IE87094B1 - Gel comprising chlorhexidine - Google Patents

Gel comprising chlorhexidine Download PDF

Info

Publication number: IE87094B1
Authority: IE; Ireland
Prior art keywords: chlorhexidine; gel composition; gel; salt; cellulose
Prior art date: 2017-08-04

Application number

IE20170230A

Other languages

English (en)

Other versions

IE20170230A1 (en

Inventor

Embid López Marta

Balasch Risueño Joaquín

Original Assignee

Laboratorios Kin S A

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-08-04

Filing date

2017-11-02

Publication date

2020-05-13

2017-11-02 Application filed by Laboratorios Kin S A filed Critical Laboratorios Kin S A

2017-11-02 Priority to IE20170230A priority Critical patent/IE87094B1/en

2018-08-03 Priority to PE2020000181A priority patent/PE20200698A1/es

2018-08-03 Priority to CR20200058A priority patent/CR20200058A/es

2018-08-03 Priority to BR112020002106-7A priority patent/BR112020002106B1/pt

2018-08-03 Priority to MX2020001363A priority patent/MX2020001363A/es

2018-08-03 Priority to PCT/EP2018/071155 priority patent/WO2019025599A1/en

2018-08-03 Priority to CN201880052414.5A priority patent/CN110996891B/zh

2018-08-03 Priority to EP18746958.0A priority patent/EP3661480A1/en

2019-02-06 Publication of IE20170230A1 publication Critical patent/IE20170230A1/en

2020-01-21 Priority to PH12020550032A priority patent/PH12020550032A1/en

2020-01-28 Priority to NI202000007A priority patent/NI202000007A/es

2020-01-31 Priority to CL2020000293A priority patent/CL2020000293A1/es

2020-05-13 Publication of IE87094B1 publication Critical patent/IE87094B1/en

Links

229960003260 chlorhexidine Drugs 0.000 title claims abstract description 71
GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 title claims abstract description 69
239000000203 mixture Substances 0.000 claims abstract description 150
150000003839 salts Chemical class 0.000 claims abstract description 104
229920002674 hyaluronan Polymers 0.000 claims abstract description 71
229960003160 hyaluronic acid Drugs 0.000 claims abstract description 71
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 69
229920002678 cellulose Polymers 0.000 claims abstract description 40
239000001913 cellulose Substances 0.000 claims abstract description 40
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 33
239000002537 cosmetic Substances 0.000 claims abstract description 26
239000011159 matrix material Substances 0.000 claims abstract description 25
238000000034 method Methods 0.000 claims abstract description 9
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 45
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 36
229920013820 alkyl cellulose Polymers 0.000 claims description 31
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 24
239000001768 carboxy methyl cellulose Substances 0.000 claims description 21
239000003349 gelling agent Substances 0.000 claims description 21
-1 alkali metal salts Chemical class 0.000 claims description 19
239000002904 solvent Substances 0.000 claims description 19
150000001875 compounds Chemical class 0.000 claims description 16
239000000546 pharmaceutical excipient Substances 0.000 claims description 16
229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 15
235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 15
239000008112 carboxymethyl-cellulose Substances 0.000 claims description 15
239000000969 carrier Substances 0.000 claims description 12
235000011187 glycerol Nutrition 0.000 claims description 12
229920001515 polyalkylene glycol Polymers 0.000 claims description 12
239000006185 dispersion Substances 0.000 claims description 11
229910052783 alkali metal Inorganic materials 0.000 claims description 9
239000003795 chemical substances by application Substances 0.000 claims description 9
YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims description 9
239000002738 chelating agent Substances 0.000 claims description 8
229920002385 Sodium hyaluronate Polymers 0.000 claims description 7
229960003333 chlorhexidine gluconate Drugs 0.000 claims description 7
229940010747 sodium hyaluronate Drugs 0.000 claims description 7
YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 7
239000000341 volatile oil Substances 0.000 claims description 7
239000003814 drug Substances 0.000 claims description 6
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239000003755 preservative agent Substances 0.000 claims description 5
229910052784 alkaline earth metal Inorganic materials 0.000 claims description 4
230000002335 preservative effect Effects 0.000 claims description 4
239000008135 aqueous vehicle Substances 0.000 claims description 2
229960002152 chlorhexidine acetate Drugs 0.000 claims description 2
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239000003906 humectant Substances 0.000 claims description 2
MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 claims description 2
150000001340 alkali metals Chemical class 0.000 claims 1
239000000499 gel Substances 0.000 abstract description 142
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DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 13
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KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
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KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 9
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NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 5
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RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 description 5
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NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 4
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125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
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QYNMSPKSYXPZHG-UHFFFAOYSA-M sodium;4-ethoxycarbonylphenolate Chemical compound [Na+].CCOC(=O)C1=CC=C([O-])C=C1 QYNMSPKSYXPZHG-UHFFFAOYSA-M 0.000 description 4
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IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 3
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229960000686 benzalkonium chloride Drugs 0.000 description 3
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 3
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Birds (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Oral & Maxillofacial Surgery (AREA)
Dermatology (AREA)
Cosmetics (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IE20170230A 2017-08-04 2017-11-02 Gel comprising chlorhexidine IE87094B1 (en)

Priority Applications (11)

Application Number	Priority Date	Filing Date	Title
IE20170230A IE87094B1 (en)	2017-08-04	2017-11-02	Gel comprising chlorhexidine
PCT/EP2018/071155 WO2019025599A1 (en)	2017-08-04	2018-08-03	GEL COMPRISING CHLORHEXIDINE
CR20200058A CR20200058A (es)	2017-08-04	2018-08-03	Gel que comprende clorhexidina
BR112020002106-7A BR112020002106B1 (pt)	2017-08-04	2018-08-03	Composição em gel, método de preparo e uso da mesma
MX2020001363A MX2020001363A (es)	2017-08-04	2018-08-03	Gel que comprende clorhexidina.
PE2020000181A PE20200698A1 (es)	2017-08-04	2018-08-03	Gel que comprende clorhexidina
CN201880052414.5A CN110996891B (zh)	2017-08-04	2018-08-03	包含氯己定的凝胶
EP18746958.0A EP3661480A1 (en)	2017-08-04	2018-08-03	Gel comprising chlorhexidine
PH12020550032A PH12020550032A1 (en)	2017-08-04	2020-01-21	Gel comprising chlorhexidine
NI202000007A NI202000007A (es)	2017-08-04	2020-01-28	Gel que comprende clorhexidina
CL2020000293A CL2020000293A1 (es)	2017-08-04	2020-01-31	Gel que comprende clorhexidina.

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP17382547		2017-08-04
IE20170230A IE87094B1 (en)	2017-08-04	2017-11-02	Gel comprising chlorhexidine

Publications (2)

Publication Number	Publication Date
IE20170230A1 IE20170230A1 (en)	2019-02-06
IE87094B1 true IE87094B1 (en)	2020-05-13

Family

ID=63047391

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IE20170230A IE87094B1 (en)	2017-08-04	2017-11-02	Gel comprising chlorhexidine

Country Status (11)

Country	Link
EP (1)	EP3661480A1 (es)
CN (1)	CN110996891B (es)
BR (1)	BR112020002106B1 (es)
CL (1)	CL2020000293A1 (es)
CR (1)	CR20200058A (es)
IE (1)	IE87094B1 (es)
MX (1)	MX2020001363A (es)
NI (1)	NI202000007A (es)
PE (1)	PE20200698A1 (es)
PH (1)	PH12020550032A1 (es)
WO (1)	WO2019025599A1 (es)

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JP2022538521A (ja) *	2019-06-14	2022-09-05	ザプロクターアンドギャンブルカンパニー	洗い流さない口腔ケア組成物
WO2020248239A1 (en) *	2019-06-14	2020-12-17	The Procter & Gamble Company	Leave-on oral care compositions
EP3982917A1 (en)	2019-06-14	2022-04-20	The Procter & Gamble Company	Leave-on oral care compositions
CN114040742A (zh)	2019-06-14	2022-02-11	宝洁公司	免洗型口腔护理组合物
WO2020248232A1 (en) *	2019-06-14	2020-12-17	The Procter & Gamble Company	Leave-on oral care compositions
CN111494376A (zh) *	2020-06-15	2020-08-07	牡丹江医学院	一种用于治疗牙龈炎的药物及其制备方法
IT202000029288A1 (it) *	2020-12-01	2022-06-01	Altergon Sa	Sali di microbiocidi biguanidinici con glicosamminoglicani
EP4203910A1 (en) *	2021-05-26	2023-07-05	Colgate-Palmolive Company	Oral care compositions
CN113440441B (zh) *	2021-07-29	2022-09-16	山东福瑞达生物股份有限公司	一种含精油的口腔抑菌组合物及其制备方法
EP4483889A1 (en)	2023-06-28	2025-01-01	Igen Biolab Group AG	Postbiotic composition for oral administration for preventing or treating oral dysbiosis
GR1010853B (el) *	2023-11-10	2025-01-10	Ιουλια Τσετη	Συνθεση υαλουρονικου νατριου και σουκραλφατης καταλληλη για χορηγηση στη στοματικη κοιλοτητα
CN119033680A (zh) *	2024-08-28	2024-11-29	西南医科大学附属口腔医院	一种用于口腔黏膜损伤的水凝胶的制备方法及应用
CN120309762B (zh) *	2025-04-29	2026-01-06	杭州三言生物科技有限公司	一种具有抑菌作用的透明质酸氯己定的制备方法

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US5192802A (en)	1991-09-25	1993-03-09	Mcneil-Ppc, Inc.	Bioadhesive pharmaceutical carrier
CH691030A5 (it)	1995-09-26	2001-04-12	Apr Applied Pharma Res Sa	Formulazioni per uso topico contenenti carragenina ed un sale dell'acido ialuronico.
JPH1160505A (ja)	1997-05-20	1999-03-02	Senju Pharmaceut Co Ltd	防腐組成物
US6117415A (en)	1999-06-17	2000-09-12	Alpharx Inc.	Toothpaste comprising bioadhesive submicron emulsion for improved delivery of antibacterial and anticaries agents
US8283135B2 (en) *	2000-06-30	2012-10-09	The Procter & Gamble Company	Oral care compositions containing combinations of anti-bacterial and host-response modulating agents
RU2286764C1 (ru)	2005-06-16	2006-11-10	Георгий Георгиевич Ростиашвили	Средство "гиалудент" пролонгированного действия для лечения воспалительных заболеваний полости рта
US8609634B2 (en)	2007-05-16	2013-12-17	Mcneil-Ppc, Inc.	Preserved compositions containing hyaluronic acid or a pharmaceutically-acceptable salt thereof and related methods
US20090068122A1 (en) *	2007-09-06	2009-03-12	Shira Pilch	Dentifrice Compositions for Treating Xerostomia
EP2520279A1 (en) *	2011-05-02	2012-11-07	TERES S.r.l.	Thermoreversible gel pharamaceutical compositions for odontoiatric use
CN104474582A (zh) *	2014-12-17	2015-04-01	安徽省健源医疗器械设备有限公司	一种含透明质酸的止血纱布及其制备方法
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CN106540281A (zh) *	2016-12-08	2017-03-29	邓丽萍	B超耦合剂及其制备工艺

2017
- 2017-11-02 IE IE20170230A patent/IE87094B1/en unknown
2018
- 2018-08-03 WO PCT/EP2018/071155 patent/WO2019025599A1/en not_active Ceased
- 2018-08-03 PE PE2020000181A patent/PE20200698A1/es unknown
- 2018-08-03 BR BR112020002106-7A patent/BR112020002106B1/pt active IP Right Grant
- 2018-08-03 CN CN201880052414.5A patent/CN110996891B/zh active Active
- 2018-08-03 MX MX2020001363A patent/MX2020001363A/es unknown
- 2018-08-03 CR CR20200058A patent/CR20200058A/es unknown
- 2018-08-03 EP EP18746958.0A patent/EP3661480A1/en active Pending
2020
- 2020-01-21 PH PH12020550032A patent/PH12020550032A1/en unknown
- 2020-01-28 NI NI202000007A patent/NI202000007A/es unknown
- 2020-01-31 CL CL2020000293A patent/CL2020000293A1/es unknown

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CL2020000293A1 (es)	2020-08-14
CN110996891A (zh)	2020-04-10
BR112020002106B1 (pt)	2023-04-18
WO2019025599A1 (en)	2019-02-07
CR20200058A (es)	2020-03-28
PE20200698A1 (es)	2020-06-16
BR112020002106A8 (pt)	2020-12-01
PH12020550032A1 (en)	2021-02-15
IE20170230A1 (en)	2019-02-06
CN110996891B (zh)	2023-02-28
MX2020001363A (es)	2020-03-20
BR112020002106A2 (pt)	2020-08-04
EP3661480A1 (en)	2020-06-10

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