IL109547A - 3-(Tricyclic indolyl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione derivatives their preparation and pharmaceutical compositions containing them - Google Patents

3-(Tricyclic indolyl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione derivatives their preparation and pharmaceutical compositions containing them

Info

Publication number: IL109547A
Authority: IL; Israel
Prior art keywords: indol; methyl; indolyl; pyrrole; dione
Prior art date: 1993-05-10

Application number

IL10954794A

Other languages

English (en)

Other versions

IL109547A0 (en

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-10

Filing date

1994-05-04

Publication date

1998-07-15

1993-05-10 Priority claimed from GB939309602A external-priority patent/GB9309602D0/en

1994-05-04 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1994-08-26 Publication of IL109547A0 publication Critical patent/IL109547A0/xx

1998-07-15 Publication of IL109547A publication Critical patent/IL109547A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Virology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Communicable Diseases (AREA)
Emergency Medicine (AREA)
Pulmonology (AREA)
Hematology (AREA)
Obesity (AREA)
Oncology (AREA)
Rheumatology (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Cephalosporin Compounds (AREA)

IL10954794A 1993-05-10 1994-05-04 3-(Tricyclic indolyl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione derivatives their preparation and pharmaceutical compositions containing them IL109547A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939309602A GB9309602D0 (en)	1993-05-10	1993-05-10	Substituted pyrroles
GB9403249A GB9403249D0 (en)	1993-05-10	1994-02-21	Substituted pyrroles

Publications (2)

Publication Number	Publication Date
IL109547A0 IL109547A0 (en)	1994-08-26
IL109547A true IL109547A (en)	1998-07-15

Family

ID=26302877

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL10954794A IL109547A (en)	1993-05-10	1994-05-04	3-(Tricyclic indolyl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione derivatives their preparation and pharmaceutical compositions containing them

Country Status (25)

Country	Link
EP (1)	EP0624586B1 (zh)
JP (1)	JP2668818B2 (zh)
CN (1)	CN1048014C (zh)
AT (1)	ATE184007T1 (zh)
AU (1)	AU678435B2 (zh)
BG (1)	BG98761A (zh)
BR (1)	BR9401935A (zh)
CA (1)	CA2121567A1 (zh)
CZ (1)	CZ112894A3 (zh)
DE (1)	DE69420310T2 (zh)
DK (1)	DK0624586T3 (zh)
ES (1)	ES2137281T3 (zh)
FI (1)	FI106961B (zh)
GR (1)	GR3031901T3 (zh)
HR (1)	HRP940287B1 (zh)
HU (1)	HU215954B (zh)
IL (1)	IL109547A (zh)
IS (1)	IS1690B (zh)
LT (1)	LT3288B (zh)
LV (1)	LV11173B (zh)
NO (1)	NO301230B1 (zh)
NZ (1)	NZ260475A (zh)
RU (1)	RU2141960C1 (zh)
SI (1)	SI0624586T1 (zh)
SK (1)	SK53594A3 (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA44690C2 (uk) *	1993-12-07	2002-03-15	Елі Ліллі Енд Компані	Макроциклічна сполука іміду біс-індол-малеїнової кислоти, спосіб її одержання та фармацевтична композиція, макроциклічні сполуки іміду біс-індол-малеїнової кислоти та біс-індол-малеїнового ангідриду, спосіб одержання (варіанти)
US5624949A (en) *	1993-12-07	1997-04-29	Eli Lilly And Company	Protein kinase C inhibitors
US5843935A (en) *	1993-12-07	1998-12-01	Eli Lilly And Company	Protein kinase C inhibitors
US5723456A (en) *	1993-12-07	1998-03-03	Eli Lilly & Company	Therapeutic treatment for cardiovascular diseases
AU1339895A (en) *	1993-12-23	1995-07-10	Eli Lilly And Company	Protein kinase c inhibitors
EP0695755B1 (en) *	1994-08-04	1998-10-21	F. Hoffmann-La Roche AG	Pyrrolocarbazole
CA2249205A1 (en) *	1996-03-20	1997-09-25	Eli Lilly And Company	Synthesis of indolylmaleimides
KR100499190B1 (ko) *	1996-03-29	2006-04-17	교와 핫꼬 고교 가부시끼가이샤	육모제
US5859261A (en) *	1997-03-20	1999-01-12	Eli Lilly And Company	Synthesis of indolylmaleimides
PL366701A1 (en)	2000-07-27	2005-02-07	F.Hoffmann-La Roche Ag	3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta
HU230798B1 (hu)	2001-10-30	2018-06-28	Novartis Ag	Staurosporin-származékok mint az FLT3 receptor tirozin-kináz aktivitás inhibitorai
CA2393720C (en)	2002-07-12	2010-09-14	Eli Lilly And Company	Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
EP1653973A1 (en)	2003-08-08	2006-05-10	Novartis AG	Combinations comprising staurosporines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3803620A1 (de) *	1988-02-06	1989-08-17	Goedecke Ag	Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
CZ280738B6 (cs) *	1988-02-10	1996-04-17	F. Hoffmann - La Roche And Co., Aktiengesellschaft	Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi
DE3833008A1 (de) *	1988-09-29	1990-04-05	Goedecke Ag	Pyrrolocarbozol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
MC2096A1 (fr) *	1989-02-23	1991-02-15	Hoffmann La Roche	Pyrroles substitues
CA2046801C (en) *	1990-08-07	2002-02-26	Peter D. Davis	Substituted pyrroles

1994
- 1994-04-15 AU AU60555/94A patent/AU678435B2/en not_active Ceased
- 1994-04-26 CA CA002121567A patent/CA2121567A1/en not_active Abandoned
- 1994-05-02 DK DK94106812T patent/DK0624586T3/da active
- 1994-05-02 EP EP94106812A patent/EP0624586B1/en not_active Expired - Lifetime
- 1994-05-02 SI SI9430273T patent/SI0624586T1/xx unknown
- 1994-05-02 AT AT94106812T patent/ATE184007T1/de not_active IP Right Cessation
- 1994-05-02 DE DE69420310T patent/DE69420310T2/de not_active Expired - Fee Related
- 1994-05-02 ES ES94106812T patent/ES2137281T3/es not_active Expired - Lifetime
- 1994-05-04 IL IL10954794A patent/IL109547A/en not_active IP Right Cessation
- 1994-05-04 HU HU9401298A patent/HU215954B/hu not_active IP Right Cessation
- 1994-05-05 HR HR9309602.2A patent/HRP940287B1/xx not_active IP Right Cessation
- 1994-05-05 RU RU94015830A patent/RU2141960C1/ru active
- 1994-05-06 NO NO941682A patent/NO301230B1/no not_active IP Right Cessation
- 1994-05-06 NZ NZ260475A patent/NZ260475A/en unknown
- 1994-05-06 CZ CZ941128A patent/CZ112894A3/cs unknown
- 1994-05-09 BR BR9401935A patent/BR9401935A/pt not_active Application Discontinuation
- 1994-05-09 SK SK535-94A patent/SK53594A3/sk unknown
- 1994-05-09 CN CN94105846A patent/CN1048014C/zh not_active Expired - Fee Related
- 1994-05-09 JP JP6119542A patent/JP2668818B2/ja not_active Expired - Fee Related
- 1994-05-09 LV LVP-94-100A patent/LV11173B/en unknown
- 1994-05-09 LT LTIP1927A patent/LT3288B/lt not_active IP Right Cessation
- 1994-05-09 IS IS4162A patent/IS1690B/is unknown
- 1994-05-10 BG BG98761A patent/BG98761A/xx unknown
- 1994-05-10 FI FI942158A patent/FI106961B/fi not_active IP Right Cessation
1999
- 1999-11-18 GR GR990402995T patent/GR3031901T3/el unknown

Also Published As

Publication number	Publication date
AU678435B2 (en)	1997-05-29
JP2668818B2 (ja)	1997-10-27
DE69420310D1 (de)	1999-10-07
IL109547A0 (en)	1994-08-26
FI942158A0 (fi)	1994-05-10
HRP940287A2 (en)	1996-12-31
CZ112894A3 (en)	1994-12-15
BR9401935A (pt)	1995-03-07
GR3031901T3 (en)	2000-02-29
LV11173A (lv)	1996-04-20
EP0624586A1 (en)	1994-11-17
NO941682D0 (no)	1994-05-06
FI942158A7 (fi)	1994-11-11
LV11173B (en)	1996-06-20
FI106961B (fi)	2001-05-15
CA2121567A1 (en)	1994-11-11
AU6055594A (en)	1994-11-17
LTIP1927A (en)	1994-11-25
EP0624586B1 (en)	1999-09-01
CN1048014C (zh)	2000-01-05
NZ260475A (en)	1996-02-27
NO941682L (no)	1994-11-11
DK0624586T3 (da)	2000-03-27
HU9401298D0 (en)	1994-08-29
ES2137281T3 (es)	1999-12-16
LT3288B (en)	1995-06-26
HUT71492A (en)	1995-11-28
RU2141960C1 (ru)	1999-11-27
HRP940287B1 (en)	2000-02-29
DE69420310T2 (de)	2000-04-13
CN1103402A (zh)	1995-06-07
IS4162A (is)	1994-11-11
IS1690B (is)	1998-04-20
HU215954B (hu)	1999-03-29
NO301230B1 (no)	1997-09-29
SI0624586T1 (en)	1999-12-31
SK53594A3 (en)	1995-02-08
ATE184007T1 (de)	1999-09-15
JPH06329672A (ja)	1994-11-29
BG98761A (en)	1995-03-31

Publication	Publication Date	Title
RU2075474C1 (ru)	1997-03-20	Замещенные пирролы, а также их фармацевтически приемлемые кислотноаддитивные соли, способ их получения и фармацевтическая композиция
US5292747A (en)	1994-03-08	Substituted pyrroles
CA2010636C (en)	1999-12-14	Substituted pyrroles
RU2114620C1 (ru)	1998-07-10	Ингибитор атеросклеротического утолщения внутренней оболочки сосудов
EP0624586B1 (en)	1999-09-01	Substituted pyrroles
KR0173450B1 (ko)	1999-02-01	치환된 피롤, 이의 제조방법 및 이를 함유하는 의약품
WO2007097981A2 (en)	2007-08-30	Alpha carbolines and uses thereof
HU190984B (en)	1986-12-28	Process for producing new furo-, thieno- or pinolo-azepin derivatives
US5721230A (en)	1998-02-24	Substituted pyrroles
EP0338989B1 (en)	1993-03-17	Heterotetracyclic lactam derivatives, process for their preparation, and pharmaceutical compositions containing them
EP0347980A1 (en)	1989-12-27	8,9-Annelated beta-carbolines and 8,9-anelated-3,4-dihydro-beta-carbolines
KR100331515B1 (ko)	2002-08-19	치환된피롤
HU207318B (en)	1993-03-29	Process for producing lactame derivatives and pharmaceutical compositions containing them

Legal Events

Date	Code	Title
1998-12-06	FF	Patent granted
2000-08-31	KB	Patent renewed
2005-07-25	MM9K	Patent not in force due to non-payment of renewal fees