IL124268A - Hypocholesterolemic (1-aryl-2-oxo-3-substituted-4-azetidinyl) phenylglucopyranose derivatives and pharmaceutical compositions containing them - Google Patents

Hypocholesterolemic (1-aryl-2-oxo-3-substituted-4-azetidinyl) phenylglucopyranose derivatives and pharmaceutical compositions containing them

Info

Publication number: IL124268A
Authority: IL; Israel
Prior art keywords: phenylglucopyranose; hypocholesterolemic; azetidinyl; oxo; aryl
Prior art date: 1995-10-31

Application number

IL12426896A

Other languages

English (en)

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-31

Filing date

1996-10-29

Publication date

2005-08-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26677904&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL124268(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1996-10-29 Application filed by Schering Corp filed Critical Schering Corp

2005-08-31 Publication of IL124268A publication Critical patent/IL124268A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)
Steroid Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IL12426896A 1995-10-31 1996-10-29 Hypocholesterolemic (1-aryl-2-oxo-3-substituted-4-azetidinyl) phenylglucopyranose derivatives and pharmaceutical compositions containing them IL124268A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US818595P	1995-10-31	1995-10-31
US57084795A	1995-12-12	1995-12-12

Publications (1)

Publication Number	Publication Date
IL124268A true IL124268A (en)	2005-08-31

Family

ID=26677904

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12426896A IL124268A (en)	1995-10-31	1996-10-29	Hypocholesterolemic (1-aryl-2-oxo-3-substituted-4-azetidinyl) phenylglucopyranose derivatives and pharmaceutical compositions containing them

Country Status (27)

Country	Link
EP (1)	EP0877750B1 (xx)
JP (2)	JP3385031B2 (xx)
KR (1)	KR100311554B1 (xx)
CN (1)	CN1103780C (xx)
AR (1)	AR004701A1 (xx)
AT (1)	ATE219495T1 (xx)
AU (1)	AU712158B2 (xx)
BR (2)	BR9611401B1 (xx)
CA (1)	CA2235943C (xx)
CY (1)	CY2353B1 (xx)
CZ (1)	CZ293957B6 (xx)
DE (1)	DE69621952T2 (xx)
DK (1)	DK0877750T3 (xx)
ES (1)	ES2175141T3 (xx)
GE (1)	GEP20033006B (xx)
HU (1)	HU226822B1 (xx)
ID (1)	ID16177A (xx)
IL (1)	IL124268A (xx)
MX (1)	MX9803447A (xx)
MY (1)	MY114803A (xx)
NO (1)	NO311692B1 (xx)
NZ (1)	NZ321766A (xx)
PL (1)	PL184698B1 (xx)
PT (1)	PT877750E (xx)
SK (1)	SK283552B6 (xx)
TW (1)	TW448181B (xx)
WO (1)	WO1997016455A1 (xx)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5633246A (en) *	1994-11-18	1997-05-27	Schering Corporation	Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
DE10042447A1 (de) *	2000-08-29	2002-03-28	Aventis Pharma Gmbh	Protein aus dem Darm von Wirbeltieren, welches Cholesterin absorbiert, sowie Verwendung dieses Proteins zur Identifizierung von Inhibitoren des intestinalen Cholesterintransports
SK286703B6 (sk) *	2000-12-20	2009-03-05	Schering Corporation	Cukrom-substituované 2-azetidinóny, farmaceutický prostriedok s ich obsahom a ich použitie
US6982251B2 (en)	2000-12-20	2006-01-03	Schering Corporation	Substituted 2-azetidinones useful as hypocholesterolemic agents
EP1510521A1 (en) *	2000-12-20	2005-03-02	Schering Corporation	Sugar-substituted 2-Azetidinones useful as hypocholesterolemic agents
DE10064398A1 (de) *	2000-12-21	2002-06-27	Aventis Pharma Gmbh	Neue Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE50111751D1 (de)	2000-12-21	2007-02-08	Sanofi Aventis Deutschland	Neue diphenzylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung zur behandlung von lipidstoffwechselstörungen
US7071181B2 (en)	2001-01-26	2006-07-04	Schering Corporation	Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
SI1355644T1 (sl) *	2001-01-26	2006-10-31	Schering Corp	Uporaba substituiranih azetidinonskih spojin za zdravljenje sitosterolemije
KR20040025890A (ko) *	2001-01-26	2004-03-26	쉐링 코포레이션	혈관성 질환을 치료하기 위한 스테롤 흡수 억제제와 혈액조절제의 조합물
AU2005246926B2 (en) *	2001-01-26	2008-02-28	Merck Sharp & Dohme Corp.	The use of substituted azetidinone compounds for the treatment of sitosterolemia
IL156445A0 (en)	2001-01-26	2004-01-04	Schering Corp	Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications
TWI291957B (en) *	2001-02-23	2008-01-01	Kotobuki Pharmaceutical Co Ltd	Beta-lactam compounds, process for repoducing the same and serum cholesterol-lowering agents containing the same
RS50386B (sr)	2001-03-28	2009-12-31	Schering Corporation,	Enantioselektivna sinteza intermedijarnih jedinjenja azetidinona
US7056906B2 (en)	2001-09-21	2006-06-06	Schering Corporation	Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US7053080B2 (en)	2001-09-21	2006-05-30	Schering Corporation	Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
DK1429756T3 (da)	2001-09-21	2007-03-19	Schering Corp	Behandling af xanthoma med azetidinonderivater som sterolabsorptionsinhibitorer
US7671047B2 (en)	2002-06-19	2010-03-02	Sanofi-Aventis Deutschland Gmbh	Cationically substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
DE10227506A1 (de) *	2002-06-19	2004-01-08	Aventis Pharma Deutschland Gmbh	Ringsubstituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
US7176193B2 (en)	2002-06-19	2007-02-13	Sanofi-Aventis Deutschland Gmbh	Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
US7176194B2 (en)	2002-06-19	2007-02-13	Sanofi-Aventis Deutschland Gmbh	Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
GB0215579D0 (en)	2002-07-05	2002-08-14	Astrazeneca Ab	Chemical compounds
AR040588A1 (es)	2002-07-26	2005-04-13	Schering Corp	Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
US20040092499A1 (en)	2002-11-06	2004-05-13	Schering Corporation	Methods and therapeutic combinations for the treatment of autoimmune disorders
ATE418551T1 (de)	2003-03-07	2009-01-15	Schering Corp	Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
WO2004081002A1 (en)	2003-03-07	2004-09-23	Schering Corporation	Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
CN1756755A (zh)	2003-03-07	2006-04-05	先灵公司	取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
AR041089A1 (es)	2003-05-15	2005-05-04	Merck & Co Inc	Procedimiento y composiciones farmaceutiicas para tratar aterosclerosis, dislipidemias y afecciones relacionadas
JP2005015434A (ja)	2003-06-27	2005-01-20	Kotobuki Seiyaku Kk	血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤
EP1522541A1 (en)	2003-10-07	2005-04-13	Lipideon Biotechnology AG	Novel hypocholesterolemic compounds
CN1870988A (zh) *	2003-10-30	2006-11-29	默克公司	作为抗高胆固醇血症药的2－氮杂环丁烷酮
WO2005061452A1 (en)	2003-12-23	2005-07-07	Astrazeneca Ab	Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity
US20060211752A1 (en)	2004-03-16	2006-09-21	Kohn Leonard D	Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
JP2008539255A (ja) *	2005-04-26	2008-11-13	マイクロビアインコーポレーテッド	高コレステロール血症のための４−ビアリーリル−１−フェニルアゼチジン−２−オングルクロニド誘導体
SA06270191B1 (ar)	2005-06-22	2010-03-29	استرازينيكا ايه بي	مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
WO2007048027A2 (en)	2005-10-21	2007-04-26	Novartis Ag	Combination of a renin-inhibitor and an anti-dyslipidemic agent and/or an antiobesity agent
AR060623A1 (es)	2006-04-27	2008-07-02	Astrazeneca Ab	Compuestos derivados de 2-azetidinona y un metodo de preparacion
US20080319221A1 (en)	2007-06-22	2008-12-25	Bernd Junker	Esters of Pentahydroxyhexylcarbamoyl Alkanoic Acids
DE102007063671A1 (de)	2007-11-13	2009-06-25	Sanofi-Aventis Deutschland Gmbh	Neue kristalline Diphenylazetidinonhydrate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
CA2754384A1 (en)	2009-03-06	2010-09-10	Lipideon Biotechnology Ag	Pharmaceutical hypocholesterolemic compositions
CN101993403B (zh)	2009-08-11	2012-07-11	浙江海正药业股份有限公司	氮杂环丁酮类化合物及医药应用
CN103102297A (zh) *	2012-09-28	2013-05-15	北京赛林泰医药技术有限公司	一种新的依折麦布的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LT3595B (en)	1993-01-21	1995-12-27	Schering Corp	Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents
CA2120221A1 (en) *	1993-04-23	1994-10-24	Allan W. Rey	N-substituted 2-azetidinones
US5631365A (en) *	1993-09-21	1997-05-20	Schering Corporation	Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US5627176A (en)	1994-03-25	1997-05-06	Schering Corporation	Substituted azetidinone compounds useful as hypocholesterolemic agents
US5633246A (en)	1994-11-18	1997-05-27	Schering Corporation	Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents

1996
- 1996-10-29 AT AT96937702T patent/ATE219495T1/de active
- 1996-10-29 CA CA002235943A patent/CA2235943C/en not_active Expired - Lifetime
- 1996-10-29 CN CN96199226A patent/CN1103780C/zh not_active Expired - Lifetime
- 1996-10-29 EP EP96937702A patent/EP0877750B1/en not_active Expired - Lifetime
- 1996-10-29 NZ NZ321766A patent/NZ321766A/xx not_active IP Right Cessation
- 1996-10-29 IL IL12426896A patent/IL124268A/xx not_active IP Right Cessation
- 1996-10-29 SK SK483-98A patent/SK283552B6/sk not_active IP Right Cessation
- 1996-10-29 KR KR1019980703155A patent/KR100311554B1/ko not_active Expired - Fee Related
- 1996-10-29 DK DK96937702T patent/DK0877750T3/da active
- 1996-10-29 BR BRPI9611401-0A patent/BR9611401B1/pt not_active IP Right Cessation
- 1996-10-29 ES ES96937702T patent/ES2175141T3/es not_active Expired - Lifetime
- 1996-10-29 JP JP51738697A patent/JP3385031B2/ja not_active Expired - Fee Related
- 1996-10-29 HU HU9802539A patent/HU226822B1/hu unknown
- 1996-10-29 AR ARP960104954A patent/AR004701A1/es not_active Application Discontinuation
- 1996-10-29 GE GEAP19966589A patent/GEP20033006B/en unknown
- 1996-10-29 WO PCT/US1996/016823 patent/WO1997016455A1/en not_active Ceased
- 1996-10-29 MY MYPI96004488A patent/MY114803A/en unknown
- 1996-10-29 PT PT96937702T patent/PT877750E/pt unknown
- 1996-10-29 DE DE69621952T patent/DE69621952T2/de not_active Expired - Lifetime
- 1996-10-29 AU AU75179/96A patent/AU712158B2/en not_active Ceased
- 1996-10-29 CZ CZ19981294A patent/CZ293957B6/cs not_active IP Right Cessation
- 1996-10-29 TW TW085113142A patent/TW448181B/zh not_active IP Right Cessation
- 1996-10-29 PL PL96327987A patent/PL184698B1/pl not_active IP Right Cessation
- 1996-10-29 BR BRPI9612998-0A patent/BR9612998B1/pt not_active IP Right Cessation
- 1996-10-30 ID IDP963136A patent/ID16177A/id unknown
1998
- 1998-04-29 NO NO19981950A patent/NO311692B1/no not_active IP Right Cessation
- 1998-04-30 MX MX9803447A patent/MX9803447A/es unknown
2000
- 2000-07-17 JP JP2000216704A patent/JP2001048895A/ja not_active Withdrawn
2003
- 2003-01-29 CY CY0300007A patent/CY2353B1/xx unknown

Also Published As

Publication number	Publication date
EP0877750B1 (en)	2002-06-19
HUP9802539A3 (en)	1999-12-28
CN1205707A (zh)	1999-01-20
JPH10512592A (ja)	1998-12-02
ID16177A (id)	1997-09-11
JP3385031B2 (ja)	2003-03-10
DK0877750T3 (da)	2002-07-15
CY2353B1 (en)	2004-06-04
ATE219495T1 (de)	2002-07-15
DE69621952D1 (de)	2002-07-25
AR004701A1 (es)	1999-03-10
GEP20033006B (en)	2003-07-10
CN1103780C (zh)	2003-03-26
HK1012507A1 (en)	1999-08-06
AU712158B2 (en)	1999-10-28
CZ293957B6 (cs)	2004-08-18
ES2175141T3 (es)	2002-11-16
CA2235943A1 (en)	1997-05-09
MY114803A (en)	2003-01-31
JP2001048895A (ja)	2001-02-20
SK283552B6 (sk)	2003-09-11
SK48398A3 (en)	1998-11-04
AU7517996A (en)	1997-05-22
NO981950L (no)	1998-06-26
BR9611401A (pt)	1999-01-05
KR19990067202A (ko)	1999-08-16
PL327987A1 (en)	1999-01-04
BR9612998B1 (pt)	2010-03-23
HUP9802539A2 (hu)	1998-11-30
PT877750E (pt)	2002-09-30
NO981950D0 (no)	1998-04-29
WO1997016455A1 (en)	1997-05-09
CA2235943C (en)	2002-10-01
CZ129498A3 (cs)	1998-10-14
TW448181B (en)	2001-08-01
PL184698B1 (pl)	2002-12-31
NO311692B1 (no)	2002-01-07
DE69621952T2 (de)	2003-01-16
EP0877750A1 (en)	1998-11-18
MX9803447A (es)	1998-09-30
BR9611401B1 (pt)	2010-08-10
HU226822B1 (en)	2009-11-30
NZ321766A (en)	1999-07-29
KR100311554B1 (ko)	2002-06-20

Publication	Publication Date	Title
IL124268A (en)	2005-08-31	Hypocholesterolemic (1-aryl-2-oxo-3-substituted-4-azetidinyl) phenylglucopyranose derivatives and pharmaceutical compositions containing them
IL116851A (en)	2000-06-01	3-arylidene-2-oxindole derivatives and pharmaceutical compositions containing them
IL119078A (en)	2003-11-23	Substituted benzylaminopiperidine compounds and pharmaceutical compositions comprising them
IL114622A0 (en)	1995-11-27	Heteroaryl-oxazolidinones and pharmaceutical compositions containing them
IL116917A (en)	2000-08-31	Piperidine derivatives and pharmaceutical compositions containing them
IL111221A0 (en)	1995-01-24	N-alkyl-n- arylpyrimidinamine derivatives and pharmaceutical compositions containing them
AU6613996A (en)	1997-02-10	Heterocyclic compounds and pharmaceutical compositions containing them
AP9701160A0 (en)	1998-01-31	Compounds and pharmaceutical compositions containing them
HUP9900424A2 (hu)	1999-05-28	Tiazolil-benzfurán-származékok és a vegyületeket tartalmazó gyógyászati készítmények
IL119559A0 (en)	1997-02-18	Purin -6- one derivatives their preparation and pharmaceutical compositions containing them
HUP9901344A3 (en)	2001-05-28	Radicicol derivatives and pharmaceutical compositions thereof
HUP9801356A3 (en)	2000-07-28	Triciclic (2-hydroxy-2-methyl-3,3,3-trifluoropropanoyl)-amino-benzoxepine, -benzothiepine, -benzocycloheptene, -indene derivatives and pharmaceutical compositions containing them
HUP9802290A3 (en)	2002-02-28	Pyrrole derivatives and pharmaceutical compositions containing them
IL117554A0 (en)	1996-07-23	Imidazoquinazolines their preparation and pharmaceutical compositions containing them
AU5856898A (en)	1998-07-31	Heteroarylsulfonamide derivatives and pharmaceutical compositions containing them
ZA967800B (en)	1997-04-03	Heteroaryllsubstituted acryloylguanidine derivatives and pharmaceutical compositions comprising them
HUP9602196A3 (en)	1998-07-28	Sulfonyl- and sulfinyl-benzoyl-guanidine derivatives and pharmaceutical compositions thereof
IL117397A (en)	2000-10-31	Substituted naphthyl compounds and pharmaceutical compositions comprising them
HU9500386D0 (en)	1995-03-28	Benzodiazepine derivatives and pharmaceutical compositions containing them
IL119371A0 (en)	1997-01-10	Sulfonylaminopyrimidines their preparation and pharmaceutical compositions containing them
IL118672A0 (en)	1996-10-16	Benzisothiazolyl-substituted aminomethylchromans their preparation and pharmaceutical compositions containing them
AU3710695A (en)	1996-11-18	Quinolonylcarboxyerythromycin derivatives and pharmaceutical compositions containing them
HUP9802291A3 (en)	1999-06-28	Penicillaminamide derivatives and pharmaceutical compositions containing them
IL115982A (en)	1999-10-28	Cyclolignan derivatives and pharmaceutical compositions containing them
IL116893A (en)	2000-02-29	Piperazine derivatives and pharmaceutical compositions containing them

Legal Events

Date	Code	Title
2006-02-21	FF	Patent granted
2006-03-12	KB	Patent renewed
2006-12-07	KB	Patent renewed
2014-11-30	KB	Patent renewed
2017-05-29	EXP	Patent expired