IL126003A0 - Spiro [cyclopent [b] indole-piperidines] and n-[phenyl-hydrazon intermediates for their preparation both being acetyl cholinesterase and mao inhibitors - Google Patents
Spiro [cyclopent [b] indole-piperidines] and n-[phenyl-hydrazon intermediates for their preparation both being acetyl cholinesterase and mao inhibitorsInfo
- Publication number
- IL126003A0 IL126003A0 IL12600397A IL12600397A IL126003A0 IL 126003 A0 IL126003 A0 IL 126003A0 IL 12600397 A IL12600397 A IL 12600397A IL 12600397 A IL12600397 A IL 12600397A IL 126003 A0 IL126003 A0 IL 126003A0
- Authority
- IL
- Israel
- Prior art keywords
- hydrazon
- cyclopent
- piperidines
- spiro
- indole
- Prior art date
Links
- 102100033639 Acetylcholinesterase Human genes 0.000 title 1
- 108010022752 Acetylcholinesterase Proteins 0.000 title 1
- 229940022698 acetylcholinesterase Drugs 0.000 title 1
- 229940082992 antihypertensives mao inhibitors Drugs 0.000 title 1
- 239000000544 cholinesterase inhibitor Substances 0.000 title 1
- LMKPHJYTFHAGHK-UHFFFAOYSA-N cyclodrine Chemical compound C1CCCC1(O)C(C(=O)OCCN(CC)CC)C1=CC=CC=C1 LMKPHJYTFHAGHK-UHFFFAOYSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 239000002899 monoamine oxidase inhibitor Substances 0.000 title 1
- 125000003003 spiro group Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63064196A | 1996-04-10 | 1996-04-10 | |
| PCT/US1997/003864 WO1997037992A2 (en) | 1996-04-10 | 1997-03-10 | Spiro[cyclopent[b]indole-piperidines] and n-phenyl-hydrazon intermediates for their preparation, both being acetylcholinesterase and mao inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL126003A0 true IL126003A0 (en) | 1999-04-11 |
Family
ID=24527997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12600397A IL126003A0 (en) | 1996-04-10 | 1997-03-01 | Spiro [cyclopent [b] indole-piperidines] and n-[phenyl-hydrazon intermediates for their preparation both being acetyl cholinesterase and mao inhibitors |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0892802B1 (es) |
| JP (1) | JP3615225B2 (es) |
| KR (1) | KR100270145B1 (es) |
| CN (1) | CN1233249A (es) |
| AR (1) | AR006553A1 (es) |
| AT (1) | ATE252581T1 (es) |
| AU (1) | AU708124B2 (es) |
| BR (1) | BR9708563A (es) |
| CA (1) | CA2251545C (es) |
| DE (1) | DE69725713T2 (es) |
| DK (1) | DK0892802T3 (es) |
| ES (1) | ES2207718T3 (es) |
| HU (1) | HUP9902755A3 (es) |
| IL (1) | IL126003A0 (es) |
| NO (1) | NO984739L (es) |
| PT (1) | PT892802E (es) |
| WO (1) | WO1997037992A2 (es) |
| ZA (1) | ZA972984B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100639543B1 (ko) | 1998-09-30 | 2006-10-31 | 다케다 야쿠힌 고교 가부시키가이샤 | 방광 배출력 개선제 |
| WO2011101774A1 (en) | 2010-02-16 | 2011-08-25 | Pfizer Inc. | (r)-4-((4-((4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazol-3-yloxy)methyl)piperidin-1-yl)methyl)tetrahydro-2h-pyran-4-ol, a partial agonist of 5-ht4 receptors |
| US10562857B2 (en) | 2015-11-12 | 2020-02-18 | Afasci, Inc. | Ion channel inhibitory compounds, pharmaceutical formulations, and uses |
| WO2020048829A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 3,9-diazaspiro[5.5]undecane compounds |
| WO2020048828A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Pharma Aktiengesellschaft | 5-heteroaryl-3,9-diazaspiro[5.5]undecane compounds |
| WO2020048827A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 1, 3, 9-triazaspiro[5.5] undecan-2-one compounds |
-
1997
- 1997-03-01 IL IL12600397A patent/IL126003A0/xx unknown
- 1997-03-10 DE DE69725713T patent/DE69725713T2/de not_active Expired - Fee Related
- 1997-03-10 WO PCT/US1997/003864 patent/WO1997037992A2/en not_active Ceased
- 1997-03-10 ES ES97908068T patent/ES2207718T3/es not_active Expired - Lifetime
- 1997-03-10 AU AU19909/97A patent/AU708124B2/en not_active Ceased
- 1997-03-10 KR KR1019980708047A patent/KR100270145B1/ko not_active Expired - Fee Related
- 1997-03-10 PT PT97908068T patent/PT892802E/pt unknown
- 1997-03-10 AT AT97908068T patent/ATE252581T1/de not_active IP Right Cessation
- 1997-03-10 JP JP53619797A patent/JP3615225B2/ja not_active Expired - Fee Related
- 1997-03-10 BR BR9708563A patent/BR9708563A/pt not_active IP Right Cessation
- 1997-03-10 HU HU9902755A patent/HUP9902755A3/hu unknown
- 1997-03-10 CN CN97193690A patent/CN1233249A/zh active Pending
- 1997-03-10 EP EP97908068A patent/EP0892802B1/en not_active Expired - Lifetime
- 1997-03-10 DK DK97908068T patent/DK0892802T3/da active
- 1997-03-10 CA CA002251545A patent/CA2251545C/en not_active Expired - Fee Related
- 1997-04-08 ZA ZA9702984A patent/ZA972984B/xx unknown
- 1997-04-08 AR ARP970101376A patent/AR006553A1/es not_active Application Discontinuation
-
1998
- 1998-10-09 NO NO984739A patent/NO984739L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2207718T3 (es) | 2004-06-01 |
| WO1997037992A2 (en) | 1997-10-16 |
| CA2251545C (en) | 2002-01-08 |
| HUP9902755A3 (en) | 2000-05-29 |
| NO984739D0 (no) | 1998-10-09 |
| PT892802E (pt) | 2004-03-31 |
| AR006553A1 (es) | 1999-09-08 |
| DK0892802T3 (da) | 2003-12-01 |
| ATE252581T1 (de) | 2003-11-15 |
| HUP9902755A2 (hu) | 2000-03-28 |
| EP0892802A1 (en) | 1999-01-27 |
| DE69725713D1 (de) | 2003-11-27 |
| BR9708563A (pt) | 1999-08-03 |
| KR20000005328A (ko) | 2000-01-25 |
| AU708124B2 (en) | 1999-07-29 |
| NO984739L (no) | 1998-12-09 |
| JP3615225B2 (ja) | 2005-02-02 |
| AU1990997A (en) | 1997-10-29 |
| EP0892802B1 (en) | 2003-10-22 |
| ZA972984B (en) | 1997-11-03 |
| CN1233249A (zh) | 1999-10-27 |
| JP2002509520A (ja) | 2002-03-26 |
| KR100270145B1 (ko) | 2000-11-01 |
| CA2251545A1 (en) | 1997-10-16 |
| DE69725713T2 (de) | 2004-05-13 |
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