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IL114849A - Tricyclic pyrazole derivatives their manufacture and pharmaceutical compositions containing them - Google Patents

Tricyclic pyrazole derivatives their manufacture and pharmaceutical compositions containing them

Info

Publication number
IL114849A
IL114849A IL11484995A IL11484995A IL114849A IL 114849 A IL114849 A IL 114849A IL 11484995 A IL11484995 A IL 11484995A IL 11484995 A IL11484995 A IL 11484995A IL 114849 A IL114849 A IL 114849A
Authority
IL
Israel
Prior art keywords
manufacture
pharmaceutical compositions
compositions containing
pyrazole derivatives
tricyclic pyrazole
Prior art date
Application number
IL11484995A
Other languages
English (en)
Other versions
IL114849A0 (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL114849A0 publication Critical patent/IL114849A0/xx
Publication of IL114849A publication Critical patent/IL114849A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
IL11484995A 1994-08-12 1995-08-07 Tricyclic pyrazole derivatives their manufacture and pharmaceutical compositions containing them IL114849A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH249094 1994-08-12

Publications (2)

Publication Number Publication Date
IL114849A0 IL114849A0 (en) 1995-12-08
IL114849A true IL114849A (en) 1999-11-30

Family

ID=4234975

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11484995A IL114849A (en) 1994-08-12 1995-08-07 Tricyclic pyrazole derivatives their manufacture and pharmaceutical compositions containing them

Country Status (30)

Country Link
US (1) US5561150A (fr)
EP (1) EP0700905B1 (fr)
JP (1) JP2755560B2 (fr)
KR (1) KR100385384B1 (fr)
CN (1) CN1056607C (fr)
AT (1) ATE207905T1 (fr)
AU (1) AU691310B2 (fr)
BR (1) BR9503630A (fr)
CA (1) CA2153937C (fr)
CO (1) CO4410331A1 (fr)
CZ (1) CZ289027B6 (fr)
DE (1) DE59509777D1 (fr)
DK (1) DK0700905T3 (fr)
ES (1) ES2164730T3 (fr)
FI (1) FI113264B (fr)
HU (1) HUT72066A (fr)
IL (1) IL114849A (fr)
MA (1) MA23643A1 (fr)
MY (1) MY133619A (fr)
NO (1) NO305026B1 (fr)
NZ (1) NZ272731A (fr)
PE (1) PE34096A1 (fr)
PH (1) PH31424A (fr)
PL (1) PL182480B1 (fr)
PT (1) PT700905E (fr)
RU (1) RU2152388C1 (fr)
TR (1) TR199500977A2 (fr)
TW (1) TW403738B (fr)
UY (1) UY24016A1 (fr)
ZA (1) ZA956553B (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU727654B2 (en) 1997-06-13 2000-12-21 Yamanouchi Pharmaceutical Co., Ltd. Tricyclic pyrazole derivative
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
GB9819019D0 (en) * 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds II
GB9820767D0 (en) * 1998-09-23 1998-11-18 Cerebrus Ltd Chemical compounds VIII
GB9918962D0 (en) * 1999-08-11 1999-10-13 Cerebrus Ltd Chemical compounds xxii
GB9918965D0 (en) * 1999-08-11 1999-10-13 Cerebrus Ltd Chemical compounds xxi
US6291504B1 (en) * 1999-10-20 2001-09-18 Dupont Pharmaceuticals Company Acylsemicarbazides and their uses
US20040048844A1 (en) * 1999-10-20 2004-03-11 Bristol-Myers Squibb Pharma Company Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
EP1132389A1 (fr) 2000-03-06 2001-09-12 Vernalis Research Limited Nouveaux dérivés de l'azaindole pour le traitement de l'obésité
EP1268493B1 (fr) * 2000-03-31 2006-02-15 Purdue Research Foundation Promedicaments a base de phorphoramidates
WO2004098807A1 (fr) * 2000-11-21 2004-11-18 Barsplice Products, Inc. Procede de fabrication de coupleurs en acier permettant d'assembler des barres d'armature du beton
CA2432122A1 (fr) 2000-12-20 2002-08-01 Bristol-Myers Squibb Pharma Company Ligands d'agoniste et d'antagoniste du recepteur de serotonine a substitution aryle et aminoaryle
CN100384417C (zh) * 2001-06-01 2008-04-30 艾尔科公司 吡喃并吲唑类化合物及其用于制备治疗青光眼药物的用途
WO2002098860A1 (fr) * 2001-06-01 2002-12-12 Alcon, Inc. Indazoles et indoles nouveaux fusionnes et leur utilisation dans le traitement de glaucomes
US6884816B2 (en) * 2001-08-31 2005-04-26 Alcon, Inc. Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma
US20060269611A1 (en) * 2001-11-29 2006-11-30 Steiner Mitchell S Prevention and treatment of androgen-deprivation induced osteoporosis
US20070197664A1 (en) * 2001-11-29 2007-08-23 Steiner Mitchell S Prevention and treatment of androgen-deprivation induced osteoporosis
US20080249183A1 (en) * 2001-11-29 2008-10-09 Steiner Mitchell S Treatment of androgen-deprivation induced osteoporosis
US20040214898A1 (en) * 2001-11-29 2004-10-28 Steiner Mitchell S. Methods for treating hot flashes
US20050080143A1 (en) * 2001-11-29 2005-04-14 Steiner Mitchell S. Treatment of androgen-deprivation induced osteoporosis
TW593302B (en) * 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
WO2003057673A1 (fr) * 2001-12-28 2003-07-17 Bayer Pharmaceuticals Corporation Composes derives de 1h-pyrozolyle, pouvant etre utilises dans les maladies associees au recepteur 5-ht2c
WO2003057161A2 (fr) * 2001-12-28 2003-07-17 Bayer Pharmaceuticals Corporation Composes de benzothieno[3,2-c]pyrazolyl et benzofurano[3,2-c]pyrazolyl, leur utilisation lors de maladies associees au recepteur 5-ht2c et leurs composes intermediaires
JP2005517681A (ja) * 2001-12-28 2005-06-16 バイエル・フアーマシユーチカルズ・コーポレーシヨン ５−ｈｔ２ｃ受容体と関連する疾患における使用のための４−スルフィド／スルホキシド／スルホニル−１ｈ−ピラゾリル誘導体化合物
EP1545501A2 (fr) * 2002-08-30 2005-06-29 Alcon, Inc. Composes de 5-chroman-5-yl-ethylamine substitues et leur utilisation dans le traitement du glaucome
MXPA05006277A (es) * 2002-12-13 2005-09-08 Alcon Inc Analogos de benzopirano novedosos y su uso para el tratamiento de glaucoma.
US7476687B2 (en) * 2003-11-26 2009-01-13 Alcon, Inc. Substituted furo[2,3-g]indazoles for the treatment of glaucoma
TW200520760A (en) * 2003-12-15 2005-07-01 Alcon Inc Substituted [1,4] oxazino [2,3-g] indazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
US7129257B1 (en) * 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
FR2870239B1 (fr) * 2004-05-11 2006-06-16 Sanofi Synthelabo Derives de carbamate de 2h- ou 3h-benzo[e]indazol-1-yle, leur preparation et leur application en therapeutique.
WO2006062839A1 (fr) * 2004-12-08 2006-06-15 Alcon, Inc. Utilisation de dioxindoindazoles et de dioxoloindazoles pour traiter le glaucome
TW200744567A (en) * 2005-09-23 2007-12-16 Alcon Inc Phenylethylamine analogs and their use for treating glaucoma
US20070293475A1 (en) * 2006-06-20 2007-12-20 Alcon Manufacturing Ltd. Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US392430A (en) * 1888-11-06 Tubular lantern
GB1228792A (fr) * 1967-07-20 1971-04-21
BE789948A (fr) * 1971-10-13 1973-04-11 Sandoz Sa Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments
US3957816A (en) * 1973-01-31 1976-05-18 Sandoz, Inc. Substituted naphtho pyrazoles
SU1676453A3 (ru) * 1987-09-18 1991-09-07 Фармиталиа Карло Эрба С.Р.Л.(Фирма) Способ получени конденсированных производных пиразола или их фармацевтически приемлемых солей

Also Published As

Publication number Publication date
EP0700905A1 (fr) 1996-03-13
NO953162L (no) 1996-02-13
JP2755560B2 (ja) 1998-05-20
IL114849A0 (en) 1995-12-08
KR960007568A (ko) 1996-03-22
NO953162D0 (no) 1995-08-11
ATE207905T1 (de) 2001-11-15
CN1056607C (zh) 2000-09-20
CA2153937C (fr) 2007-04-10
US5561150A (en) 1996-10-01
AU2838295A (en) 1996-02-22
BR9503630A (pt) 1996-05-28
PL309974A1 (en) 1996-02-19
MA23643A1 (fr) 1996-04-01
KR100385384B1 (ko) 2003-09-19
PH31424A (en) 1998-10-29
CO4410331A1 (es) 1997-01-09
TW403738B (en) 2000-09-01
TR199500977A2 (tr) 1996-06-21
PE34096A1 (es) 1996-10-04
PL182480B1 (pl) 2002-01-31
DE59509777D1 (de) 2001-12-06
HUT72066A (en) 1996-03-28
JPH0859623A (ja) 1996-03-05
RU2152388C1 (ru) 2000-07-10
CA2153937A1 (fr) 1996-02-13
MY133619A (en) 2007-11-30
CZ289027B6 (cs) 2001-10-17
DK0700905T3 (da) 2002-02-18
ES2164730T3 (es) 2002-03-01
FI113264B (fi) 2004-03-31
EP0700905B1 (fr) 2001-10-31
NZ272731A (en) 1996-09-25
PT700905E (pt) 2002-04-29
CN1131666A (zh) 1996-09-25
FI953827A0 (fi) 1995-08-11
FI953827L (fi) 1996-02-13
ZA956553B (en) 1996-02-12
AU691310B2 (en) 1998-05-14
UY24016A1 (es) 2000-12-29
HK1012342A1 (zh) 1999-07-30
NO305026B1 (no) 1999-03-22
CZ9502013A3 (en) 1996-03-13

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees