NO992426D0 - N- (aryl / heteroaryl) amino acid derivatives, pharmaceutical compositions comprising the same, and methods for inhibiting <beta> -amyloid peptide release and / or its synthesis using such compounds - Google Patents
N- (aryl / heteroaryl) amino acid derivatives, pharmaceutical compositions comprising the same, and methods for inhibiting <beta> -amyloid peptide release and / or its synthesis using such compoundsInfo
- Publication number
- NO992426D0 NO992426D0 NO992426A NO992426A NO992426D0 NO 992426 D0 NO992426 D0 NO 992426D0 NO 992426 A NO992426 A NO 992426A NO 992426 A NO992426 A NO 992426A NO 992426 D0 NO992426 D0 NO 992426D0
- Authority
- NO
- Norway
- Prior art keywords
- heteroaryl
- beta
- inhibiting
- aryl
- synthesis
- Prior art date
Links
- 150000003862 amino acid derivatives Chemical class 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75533496A | 1996-11-22 | 1996-11-22 | |
| PCT/US1997/018704 WO1998022493A2 (en) | 1996-11-22 | 1997-11-20 | N-(ARYL/HETEROARYL) AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO992426D0 true NO992426D0 (en) | 1999-05-20 |
| NO992426L NO992426L (en) | 1999-06-30 |
Family
ID=25038718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO992426A NO992426L (en) | 1996-11-22 | 1999-05-20 | N- (aryl / heteroaryl) amino acid derivatives, pharmaceutical compositions comprising the same, and methods for inhibiting <beta> -amyloid peptide release and / or its synthesis using such compounds |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0942923A2 (en) |
| JP (1) | JP2001519769A (en) |
| CN (1) | CN1237978A (en) |
| AU (1) | AU5354398A (en) |
| BR (1) | BR9714358A (en) |
| CA (1) | CA2270876A1 (en) |
| HU (1) | HUP0001383A3 (en) |
| ID (1) | ID22275A (en) |
| IL (1) | IL129477A0 (en) |
| NO (1) | NO992426L (en) |
| NZ (1) | NZ335157A (en) |
| TR (1) | TR199901132T2 (en) |
| WO (1) | WO1998022493A2 (en) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ509241A (en) | 1998-08-07 | 2003-08-29 | Du Pont Pharm Co | Succinoylamino lactams as inhibitors of alpha-beta protein production |
| HRP990246A2 (en) | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
| EP1131634A2 (en) | 1998-09-30 | 2001-09-12 | Elan Pharmaceuticals, Inc. | Determining the mechanism of beta-amyloid peptide generation |
| US6737038B1 (en) | 1998-11-12 | 2004-05-18 | Bristol-Myers Squibb Company | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging |
| CA2347671A1 (en) | 1998-12-24 | 2000-07-06 | Dupont Pharmaceuticals Company | Succinoylamino benzodiazepines as inhibitors of a.beta. protein production |
| US6960576B2 (en) | 1999-09-13 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production |
| US6503902B2 (en) | 1999-09-13 | 2003-01-07 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production |
| AU7997700A (en) | 1999-10-08 | 2001-04-23 | Du Pont Pharmaceuticals Company | Amino lactam sulfonamides as inhibitors of abeta protein production |
| JP2003523345A (en) | 2000-02-17 | 2003-08-05 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | Succinoylamino carbocycles and heterocycles as inhibitors of Aβ protein production |
| CA2404023A1 (en) | 2000-04-03 | 2001-10-11 | Richard E. Olson | Cyclic lactams as inhibitors of a.beta. protein production |
| US6713476B2 (en) | 2000-04-03 | 2004-03-30 | Dupont Pharmaceuticals Company | Substituted cycloalkyls as inhibitors of a beta protein production |
| JP2004500419A (en) | 2000-04-11 | 2004-01-08 | デュポン ファーマシューティカルズ カンパニー | Substituted lactams as Aβ protein production inhibitors |
| AU2001261728A1 (en) | 2000-05-17 | 2001-11-26 | Bristol-Myers Squibb Pharma Company | Use of small molecule radioligands for diagnostic imaging |
| HK1049333A1 (en) | 2000-06-01 | 2003-05-09 | Bristol-Myers Squibb Pharma Company | Lactams substituted by cyclic succinates as inhibitors of a-beta protein production |
| US6432944B1 (en) | 2000-07-06 | 2002-08-13 | Bristol-Myers Squibb Company | Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives |
| PT1334091E (en) | 2000-08-24 | 2013-01-07 | Univ Pittsburgh | Thioflavin derivatives and their use in diagnosis and therapy of alzheimer`s disease |
| US7270800B2 (en) | 2000-08-24 | 2007-09-18 | University Of Pittsburgh | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
| US6657070B2 (en) | 2000-12-13 | 2003-12-02 | Wyeth | Production of chirally pure α-amino acids and N-sulfonyl α-amino acids |
| BR0116063A (en) | 2000-12-13 | 2004-08-03 | Wyeth Corp | Heterocyclically Sulfonamide Inhibitors of Beta Amyloid Production and Its Uses |
| CH698246B1 (en) * | 2001-12-20 | 2009-06-30 | Hoffmann La Roche | Test to identify inhibitors of beta secretases. |
| DE10306202A1 (en) | 2003-02-13 | 2004-08-26 | Grünenthal GmbH | 2-(hetero)aryl-2-(N-((hetero)aryl)-amino)-acetic acid derivatives useful e.g. for treating anxiety, inflammation, allergy, depression, diarrhea or especially pain is NMDA antagonist |
| SI1611115T1 (en) * | 2003-03-14 | 2012-12-31 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Benzothiazole derivative compounds, compositions and uses |
| NZ542468A (en) | 2003-03-31 | 2009-01-31 | Wyeth Corp | Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof |
| EP1633350B1 (en) | 2003-06-05 | 2012-10-03 | Elan Pharmaceuticals, Inc. | Acylated amino acid amidyl pyrazoles and related compounds |
| US8236282B2 (en) | 2003-08-22 | 2012-08-07 | University of Pittsburgh—of the Commonwealth System of Higher Education | Benzothiazole derivative compounds, compositions and uses |
| ES2330451T3 (en) | 2004-01-16 | 2009-12-10 | Wyeth | HETEROCICLIC SULFONAMID BASED INHIBITORS FROM THE PRODUCTION OF BETA-AMYLOOIDS CONTAINING AN AZOL. |
| JP4805909B2 (en) | 2004-03-03 | 2011-11-02 | スミスクライン ビーチャム コーポレーション | Aniline derivatives as selective androgen receptor modulators |
| JP2008536868A (en) * | 2005-04-15 | 2008-09-11 | スミスクライン・ビーチャム・コーポレイション | Cyanoarylamine |
| CN100999546B (en) * | 2007-01-11 | 2010-08-11 | 清华大学 | Polypeptide compound with nitrogen-containing heterocycle modification and application thereof |
| WO2012172449A1 (en) | 2011-06-13 | 2012-12-20 | Pfizer Inc. | Lactams as beta secretase inhibitors |
| CN111777571B (en) * | 2020-06-28 | 2023-07-11 | 武汉药明康德新药开发有限公司 | Synthesis method of chiral 2-amino-3- (1, 3-benzothiazole-2-yl) propionic acid hydrochloride |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT721449E (en) * | 1993-10-01 | 2002-06-28 | Merrell Pharma Inc | BETA-AMYLOID PROTEIN PRODUCTION INHIBITORS |
| US5863902A (en) * | 1995-01-06 | 1999-01-26 | Sibia Neurosciences, Inc. | Methods of treating neurodegenerative disorders using protease inhibitors |
-
1997
- 1997-11-20 ID IDW990395A patent/ID22275A/en unknown
- 1997-11-20 AU AU53543/98A patent/AU5354398A/en not_active Abandoned
- 1997-11-20 HU HU0001383A patent/HUP0001383A3/en unknown
- 1997-11-20 EP EP97950576A patent/EP0942923A2/en not_active Withdrawn
- 1997-11-20 TR TR1999/01132T patent/TR199901132T2/en unknown
- 1997-11-20 NZ NZ335157A patent/NZ335157A/en unknown
- 1997-11-20 IL IL12947797A patent/IL129477A0/en unknown
- 1997-11-20 BR BR9714358A patent/BR9714358A/en not_active IP Right Cessation
- 1997-11-20 WO PCT/US1997/018704 patent/WO1998022493A2/en not_active Ceased
- 1997-11-20 JP JP52364998A patent/JP2001519769A/en active Pending
- 1997-11-20 CA CA002270876A patent/CA2270876A1/en not_active Abandoned
- 1997-11-20 CN CN97199776A patent/CN1237978A/en active Pending
-
1999
- 1999-05-20 NO NO992426A patent/NO992426L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ335157A (en) | 2001-01-26 |
| IL129477A0 (en) | 2000-02-29 |
| BR9714358A (en) | 2000-03-21 |
| TR199901132T2 (en) | 1999-08-23 |
| ID22275A (en) | 1999-09-23 |
| CN1237978A (en) | 1999-12-08 |
| WO1998022493A3 (en) | 1998-07-23 |
| CA2270876A1 (en) | 1998-05-28 |
| JP2001519769A (en) | 2001-10-23 |
| HUP0001383A1 (en) | 2001-05-28 |
| AU5354398A (en) | 1998-06-10 |
| WO1998022493A2 (en) | 1998-05-28 |
| HUP0001383A3 (en) | 2001-11-28 |
| EP0942923A2 (en) | 1999-09-22 |
| NO992426L (en) | 1999-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |