IE56151B1 - Tablet formulation - Google Patents

Tablet formulation

Info

Publication number: IE56151B1
Authority: IE; Ireland
Prior art keywords: formulation according; tablet; tablet formulation; membrane; active ingredient
Prior art date: 1983-10-20

Application number

IE246883A

Other languages

English (en)

Original Assignee

Elan Corp Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-10-20

Filing date

1983-10-20

Publication date

1991-05-08

1983-10-20 Application filed by Elan Corp Plc filed Critical Elan Corp Plc

1983-10-20 Priority to IE246883A priority Critical patent/IE56151B1/en

1984-10-15 Priority to BE0/213834A priority patent/BE900824A/fr

1991-05-08 Publication of IE56151B1 publication Critical patent/IE56151B1/en

Links

239000007916 tablet composition Substances 0.000 title claims description 31
239000012528 membrane Substances 0.000 claims abstract description 43
238000004090 dissolution Methods 0.000 claims abstract description 16
239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 10
229940079593 drug Drugs 0.000 claims description 32
239000003814 drug Substances 0.000 claims description 32
239000004480 active ingredient Substances 0.000 claims description 30
238000000576 coating method Methods 0.000 claims description 23
239000011248 coating agent Substances 0.000 claims description 19
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 18
239000000203 mixture Substances 0.000 claims description 18
239000004615 ingredient Substances 0.000 claims description 15
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 14
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical group [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 14
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 10
238000000034 method Methods 0.000 claims description 10
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical group CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 8
230000001419 dependent effect Effects 0.000 claims description 8
239000000463 material Substances 0.000 claims description 8
239000001530 fumaric acid Substances 0.000 claims description 7
235000011087 fumaric acid Nutrition 0.000 claims description 7
239000001103 potassium chloride Substances 0.000 claims description 7
235000011164 potassium chloride Nutrition 0.000 claims description 7
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 7
YKFCISHFRZHKHY-NGQGLHOPSA-N (2s)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;trihydrate Chemical group O.O.O.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1 YKFCISHFRZHKHY-NGQGLHOPSA-N 0.000 claims description 6
229940083181 centrally acting adntiadrenergic agent methyldopa Drugs 0.000 claims description 6
235000015165 citric acid Nutrition 0.000 claims description 6
238000009472 formulation Methods 0.000 claims description 6
229960005489 paracetamol Drugs 0.000 claims description 6
KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 6
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 5
229920003152 Eudragit® RS polymer Polymers 0.000 claims description 5
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 5
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 5
FSXVSUSRJXIJHB-UHFFFAOYSA-M ethyl prop-2-enoate;methyl 2-methylprop-2-enoate;trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium;chloride Chemical compound [Cl-].CCOC(=O)C=C.COC(=O)C(C)=C.CC(=C)C(=O)OCC[N+](C)(C)C FSXVSUSRJXIJHB-UHFFFAOYSA-M 0.000 claims description 5
XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims description 5
230000037452 priming Effects 0.000 claims description 5
235000017550 sodium carbonate Nutrition 0.000 claims description 5
229910000029 sodium carbonate Inorganic materials 0.000 claims description 5
239000001509 sodium citrate Substances 0.000 claims description 5
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 5
235000011083 sodium citrates Nutrition 0.000 claims description 5
239000011975 tartaric acid Substances 0.000 claims description 5
235000002906 tartaric acid Nutrition 0.000 claims description 5
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 4
229920003151 Eudragit® RL polymer Polymers 0.000 claims description 4
239000004372 Polyvinyl alcohol Substances 0.000 claims description 4
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 4
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 4
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 4
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 4
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 4
235000011090 malic acid Nutrition 0.000 claims description 4
239000001630 malic acid Substances 0.000 claims description 4
DNKKLDKIFMDAPT-UHFFFAOYSA-N n,n-dimethylmethanamine;2-methylprop-2-enoic acid Chemical compound CN(C)C.CC(=C)C(O)=O.CC(=C)C(O)=O DNKKLDKIFMDAPT-UHFFFAOYSA-N 0.000 claims description 4
-1 polyethylene Polymers 0.000 claims description 4
229920002451 polyvinyl alcohol Polymers 0.000 claims description 4
229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 4
239000001267 polyvinylpyrrolidone Substances 0.000 claims description 4
235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 4
238000009495 sugar coating Methods 0.000 claims description 4
229920003148 Eudragit® E polymer Polymers 0.000 claims description 3
229920003137 Eudragit® S polymer Polymers 0.000 claims description 3
NEDGUIRITORSKL-UHFFFAOYSA-N butyl 2-methylprop-2-enoate;2-(dimethylamino)ethyl 2-methylprop-2-enoate;methyl 2-methylprop-2-enoate Chemical compound COC(=O)C(C)=C.CCCCOC(=O)C(C)=C.CN(C)CCOC(=O)C(C)=C NEDGUIRITORSKL-UHFFFAOYSA-N 0.000 claims description 3
229920002301 cellulose acetate Polymers 0.000 claims description 3
229920000609 methyl cellulose Polymers 0.000 claims description 3
239000001923 methylcellulose Substances 0.000 claims description 3
235000010981 methylcellulose Nutrition 0.000 claims description 3
150000002772 monosaccharides Chemical class 0.000 claims description 3
229940100467 polyvinyl acetate phthalate Drugs 0.000 claims description 3
239000004800 polyvinyl chloride Substances 0.000 claims description 3
229920000915 polyvinyl chloride Polymers 0.000 claims description 3
239000001384 succinic acid Substances 0.000 claims description 3
235000011044 succinic acid Nutrition 0.000 claims description 3
229920000623 Cellulose acetate phthalate Polymers 0.000 claims description 2
229920003136 Eudragit® L polymer Polymers 0.000 claims description 2
239000004698 Polyethylene Substances 0.000 claims description 2
239000004743 Polypropylene Substances 0.000 claims description 2
239000001744 Sodium fumarate Substances 0.000 claims description 2
229940081734 cellulose acetate phthalate Drugs 0.000 claims description 2
150000002016 disaccharides Chemical class 0.000 claims description 2
MSJMDZAOKORVFC-SEPHDYHBSA-L disodium fumarate Chemical compound [Na+].[Na+].[O-]C(=O)\C=C\C([O-])=O MSJMDZAOKORVFC-SEPHDYHBSA-L 0.000 claims description 2
239000007788 liquid Substances 0.000 claims description 2
230000035699 permeability Effects 0.000 claims description 2
229920000515 polycarbonate Polymers 0.000 claims description 2
239000004417 polycarbonate Substances 0.000 claims description 2
229920000573 polyethylene Polymers 0.000 claims description 2
229920001155 polypropylene Polymers 0.000 claims description 2
229920002635 polyurethane Polymers 0.000 claims description 2
239000004814 polyurethane Substances 0.000 claims description 2
235000019294 sodium fumarate Nutrition 0.000 claims description 2
229940005573 sodium fumarate Drugs 0.000 claims description 2
101100290380 Caenorhabditis elegans cel-1 gene Proteins 0.000 claims 1
102220517445 Denticleless protein homolog_T90S_mutation Human genes 0.000 claims 1
239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical group N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 claims 1
229920001800 Shellac Polymers 0.000 claims 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims 1
229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims 1
150000002500 ions Chemical class 0.000 claims 1
229960002036 phenytoin Drugs 0.000 claims 1
239000011148 porous material Substances 0.000 claims 1
239000004208 shellac Substances 0.000 claims 1
229940113147 shellac Drugs 0.000 claims 1
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 claims 1
235000013874 shellac Nutrition 0.000 claims 1
159000000000 sodium salts Chemical class 0.000 claims 1
239000002195 soluble material Substances 0.000 claims 1
238000010521 absorption reaction Methods 0.000 abstract description 4
239000003826 tablet Substances 0.000 description 60
210000004379 membrane Anatomy 0.000 description 32
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
235000000346 sugar Nutrition 0.000 description 8
238000013270 controlled release Methods 0.000 description 7
239000000843 powder Substances 0.000 description 7
239000000454 talc Substances 0.000 description 7
229910052623 talc Inorganic materials 0.000 description 7
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 6
238000002156 mixing Methods 0.000 description 6
241000220479 Acacia Species 0.000 description 5
235000010643 Leucaena leucocephala Nutrition 0.000 description 5
238000010410 dusting Methods 0.000 description 5
229960002790 phenytoin sodium Drugs 0.000 description 5
FJPYVLNWWICYDW-UHFFFAOYSA-M sodium;5,5-diphenylimidazolidin-1-ide-2,4-dione Chemical compound [Na+].O=C1[N-]C(=O)NC1(C=1C=CC=CC=1)C1=CC=CC=C1 FJPYVLNWWICYDW-UHFFFAOYSA-M 0.000 description 5
239000007921 spray Substances 0.000 description 5
238000009498 subcoating Methods 0.000 description 5
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
239000000654 additive Substances 0.000 description 4
FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 description 4
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
239000004014 plasticizer Substances 0.000 description 4
238000005507 spraying Methods 0.000 description 4
239000001856 Ethyl cellulose Substances 0.000 description 3
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 3
108010010803 Gelatin Proteins 0.000 description 3
239000002253 acid Substances 0.000 description 3
230000008901 benefit Effects 0.000 description 3
229920001249 ethyl cellulose Polymers 0.000 description 3
235000019325 ethyl cellulose Nutrition 0.000 description 3
229920000159 gelatin Polymers 0.000 description 3
239000008273 gelatin Substances 0.000 description 3
235000019322 gelatine Nutrition 0.000 description 3
235000011852 gelatine desserts Nutrition 0.000 description 3
229960000905 indomethacin Drugs 0.000 description 3
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
239000000126 substance Substances 0.000 description 3
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
239000004150 EU approved colour Substances 0.000 description 2
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
229920003134 Eudragit® polymer Polymers 0.000 description 2
235000021355 Stearic acid Nutrition 0.000 description 2
229960001138 acetylsalicylic acid Drugs 0.000 description 2
229940035676 analgesics Drugs 0.000 description 2
239000000730 antalgic agent Substances 0.000 description 2
239000000872 buffer Substances 0.000 description 2
229910000019 calcium carbonate Inorganic materials 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
238000007907 direct compression Methods 0.000 description 2
239000006185 dispersion Substances 0.000 description 2
238000001035 drying Methods 0.000 description 2
230000002496 gastric effect Effects 0.000 description 2
239000002085 irritant Substances 0.000 description 2
231100000021 irritant Toxicity 0.000 description 2
235000019359 magnesium stearate Nutrition 0.000 description 2
239000011159 matrix material Substances 0.000 description 2
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
229940006093 opthalmologic coloring agent diagnostic Drugs 0.000 description 2
HHAVHBDPWSUKHZ-UHFFFAOYSA-N propan-2-ol;propan-2-one Chemical compound CC(C)O.CC(C)=O HHAVHBDPWSUKHZ-UHFFFAOYSA-N 0.000 description 2
235000017557 sodium bicarbonate Nutrition 0.000 description 2
229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
239000007787 solid Substances 0.000 description 2
239000008117 stearic acid Substances 0.000 description 2
239000006188 syrup Substances 0.000 description 2
235000020357 syrup Nutrition 0.000 description 2
ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
239000004408 titanium dioxide Substances 0.000 description 2
239000001993 wax Substances 0.000 description 2
230000004584 weight gain Effects 0.000 description 2
235000019786 weight gain Nutrition 0.000 description 2
RDJGLLICXDHJDY-NSHDSACASA-N (2s)-2-(3-phenoxyphenyl)propanoic acid Chemical compound OC(=O)[C@@H](C)C1=CC=CC(OC=2C=CC=CC=2)=C1 RDJGLLICXDHJDY-NSHDSACASA-N 0.000 description 1
ZHNFLHYOFXQIOW-AHSOWCEXSA-N (s)-[(2r,4s,5r)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;sulfuric acid;dihydrate Chemical compound O.O.OS(O)(=O)=O.C([C@H]([C@H](C1)C=C)C2)CN1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21.C([C@H]([C@H](C1)C=C)C2)CN1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 ZHNFLHYOFXQIOW-AHSOWCEXSA-N 0.000 description 1
ZCSWOYDEEZMOMR-UHFFFAOYSA-N 1-ethyl-6-fluoro-7-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound FC1=C(C)C=C2N(CC)C=C(C(O)=O)C(=O)C2=C1 ZCSWOYDEEZMOMR-UHFFFAOYSA-N 0.000 description 1
MEAPRSDUXBHXGD-UHFFFAOYSA-N 3-chloro-n-(4-propan-2-ylphenyl)propanamide Chemical compound CC(C)C1=CC=C(NC(=O)CCCl)C=C1 MEAPRSDUXBHXGD-UHFFFAOYSA-N 0.000 description 1
NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
101100310222 Caenorhabditis briggsae she-1 gene Proteins 0.000 description 1
206010053155 Epigastric discomfort Diseases 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
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CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 description 1
229930182555 Penicillin Natural products 0.000 description 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
DOQPXTMNIUCOSY-UHFFFAOYSA-N [4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl]-[2-(3,4-dimethoxyphenyl)ethyl]-methylazanium;chloride Chemical compound [H+].[Cl-].C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 DOQPXTMNIUCOSY-UHFFFAOYSA-N 0.000 description 1
235000013871 bee wax Nutrition 0.000 description 1
239000012166 beeswax Substances 0.000 description 1
239000002775 capsule Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
XMEVHPAGJVLHIG-FMZCEJRJSA-N chembl454950 Chemical compound [Cl-].C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H]([NH+](C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O XMEVHPAGJVLHIG-FMZCEJRJSA-N 0.000 description 1
239000003245 coal Substances 0.000 description 1
238000009500 colour coating Methods 0.000 description 1
238000007906 compression Methods 0.000 description 1
230000006835 compression Effects 0.000 description 1
IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 1
229960002768 dipyridamole Drugs 0.000 description 1
239000008298 dragée Substances 0.000 description 1
229960003276 erythromycin Drugs 0.000 description 1
238000013265 extended release Methods 0.000 description 1
IDKAXRLETRCXKS-UHFFFAOYSA-N fenclofenac Chemical compound OC(=O)CC1=CC=CC=C1OC1=CC=C(Cl)C=C1Cl IDKAXRLETRCXKS-UHFFFAOYSA-N 0.000 description 1
229950006236 fenclofenac Drugs 0.000 description 1
229960001419 fenoprofen Drugs 0.000 description 1
SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 description 1
229960003898 flurbiprofen sodium Drugs 0.000 description 1
230000037406 food intake Effects 0.000 description 1
210000001156 gastric mucosa Anatomy 0.000 description 1
239000008103 glucose Substances 0.000 description 1
125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
229960001680 ibuprofen Drugs 0.000 description 1
239000012729 immediate-release (IR) formulation Substances 0.000 description 1
DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 1
229960000991 ketoprofen Drugs 0.000 description 1
239000004922 lacquer Substances 0.000 description 1
239000008101 lactose Substances 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
229960002009 naproxen Drugs 0.000 description 1
CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
239000003605 opacifier Substances 0.000 description 1
239000006186 oral dosage form Substances 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
229960000649 oxyphenbutazone Drugs 0.000 description 1
HFHZKZSRXITVMK-UHFFFAOYSA-N oxyphenbutazone Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=C(O)C=C1 HFHZKZSRXITVMK-UHFFFAOYSA-N 0.000 description 1
229940049954 penicillin Drugs 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
229960002895 phenylbutazone Drugs 0.000 description 1
VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 1
239000000049 pigment Substances 0.000 description 1
229960002702 piroxicam Drugs 0.000 description 1
QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 1
229940113115 polyethylene glycol 200 Drugs 0.000 description 1
229940068918 polyethylene glycol 400 Drugs 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229960002816 potassium chloride Drugs 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
229960004604 propranolol hydrochloride Drugs 0.000 description 1
AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol hydrochloride Natural products C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 1
239000013557 residual solvent Substances 0.000 description 1
238000004513 sizing Methods 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
239000007940 sugar coated tablet Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000009492 tablet coating Methods 0.000 description 1
239000002700 tablet coating Substances 0.000 description 1
229960004989 tetracycline hydrochloride Drugs 0.000 description 1
229960000278 theophylline Drugs 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
229960000881 verapamil hydrochloride Drugs 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Inorganic Chemistry (AREA)
Medicinal Preparation (AREA)

IE246883A 1983-10-20 1983-10-20 Tablet formulation IE56151B1 (en)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
IE246883A IE56151B1 (en)	1983-10-20	1983-10-20	Tablet formulation
BE0/213834A BE900824A (fr)	1983-10-20	1984-10-15	Composition de comprimes.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IE246883A IE56151B1 (en)	1983-10-20	1983-10-20	Tablet formulation

Publications (1)

Publication Number	Publication Date
IE56151B1 true IE56151B1 (en)	1991-05-08

Family

ID=11034957

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IE246883A IE56151B1 (en)	1983-10-20	1983-10-20	Tablet formulation

Country Status (2)

Country	Link
BE (1)	BE900824A (fr)
IE (1)	IE56151B1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS62195323A (ja) *	1986-02-24	1987-08-28	Eisai Co Ltd	胃内滞留型粒子
IE58401B1 (en) *	1986-06-20	1993-09-08	Elan Corp Plc	Controlled absorption pharmaceutical composition
US4795641A (en) *	1987-08-20	1989-01-03	Eastman Kodak Company	Polymer blends having reverse phase morphology for controlled delivery of bioactive agents
US4851226A (en) *	1987-11-16	1989-07-25	Mcneil Consumer Products Company	Chewable medicament tablet containing means for taste masking
NZ226822A (en) *	1987-11-16	1990-03-27	Mcneil Consumer Prod	Chewable medicament tablet containing means for taste masking
IE60383B1 (en) *	1988-05-27	1994-07-13	Elan Corp Plc	Controlled release pharmaceutical formulation
AU632602B2 (en) *	1989-08-02	1993-01-07	John David Arnold	Method and preparation for reducing risk of myocardial infarction
US5000962A (en) *	1989-08-25	1991-03-19	Schering Corporation	Long acting diltiazem formulation
US4992277A (en) *	1989-08-25	1991-02-12	Schering Corporation	Immediate release diltiazem formulation

1983
- 1983-10-20 IE IE246883A patent/IE56151B1/en not_active IP Right Cessation
1984
- 1984-10-15 BE BE0/213834A patent/BE900824A/fr not_active IP Right Cessation

Also Published As

Publication number	Publication date
BE900824A (fr)	1985-02-01

Publication	Publication Date	Title
US6177102B1 (en)	2001-01-23	Once daily analgesic tablet
US4816264A (en)	1989-03-28	Sustained release formulations
EP0239361B1 (fr)	1992-12-02	Préparation pharmaceutique à libération prolongée
CA2324493C (fr)	2006-02-14	Comprimes oraux a noyau monolithique a liberation controlee
US5178868A (en)	1993-01-12	Dosage form
US5238686A (en)	1993-08-24	Sustained-release pharmaceutical preparation
EP2379063B1 (fr)	2013-03-13	Formule pharmaceutique comportant un ou plusieurs esters d'acide fumarique dans une matrice erosive
ES2304980T3 (es)	2008-11-01	Sistemas de matriz de liberacion sostenida para farmacos altamente solubles.
US20040052844A1 (en)	2004-03-18	Time-controlled, sustained release, pharmaceutical composition containing water-soluble resins
NZ270737A (en)	1996-11-26	Enteric coated tablet: active core, erodible polymer layer containing cellulose ether derivative, and enteric outer coating
JP2006188540A (ja)	2006-07-20	エチルセルローズ水性分散液で被覆した放出制御製剤
JPH0735328B2 (ja)	1995-04-19	複数回の放出を行なう製剤
JPS59193831A (ja)	1984-11-02	腸溶性製剤の製造法
US20120251588A1 (en)	2012-10-04	Coating Composition, Solid Preparation Coated Therewith, and Method for Preparing Solid Preparation
US20030099710A1 (en)	2003-05-29	Granule modulating hydrogel system
CA2000932C (fr)	1999-12-28	Forme pharmaceutique orale multiparticulaire a liberation controlee
JPH08109126A (ja)	1996-04-30	耐衝撃性腸溶性顆粒剤およびこれを含有する錠剤
IE56151B1 (en)	1991-05-08	Tablet formulation
EP1216032B1 (fr)	2008-01-23	Formulations orales a liberation controlee
CA2647765A1 (fr)	2007-10-11	Formulations enduites
WO2001026633A1 (fr)	2001-04-19	Comprimes enrobes de gomme de caroube, de gomme de guar ou de gomme de mousse d'irlande
WO2006080630A1 (fr)	2006-08-03	Preparation de combinaison pharmaceutique par voie orale destinee au traitement du diabete sucre
JP4856323B2 (ja)	2012-01-18	安定な腸溶性糖衣錠の製造法
WO2004108164A1 (fr)	2004-12-16	Composition d'enrobage et preparation enrobee
US20040228918A1 (en)	2004-11-18	Granule modulating hydrogel system

Legal Events

Date	Code	Title	Description
2004-12-01	MK9A	Patent expired