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GB2004745A - Injectable suspensions of drug- containing liposomes. - Google Patents

Injectable suspensions of drug- containing liposomes.

Info

Publication number
GB2004745A
GB2004745A GB7838495A GB7838495A GB2004745A GB 2004745 A GB2004745 A GB 2004745A GB 7838495 A GB7838495 A GB 7838495A GB 7838495 A GB7838495 A GB 7838495A GB 2004745 A GB2004745 A GB 2004745A
Authority
GB
United Kingdom
Prior art keywords
drug
resin
containing liposomes
injectable suspensions
suspensions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7838495A
Other versions
GB2004745B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Publication of GB2004745A publication Critical patent/GB2004745A/en
Application granted granted Critical
Publication of GB2004745B publication Critical patent/GB2004745B/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

Injectable pharmaceutical suspensions of liposomes containing a drug (eg. doxcrubicin hydrochloride or 5-fluorouracil) are prepared by a conventional method, and then the liposomes are separated from non-entrapped drug by shaking the suspension with a polymeric ion exchange resin or a polymeric adsorbent resin to adsorb the non-entrapped drug, then filtering off the resin. The ion exchange resin may be a strong or weak, anionic or cationic resin. The resultant liposomic suspensions may be lyophilised.
GB7838495A 1977-09-30 1978-09-28 Liposomic suspensions Expired GB2004745B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2814777 1977-09-30

Publications (2)

Publication Number Publication Date
GB2004745A true GB2004745A (en) 1979-04-11
GB2004745B GB2004745B (en) 1982-04-07

Family

ID=11223032

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7838495A Expired GB2004745B (en) 1977-09-30 1978-09-28 Liposomic suspensions

Country Status (13)

Country Link
JP (1) JPS5459314A (en)
AT (1) AT368879B (en)
AU (1) AU528260B2 (en)
BE (1) BE870882A (en)
CA (1) CA1116518A (en)
CH (1) CH642540A5 (en)
DE (1) DE2842608C2 (en)
DK (1) DK154048C (en)
FR (1) FR2404454A1 (en)
GB (1) GB2004745B (en)
NL (1) NL7809709A (en)
SE (1) SE433038B (en)
ZA (1) ZA785510B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2446635A1 (en) * 1979-01-19 1980-08-14 Erba Farmitalia PHARMACEUTICAL COMPOSITIONS CONSISTING OF LIPOSOMES AND PROCESS FOR PREPARING THE SAME
EP0186352A3 (en) * 1984-12-24 1987-08-05 Technicon Instruments Corporation Preparation of lipid vesicles
WO2003011459A1 (en) * 2001-07-26 2003-02-13 Institut für Diagnostikforschung GmbH an der Freien Universität Berlin Method for producing pharmaceutical preparations

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5775916A (en) * 1980-10-29 1982-05-12 Nippon Chemiphar Co Ltd Coenzyme q pharmaceutical and its preparation
JPS5782310A (en) * 1980-11-11 1982-05-22 Tanabe Seiyaku Co Ltd Production of liposome preparation
CA1270198C (en) * 1984-08-08 1990-06-12 Marcel B Bally Encapsulation of antineoplastic agents in liposomes
DE4038075C1 (en) * 1990-11-29 1992-03-19 B. Braun Melsungen Ag, 3508 Melsungen, De Encapsulating solid or liq. lipophilic agents - comprises mixing hydration medium with phospholipid increasing temp. to above soln. phase change temp. and adding remaining medium

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2249552A1 (en) * 1971-10-12 1973-05-30 Inchema S A PROCESS FOR THE INCAPSULATION OF IN PARTICULAR WATER-SOLUBLE COMPOUNDS
GB1523965A (en) * 1976-03-19 1978-09-06 Ici Ltd Pharmaceutical compositions containing steroids

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2446635A1 (en) * 1979-01-19 1980-08-14 Erba Farmitalia PHARMACEUTICAL COMPOSITIONS CONSISTING OF LIPOSOMES AND PROCESS FOR PREPARING THE SAME
EP0186352A3 (en) * 1984-12-24 1987-08-05 Technicon Instruments Corporation Preparation of lipid vesicles
WO2003011459A1 (en) * 2001-07-26 2003-02-13 Institut für Diagnostikforschung GmbH an der Freien Universität Berlin Method for producing pharmaceutical preparations

Also Published As

Publication number Publication date
SE7810109L (en) 1979-03-31
ZA785510B (en) 1979-09-26
SE433038B (en) 1984-05-07
JPS6134402B2 (en) 1986-08-07
AT368879B (en) 1982-11-25
BE870882A (en) 1979-03-29
FR2404454A1 (en) 1979-04-27
AU528260B2 (en) 1983-04-21
CA1116518A (en) 1982-01-19
JPS5459314A (en) 1979-05-12
DK425478A (en) 1979-03-31
NL7809709A (en) 1979-04-03
AU4017478A (en) 1980-04-03
DK154048C (en) 1989-03-13
FR2404454B1 (en) 1980-06-20
GB2004745B (en) 1982-04-07
CH642540A5 (en) 1984-04-30
DK154048B (en) 1988-10-10
DE2842608A1 (en) 1979-04-12
ATA693178A (en) 1982-04-15
DE2842608C2 (en) 1986-02-06

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19920928