IL126951A0 - Carboline derivatives - Google Patents

Carboline derivatives

Info

Publication number: IL126951A0
Authority: IL; Israel
Prior art keywords: carboline derivatives; carboline; derivatives
Prior art date: 1996-05-10

Application number

IL12695197A

Other languages

English (en)

Original Assignee

Icos Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-10

Filing date

1997-05-05

Publication date

1999-09-22

1996-05-10 Priority claimed from GBGB9609777.9A external-priority patent/GB9609777D0/en

1996-05-10 Priority claimed from GBGB9609820.7A external-priority patent/GB9609820D0/en

1997-05-05 Application filed by Icos Corp filed Critical Icos Corp

1999-09-22 Publication of IL126951A0 publication Critical patent/IL126951A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL12695197A 1996-05-10 1997-05-05 Carboline derivatives IL126951A0 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9609777.9A GB9609777D0 (en)	1996-05-10	1996-05-10	Chemical compounds
GBGB9609820.7A GB9609820D0 (en)	1996-05-10	1996-05-10	Chemical compounds
PCT/EP1997/002277 WO1997043287A1 (en)	1996-05-10	1997-05-05	Carboline derivatives

Publications (1)

Publication Number	Publication Date
IL126951A0 true IL126951A0 (en)	1999-09-22

Family

ID=26309303

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12695197A IL126951A0 (en)	1996-05-10	1997-05-05	Carboline derivatives

Country Status (26)

Country	Link
US (2)	US6117881A (pt)
EP (1)	EP0912567B1 (pt)
JP (1)	JP3418405B2 (pt)
KR (1)	KR20000010918A (pt)
CN (1)	CN1067071C (pt)
AP (1)	AP9801365A0 (pt)
AT (1)	ATE215950T1 (pt)
AU (1)	AU711885B2 (pt)
BG (1)	BG102879A (pt)
BR (1)	BR9709230A (pt)
CA (1)	CA2253948C (pt)
CZ (1)	CZ358598A3 (pt)
DE (1)	DE69711882T2 (pt)
EA (1)	EA199800907A1 (pt)
EE (1)	EE9800390A (pt)
ES (1)	ES2175404T3 (pt)
HU (1)	HUP9901478A3 (pt)
IL (1)	IL126951A0 (pt)
IS (1)	IS4864A (pt)
NO (1)	NO985222L (pt)
OA (1)	OA10920A (pt)
PL (1)	PL329875A1 (pt)
SK (1)	SK154498A3 (pt)
TR (1)	TR199802282T2 (pt)
WO (1)	WO1997043287A1 (pt)
YU (1)	YU49898A (pt)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SK154498A3 (en) *	1996-05-10	2000-01-18	Icos Corp	Carboline derivatives, process for the preparation thereof, pharmaceutical compositions containing same and use of mentioned derivatives as drugs
US6331543B1 (en)	1996-11-01	2001-12-18	Nitromed, Inc.	Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
DE19837069C1 (de)	1998-08-17	2000-01-05	Bayer Ag	Substituierte Zimtsäuren und Zimtsäureester, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von substituierten Indanoncarbonsäureestern
AU1025899A (en) *	1998-09-16	2000-04-03	Icos Corporation	Carboline derivatives as cgmp phosphodiesterase inhibitors
DE19903087A1 (de) *	1999-01-27	2000-08-10	Forssmann Wolf Georg	Behandlung von erektilen Dysfunktionen mit C-Typ Natriuretischem Polypeptid (CNP) als Monotherapie oder in Kombination mit Phosphodiesterasehemmern
WO2000056304A2 (en) *	1999-03-24	2000-09-28	Harbor Branch Oceanographic Institution, Inc.	Anti-inflammatory uses of manzamines
NO20002097L (no)	1999-04-30	2001-10-26	Lilly Icos Llc	Fremstillingsgjenstander
US6451807B1 (en)	1999-04-30	2002-09-17	Lilly Icos, Llc.	Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor
WO2001078711A2 (en)	2000-04-19	2001-10-25	Lilly Icos, Llc.	Pde-v inhibitors for treatment of parkinson's disease
UA74826C2 (en)	2000-05-17	2006-02-15	Ortho Mcneil Pharm Inc	?-carboline derivatives as phosphodiesterase inhibitors
EP1294721B1 (en)	2000-06-23	2006-07-19	Lilly Icos LLC	Cyclic gmp-specific phosphodiesterase inhibitors
US6821978B2 (en)	2000-09-19	2004-11-23	Schering Corporation	Xanthine phosphodiesterase V inhibitors
CA2437718C (en) *	2001-02-12	2010-03-16	Lilly Icos Llc	Carboline derivatives
CA2437715C (en)	2001-02-12	2010-11-02	Lilly Icos Llc	Carboline derivatives
MXPA03009750A (es) *	2001-04-25	2004-06-30	Lilly Icos Llc	Compuestos quimicos.
CA2445460A1 (en)	2001-06-05	2002-12-12	Lilly Icos Llc	Carboline derivatives as pde-5 inhibitors
CA2445189C (en)	2001-06-21	2009-02-17	Lilly Icos Llc	Carboline derivatives as pdev inhibitors
US6943171B2 (en)	2001-11-09	2005-09-13	Schering Corporation	Polycyclic guanine derivative phosphodiesterase V inhibitors
AU2002358772B2 (en) *	2001-12-20	2008-11-20	Merck Serono Sa	Pyrrolidine derivatives as prostaglandin modulators
TWI329111B (en)	2002-05-24	2010-08-21	X Ceptor Therapeutics Inc	Azepinoindole and pyridoindole derivatives as pharmaceutical agents
US7595311B2 (en)	2002-05-24	2009-09-29	Exelixis, Inc.	Azepinoindole derivatives as pharmaceutical agents
JP2007501866A (ja)	2003-06-13	2007-02-01	マイクロバイアインコーポレイテッド	胃腸疾患の治療のための方法および組成物
US7872133B2 (en)	2003-06-23	2011-01-18	Ono Pharmaceutical Co., Ltd.	Tricyclic heterocycle compound
US8076353B2 (en)	2004-03-15	2011-12-13	Ptc Therapeutics, Inc.	Inhibition of VEGF translation
AU2005222632B2 (en)	2004-03-15	2012-02-09	Ptc Therapeutics, Inc.	Carboline derivatives useful in the inhibition of angiogenesis
US7767689B2 (en) *	2004-03-15	2010-08-03	Ptc Therapeutics, Inc.	Carboline derivatives useful in the treatment of cancer
US8076352B2 (en)	2004-03-15	2011-12-13	Ptc Therapeutics, Inc.	Administration of carboline derivatives useful in the treatment of cancer and other diseases
SA05260149B1 (ar) *	2004-05-26	2010-06-16	إيساي آر آند دي منجمنت كو.، ليمتد	مركب سيناميد
WO2005115990A1 (ja)	2004-05-26	2005-12-08	Eisai R & D Management Co., Ltd.	シンナミド化合物
ES2338904T3 (es)	2004-10-26	2010-05-13	EISAI R&D MANAGEMENT CO., LTD.	Forma amorfa de compuestos de cinamida.
EP1829874B1 (en)	2004-12-22	2014-02-12	Ono Pharmaceutical Co., Ltd.	Tricyclic compound and use thereof
US8506934B2 (en)	2005-04-29	2013-08-13	Robert I. Henkin	Methods for detection of biological substances
EP2275096A3 (en)	2005-08-26	2011-07-13	Braincells, Inc.	Neurogenesis via modulation of the muscarinic receptors
EP2258359A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation with sabcomelin
EP1940389A2 (en)	2005-10-21	2008-07-09	Braincells, Inc.	Modulation of neurogenesis by pde inhibition
JP2009513672A (ja)	2005-10-31	2009-04-02	ブレインセルス，インコーポレイティド	神経発生のｇａｂａ受容体媒介調節
BRPI0618643A2 (pt)	2005-11-09	2011-09-06	Combinatorx Inc	composição compreendendo um par de fármacos, composição compreendendo um corticosteróide e um imunossupressor dependente de imunofilina não-esteróide, kits e uso
AU2006316005A1 (en) *	2005-11-18	2007-05-24	Eisai R & D Management Co., Ltd.	Process for production of cinnamamide derivative
WO2007058304A1 (ja) *	2005-11-18	2007-05-24	Eisai R & D Management Co., Ltd.	シンナミド化合物の塩またはそれらの溶媒和物
TWI370130B (en)	2005-11-24	2012-08-11	Eisai R&D Man Co Ltd	Two cyclic cinnamide compound
US20070117839A1 (en) *	2005-11-24	2007-05-24	Eisai R&D Management Co., Ltd.	Two cyclic cinnamide compound
MY144960A (en)	2005-11-24	2011-11-30	Eisai R&D Man Co Ltd	Morpholine type cinnamide compound
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
TWI378091B (en)	2006-03-09	2012-12-01	Eisai R&D Man Co Ltd	Multi-cyclic cinnamide derivatives
CA2651862A1 (en)	2006-05-09	2007-11-22	Braincells, Inc.	5 ht receptor mediated neurogenesis
EP2382975A3 (en)	2006-05-09	2012-02-29	Braincells, Inc.	Neurogenesis by modulating angiotensin
US7737141B2 (en)	2006-07-28	2010-06-15	Eisai R&D Management Co., Ltd.	Prodrug of cinnamide compound
KR20090064418A (ko)	2006-09-08	2009-06-18	브레인셀즈 인코퍼레이션	4-아실아미노피리딘 유도체 포함 조합물
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
US8293489B2 (en)	2007-01-31	2012-10-23	Henkin Robert I	Methods for detection of biological substances
TW200848054A (en)	2007-02-28	2008-12-16	Eisai R&D Man Co Ltd	Two cyclic oxomorpholine derivatives
CN101679360A (zh) *	2007-05-16	2010-03-24	卫材R&D管理有限公司	一步生产肉桂酰胺衍生物的方法
CA2694401C (en)	2007-08-31	2012-12-04	Eisai R&D Management Co., Ltd.	Polycyclic compound
US7935815B2 (en)	2007-08-31	2011-05-03	Eisai R&D Management Co., Ltd.	Imidazoyl pyridine compounds and salts thereof
CA2712095A1 (en) *	2008-01-28	2009-08-06	Eisai R&D Management Co., Ltd.	Crystalline cinnamide compounds or salts thereof
US8580801B2 (en)	2008-07-23	2013-11-12	Robert I. Henkin	Phosphodiesterase inhibitor treatment
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
US20150119399A1 (en)	2012-01-10	2015-04-30	President And Fellows Of Harvard College	Beta-cell replication promoting compounds and methods of their use
WO2014055801A1 (en)	2012-10-05	2014-04-10	Henkin Robert I	Phosphodiesterase inhibitors for treating taste and smell disorders
WO2015126944A1 (en)	2014-02-18	2015-08-27	Henkin Robert I	Methods and compositions for diagnosing and treating loss and/or distortion of taste or smell
AU2016326718B2 (en) *	2015-09-23	2022-12-15	Minerva Biotechnologies Corporation	Method of screening for agents for differentiating stem cells

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3644384A (en) *	1969-06-09	1972-02-22	Sterling Drug Inc	Certain 2-(alpha-haloacetyl) - 1 2 3 4-tetrahydro - 9h - pyrido(3 4-b)indole-3-carboxylates and derivatives
US3717638A (en) *	1971-03-11	1973-02-20	Sterling Drug Inc	1,2,3,4,6,7,12,12A-OCTAHYDRO-2-PHENYLPYRAZINO[2',1':6,1]PYRIDO[3,4-b]INDOLES AND INTERMEDIATES THEREFOR
US3917599A (en) *	1973-03-30	1975-11-04	Council Scient Ind Res	2-Substituted-1,2,3,4,6,7,12,12A-octahydropyrazino(2{40 ,1{40 :6,1)pyrido(3,4-B)indoles
GB1454171A (en) *	1973-10-19	1976-10-27	Council Scient Ind Res	Tetracyclic compounds
US4188390A (en) *	1977-11-05	1980-02-12	Pfizer Inc.	Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines
GR79603B (pt) *	1982-07-24	1984-10-31	Pfizer
IT1217190B (it) *	1988-04-22	1990-03-14	Recordati Chem Pharm	Composti utili per il trattamento e diagnosi di disfunzioni frettili
FI892362A7 (fi) *	1988-06-01	1989-12-02	Eisai Co Ltd	Buteeni- tai propeenihappojohdannainen
EP0357122A3 (en) *	1988-08-29	1991-10-23	Duphar International Research B.V	Use of beta-carbolines, their bio-isosteric benzofuran and benzothiophene analogues for the manufacture of a medicament having cytostatic properties
DE3830096A1 (de) *	1988-09-03	1990-03-15	Hoechst Ag	Piperazindione mit psychotroper wirkung
FR2649613B1 (fr) *	1989-07-11	1991-09-27	Virag Ronald	Medicament vaso-actif
JPH0344324A (ja) *	1989-07-13	1991-02-26	Kazuoki Tsuchiya	性機能賦活剤
DE69105040T2 (de) *	1990-05-31	1995-03-23	Pfizer, Inc., New York, N.Y.	Arzneimittel gegen Impotenz.
US5270323A (en) *	1990-05-31	1993-12-14	Pfizer Inc.	Method of treating impotence
GB9013750D0 (en) *	1990-06-20	1990-08-08	Pfizer Ltd	Therapeutic agents
GB9114760D0 (en) *	1991-07-09	1991-08-28	Pfizer Ltd	Therapeutic agents
GB9218322D0 (en) *	1992-08-28	1992-10-14	Pfizer Ltd	Therapeutic agents
GB9311920D0 (en) *	1993-06-09	1993-07-28	Pfizer Ltd	Therapeutic agents
GB9401090D0 (en) *	1994-01-21	1994-03-16	Glaxo Lab Sa	Chemical compounds
SK154498A3 (en) *	1996-05-10	2000-01-18	Icos Corp	Carboline derivatives, process for the preparation thereof, pharmaceutical compositions containing same and use of mentioned derivatives as drugs
US5874437A (en) *	1996-11-01	1999-02-23	Nitromed, Inc.	Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US6043252A (en) *	1997-05-05	2000-03-28	Icos Corporation	Carboline derivatives

1997
- 1997-05-05 SK SK1544-98A patent/SK154498A3/sk unknown
- 1997-05-05 AT AT97922960T patent/ATE215950T1/de not_active IP Right Cessation
- 1997-05-05 HU HU9901478A patent/HUP9901478A3/hu unknown
- 1997-05-05 ES ES97922960T patent/ES2175404T3/es not_active Expired - Lifetime
- 1997-05-05 DE DE69711882T patent/DE69711882T2/de not_active Expired - Fee Related
- 1997-05-05 AU AU28910/97A patent/AU711885B2/en not_active Ceased
- 1997-05-05 TR TR1998/02282T patent/TR199802282T2/xx unknown
- 1997-05-05 KR KR1019980709066A patent/KR20000010918A/ko not_active Withdrawn
- 1997-05-05 YU YU49898A patent/YU49898A/sh unknown
- 1997-05-05 CN CN97194508A patent/CN1067071C/zh not_active Expired - Fee Related
- 1997-05-05 JP JP54045697A patent/JP3418405B2/ja not_active Expired - Fee Related
- 1997-05-05 IL IL12695197A patent/IL126951A0/xx unknown
- 1997-05-05 CZ CZ983585A patent/CZ358598A3/cs unknown
- 1997-05-05 EP EP97922960A patent/EP0912567B1/en not_active Expired - Lifetime
- 1997-05-05 EA EA199800907A patent/EA199800907A1/ru unknown
- 1997-05-05 WO PCT/EP1997/002277 patent/WO1997043287A1/en not_active Ceased
- 1997-05-05 EE EE9800390A patent/EE9800390A/xx unknown
- 1997-05-05 CA CA002253948A patent/CA2253948C/en not_active Expired - Fee Related
- 1997-05-05 AP APAP/P/1998/001365A patent/AP9801365A0/en unknown
- 1997-05-05 PL PL97329875A patent/PL329875A1/xx unknown
- 1997-05-05 BR BR9709230A patent/BR9709230A/pt not_active IP Right Cessation
- 1997-05-05 US US09/155,811 patent/US6117881A/en not_active Expired - Fee Related
1998
- 1998-10-13 IS IS4864A patent/IS4864A/is unknown
- 1998-10-29 BG BG102879A patent/BG102879A/xx unknown
- 1998-11-09 OA OA9800218A patent/OA10920A/en unknown
- 1998-11-09 NO NO985222A patent/NO985222L/no not_active Application Discontinuation
2000
- 2000-06-12 US US09/592,514 patent/US6306870B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69711882T2 (de)	2002-10-31
CA2253948C (en)	2005-07-26
ES2175404T3 (es)	2002-11-16
HUP9901478A2 (hu)	1999-08-30
AU711885B2 (en)	1999-10-21
NO985222D0 (no)	1998-11-09
EP0912567B1 (en)	2002-04-10
CN1067071C (zh)	2001-06-13
KR20000010918A (ko)	2000-02-25
CZ358598A3 (cs)	1999-03-17
BR9709230A (pt)	1999-08-10
CA2253948A1 (en)	1997-11-20
JP2000513717A (ja)	2000-10-17
BG102879A (en)	1999-09-30
NO985222L (no)	1999-01-11
IS4864A (is)	1998-10-13
PL329875A1 (en)	1999-04-12
OA10920A (en)	2003-02-21
YU49898A (sh)	2000-03-21
AU2891097A (en)	1997-12-05
EA199800907A1 (ru)	1999-04-29
TR199802282T2 (xx)	1999-03-22
ATE215950T1 (de)	2002-04-15
US6306870B1 (en)	2001-10-23
US6117881A (en)	2000-09-12
EE9800390A (et)	1999-06-15
AP9801365A0 (en)	1998-12-31
SK154498A3 (en)	2000-01-18
HUP9901478A3 (en)	1999-11-29
DE69711882D1 (en)	2002-05-16
EP0912567A1 (en)	1999-05-06
CN1218471A (zh)	1999-06-02
JP3418405B2 (ja)	2003-06-23
WO1997043287A1 (en)	1997-11-20

Publication	Publication Date	Title
IL126951A0 (en)	1999-09-22	Carboline derivatives
IL129502A0 (en)	2000-02-29	Naphthyridine derivatives
AP9700954A0 (en)	1997-04-30	6-ohenylpyridyl-2-amine derivatives
ZA9710906B (en)	1999-06-09	6-Phenylpyridyl-2-amine derivatives
IL125379A (en)	2003-05-29	19-nor-pregnene derivatives
IL125226A0 (en)	1999-03-12	Heterocycle-condensed morphinoid derivatives (II)
ZA974053B (en)	1998-11-09	Alkylaminobenzothiazole and -benzoxazole derivatives
ZA984560B (en)	1998-11-30	Ergoline derivatives
HUP9701835A3 (en)	2001-04-28	Vinyl-pirrolidinone-cephalosporin derivatives
IL129418A0 (en)	2000-02-17	2-Methoxyphenylpiperazine derivatives
IL125149A0 (en)	1999-01-26	Pyrazol-4-yl-hetaroyl derivatives
PL334558A1 (en)	2000-03-13	Cephalosporinic derivatives
HU9701479D0 (en)	1997-10-28	N-benzylazolium derivatives
GB9604996D0 (en)	1996-05-08	Benzodiazonine derivatives
GB9603226D0 (en)	1996-04-17	Heterocyclyl-ergoline derivatives
GB9600063D0 (en)	1996-03-06	Guaridine derivatives
GB9613571D0 (en)	1996-08-28	Antineurodegenerative ergoline derivatives
IL130283A0 (en)	2000-06-01	Polysaccharide-peptide derivatives
IL125974A0 (en)	1999-04-11	2-thioxotetrahydropyrimidin-4-one derivatives
GB9702049D0 (en)	1997-03-19	Tetrahhydroisoquinoline derivatives
GB2308593B (en)	1999-01-27	Imidazopyridine derivatives
HU9601036D0 (en)	1996-06-28	Aryl-sulfonyl-hydroxamic-acid derivatives
GB9608592D0 (en)	1996-07-03	Imidazopyridine derivatives
HK1017353A (en)	1999-11-19	Carboline derivatives
GB9610888D0 (en)	1996-07-31	Aralkoxy-morphinan derivatives