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IE41426L - Stabilized polyalkylene glycols - Google Patents

Stabilized polyalkylene glycols

Info

Publication number
IE41426L
IE41426L IE751596A IE159675A IE41426L IE 41426 L IE41426 L IE 41426L IE 751596 A IE751596 A IE 751596A IE 159675 A IE159675 A IE 159675A IE 41426 L IE41426 L IE 41426L
Authority
IE
Ireland
Prior art keywords
carbon atoms
alkyl
aggregate
phenyl
hydrogen
Prior art date
Application number
IE751596A
Other versions
IE41426B1 (en
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH998374A external-priority patent/CH605936A5/en
Priority claimed from CH1103174A external-priority patent/CH605938A5/en
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Priority to IE2048/78A priority Critical patent/IE41428B1/en
Priority to IE2047/78A priority patent/IE41427B1/en
Publication of IE41426L publication Critical patent/IE41426L/en
Publication of IE41426B1 publication Critical patent/IE41426B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

8?-ERGOLINE I COMPOUNDS This invention provides new compounds of formula I, I wherein X is hydrogen, chlorine or bromine, R1 is methyl or ethyl, and R2 is CH2-CN, or a group NR3R4, wherein R3 is hydrogen or alkyl of 1 to 4 carbon atoms, and R4 is formyl, alkanoyl of 2 to 5 carbon atoms in the aggregate thereof, alkoxycarbonyl of 2 to 5 carbon atoms in the aggregate thereof, mono- to trihalogenalkoxycarbonyl of 3 to 5 carbon atoms in the aggregate thereof, the alkoxy radical of which is substituted by halogen in a position other than .alpha. to the oxygen, or the radical SO2R5, wherein R5 is alkyl of 1 to 4 carbon atoms, monoto tri-halogenalkyl of 1 to 4 carbon atoms, phenyl, pyridyl, phenyl monosubstituted by halogen or alkoxy of 1 to 4 carbon atoms, or a group NR6R7, wherein each of R6 and R7 is independently hydrogen or alkyl of 1 to 4 carbon atoms, or R6 and R7 together are one of the groups (CH2)n or (CH2)2-A-(CH2)2, wherein n is a number from 3 to 7, and A is oxygen, sulphur or nitrogen substituted by alkyl of 1 to 4 carbon atoms or phenyl, useful as prolactin secretion agents and antiparkinson agents. [CA1073452A]
IE1596/75A 1974-07-19 1975-07-17 8 -substituted ergoline i derivatives IE41426B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IE2048/78A IE41428B1 (en) 1974-07-19 1975-07-17 6-methyl-8 -n,n-dimethyl sulphamoylaminoergoline i
IE2047/78A IE41427B1 (en) 1974-07-19 1975-07-17 6-methyl-8 -cyanomethylergoline i

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH998374A CH605936A5 (en) 1974-07-19 1974-07-19 8-Alpha-(Amino-or cyanomethyl)-ergoline derivs
CH1103174A CH605938A5 (en) 1974-08-13 1974-08-13 8-Alpha-(Amino-or cyanomethyl)-ergoline derivs

Publications (2)

Publication Number Publication Date
IE41426L true IE41426L (en) 1976-01-19
IE41426B1 IE41426B1 (en) 1980-01-02

Family

ID=25705648

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1596/75A IE41426B1 (en) 1974-07-19 1975-07-17 8 -substituted ergoline i derivatives

Country Status (17)

Country Link
JP (1) JPS5134199A (en)
AU (1) AU505314B2 (en)
CA (1) CA1073452A (en)
DD (1) DD118635A5 (en)
DE (1) DE2530577A1 (en)
DK (2) DK143902C (en)
ES (1) ES439548A1 (en)
FI (1) FI61188C (en)
FR (1) FR2282889A1 (en)
GB (3) GB1517971A (en)
HK (2) HK56880A (en)
IE (1) IE41426B1 (en)
IL (1) IL47735A (en)
MY (2) MY8100215A (en)
NL (1) NL7508416A (en)
NO (1) NO752493L (en)
PH (1) PH16594A (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1573621A (en) * 1976-01-02 1980-08-28 Sandoz Ltd Acylated 6-methyl-8a-amino-ergoline i compounds
DE2656344A1 (en) * 1975-12-23 1977-07-07 Sandoz Ag ERGOLIN DERIVATIVES, THEIR USE AND MANUFACTURING
IT1064473B (en) * 1976-11-24 1985-02-18 Simes 8-BETA-AMINOMETHYLERGOLINE DERIVATIVES ON SULFAMOIL
BE889713A (en) * 1980-07-25 1982-01-25 Sandoz Sa NEW ERGOLIN DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS
WO1982000463A1 (en) * 1980-07-25 1982-02-18 Ag Sandoz Ergoline derivatives,method for their preparation,pharmaceutical compositions containing them and their therapeutic application
CH644606A5 (en) * 1980-09-23 1984-08-15 Sandoz Ag METHOD FOR ISOMERIZING 9,10-DIHYDROLYSE ENERGY DERIVATIVES.
DE3101535A1 (en) * 1981-01-14 1982-08-12 Schering Ag, 1000 Berlin Und 4619 Bergkamen NEW (2-HALOGEN-ERGOLINYL) -N'.N'-DIETHYL-UREA DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT
JPS58174081A (en) * 1982-04-05 1983-10-13 Mitsubishi Heavy Ind Ltd Ventilator for engine room of ship
HU197569B (en) * 1984-01-12 1989-04-28 Sandoz Ag Process for producing 8alpha-acylaminoergoline derivatives and pharmaceuticals comprising such compounds
CH666035A5 (en) * 1984-12-24 1988-06-30 Sandoz Ag 8-ALPHA ACYLAMINOERGOLENE.
HUT45248A (en) * 1986-01-24 1988-06-28 Sandoz Ag Process for producing 8alpha-(acylamino)-ergoline derivatives and pharmaceuticals comprising such compounds
AT392945B (en) * 1988-06-27 1991-07-10 Gerhard Mader Ges M B H Ing STORAGE AND TRANSPORTATION CONTAINERS FOR Bulk goods and loose materials
DE4033496A1 (en) * 1990-10-20 1992-04-23 Sandoz Ag NEW ERGOL DERIVATIVES, THEIR PRODUCTION AND USE

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3218323A (en) * 1965-11-16 Esters of i,g-dimethyl-b-ergolenyl carbamic acid
FR1360618A (en) * 1963-06-17 1964-05-08 Sandoz Sa New urethanes of the lysergic series and their preparation
CH507248A (en) * 1967-03-16 1971-05-15 Spofa Vereinigte Pharma Werke Process for the preparation of D-6-methylergolin (I) ylacetic acid
NL6818658A (en) * 1968-01-18 1969-07-22
AR206772A1 (en) * 1972-07-21 1976-08-23 Lilly Co Eli PROCEDURE TO PREPARE A NEW D-2-HALO-6-METHYL-8-CYANE (CARBOXAMIDE) METHYL ERGOLINE

Also Published As

Publication number Publication date
IE41426B1 (en) 1980-01-02
JPS5134199A (en) 1976-03-23
HK56880A (en) 1980-10-16
IL47735A0 (en) 1975-10-15
DE2530577C2 (en) 1990-11-08
GB1517973A (en) 1978-07-19
DE2530577A1 (en) 1976-01-29
GB1517971A (en) 1978-07-19
DK313175A (en) 1976-01-20
DK143902B (en) 1981-10-26
FI752011A7 (en) 1976-01-20
IL47735A (en) 1979-11-30
FR2282889B1 (en) 1979-08-10
DK143902C (en) 1982-04-13
PH16594A (en) 1983-11-22
NL7508416A (en) 1976-01-21
AU505314B2 (en) 1979-11-15
CA1073452A (en) 1980-03-11
DK145542C (en) 1983-05-02
ES439548A1 (en) 1977-06-16
DK298980A (en) 1980-07-10
MY8100217A (en) 1981-12-31
FI61188B (en) 1982-02-26
FI61188C (en) 1982-06-10
NO752493L (en) 1976-01-20
FR2282889A1 (en) 1976-03-26
DD118635A5 (en) 1976-03-12
MY8100215A (en) 1981-12-31
GB1517972A (en) 1978-07-19
AU8316275A (en) 1977-01-20
DK145542B (en) 1982-12-06
HK56980A (en) 1980-10-16

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