IE42290L - 4-aminoquinoline derivatives - Google Patents
4-aminoquinoline derivativesInfo
- Publication number
- IE42290L IE42290L IE752810A IE281075A IE42290L IE 42290 L IE42290 L IE 42290L IE 752810 A IE752810 A IE 752810A IE 281075 A IE281075 A IE 281075A IE 42290 L IE42290 L IE 42290L
- Authority
- IE
- Ireland
- Prior art keywords
- rnh
- compounds
- jan
- halogen
- substituted
- Prior art date
Links
- 150000005011 4-aminoquinolines Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- -1 N- substituted piperidine Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000005936 piperidyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
1474296 4-Aminoquinoline derivatives JOHN WYETH & BRO Ltd 23 Jan 1976 [23 Jan 1975] 2924/75 Addition to 1416872 Heading C2C The invention comprises compounds of formula and their acid addition salts, wherein X is halogen or CF 3 ; Z is H, halogen, CF 3 , OH, NO 2 , R, RO, RNH or (R) 2 N, where R is C 1-6 alkyl; R<SP>1</SP> is H or R; and R<SP>2</SP> is RNH-A or (R) 2 N-A (A being C 1-6 alkylene), or piperidyl (optionally 1-substituted by aryl-A- or R); or NR<SP>1</SP>R<SP>2</SP> is RNH- or (R) 2 N- substituted piperidine. In examples, these compounds are prepared by reacting the corresponding acid chloride with HNH<SP>1</SP>R<SP>2</SP>. Therapeutic compositions having antiinflammatory activity, and in certain eases antihypertensive or blood platelet aggregation inhibiting activity, comprise compounds of the above formula, and may be administered (e.g.) orally or parenterally.
[GB1474296A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB292475A GB1474296A (en) | 1975-01-23 | 1975-01-23 | 4-aminoquinoline derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE42290L true IE42290L (en) | 1976-07-23 |
| IE42290B1 IE42290B1 (en) | 1980-07-16 |
Family
ID=9748630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2810/75A IE42290B1 (en) | 1975-01-23 | 1975-12-23 | 4-aminoquinoline derivatives |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS6015620B2 (en) |
| BE (1) | BE837698A (en) |
| CA (1) | CA1067080A (en) |
| CH (2) | CH586681A5 (en) |
| DE (1) | DE2559104A1 (en) |
| FR (1) | FR2298330A2 (en) |
| GB (1) | GB1474296A (en) |
| IE (1) | IE42290B1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1573186A (en) * | 1977-09-14 | 1980-08-20 | Wyeth John & Brother Ltd | 4-aminoquinoline derivatives |
| SE448091B (en) * | 1977-12-15 | 1987-01-19 | Roussel Uclaf | NEW 2 - / (4-QUINOLINYL) -AMINO / -5-FLUOROBENOIC ACID DERIVATIVES, PROCEDURES FOR PREPARING IT, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES |
| PH22302A (en) * | 1985-02-11 | 1988-07-22 | Fujisawa Pharmaceutical Co | Piperidine compounds |
| AU692439B2 (en) * | 1993-03-29 | 1998-06-11 | Zeneca Limited | Heterocyclic compounds as platelet aggregation inhibitors |
| US5750754A (en) * | 1993-03-29 | 1998-05-12 | Zeneca Limited | Heterocyclic compounds |
| US5753659A (en) * | 1993-03-29 | 1998-05-19 | Zeneca Limited | Heterocyclic compouds |
| US5652242A (en) * | 1993-03-29 | 1997-07-29 | Zeneca Limited | Heterocyclic derivatives |
| DK0691959T3 (en) * | 1993-03-29 | 1999-04-26 | Zeneca Ltd | Heterocyclic derivatives as platelet aggregation inhibitors |
| US7307088B2 (en) | 2002-07-09 | 2007-12-11 | Amgen Inc. | Substituted anthranilic amide derivatives and methods of use |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1416872A (en) * | 1972-03-10 | 1975-12-10 | Wyeth John & Brother Ltd | 4-aminoquinoline derivatives |
| CH585221A5 (en) * | 1972-07-28 | 1977-02-28 | Synthelabo |
-
1975
- 1975-01-23 GB GB292475A patent/GB1474296A/en not_active Expired
- 1975-12-23 IE IE2810/75A patent/IE42290B1/en unknown
- 1975-12-30 DE DE19752559104 patent/DE2559104A1/en not_active Withdrawn
-
1976
- 1976-01-19 BE BE163621A patent/BE837698A/en not_active IP Right Cessation
- 1976-01-21 FR FR7601573A patent/FR2298330A2/en active Granted
- 1976-01-22 JP JP51005529A patent/JPS6015620B2/en not_active Expired
- 1976-01-23 CH CH84876A patent/CH586681A5/xx not_active IP Right Cessation
- 1976-01-23 CH CH1602276A patent/CH586682A5/xx not_active IP Right Cessation
- 1976-01-23 CA CA244,164A patent/CA1067080A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2559104A1 (en) | 1976-07-29 |
| FR2298330B2 (en) | 1982-08-27 |
| CH586681A5 (en) | 1977-04-15 |
| JPS5195080A (en) | 1976-08-20 |
| BE837698A (en) | 1976-07-19 |
| FR2298330A2 (en) | 1976-08-20 |
| GB1474296A (en) | 1977-05-18 |
| CH586682A5 (en) | 1977-04-15 |
| JPS6015620B2 (en) | 1985-04-20 |
| IE42290B1 (en) | 1980-07-16 |
| CA1067080A (en) | 1979-11-27 |
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