IL106237A0 - Piperidyl amides,sulfonamides and sulfoxamides as inhibitors of cholesterol biosynthesis - Google Patents
Piperidyl amides,sulfonamides and sulfoxamides as inhibitors of cholesterol biosynthesisInfo
- Publication number
- IL106237A0 IL106237A0 IL106237A IL10623793A IL106237A0 IL 106237 A0 IL106237 A0 IL 106237A0 IL 106237 A IL106237 A IL 106237A IL 10623793 A IL10623793 A IL 10623793A IL 106237 A0 IL106237 A0 IL 106237A0
- Authority
- IL
- Israel
- Prior art keywords
- inhibitors
- sulfoxamides
- sulfonamides
- cholesterol biosynthesis
- piperidyl
- Prior art date
Links
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 5
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 235000012000 cholesterol Nutrition 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- -1 Piperidyl amides Chemical class 0.000 title 1
- 229940124530 sulfonamide Drugs 0.000 title 1
- 150000003456 sulfonamides Chemical class 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- LWMPFIOTEAXAGV-UHFFFAOYSA-N piperidin-1-amine Chemical class NN1CCCCC1 LWMPFIOTEAXAGV-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other Liquid Machine Or Engine Such As Wave Power Use (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91060492A | 1992-07-08 | 1992-07-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL106237A0 true IL106237A0 (en) | 1993-11-15 |
Family
ID=25429048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL106237A IL106237A0 (en) | 1992-07-08 | 1993-07-05 | Piperidyl amides,sulfonamides and sulfoxamides as inhibitors of cholesterol biosynthesis |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US5350758A (es) |
| EP (1) | EP0650474B1 (es) |
| JP (1) | JPH07508732A (es) |
| KR (1) | KR100286410B1 (es) |
| AT (1) | ATE169618T1 (es) |
| AU (1) | AU678973B2 (es) |
| CA (1) | CA2136841C (es) |
| DE (1) | DE69320352T2 (es) |
| ES (1) | ES2120506T3 (es) |
| IL (1) | IL106237A0 (es) |
| MX (1) | MX9304070A (es) |
| NZ (1) | NZ253592A (es) |
| WO (1) | WO1994001404A1 (es) |
| ZA (1) | ZA934777B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6103733A (en) * | 1998-09-09 | 2000-08-15 | Bachmann; Kenneth A. | Method for increasing HDL cholesterol levels using heteroaromatic phenylmethanes |
| KR100601501B1 (ko) * | 2004-09-24 | 2006-07-18 | 삼성에스디아이 주식회사 | 이차전지의 팩 케이스 |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| WO2008070496A2 (en) | 2006-12-01 | 2008-06-12 | Bristol-Myers Squibb Company | N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
| JP2013528172A (ja) | 2010-05-21 | 2013-07-08 | ファイザー・インク | ２−フェニルベンゾイルアミド |
| US20130345392A1 (en) | 2011-03-04 | 2013-12-26 | Pfizer Inc | Edn3-like peptides and uses thereof |
| BR112015026513A2 (pt) | 2013-04-17 | 2017-07-25 | Pfizer | derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| MA54261B1 (fr) | 2019-01-18 | 2025-03-28 | Astrazeneca Ab | Inhibiteurs de pcsk9 et leurs procédés d'utilisation |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2580411A (en) * | 1948-10-23 | 1952-01-01 | Searle & Co | Dihexyl alanine dialkylamides |
| FR1261160A (fr) * | 1955-07-28 | 1961-05-19 | Procédé de préparation de n-t-alkyl-dialkylamino-amides | |
| NL109859C (es) * | 1957-09-27 | |||
| US3185678A (en) * | 1961-08-04 | 1965-05-25 | Colgate Palmolive Co | Polymethyleniminoalkylamides |
| US3178439A (en) * | 1963-05-06 | 1965-04-13 | Reilly Tar & Chem Corp | N-alkanoyl and alkenoyl hydroxy alkyl piperidides |
| CH448086A (de) * | 1965-01-15 | 1967-12-15 | Geigy Ag J R | Verfahren zur Herstellung von neuen Derivaten des 1,2,3,6-Tetrahydro-pyridins |
| DE1719388B2 (de) * | 1968-02-09 | 1976-04-29 | Bayer Ag, 5090 Leverkusen | Verfahren zum faerben von fasermaterialien aus polyacrylnitril oder acrylnitrilhaltigen mischpolymerisaten |
| GB1415682A (en) * | 1972-06-30 | 1975-11-26 | Wyeth John & Brother Ltd | Amides and thioamides |
| GB1420758A (en) * | 1972-07-12 | 1976-01-14 | Wyeth John & Brother Ltd | Anti-ulcer compositions |
| US3968211A (en) * | 1974-02-11 | 1976-07-06 | The Upjohn Company | Compositions and methods of use of amidines for anti-arrhythmic purposes |
| JPS5344573A (en) * | 1976-10-01 | 1978-04-21 | Teijin Ltd | Optical active 2-piperidineethanols and their preparation |
| US4316903A (en) * | 1977-07-18 | 1982-02-23 | Merck & Co., Inc. | Anti-microbial piperidino buten-2-ones |
| JPS55129255A (en) * | 1979-03-28 | 1980-10-06 | Kuraray Co Ltd | Farnesylacetamide compounds or their salts |
| DE2947649A1 (de) * | 1979-11-27 | 1981-08-06 | C.F. Spiess & Sohn GmbH & Co, 6719 Kleinkarlbach | Insektizide mittel |
| US4565819A (en) * | 1979-12-07 | 1986-01-21 | Adir | Substituted imino diacids, their preparation and pharmaceutical compositions which contain them |
| US4326067A (en) * | 1980-12-03 | 1982-04-20 | The Dow Chemical Company | Process for making N-(2-aminoethyl)amides |
| US4695575A (en) * | 1984-11-13 | 1987-09-22 | Janssen Pharmaceutica, N.V. | 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines |
| DE3433036A1 (de) * | 1984-09-08 | 1986-03-20 | Basf Ag, 6700 Ludwigshafen | Piperidinderivate und diese enthaltende fungizide sowie verfahren zur bekaempfung von pilzen |
| US4812451A (en) * | 1984-10-19 | 1989-03-14 | A. H. Robins Company, Incorporated | 1-(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-α,.alpha. |
| US4906659A (en) * | 1985-06-18 | 1990-03-06 | Takeda Chemical Industries, Ltd. | Antibiotic tan-749, its derivatives, production and use thereof |
| CA1318913C (en) * | 1986-02-01 | 1993-06-08 | Toshiro Kamishiro | Alkylenediamine derivatives |
| DE3814549A1 (de) * | 1987-10-30 | 1989-05-18 | Bayer Ag | N-substituierte derivate von 1-desoxynojirimycin und 1-desoxymannonojirimycin, verfahren zu deren herstellung und deren verwendung in arzneimitteln |
| DK168069B1 (da) * | 1987-11-11 | 1994-01-31 | Hoffmann La Roche | Isoquinolinderivater og en fremgangsmaade til fremstilling af octahydroisoquinoliner ud fra derivaterne |
| FR2649490B1 (fr) * | 1989-07-07 | 1991-09-20 | Thomson Csf | Capteur de rayonnement d'energie electromagnetique |
| CA2025490C (en) * | 1989-09-22 | 2003-09-16 | James R. Mccarthy | Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis |
| DE69016335T2 (de) * | 1989-10-06 | 1995-06-01 | Fujirebio Kk | Pantothensäure Derivate. |
| NZ239023A (en) * | 1990-07-24 | 1993-12-23 | Merrell Dow Pharma | N-substituted-hydroxyalkyl piperidine derivatives and pharmaceutical |
| CA2047375C (en) * | 1990-07-25 | 2003-04-15 | Charlotte L. Barney | Piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis |
| US5244908A (en) * | 1990-07-30 | 1993-09-14 | Takeda Chemical Industries, Ltd. | Imidazopyridine derivatives and their pharmaceutical use |
| US5084461A (en) * | 1991-03-27 | 1992-01-28 | Merrell Dow Pharmaceuticals Inc. | Azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis |
-
1992
- 1992-12-18 US US07/993,497 patent/US5350758A/en not_active Expired - Fee Related
-
1993
- 1993-06-03 JP JP6502739A patent/JPH07508732A/ja active Pending
- 1993-06-03 DE DE69320352T patent/DE69320352T2/de not_active Expired - Fee Related
- 1993-06-03 AT AT93914338T patent/ATE169618T1/de not_active IP Right Cessation
- 1993-06-03 CA CA002136841A patent/CA2136841C/en not_active Expired - Fee Related
- 1993-06-03 NZ NZ253592A patent/NZ253592A/en unknown
- 1993-06-03 ES ES93914338T patent/ES2120506T3/es not_active Expired - Lifetime
- 1993-06-03 AU AU44037/93A patent/AU678973B2/en not_active Ceased
- 1993-06-03 KR KR1019950700066A patent/KR100286410B1/ko not_active Expired - Fee Related
- 1993-06-03 WO PCT/US1993/005265 patent/WO1994001404A1/en not_active Ceased
- 1993-06-03 EP EP93914338A patent/EP0650474B1/en not_active Expired - Lifetime
- 1993-07-02 ZA ZA934777A patent/ZA934777B/xx unknown
- 1993-07-05 IL IL106237A patent/IL106237A0/xx unknown
- 1993-07-07 MX MX9304070A patent/MX9304070A/es not_active IP Right Cessation
-
1994
- 1994-05-25 US US08/248,894 patent/US5489600A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ZA934777B (en) | 1994-01-20 |
| ES2120506T3 (es) | 1998-11-01 |
| WO1994001404A1 (en) | 1994-01-20 |
| CA2136841A1 (en) | 1994-01-20 |
| US5489600A (en) | 1996-02-06 |
| EP0650474A1 (en) | 1995-05-03 |
| AU4403793A (en) | 1994-01-31 |
| DE69320352D1 (de) | 1998-09-17 |
| NZ253592A (en) | 1996-04-26 |
| KR100286410B1 (ko) | 2001-04-16 |
| EP0650474B1 (en) | 1998-08-12 |
| CA2136841C (en) | 1998-10-06 |
| KR950702534A (ko) | 1995-07-29 |
| ATE169618T1 (de) | 1998-08-15 |
| AU678973B2 (en) | 1997-06-19 |
| JPH07508732A (ja) | 1995-09-28 |
| US5350758A (en) | 1994-09-27 |
| DE69320352T2 (de) | 1998-12-17 |
| MX9304070A (es) | 1994-02-28 |
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