IL113818A0 - Pharmaceutical active cns compounds and pharmaceutical compositions containing them - Google Patents

Pharmaceutical active cns compounds and pharmaceutical compositions containing them

Info

Publication number: IL113818A0
Authority: IL; Israel
Prior art keywords: pharmaceutical; compositions containing; active cns; pharmaceutical compositions; cns compounds
Prior art date: 1988-12-07

Application number

IL11381895A

Other languages

English (en)

Inventor

Alistair Ainslie Miller

Malcolm Stuart Nobbs

Richard Martin Hyde

Michael John Leach

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-07

Filing date

1995-05-23

Publication date

1995-08-31

1988-12-07 Priority claimed from GB888828620A external-priority patent/GB8828620D0/en

1989-04-14 Priority claimed from GB898908561A external-priority patent/GB8908561D0/en

1989-08-18 Priority claimed from GB8918893A external-priority patent/GB8918893D0/en

1995-05-23 Application filed by Wellcome Found filed Critical Wellcome Found

1995-08-31 Publication of IL113818A0 publication Critical patent/IL113818A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/58—Two sulfur atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL11381895A 1988-12-07 1995-05-23 Pharmaceutical active cns compounds and pharmaceutical compositions containing them IL113818A0 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB888828620A GB8828620D0 (en)	1988-12-07	1988-12-07	Pharmaceutically active cns compounds
GB898908561A GB8908561D0 (en)	1989-04-14	1989-04-14	Pharmaceutically active cns compounds
GB8918893A GB8918893D0 (en)	1989-08-18	1989-08-18	Pharmacologically active cns compounds
IL9255889A IL92558A (en)	1988-12-07	1989-12-06	4-amino-2-(4-methylpiperazin-1-yl)-5-(2,3,5-trichlorophenyl) pyrimidine and pharmaceutical compositions containing it

Publications (1)

Publication Number	Publication Date
IL113818A0 true IL113818A0 (en)	1995-08-31

Family

ID=27264228

Family Applications (7)

Application Number	Title	Priority Date	Filing Date
IL11433589A IL114335A (en)	1988-12-07	1989-12-06	Pharmacologically active CNS compounds process for their preparation and pharmaceutical compositions containing them
IL111627A IL111627A (en)	1988-12-07	1989-12-06	Substituted phenylpyrimidine compounds, their preparation and pharmaceutical compositions containing them
IL9255889A IL92558A (en)	1988-12-07	1989-12-06	4-amino-2-(4-methylpiperazin-1-yl)-5-(2,3,5-trichlorophenyl) pyrimidine and pharmaceutical compositions containing it
IL11381895A IL113818A0 (en)	1988-12-07	1995-05-23	Pharmaceutical active cns compounds and pharmaceutical compositions containing them
IL11401995A IL114019A0 (en)	1988-12-07	1995-06-06	Pharmacologically active CNS compounds
IL11404095A IL114040A0 (en)	1988-12-07	1995-06-07	Pharmacologically active CNS compounds
IL11433595A IL114335A0 (en)	1988-12-07	1995-06-26	Pharmacologically active CNS compounds

Family Applications Before (3)

Application Number	Title	Priority Date	Filing Date
IL11433589A IL114335A (en)	1988-12-07	1989-12-06	Pharmacologically active CNS compounds process for their preparation and pharmaceutical compositions containing them
IL111627A IL111627A (en)	1988-12-07	1989-12-06	Substituted phenylpyrimidine compounds, their preparation and pharmaceutical compositions containing them
IL9255889A IL92558A (en)	1988-12-07	1989-12-06	4-amino-2-(4-methylpiperazin-1-yl)-5-(2,3,5-trichlorophenyl) pyrimidine and pharmaceutical compositions containing it

Family Applications After (3)

Application Number	Title	Priority Date	Filing Date
IL11401995A IL114019A0 (en)	1988-12-07	1995-06-06	Pharmacologically active CNS compounds
IL11404095A IL114040A0 (en)	1988-12-07	1995-06-07	Pharmacologically active CNS compounds
IL11433595A IL114335A0 (en)	1988-12-07	1995-06-26	Pharmacologically active CNS compounds

Country Status (35)

Country	Link
US (7)	US5587380A (xx)
EP (8)	EP0372934B1 (xx)
JP (1)	JP2795498B2 (xx)
KR (1)	KR0145308B1 (xx)
CN (5)	CN1052306A (xx)
AP (1)	AP164A (xx)
AT (4)	ATE384703T1 (xx)
AU (5)	AU669929B2 (xx)
CA (2)	CA2004747C (xx)
CY (1)	CY2139B1 (xx)
DD (1)	DD292250A5 (xx)
DE (4)	DE68929554T2 (xx)
DK (2)	DK175796B1 (xx)
ES (4)	ES2095842T3 (xx)
FI (4)	FI895821A7 (xx)
GE (1)	GEP19970891B (xx)
GR (1)	GR3022031T3 (xx)
HU (3)	HUT55764A (xx)
IE (1)	IE80711B1 (xx)
IL (7)	IL114335A (xx)
LT (1)	LT3415B (xx)
LV (1)	LV10442B (xx)
MC (1)	MC2076A1 (xx)
MX (1)	MX9203422A (xx)
MY (1)	MY115951A (xx)
NO (4)	NO178926C (xx)
NZ (4)	NZ231650A (xx)
OA (1)	OA09148A (xx)
PH (1)	PH31658A (xx)
PL (1)	PL162957B1 (xx)
PT (1)	PT92502B (xx)
RU (2)	RU2079493C1 (xx)
SG (1)	SG43314A1 (xx)
SK (2)	SK279988B6 (xx)
UA (2)	UA41245C2 (xx)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI895821A7 (fi) *	1988-12-07	1990-06-08	The Wellcome Foundation Ltd	Farmaseuttisesti aktivisia CNS-yhdisteitä
GB9012316D0 (en) *	1990-06-01	1990-07-18	Wellcome Found	Pharmacologically active cns compounds
US5629016A (en) *	1991-01-30	1997-05-13	Glaxo Wellcome Inc.	Water-dispersible tablets
UA37214C2 (uk) *	1991-01-30	2001-05-15	Дзе Веллкам Фаундейшн Лімітед	Таблетки, що диспергуються у воді, та спосіб їх виготовлення
GB9215908D0 (en) *	1992-07-27	1992-09-09	Wellcome Found	Water dispersible tablets
AU5704594A (en) *	1992-12-18	1994-07-19	Wellcome Foundation Limited, The	Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors
GB9226377D0 (en) *	1992-12-18	1993-02-10	Babbedge Rachel C	Pharmaceutical compositions
US5698226A (en) *	1993-07-13	1997-12-16	Glaxo Wellcome Inc.	Water-dispersible tablets
WO1995007265A1 (en) *	1993-09-10	1995-03-16	E.I. Du Pont De Nemours And Company	Improved process for preparing 2-amino-4,6-dichloropyrimidine
GB9424766D0 (en) *	1994-12-07	1995-02-08	Wellcome Found	Pharmaceutical composition
GB9518027D0 (en) *	1995-09-05	1995-11-08	Wellcome Found	Pharmacologically active compound
US6025355A (en)	1997-05-19	2000-02-15	Cambridge Neuroscience, Inc.	Pharmaceutically active compounds and methods of use
US6242198B1 (en)	1996-07-25	2001-06-05	Cambridge Neuroscience, Inc.	Methods of treatment of eye trauma and disorders
US6756389B2 (en)	1996-08-09	2004-06-29	Cambridge Neuroscience, Inc.	Pharmaceutically active compounds and methods of use
US6110902A (en) *	1997-06-23	2000-08-29	Moehler; Hanns	Method for the inhibition of neuronal activity leading to a focal epileptic seizure by local delivery of adenosine
US6440965B1 (en)	1997-10-15	2002-08-27	Krenitsky Pharmaceuticals, Inc.	Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
IT1300056B1 (it) *	1998-04-17	2000-04-05	Boehringer Ingelheim Italia	Eterocicli con anello a 6 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmaci
US6420354B1 (en)	1998-06-08	2002-07-16	Advanced Medicine, Inc.	Sodium channel drugs and uses
US6583148B1 (en)	1999-04-08	2003-06-24	Krenitsky Pharmaceuticals, Inc.	Neurotrophic substituted pyrimidines
US6479498B1 (en)	1999-06-04	2002-11-12	Theravance, Inc.	Sodium channel drugs and uses
DE19941217A1 (de) *	1999-08-30	2001-03-15	Asta Medica Ag	Behandlung der Migräne durch Verabreichung von alpha-Liponsäure oder Derivaten derselben
AR029489A1 (es) *	2000-03-10	2003-07-02	Euro Celtique Sa	Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento
EP1303495B1 (en)	2000-07-24	2010-05-26	Krenitsky Pharmaceuticals, Inc.	Substituted 5-alkynyl pyrimidines having neurotrophic activity
AR037233A1 (es) *	2001-09-07	2004-11-03	Euro Celtique Sa	Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento
CN1312134C (zh)	2001-11-19	2007-04-25	巴斯福股份公司	5－苯基嘧啶化合物、包含它们的组合物、其制备方法及其用途
GB0300783D0 (en) *	2003-01-14	2003-02-12	Btg Int Ltd	Treatment of neurodegenerative conditions
US8007826B2 (en)	2003-12-11	2011-08-30	Acorda Therapeutics, Inc.	Sustained release aminopyridine composition
US8354437B2 (en)	2004-04-09	2013-01-15	Acorda Therapeutics, Inc.	Method of using sustained release aminopyridine compositions
EP1751132B1 (de)	2004-05-19	2008-03-26	Basf Se	2-substituierte pyrimidine und ihre verwendung als pestizide
US7541357B2 (en)	2004-07-15	2009-06-02	Amr Technology, Inc.	Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
GB0603087D0 (en) *	2006-02-15	2006-03-29	Glaxo Group Ltd	Novel use
JP2010516731A (ja) *	2007-01-24	2010-05-20	グラクソグループリミテッド	２−メトキシ−５−（５−トリフルオロメチル−テトラゾール−１−イル）−ベンジル］−（２ｓ−フェニル−ピペリジン−３ｓ−イル）−アミンを含む医薬組成物
GB0800741D0 (en)	2008-01-16	2008-02-20	Univ Greenwich	Cyclic triazo and diazo sodium channel blockers
KR20110002465A (ko) *	2008-03-31	2011-01-07	젠야쿠코교가부시키가이샤	세포 보호 작용을 갖는 피리미딘 유도체 및 그 용도
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
CN101343253B (zh) *	2008-06-24	2011-03-16	陕西师范大学	2-氨基-4,5-二芳基嘧啶类化合物及其制备方法和药物用途
KR20120034644A (ko)	2009-05-12	2012-04-12	알바니 몰레큘라 리써치, 인크.	아릴, 헤테로아릴, 및 헤테로사이클 치환된 테트라하이드로이소퀴놀린 및 이의 용도
EP2429293B1 (en)	2009-05-12	2014-10-29	Bristol-Myers Squibb Company	CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF
GB201111712D0 (en)	2011-07-08	2011-08-24	Gosforth Ct Holdings Pty Ltd	Pharmaceutical compositions
US20150065509A1 (en) *	2012-03-16	2015-03-05	Kalyanaraman Ramnarayan	Highly 6-substituted -2,4-diaminopyrimidines as inhibitors of anthrax
DE102013100799A1 (de) *	2012-12-21	2014-06-26	Endress + Hauser Flowtec Ag	Umformerschaltung mit einer Stromschnittstelle sowie Meßgerät mit einer solchen Umformerschaltung
TWI644899B (zh) *	2013-02-04	2018-12-21	健生藥品公司	Ｆｌａｐ調節劑
JP6424173B2 (ja)	2013-02-04	2018-11-14	ヤンセンファーマシューティカエヌ．ベー．	Ｆｌａｐ調節因子
GB2560903A (en) *	2017-03-27	2018-10-03	Azad Pharmaceutical Ingredients Ag	New synthetic path to pharmaceutically acceptable vismodegib
GB202006080D0 (en)	2020-04-24	2020-06-10	Univ Greenwich	Cytokine storm syndrome
GB202006076D0 (en)	2020-04-24	2020-06-10	Univ Greenwich	Interleukin inhibitors

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2624731A (en) *		1953-01-06		S-phenylpyrimidkn e x derivativesx
CA741825A (en) *		1966-08-30	Stenbuck Paul	Propionitrile condensation intermediates
US2576939A (en) *		1951-12-04		-diamino-s-phenyl-e-alkyl-
US2594309A (en) *		1952-04-29		Antimalarial agents and method of
BE518622A (xx) *
US2602794A (en) *		1952-07-08		Process for preparation of x-amino-s
CH207759A (de) *	1938-03-07	1939-11-30	Mayer & Schmidt Schleifmaschin	Feinbohrspindel mit radial verschiebbarem Werkzeugträger.
GB691020A (en) *	1950-02-15	1953-05-06	Wellcome Found	Improvements in or relating to pyrimidine derivatives of therapeutic value and to the manufacture thereof
GB715813A (en) *	1950-06-14	1954-09-22	Wellcome Found	Improvements in derivatives of pyrimidine
US2688019A (en) *	1951-08-25	1954-08-31	Burroughs Wellcome Co	6-aryl-2,4-diamino pyrimidines and process of preparing same
DE956306C (de) *	1952-01-30	1957-01-17	Rhone Poulenc Sa	Verfahren zur Herstellung von neuen Derivaten des Pyrimidins
DE951991C (de) *	1952-01-30	1956-11-08	Rhone Poulenc Sa	Verfahren zur Herstellung von neuen chlorierten Derivaten des Pyrimidins
GB760944A (en) *	1952-11-04	1956-11-07	Wellcome Found	Improvements in and relating to pyrimidine derivatives and their manufacture
DE1009188B (de) *	1953-05-21	1957-05-29	Rhone Poulenc Sa	Verfahren zur Herstellung von Pyrimidinderivaten
DE1303727B (de) *	1959-09-03	1976-02-05	Ausscheidung aus: 14 45 176 The Wellcome Foundation Ltd., London	Alpha-Arylidensubstituierte Propioni-Irile
US3980781A (en) *	1966-03-31	1976-09-14	Imperial Chemical Industries Limited	Fungicidal composition and method containing 2-amino-pyrimidines
DE1670854B2 (de) *	1967-04-20	1977-04-28	Bayer Ag, 5090 Leverkusen	Verfahren zur herstellung von 2,4,6- trichlorpyrimidinen
US3956327A (en) *	1969-03-06	1976-05-11	Burroughs Wellcome Co.	Method of preparing 2,4-diamino-5-benzyl pyrimidines
US4006235A (en) *	1973-03-23	1977-02-01	Burroughs Wellcome Co.	Treating CNS lymphoma
US4005204A (en) *	1973-03-23	1977-01-25	Burroughs Wellcome Co.	Treatment of neoplasms in the brain with diamino dichloroalkyl pyrimidine
US4005203A (en) *	1973-03-23	1977-01-25	Burroughs Wellcome Co.	Treatment of meningeal leukemia with diamino dichlorophenyl pyrimidine
CH591457A5 (xx) *	1973-11-08	1977-09-15	Hoffmann La Roche
US3940393A (en) *	1974-06-21	1976-02-24	American Home Products Corporation	Synthesis of 2,6-diaminopyrimidines
FR2306697A1 (fr) *	1975-04-10	1976-11-05	Sogeras	Nouvelles pyrimidines utilisables comme medicaments antidiabetiques et hypocholesterolemiants
GB1582245A (en) *	1976-06-09	1981-01-07	Wellcome Found	Benzyl cyanoacetal derivatives and their conversion to pyrimidine derivatives
GR68380B (xx) *	1979-06-01	1981-12-28	Wellcome Found
US4438267A (en) *	1980-11-11	1984-03-20	Daluge Susan M	Monoheteroring compounds and their use
ZA818204B (en) *	1980-11-27	1983-07-27	Wellcome Found	Antibacterial benzylpyrimidines
FR2503162A1 (fr) *	1981-04-07	1982-10-08	Pharmindustrie	Nouveaux derives de piperazino-2 pyrimidine, procedes pour leur preparation et leur utilisation comme medicaments ou comme intermediaires pour la fabrication de medicaments
FR2535718A1 (fr) *	1982-11-09	1984-05-11	Sanofi Sa	(piperazinyl-1)-2 pyrimidines, leurs sels, procede pour leur preparation et compositions pharmaceutiques en contenant
US4496549A (en) *	1983-01-17	1985-01-29	American Cyanamid Company	Treatment of malaria with antibiotics
FR2539741A1 (fr) *	1983-01-21	1984-07-27	Sanofi Sa	Composes a noyau heterocyclique diazote, leur procede de preparation et les medicaments, actifs sur le systeme nerveux central, qui en contiennent
DE3321969A1 (de) *	1983-06-18	1984-12-20	Troponwerke GmbH & Co KG, 5000 Köln	2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3411571A1 (de) *	1984-03-29	1985-10-10	Merck Patent Gmbh, 6100 Darmstadt	Pyrimidine
FR2567518B1 (fr) *	1984-07-11	1987-11-13	Sanofi Sa	Nouveaux composes a noyau heterocyclique azote, leur preparation et les medicaments qui en contiennent
US4725600A (en) *	1984-07-13	1988-02-16	Fujisawa Pharmaceutical Co., Ltd.	Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent
US4959368A (en) *	1986-02-24	1990-09-25	Mitsui Petrochemical Industries Ltd.	Therapeutic agent for neurological diseases
AR242678A1 (es) *	1986-03-05	1993-04-30	Gonzalez Jorge Alberto	Mejoras en instrumentos musicales de cuerda de arco.
DE3620841A1 (de) *	1986-06-21	1987-12-23	Basf Ag	4-aminopyrimidinderivate
FR2602507B1 (fr) *	1986-08-08	1989-06-09	Sanofi Pharma	Procede de preparation de diamino-2,4 benzyl-5 pyrimidines
PT89780A (pt) *	1988-02-23	1989-10-04	Glaxo Group Ltd	Processo para a preparacao de derivados da tetrahidroisoquinolina
EP0330468A3 (en) *	1988-02-23	1991-04-03	Glaxo Group Limited	Use of heterocyclic derivatives as kappa-opioid receptor agonists in the treatment of cerebral ischaemia
FI895821A7 (fi) *	1988-12-07	1990-06-08	The Wellcome Foundation Ltd	Farmaseuttisesti aktivisia CNS-yhdisteitä
HU206337B (en) *	1988-12-29	1992-10-28	Mitsui Petrochemical Ind	Process for producing pyrimidine derivatives and pharmaceutical compositions
FR2642758B1 (fr) *	1989-02-09	1991-05-17	Esteve Labor Dr	Derives de pyrimidine,2-(4-((alpha)-heteroaryl-(alpha) aryl-((alpha)-alkyl)-methoxy)-butyl)-1-piperazinyl), avec activite serotoninergique
US5136080A (en) *	1989-12-04	1992-08-04	Burroughs Wellcome Co.	Nitrile compounds
GB9012316D0 (en) *	1990-06-01	1990-07-18	Wellcome Found	Pharmacologically active cns compounds
JPH06501926A (ja) *	1990-08-06	1994-03-03	藤沢薬品工業株式会社	複素環式化合物

1989
- 1989-12-05 FI FI895821A patent/FI895821A7/fi not_active IP Right Cessation
- 1989-12-06 CN CN89109759A patent/CN1052306A/zh active Pending
- 1989-12-06 AT AT03005787T patent/ATE384703T1/de not_active IP Right Cessation
- 1989-12-06 EP EP89312723A patent/EP0372934B1/en not_active Expired - Lifetime
- 1989-12-06 RU SU894742852A patent/RU2079493C1/ru active
- 1989-12-06 SG SG1996008059A patent/SG43314A1/en unknown
- 1989-12-06 CA CA002004747A patent/CA2004747C/en not_active Expired - Fee Related
- 1989-12-06 DK DK198906132A patent/DK175796B1/da not_active IP Right Cessation
- 1989-12-06 DE DE68929554T patent/DE68929554T2/de not_active Expired - Lifetime
- 1989-12-06 DD DD89335316A patent/DD292250A5/de unknown
- 1989-12-06 PT PT92502A patent/PT92502B/pt not_active IP Right Cessation
- 1989-12-06 EP EP95120491A patent/EP0715851B1/en not_active Expired - Lifetime
- 1989-12-06 EP EP95120377A patent/EP0727212A3/en not_active Withdrawn
- 1989-12-06 PL PL28263989A patent/PL162957B1/pl not_active IP Right Cessation
- 1989-12-06 NO NO894887A patent/NO178926C/no not_active IP Right Cessation
- 1989-12-06 AP APAP/P/1989/000155A patent/AP164A/en active
- 1989-12-06 CA CA002271566A patent/CA2271566C/en not_active Expired - Fee Related
- 1989-12-06 EP EP95120378A patent/EP0727213B9/en not_active Expired - Lifetime
- 1989-12-06 DE DE68929540T patent/DE68929540T2/de not_active Expired - Lifetime
- 1989-12-06 KR KR1019890018094A patent/KR0145308B1/ko not_active Expired - Fee Related
- 1989-12-06 DE DE68929460T patent/DE68929460T2/de not_active Expired - Lifetime
- 1989-12-06 IL IL11433589A patent/IL114335A/xx active IP Right Grant
- 1989-12-06 IL IL111627A patent/IL111627A/xx not_active IP Right Cessation
- 1989-12-06 JP JP1317401A patent/JP2795498B2/ja not_active Expired - Fee Related
- 1989-12-06 ES ES89312723T patent/ES2095842T3/es not_active Expired - Lifetime
- 1989-12-06 DE DE68927368T patent/DE68927368T2/de not_active Expired - Lifetime
- 1989-12-06 OA OA59692A patent/OA09148A/xx unknown
- 1989-12-06 IL IL9255889A patent/IL92558A/en not_active IP Right Cessation
- 1989-12-06 ES ES03005787T patent/ES2300513T3/es not_active Expired - Lifetime
- 1989-12-06 EP EP95120380A patent/EP0713703A3/en not_active Withdrawn
- 1989-12-06 MC MC892083A patent/MC2076A1/fr unknown
- 1989-12-06 ES ES95120491T patent/ES2194884T3/es not_active Expired - Lifetime
- 1989-12-06 NZ NZ231650A patent/NZ231650A/en unknown
- 1989-12-06 NZ NZ260820A patent/NZ260820A/en unknown
- 1989-12-06 IE IE389489A patent/IE80711B1/en not_active IP Right Cessation
- 1989-12-06 SK SK6898-89A patent/SK279988B6/sk unknown
- 1989-12-06 EP EP05023080A patent/EP1681058A3/en not_active Withdrawn
- 1989-12-06 AT AT95120378T patent/ATE307585T1/de not_active IP Right Cessation
- 1989-12-06 AT AT89312723T patent/ATE144422T1/de not_active IP Right Cessation
- 1989-12-06 HU HU896444A patent/HUT55764A/hu unknown
- 1989-12-06 AT AT95120491T patent/ATE235906T1/de not_active IP Right Cessation
- 1989-12-06 NZ NZ244881A patent/NZ244881A/en unknown
- 1989-12-06 NZ NZ244880A patent/NZ244880A/xx unknown
- 1989-12-06 EP EP03005787A patent/EP1325916B1/en not_active Expired - Lifetime
- 1989-12-06 MY MYPI95000966A patent/MY115951A/en unknown
- 1989-12-06 RU RU95116245A patent/RU2121998C1/ru not_active IP Right Cessation
- 1989-12-06 ES ES95120378T patent/ES2250967T3/es not_active Expired - Lifetime
- 1989-12-06 EP EP95120379A patent/EP0727214A3/en not_active Withdrawn
- 1989-12-06 UA UA4742852A patent/UA41245C2/uk unknown
1992
- 1992-06-25 MX MX9203422A patent/MX9203422A/es not_active Application Discontinuation
- 1992-12-18 LV LVP-92-337A patent/LV10442B/en unknown
- 1992-12-30 LT LTIP269A patent/LT3415B/lt not_active IP Right Cessation
1993
- 1993-09-09 GE GEAP19931548A patent/GEP19970891B/en unknown
- 1993-10-20 AU AU49154/93A patent/AU669929B2/en not_active Ceased
1994
- 1994-04-05 NO NO941211A patent/NO941211D0/no unknown
1995
- 1995-05-17 PH PH50547A patent/PH31658A/en unknown
- 1995-05-23 IL IL11381895A patent/IL113818A0/xx unknown
- 1995-06-06 US US08/469,518 patent/US5587380A/en not_active Expired - Lifetime
- 1995-06-06 US US08/466,138 patent/US5635507A/en not_active Expired - Lifetime
- 1995-06-06 US US08/470,948 patent/US5591746A/en not_active Expired - Lifetime
- 1995-06-06 US US08/470,951 patent/US5597828A/en not_active Expired - Lifetime
- 1995-06-06 IL IL11401995A patent/IL114019A0/xx unknown
- 1995-06-06 US US08/466,146 patent/US5597827A/en not_active Expired - Lifetime
- 1995-06-06 US US08/466,147 patent/US5684005A/en not_active Expired - Fee Related
- 1995-06-06 US US08/466,148 patent/US5712276A/en not_active Expired - Fee Related
- 1995-06-07 IL IL11404095A patent/IL114040A0/xx unknown
- 1995-06-10 CN CN95106811A patent/CN1066720C/zh not_active Expired - Fee Related
- 1995-06-10 CN CN95105850A patent/CN1066719C/zh not_active Expired - Fee Related
- 1995-06-10 CN CN95106817A patent/CN1117046A/zh active Pending
- 1995-06-10 CN CN95105625A patent/CN1119099A/zh active Pending
- 1995-06-26 IL IL11433595A patent/IL114335A0/xx unknown
- 1995-07-03 HU HU95P/P00754P patent/HU211974A9/hu unknown
- 1995-07-03 HU HU95P/P00740P patent/HU211677A9/hu unknown
- 1995-11-08 NO NO954489A patent/NO954489D0/no unknown
- 1995-11-08 NO NO953847A patent/NO304649B1/no not_active IP Right Cessation
- 1995-12-11 FI FI955939A patent/FI955939A0/fi unknown
- 1995-12-11 FI FI955941A patent/FI955941A0/fi not_active Application Discontinuation
- 1995-12-11 FI FI955940A patent/FI955940A0/fi unknown
1996
- 1996-04-24 AU AU51956/96A patent/AU5195696A/en not_active Abandoned
- 1996-04-24 AU AU51952/96A patent/AU5195296A/en not_active Abandoned
- 1996-04-24 AU AU51955/96A patent/AU690443B2/en not_active Ceased
- 1996-04-24 AU AU51953/96A patent/AU5195396A/en not_active Abandoned
- 1996-12-13 GR GR960403456T patent/GR3022031T3/el unknown
1998
- 1998-03-11 SK SK321-98A patent/SK279977B6/sk unknown
1999
- 1999-06-24 DK DK199900903A patent/DK175781B1/da not_active IP Right Cessation
- 1999-10-12 CY CY9900034A patent/CY2139B1/xx unknown
- 1999-11-04 UA UA99116068A patent/UA42885C2/uk unknown

Also Published As

Publication number	Publication date
EP1681058A2 (en)	2006-07-19
KR900009610A (ko)	1990-07-05
GEP19970891B (en)	1997-11-27
DE68929554T2 (de)	2009-01-29
US5591746A (en)	1997-01-07
CA2271566A1 (en)	1990-06-07
EP0372934A3 (en)	1992-07-15
NO954489D0 (no)	1995-11-08
IE80711B1 (en)	1998-12-16
LV10442B (en)	1995-08-20
DE68929540T2 (de)	2006-06-14
LTIP269A (en)	1994-10-25
PT92502B (pt)	1995-08-09
IL114335A (en)	2000-12-06
DE68929540D1 (de)	2005-12-01
CN1066719C (zh)	2001-06-06
ATE235906T1 (de)	2003-04-15
ES2194884T3 (es)	2003-12-01
DE68929460D1 (de)	2003-05-08
EP0713703A3 (en)	1997-10-01
DD292250A5 (de)	1991-07-25
FI955941A7 (fi)	1995-12-11
CN1066720C (zh)	2001-06-06
AU669929B2 (en)	1996-06-27
SK689889A3 (en)	1999-06-11
NO304649B1 (no)	1999-01-25
US5684005A (en)	1997-11-04
ATE384703T1 (de)	2008-02-15
US5712276A (en)	1998-01-27
JP2795498B2 (ja)	1998-09-10
EP0727213B1 (en)	2005-10-26
HU896444D0 (en)	1990-02-28
AU4596489A (en)	1990-06-14
DE68927368T2 (de)	1997-03-13
EP0727213B9 (en)	2007-11-07
NZ231650A (en)	1996-03-26
CY2139B1 (en)	2002-06-21
NZ260820A (en)	1996-04-26
EP0713703A2 (en)	1996-05-29
DE68929554D1 (de)	2008-03-13
IE893894L (en)	1990-06-07
FI955940A7 (fi)	1995-12-11
AU5195396A (en)	1996-07-04
EP0715851B1 (en)	2003-04-02
UA41245C2 (uk)	2001-09-17
FI895821A7 (fi)	1990-06-08
AU639216B2 (en)	1993-07-22
US5597828A (en)	1997-01-28
RU2121998C1 (ru)	1998-11-20
DK175796B1 (da)	2005-02-21
EP1325916A1 (en)	2003-07-09
US5597827A (en)	1997-01-28
UA42885C2 (uk)	2001-11-15
CA2271566C (en)	2003-02-04
FI895821A0 (fi)	1989-12-05
DK613289A (da)	1990-06-08
SK32198A3 (en)	1999-06-11
EP0715851A2 (en)	1996-06-12
IL111627A (en)	1997-06-10
ATE144422T1 (de)	1996-11-15
NO954489L (no)	1990-06-08
GR3022031T3 (en)	1997-03-31
EP1325916B1 (en)	2008-01-23
NZ244881A (en)	1996-03-26
DE68929460T2 (de)	2003-12-24
AU5195596A (en)	1996-07-04
RU2079493C1 (ru)	1997-05-20
US5635507A (en)	1997-06-03
EP1681058A3 (en)	2008-04-16
AU5195696A (en)	1996-07-04
PH31658A (en)	1999-01-12
MY115951A (en)	2003-10-31
IL114019A0 (en)	1995-10-31
IL92558A (en)	1996-01-31
LV10442A (lv)	1995-02-20
HU211974A9 (en)	1996-01-29
NO941211L (no)	1990-06-08
AP164A (en)	1992-01-12
CN1117046A (zh)	1996-02-21
HU211677A9 (en)	1995-12-28
FI955939A7 (fi)	1995-12-11
SG43314A1 (en)	1997-10-17
EP0372934A2 (en)	1990-06-13
IL114040A0 (en)	1995-10-31
NO894887D0 (no)	1989-12-06
HUT55764A (en)	1991-06-28
OA09148A (en)	1991-10-31
US5587380A (en)	1996-12-24
MC2076A1 (fr)	1990-10-12
NZ244880A (en)	1996-03-26
FI955941A0 (fi)	1995-12-11
EP0727214A2 (en)	1996-08-21
SK279988B6 (sk)	1999-06-11
ES2250967T3 (es)	2006-04-16
EP0727213A3 (en)	1997-09-10
CA2004747A1 (en)	1990-06-07
AU5195296A (en)	1996-07-18
IL114335A0 (en)	1995-10-31
AU4915493A (en)	1994-01-13
LT3415B (en)	1995-09-25
IL92558A0 (en)	1990-08-31
MX9203422A (es)	1992-07-01
ATE307585T1 (de)	2005-11-15
JPH02202876A (ja)	1990-08-10
ES2300513T3 (es)	2008-06-16
ES2095842T3 (es)	1997-03-01
FI955939A0 (fi)	1995-12-11
PL162957B1 (pl)	1994-01-31
NO954490L (no)	1990-06-08
EP0727212A2 (en)	1996-08-21
CN1113487A (zh)	1995-12-20
EP0372934B1 (en)	1996-10-23
PT92502A (pt)	1990-06-29
DE68927368D1 (de)	1996-11-28
HK1004092A1 (en)	1998-11-13
EP0727212A3 (en)	1997-10-01
IL111627A0 (en)	1995-01-24
CA2004747C (en)	2000-05-30
NO941211D0 (no)	1994-04-05
FI955940A0 (fi)	1995-12-11
SK279977B6 (sk)	1999-06-11
EP0727214A3 (en)	1997-10-01
CN1115756A (zh)	1996-01-31
NO954490D0 (no)	1995-11-08
KR0145308B1 (ko)	1998-07-15
EP0727213A2 (en)	1996-08-21
CN1119099A (zh)	1996-03-27
DK175781B1 (da)	2005-02-21
AP8900155A0 (en)	1990-01-31
DK199900903A (da)	1999-06-24
CN1052306A (zh)	1991-06-19
EP0715851A3 (en)	1997-10-01
NO178926B (no)	1996-03-25
NO178926C (no)	1996-07-03
DK613289D0 (da)	1989-12-06
NO894887L (no)	1990-06-08
AU690443B2 (en)	1998-04-23

Publication	Publication Date	Title
IL113818A0 (en)	1995-08-31	Pharmaceutical active cns compounds and pharmaceutical compositions containing them
IL90067A0 (en)	1989-12-15	1alpha-hydroxyvitamin-d compounds and pharmaceutical compositions containing them
IL105220A0 (en)	1994-08-26	Cyclohexanylidene compounds and pharmaceutical compositions containing them
IL105218A0 (en)	1993-12-28	Hexanones and pharmaceutical compositions containing them
IL105223A0 (en)	1994-08-26	Cyclohexane-ylidenes and pharmaceutical compositions containing them
IL93455A0 (en)	1990-11-29	19-nor-vitamin d compounds and pharmaceutical compositions containing them
IL95351A0 (en)	1991-06-30	17beta-acyl-4-aza-5alpha-androst-1-en-3-ones and pharmaceutical compositions containing them
NZ226936A (en)	1991-02-26	Azacyclic compounds and pharmaceutical compositions
IL74758A0 (en)	1985-06-30	Acyltripeptides and pharmaceutical compositions containing them
ZA857912B (en)	1986-05-28	Dipeptide compounds having pharmaceutical activity and compositions containing them
ZA864602B (en)	1988-02-24	2-arylimidazoles and pharmaceutical compositions containing these compounds
IL82221A0 (en)	1987-10-30	Phenyl-piperazines and pharmaceutical compositions containing them
DE3473827D1 (en)	1988-10-13	Highly active collagenolytic preparation and pharmaceutical compositions containing it
NZ226002A (en)	1990-06-26	Peptidylheterocyclic compounds and pharmaceutical compositions
IL106098A0 (en)	1993-10-20	Heteroarylnaphthalenes and pharmaceutical compositions containing them
NZ224347A (en)	1991-01-29	Heterocyclic compounds and pharmaceutical compositions
IL78939A0 (en)	1986-09-30	N-substituted arylalkyl-and arylalkylene-aminoheterocyclics and pharmaceutical compositions containing them
IL97122A0 (en)	1992-05-25	Aromatase-inhibiting androstendiones and pharmaceutical compositions containing them
GB2207916B (en)	1992-03-25	Nitromethane compounds and pharmaceutical compositions containing them
NZ225466A (en)	1990-02-26	1-aminoalkyl-1h-indole derivatives and pharmaceutical compositions containing certain derivatives thereof
HUT46929A (en)	1988-12-28	Sposob poluchenija aminoglycoside-steroides and pharmaceutical compositions containing them as active components
IL89155A0 (en)	1989-09-10	Ouabain-like compounds and pharmaceutical compositions containing them
PH25904A (en)	1991-12-19	Polycyclic compounds and pharmaceutical formulations containing them
PH19896A (en)	1986-08-13	4-phenyl-tetrahydro-furano-pyridine and pharmaceutical compositions containing them
IL89286A0 (en)	1989-09-10	Quinolone compounds and pharmaceutical compositions containing them