	Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives
US7270800B2 (en)	2000-08-24	2007-09-18	University Of Pittsburgh	Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
EP1334091B1 (en)	2000-08-24	2012-09-19	University of Pittsburgh - Of the Commonwealth System of Higher Education	Thioflavin derivatives and their use in diagnosis and therapy of alzheimer's disease
CN1800176A (en)	2000-12-13	2006-07-12	惠氏	Heterocyclic sulfonamide inhibitors of beta amyloid production
US6657070B2 (en)	2000-12-13	2003-12-02	Wyeth	Production of chirally pure α-amino acids and N-sulfonyl α-amino acids
CH698246B1 (en) *	2001-12-20	2009-06-30	Hoffmann La Roche	Test to identify inhibitors of beta secretases.
DE10306202A1 (en)	2003-02-13	2004-08-26	Grünenthal GmbH	2-(hetero)aryl-2-(N-((hetero)aryl)-amino)-acetic acid derivatives useful e.g. for treating anxiety, inflammation, allergy, depression, diarrhea or especially pain is NMDA antagonist
RU2440995C2 (en) *	2003-03-14	2012-01-27	Юнивесити Оф Питсбэг	Benzothiazole derivatives, pharmaceutical composition exhibiting property to bind amyloid and method for detecting amyloid deposits in mammal
MXPA05010368A (en)	2003-03-31	2005-11-17	Wyeth Corp	Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof.
WO2005009344A2 (en)	2003-06-05	2005-02-03	Elan Pharmaceuticals, Inc.	Acylated amino acid amidyl pyrazoles and related compounds
US8236282B2 (en)	2003-08-22	2012-08-07	University of Pittsburgh—of the Commonwealth System of Higher Education	Benzothiazole derivative compounds, compositions and uses
JP2007517905A (en)	2004-01-16	2007-07-05	ワイス	Beta-amyloidogenic heterocyclic sulfonamide inhibitors containing azoles
EP1725522B1 (en) *	2004-03-03	2014-09-10	GlaxoSmithKline LLC	Aniline derivatives as selective androgen receptor modulators
EP1871379A4 (en) *	2005-04-15	2010-06-02	Glaxosmithkline Llc	Cyanoarylamines
CN100999546B (en) *	2007-01-11	2010-08-11	清华大学	Polypeptide compound with nitrogen-containing heterocycle modification and application thereof
WO2012172449A1 (en)	2011-06-13	2012-12-20	Pfizer Inc.	Lactams as beta secretase inhibitors
CN111777571B (en) *	2020-06-28	2023-07-11	武汉药明康德新药开发有限公司	Synthesis method of chiral 2-amino-3- (1, 3-benzothiazole-2-yl) propionic acid hydrochloride

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ274074A (en) *	1993-10-01	1997-11-24	Merrell Pharma Inc	Various dipeptide derivatives having a reduced carboxy group, the aldehyde being optionally substituted; pharmaceutical compositions
US5863902A (en) *	1995-01-06	1999-01-26	Sibia Neurosciences, Inc.	Methods of treating neurodegenerative disorders using protease inhibitors

1997
- 1997-11-20 ID IDW990395A patent/ID22275A/en unknown
- 1997-11-20 CN CN97199776A patent/CN1237978A/en active Pending
- 1997-11-20 IL IL12947797A patent/IL129477A0/en unknown
- 1997-11-20 BR BR9714358A patent/BR9714358A/en not_active IP Right Cessation
- 1997-11-20 AU AU53543/98A patent/AU5354398A/en not_active Abandoned
- 1997-11-20 TR TR1999/01132T patent/TR199901132T2/en unknown
- 1997-11-20 NZ NZ335157A patent/NZ335157A/en unknown
- 1997-11-20 CA CA002270876A patent/CA2270876A1/en not_active Abandoned
- 1997-11-20 HU HU0001383A patent/HUP0001383A3/en unknown
- 1997-11-20 JP JP52364998A patent/JP2001519769A/en active Pending
- 1997-11-20 WO PCT/US1997/018704 patent/WO1998022493A2/en not_active Ceased
- 1997-11-20 EP EP97950576A patent/EP0942923A2/en not_active Withdrawn
1999
- 1999-05-20 NO NO992426A patent/NO992426L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
CN1237978A (en)	1999-12-08
AU5354398A (en)	1998-06-10
JP2001519769A (en)	2001-10-23
HUP0001383A1 (en)	2001-05-28
WO1998022493A3 (en)	1998-07-23
NO992426L (en)	1999-06-30
CA2270876A1 (en)	1998-05-28
NO992426D0 (en)	1999-05-20
BR9714358A (en)	2000-03-21
NZ335157A (en)	2001-01-26
ID22275A (en)	1999-09-23
EP0942923A2 (en)	1999-09-22
TR199901132T2 (en)	1999-08-23
WO1998022493A2 (en)	1998-05-28
HUP0001383A3 (en)	2001-11-28

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