IE801946L - 2-amino-3-benzoyl-phenylacetamides - Google Patents
2-amino-3-benzoyl-phenylacetamidesInfo
- Publication number
- IE801946L IE801946L IE801946A IE194680A IE801946L IE 801946 L IE801946 L IE 801946L IE 801946 A IE801946 A IE 801946A IE 194680 A IE194680 A IE 194680A IE 801946 L IE801946 L IE 801946L
- Authority
- IE
- Ireland
- Prior art keywords
- lower alkyl
- trifluoromethyl
- halogen
- amino
- phenylacetamides
- Prior art date
Links
- QEFAQIPZVLVERP-UHFFFAOYSA-N nepafenac Chemical class NC(=O)CC1=CC=CC(C(=O)C=2C=CC=CC=2)=C1N QEFAQIPZVLVERP-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
2-Amino-3-benzoyl-phenylacetamides are provided having the formula: <IMAGE> wherein: R represent hydrogen or lower alkyl, R<1> and R<2> represent hydrogen, lower alkyl, cycloalkyl, phenyl and phenyl substituted by lower alkyl, lower alkoxy, halogen, nitro and trifluoromethyl, and R<1> and R<2> when taken together with the adjacent nitrogen may form a heterocyclic residue; X represents hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl; Y represents hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl, lower alkylthio, lower alkyloxythio or lower alkyldioxythio; Am is primary amino (-NH2), methylamino or dimethylamino, and n is 1 to 2 inclusive. The compounds exhibit anti- inflammatory, antipyretic, anti-blood platelet aggregation and analgetic pharmacological activities.
[GB2059963A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7886079A | 1979-09-26 | 1979-09-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE801946L true IE801946L (en) | 1981-03-26 |
| IE50268B1 IE50268B1 (en) | 1986-03-19 |
Family
ID=22146633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1946/80A IE50268B1 (en) | 1979-09-26 | 1980-09-17 | 2-amino-3-benzoyl-phenylacetamides and cyclic homologues |
Country Status (36)
| Country | Link |
|---|---|
| JP (1) | JPS5657751A (en) |
| KR (1) | KR840000763B1 (en) |
| AT (1) | AT374170B (en) |
| AU (1) | AU532359B2 (en) |
| BE (1) | BE885393A (en) |
| BR (1) | BR8006042A (en) |
| CA (1) | CA1128512A (en) |
| CH (1) | CH646138A5 (en) |
| CS (1) | CS227012B2 (en) |
| DE (1) | DE3035688A1 (en) |
| DK (1) | DK154136C (en) |
| EG (1) | EG15020A (en) |
| ES (2) | ES8200329A1 (en) |
| FI (1) | FI72967C (en) |
| FR (1) | FR2465710A1 (en) |
| GB (1) | GB2059963B (en) |
| GR (1) | GR70049B (en) |
| HK (1) | HK59383A (en) |
| HU (1) | HU183215B (en) |
| IE (1) | IE50268B1 (en) |
| IL (1) | IL60999A (en) |
| IN (3) | IN151313B (en) |
| IT (1) | IT1133823B (en) |
| KE (1) | KE3307A (en) |
| LU (1) | LU82797A1 (en) |
| MX (1) | MX7159E (en) |
| NL (1) | NL8005346A (en) |
| NO (1) | NO152128C (en) |
| NZ (1) | NZ195061A (en) |
| PH (1) | PH22628A (en) |
| PL (1) | PL128998B1 (en) |
| PT (1) | PT71839B (en) |
| SE (1) | SE448626B (en) |
| SG (1) | SG42983G (en) |
| YU (3) | YU41734B (en) |
| ZA (1) | ZA805476B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL61945A (en) * | 1980-02-19 | 1984-09-30 | Robins Co Inc A H | 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them |
| US6066671A (en) * | 1997-12-19 | 2000-05-23 | Alcon Laboratories, Inc. | Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides |
| US6646001B2 (en) | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
| GB9727523D0 (en) * | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Alpha-aminoamide derivatives useful as analgesic agents |
| AR030345A1 (en) * | 2000-08-14 | 2003-08-20 | Alcon Inc | METHOD OF TREATMENT OF DISORDERS RELATED TO ANGIOGENESIS |
| DE60209152T2 (en) | 2001-09-03 | 2006-08-03 | Newron Pharmaceuticals S.P.A. | PHARMACEUTICAL COMPOSITION COMPRISING GABAPENTIN OR AN ANALOGON THEREOF AND AN ALPHA AMINOAMIDE |
| EP1438956A1 (en) | 2003-01-16 | 2004-07-21 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful as antimigraine agents |
| CZ2009367A3 (en) * | 2009-06-08 | 2010-06-16 | Farmak, A.S. | Process for preparing 2-amino-3-benzoylphenylacetamide (nepafenac) with minimum of by-products |
| CN112794809B (en) * | 2019-11-14 | 2023-12-29 | 南京济群医药科技股份有限公司 | Preparation method of high-purity nepafenac intermediate |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1226344A (en) * | 1967-07-31 | 1971-03-24 | ||
| SE400966B (en) * | 1975-08-13 | 1978-04-17 | Robins Co Inc A H | PROCEDURE FOR PREPARING 2-AMINO-3- (OR 5-) BENZOYL-PHENYLETIC ACIDS |
| IL61945A (en) * | 1980-02-19 | 1984-09-30 | Robins Co Inc A H | 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them |
-
1980
- 1980-09-04 ZA ZA00805476A patent/ZA805476B/en unknown
- 1980-09-08 IL IL60999A patent/IL60999A/en unknown
- 1980-09-08 AU AU62116/80A patent/AU532359B2/en not_active Ceased
- 1980-09-11 CS CS806196A patent/CS227012B2/en unknown
- 1980-09-17 IE IE1946/80A patent/IE50268B1/en unknown
- 1980-09-20 EG EG80573A patent/EG15020A/en active
- 1980-09-22 GR GR62936A patent/GR70049B/el unknown
- 1980-09-22 DE DE19803035688 patent/DE3035688A1/en active Granted
- 1980-09-22 BR BR8006042A patent/BR8006042A/en unknown
- 1980-09-23 PH PH24613A patent/PH22628A/en unknown
- 1980-09-23 AT AT0474580A patent/AT374170B/en not_active IP Right Cessation
- 1980-09-24 SE SE8006668A patent/SE448626B/en not_active IP Right Cessation
- 1980-09-24 FI FI803002A patent/FI72967C/en not_active IP Right Cessation
- 1980-09-24 LU LU82797A patent/LU82797A1/en unknown
- 1980-09-25 YU YU2450/80A patent/YU41734B/en unknown
- 1980-09-25 DK DK405780A patent/DK154136C/en not_active IP Right Cessation
- 1980-09-25 NO NO802834A patent/NO152128C/en unknown
- 1980-09-25 FR FR8020596A patent/FR2465710A1/en active Granted
- 1980-09-25 GB GB8030955A patent/GB2059963B/en not_active Expired
- 1980-09-25 PT PT71839A patent/PT71839B/en unknown
- 1980-09-25 PL PL1980226919A patent/PL128998B1/en unknown
- 1980-09-25 MX MX809050U patent/MX7159E/en unknown
- 1980-09-25 CH CH719180A patent/CH646138A5/en not_active IP Right Cessation
- 1980-09-25 KR KR1019800003740A patent/KR840000763B1/en not_active Expired
- 1980-09-25 ES ES495329A patent/ES8200329A1/en not_active Expired
- 1980-09-25 BE BE0/202226A patent/BE885393A/en not_active IP Right Cessation
- 1980-09-25 NL NL8005346A patent/NL8005346A/en not_active Application Discontinuation
- 1980-09-25 HU HU802347A patent/HU183215B/en not_active IP Right Cessation
- 1980-09-25 CA CA361,068A patent/CA1128512A/en not_active Expired
- 1980-09-26 NZ NZ195061A patent/NZ195061A/en unknown
- 1980-09-26 JP JP13415280A patent/JPS5657751A/en active Granted
- 1980-09-26 IN IN1092/CAL/80A patent/IN151313B/en unknown
- 1980-09-26 IT IT24948/80A patent/IT1133823B/en active
-
1981
- 1981-06-12 ES ES503019A patent/ES8204715A1/en not_active Expired
-
1982
- 1982-12-30 IN IN1508/CAL/82A patent/IN156254B/en unknown
- 1982-12-30 IN IN1509/CAL/82A patent/IN156255B/en unknown
-
1983
- 1983-03-28 YU YU731/83A patent/YU43306B/en unknown
- 1983-03-28 YU YU730/83A patent/YU43305B/en unknown
- 1983-07-19 SG SG42983A patent/SG42983G/en unknown
- 1983-07-21 KE KE3307A patent/KE3307A/en unknown
- 1983-11-24 HK HK593/83A patent/HK59383A/en unknown
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