IE800091L - Liposomic suspensions - Google Patents
Liposomic suspensionsInfo
- Publication number
- IE800091L IE800091L IE800091A IE9180A IE800091L IE 800091 L IE800091 L IE 800091L IE 800091 A IE800091 A IE 800091A IE 9180 A IE9180 A IE 9180A IE 800091 L IE800091 L IE 800091L
- Authority
- IE
- Ireland
- Prior art keywords
- drug
- resin
- suspensions
- solvent
- ion exchange
- Prior art date
Links
- 239000000725 suspension Substances 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 4
- 239000011347 resin Substances 0.000 abstract 3
- 229920005989 resin Polymers 0.000 abstract 3
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 2
- 239000003456 ion exchange resin Substances 0.000 abstract 2
- 229920003303 ion-exchange polymer Polymers 0.000 abstract 2
- 239000002502 liposome Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- LJRDOKAZOAKLDU-UDXJMMFXSA-N (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(2r,3s,4r,5s)-5-[(1r,2r,3s,5r,6s)-3,5-diamino-2-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric ac Chemical compound OS(O)(=O)=O.N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO LJRDOKAZOAKLDU-UDXJMMFXSA-N 0.000 abstract 1
- MWWSFMDVAYGXBV-RUELKSSGSA-N Doxorubicin hydrochloride Chemical compound Cl.O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 MWWSFMDVAYGXBV-RUELKSSGSA-N 0.000 abstract 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 abstract 1
- 230000002745 absorbent Effects 0.000 abstract 1
- 239000002250 absorbent Substances 0.000 abstract 1
- 125000000129 anionic group Chemical group 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 229960002918 doxorubicin hydrochloride Drugs 0.000 abstract 1
- 238000004945 emulsification Methods 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 229960002949 fluorouracil Drugs 0.000 abstract 1
- 239000011261 inert gas Substances 0.000 abstract 1
- 239000007971 pharmaceutical suspension Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Pharmaceutical suspensions of liposomes containing a drug (e.g. doxorubicin hydrochloride, aminosidine sulphate or 5- fluorouracil) are prepared by dissolution of lipidic components in a solvent, addition of an aqueous solution of the drug, and emulsification by insufflation of an inert gas until the solvent is completely removed by evaporation, and then the liposomes are separated from non-entrapped drug by shaking the suspension with a polymeric ion exchange resin or a polymeric absorbent resin to absorb the non- entrapped drug, then filtering off the resin. The ion exchange resin may be a strong or weak, anionic or cationic resin. The resultant liposomic suspensions may be lyophilised.
[GB2041871A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT19434/79A IT1110989B (en) | 1979-01-19 | 1979-01-19 | PHARMACEUTICAL FORMS CONSTITUTED BY LIPOSOMES AND RELATED PROCEDURES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE800091L true IE800091L (en) | 1980-07-19 |
| IE49141B1 IE49141B1 (en) | 1985-08-07 |
Family
ID=11157905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE91/80A IE49141B1 (en) | 1979-01-19 | 1980-01-16 | Liposomic suspensions |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS55100313A (en) |
| AT (1) | AT370623B (en) |
| AU (1) | AU536823B2 (en) |
| BE (1) | BE881225A (en) |
| CA (1) | CA1148470A (en) |
| CH (1) | CH648205A5 (en) |
| CS (1) | CS227010B2 (en) |
| DE (1) | DE3001842A1 (en) |
| DK (1) | DK157060C (en) |
| FI (1) | FI70672C (en) |
| FR (1) | FR2446635B1 (en) |
| GB (1) | GB2041871B (en) |
| HU (1) | HU184714B (en) |
| IE (1) | IE49141B1 (en) |
| IL (1) | IL59120A (en) |
| IT (1) | IT1110989B (en) |
| NL (1) | NL8000139A (en) |
| SE (1) | SE445171B (en) |
| SU (1) | SU1367839A3 (en) |
| YU (1) | YU44003B (en) |
| ZA (1) | ZA80269B (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU184141B (en) * | 1979-12-27 | 1984-07-30 | Human Oltoanyagtermelo | Adjuvant particles compositions containing said particles and biologically active substances adsorbed thereon and a process for the preparation thereof |
| FR2521565B1 (en) * | 1982-02-17 | 1985-07-05 | Dior Sa Parfums Christian | PULVERULENT MIXTURE OF LIPID COMPONENTS AND HYDROPHOBIC CONSTITUENTS, METHOD FOR PREPARING SAME, HYDRATED LIPID LAMELLAR PHASES AND MANUFACTURING METHOD, PHARMACEUTICAL OR COSMETIC COMPOSITIONS COMPRISING HYDRATED LAMID PHASES |
| FR2553002B1 (en) * | 1983-10-06 | 1992-03-27 | Centre Nat Rech Scient | IMPROVED PROCESS FOR OBTAINING UNILAMELLAR LIPOSOMES OF HIGH DIAMETERS, THEIR PHARMACOLOGICAL APPLICATION FOR THE ENCAPSULATING OF AN ACTIVE INGREDIENT FOR ITS EXTEMPORANEOUS ADMINISTRATION AND CORRESPONDING DEVICE |
| CA1270198C (en) * | 1984-08-08 | 1990-06-12 | Marcel B Bally | Encapsulation of antineoplastic agents in liposomes |
| US5736155A (en) * | 1984-08-08 | 1998-04-07 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| US4755388A (en) * | 1984-11-09 | 1988-07-05 | The Regents Of The University Of California | Liposome-encapsulated 5-fluoropyrimidines and methods for their use |
| IL79114A (en) * | 1985-08-07 | 1990-09-17 | Allergan Pharma | Method and composition for making liposomes |
| US6406713B1 (en) * | 1987-03-05 | 2002-06-18 | The Liposome Company, Inc. | Methods of preparing low-toxicity drug-lipid complexes |
| HK1007497A1 (en) * | 1990-07-31 | 1999-04-16 | 利普索姆公司 | Accumulations of amino acids and peptides into liposomes |
| DE4107152C2 (en) * | 1991-03-06 | 1994-03-24 | Gregor Cevc | Preparations for non-invasive administration of antidiabetics |
| DE4107153A1 (en) * | 1991-03-06 | 1992-09-10 | Gregor Cevc | Compsns. for application of active agents |
| JPH04127874U (en) * | 1991-05-13 | 1992-11-20 | 株式会社新潟鐵工所 | Pressure noise mitigation device for concrete pump transport pipes |
| JPH04134673U (en) * | 1991-06-07 | 1992-12-15 | 株式会社フジタ | Concrete pumping pressure fluctuation prevention device |
| KR100315213B1 (en) * | 1993-04-02 | 2002-07-03 | 질레스피 카롤 | Liposomal Production Method |
| IT1270678B (en) * | 1994-10-20 | 1997-05-07 | Bayer Ag | KETOPROFEN LIPOSOMES |
| DE19639811A1 (en) * | 1996-09-27 | 1998-04-02 | Artur Herzog Dr Mesmer | Use of a liposome solution to enhance the effectiveness and / or decrease the toxicity of drugs |
| JP4283355B2 (en) * | 1997-11-10 | 2009-06-24 | 久光製薬株式会社 | Pharmaceutical sustained-release agent and sustained-release pharmaceutical composition containing the same |
| EP1051977A1 (en) * | 1997-11-10 | 2000-11-15 | Hisamitsu Pharmaceutical Co., Inc. | Release-sustaining agent for drugs and sustained-release pharmaceutical composition |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2249552A1 (en) * | 1971-10-12 | 1973-05-30 | Inchema S A | PROCESS FOR THE INCAPSULATION OF IN PARTICULAR WATER-SOLUBLE COMPOUNDS |
| JPS5126213A (en) * | 1974-08-21 | 1976-03-04 | Tanabe Seiyaku Co | JOHOSEIBIRYUSHISEIZAINO SEIHO |
| US4131815A (en) * | 1977-02-23 | 1978-12-26 | Oceanography International Corporation | Solid piezoelectric sand detection probes |
| GB1575343A (en) * | 1977-05-10 | 1980-09-17 | Ici Ltd | Method for preparing liposome compositions containing biologically active compounds |
| CA1116518A (en) * | 1977-09-30 | 1982-01-19 | Guido Neri | Method for purifying a liposomic suspension |
-
1979
- 1979-01-19 IT IT19434/79A patent/IT1110989B/en active
-
1980
- 1980-01-09 NL NL8000139A patent/NL8000139A/en not_active Application Discontinuation
- 1980-01-14 IL IL59120A patent/IL59120A/en unknown
- 1980-01-14 AU AU54581/80A patent/AU536823B2/en not_active Ceased
- 1980-01-14 YU YU81/80A patent/YU44003B/en unknown
- 1980-01-14 JP JP219280A patent/JPS55100313A/en active Granted
- 1980-01-15 FR FR808000801A patent/FR2446635B1/en not_active Expired
- 1980-01-15 CA CA000343663A patent/CA1148470A/en not_active Expired
- 1980-01-15 CS CS80309A patent/CS227010B2/en unknown
- 1980-01-15 AT AT0019380A patent/AT370623B/en not_active IP Right Cessation
- 1980-01-16 ZA ZA00800269A patent/ZA80269B/en unknown
- 1980-01-16 IE IE91/80A patent/IE49141B1/en unknown
- 1980-01-17 GB GB8001545A patent/GB2041871B/en not_active Expired
- 1980-01-17 CH CH370/80A patent/CH648205A5/en not_active IP Right Cessation
- 1980-01-17 FI FI800151A patent/FI70672C/en not_active IP Right Cessation
- 1980-01-17 HU HU8097A patent/HU184714B/en not_active IP Right Cessation
- 1980-01-17 SU SU802869298A patent/SU1367839A3/en active
- 1980-01-18 DK DK022380A patent/DK157060C/en not_active IP Right Cessation
- 1980-01-18 DE DE19803001842 patent/DE3001842A1/en active Granted
- 1980-01-18 BE BE0/199021A patent/BE881225A/en not_active IP Right Cessation
- 1980-01-18 SE SE8000443A patent/SE445171B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FI70672B (en) | 1986-06-26 |
| IT7919434A0 (en) | 1979-01-19 |
| DK157060B (en) | 1989-11-06 |
| FR2446635B1 (en) | 1989-03-10 |
| BE881225A (en) | 1980-07-18 |
| ZA80269B (en) | 1981-06-24 |
| JPS55100313A (en) | 1980-07-31 |
| DK157060C (en) | 1990-04-09 |
| CH648205A5 (en) | 1985-03-15 |
| NL8000139A (en) | 1980-07-22 |
| HU184714B (en) | 1984-10-29 |
| SU1367839A3 (en) | 1988-01-15 |
| YU8180A (en) | 1983-12-31 |
| IL59120A0 (en) | 1980-05-30 |
| YU44003B (en) | 1990-02-28 |
| FR2446635A1 (en) | 1980-08-14 |
| SE445171B (en) | 1986-06-09 |
| GB2041871B (en) | 1983-04-13 |
| FI70672C (en) | 1986-10-06 |
| AU5458180A (en) | 1980-07-24 |
| FI800151A7 (en) | 1980-07-20 |
| IL59120A (en) | 1984-05-31 |
| AU536823B2 (en) | 1984-05-24 |
| GB2041871A (en) | 1980-09-17 |
| IT1110989B (en) | 1986-01-13 |
| DE3001842C2 (en) | 1990-04-26 |
| AT370623B (en) | 1983-04-25 |
| IE49141B1 (en) | 1985-08-07 |
| JPH0133446B2 (en) | 1989-07-13 |
| CA1148470A (en) | 1983-06-21 |
| SE8000443L (en) | 1980-07-20 |
| DE3001842A1 (en) | 1980-07-31 |
| CS227010B2 (en) | 1984-04-16 |
| ATA19380A (en) | 1982-09-15 |
| DK22380A (en) | 1980-07-20 |
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