IE810808L - Isophthalic acid picolylamide monohydrate - Google Patents
Isophthalic acid picolylamide monohydrateInfo
- Publication number
- IE810808L IE810808L IE810808A IE80881A IE810808L IE 810808 L IE810808 L IE 810808L IE 810808 A IE810808 A IE 810808A IE 80881 A IE80881 A IE 80881A IE 810808 L IE810808 L IE 810808L
- Authority
- IE
- Ireland
- Prior art keywords
- monohydrate
- picolylamide
- isophthalic acid
- gb2080288a
- picolyl
- Prior art date
Links
- MEBGRDAUSOSLNJ-UHFFFAOYSA-N 3-(pyridin-2-ylmethylcarbamoyl)benzoic acid hydrate Chemical compound O.N1=C(C=CC=C1)CNC(C1=CC(C(=O)O)=CC=C1)=O MEBGRDAUSOSLNJ-UHFFFAOYSA-N 0.000 title 1
- KYWCWBXGRWWINE-UHFFFAOYSA-N 4-methoxy-N1,N3-bis(3-pyridinylmethyl)benzene-1,3-dicarboxamide Chemical compound COC1=CC=C(C(=O)NCC=2C=NC=CC=2)C=C1C(=O)NCC1=CC=CN=C1 KYWCWBXGRWWINE-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000004682 monohydrates Chemical class 0.000 abstract 1
- 230000009424 thromboembolic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
N,N'-bis-(3-picolyl)-4-methoxy- isophthalamide provided in crystalline form as its monohydrate, is a stable chemical structure and shows a high pharmaceutical activity for the treatment of thromboembolic disorders.
[GB2080288A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT48494/80A IT1143942B (en) | 1980-04-23 | 1980-04-23 | PICOLYLAMIDE HYDRATED ISOPHTHALIC ACID WITH ANTI-AGGREGATING, ANTI-THROMBINIC AND ANTI-AGULANT PLASTIC ACTION AND PROCEDURE FOR ITS PREPARATION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE810808L true IE810808L (en) | 1981-10-23 |
| IE51218B1 IE51218B1 (en) | 1986-11-12 |
Family
ID=11266904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE808/81A IE51218B1 (en) | 1980-04-23 | 1981-04-09 | Isophthalic acid picolylamide monohydrate,process for the preparation and pharmaceutical use thereof |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPS6043063B2 (en) |
| AT (1) | AT375645B (en) |
| AU (1) | AU537921B2 (en) |
| BE (1) | BE888528A (en) |
| CA (1) | CA1129419A (en) |
| CH (1) | CH649533A5 (en) |
| DD (1) | DD158397A5 (en) |
| DE (1) | DE3113150C2 (en) |
| DK (1) | DK155735C (en) |
| ES (1) | ES501470A0 (en) |
| FI (1) | FI74951C (en) |
| FR (1) | FR2481283B1 (en) |
| GB (1) | GB2080288B (en) |
| IE (1) | IE51218B1 (en) |
| IL (1) | IL62509A (en) |
| IT (1) | IT1143942B (en) |
| NL (1) | NL186860C (en) |
| NO (1) | NO154193C (en) |
| NZ (1) | NZ196677A (en) |
| OA (1) | OA06795A (en) |
| PT (1) | PT72899B (en) |
| SE (1) | SE438674B (en) |
| ZA (1) | ZA812362B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1214915B (en) * | 1985-10-10 | 1990-01-31 | Manetti & Roberts Italo Brit | 4-METHOXYISOPHTALIC ACID DERIVATIVES WITH PHARMACOLOGICAL ACTIVITY IN THROMBOEMBOLIC DISORDERS AND PROCEDURE FOR ITS PREPARATION |
| US5227492A (en) * | 1988-01-20 | 1993-07-13 | Yamanouchi Pharmaceutical Co., Ltd. | Diurea derivatives useful as medicaments and processes for the preparation thereof |
| AR066696A1 (en) * | 2007-05-21 | 2009-09-09 | Dybly Ag | PICOTAMIDE SALTS. PHARMACEUTICAL COMPOSITIONS. |
| CN111154113A (en) * | 2019-12-31 | 2020-05-15 | 肇庆学院 | Metal organic complex based on binuclear cobalt (II) and preparation method thereof |
| CN111154114A (en) * | 2019-12-31 | 2020-05-15 | 肇庆学院 | Zinc (II) metal organic coordination compound based on 5-ethoxy isophthalic acid and preparation method thereof |
| CN112159347B (en) * | 2020-10-27 | 2022-06-07 | 常州工程职业技术学院 | The preparation method of picotamide |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL149810B (en) * | 1969-04-21 | 1976-06-15 | Lilly Co Eli | METHOD FOR PREPARING A PHARMACEUTICAL PREPARATION BY CONTAINING CRYSTALLINE CEPHALEXIN IN A FORM SUITABLE FOR THERAPEUTIC ADMINISTRATION, FORMED PHARMACEUTICAL PREPARATIONS, AND METHOD OF PREPARING THE APPLICATION FOR THE EXISTING ABOVE. |
| IT1016005B (en) * | 1970-07-01 | 1977-05-30 | Manetti & Roberts Italo Brit | PICOLYLAMIDES OF ISOPHTHALIC ACID 4 HYDROXIS AND ITS DERIVATIVES AND RELATIVE PREPARATION PROCEDURE |
| US3973026A (en) * | 1975-02-05 | 1976-08-03 | Societa Italo-Britannica L. Manetti-H. Roberts & C. | Inhibitor of blood plate aggregation |
-
1980
- 1980-04-23 IT IT48494/80A patent/IT1143942B/en active Protection Beyond IP Right Term
-
1981
- 1981-03-27 IL IL62509A patent/IL62509A/en not_active IP Right Cessation
- 1981-03-27 SE SE8101963A patent/SE438674B/en not_active IP Right Cessation
- 1981-03-30 NZ NZ196677A patent/NZ196677A/en unknown
- 1981-04-01 DE DE3113150A patent/DE3113150C2/en not_active Expired
- 1981-04-07 CH CH2531/81A patent/CH649533A5/en not_active IP Right Cessation
- 1981-04-08 AU AU69310/81A patent/AU537921B2/en not_active Ceased
- 1981-04-09 ZA ZA00812362A patent/ZA812362B/en unknown
- 1981-04-09 IE IE808/81A patent/IE51218B1/en not_active IP Right Cessation
- 1981-04-10 AT AT0166481A patent/AT375645B/en not_active IP Right Cessation
- 1981-04-14 CA CA375,430A patent/CA1129419A/en not_active Expired
- 1981-04-20 ES ES501470A patent/ES501470A0/en active Granted
- 1981-04-21 DK DK177281A patent/DK155735C/en not_active IP Right Cessation
- 1981-04-21 PT PT72899A patent/PT72899B/en not_active IP Right Cessation
- 1981-04-22 DD DD81229409A patent/DD158397A5/en not_active IP Right Cessation
- 1981-04-22 GB GB8112454A patent/GB2080288B/en not_active Expired
- 1981-04-22 JP JP56061120A patent/JPS6043063B2/en not_active Expired
- 1981-04-22 NO NO811360A patent/NO154193C/en unknown
- 1981-04-22 FI FI811257A patent/FI74951C/en not_active IP Right Cessation
- 1981-04-23 OA OA57386A patent/OA06795A/en unknown
- 1981-04-23 BE BE2/59122A patent/BE888528A/en not_active IP Right Cessation
- 1981-04-23 NL NLAANVRAGE8102016,A patent/NL186860C/en not_active IP Right Cessation
- 1981-04-23 FR FR8108501A patent/FR2481283B1/fr not_active Expired
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |