IE39269L - Nitrocarbostyrils; pharmaceutical compositions. - Google Patents
Nitrocarbostyrils; pharmaceutical compositions.Info
- Publication number
- IE39269L IE39269L IE741039A IE103974A IE39269L IE 39269 L IE39269 L IE 39269L IE 741039 A IE741039 A IE 741039A IE 103974 A IE103974 A IE 103974A IE 39269 L IE39269 L IE 39269L
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- pharmaceutical compositions
- benzyl
- phenyl
- hydrogen
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 abstract 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 229940124630 bronchodilator Drugs 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 229960001317 isoprenaline Drugs 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- -1 phenoxy, benzyloxy Chemical group 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1453863 Antihistamine preparations BEECHAM GROUP Ltd 15 May 1974 [19 May 1973 22 May 1973] 24000/73 and 24317/73 Heading A5B [Also in Division C2] The invention provides pharmaceutical compositions comprising compounds of the formula I and pharmaceutically acceptable salts thereof wherein R 1 , R 2 R 3 and R 4 are hydrogen, halogen, hydroxy, nitro, alkyl, alkoxy, phenyl, benzyl, pyridyl, phenoxy, benzyloxy or any adjacent two of R 1 , R 2 , R 3 and R 4 taken together are a tetramethylene or 1, 3-butadienylene group and R 5 is hydrogen, alkyl, phenyl or benzyl wherein alkyl and alkoxy groups have 1 to 6 carbon atoms, together with one or more pharmaceutically acceptable carriers. The compositions show anti-allergic or immunological activity when administered orally, parenterally or by insufflation. The composition may contain a bronchodilator such as isoprenaline.
[GB1453863A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2400073A GB1453863A (en) | 1973-05-19 | 1973-05-19 | Pharmaceutical compositions comprising nitrocarbostyrils for the treatment of allergic and immunological hypersensitivity |
| GB2431773 | 1973-05-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE39269L true IE39269L (en) | 1974-11-19 |
| IE39269B1 IE39269B1 (en) | 1978-08-30 |
Family
ID=26256830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1039/74A IE39269B1 (en) | 1973-05-19 | 1974-05-15 | Pharmaceutical compositions comprising nitrocarbostyrils for the treatment of allergic and immunological hypersensitivity |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS5030884A (en) |
| AR (1) | AR201506A1 (en) |
| AT (1) | AT334373B (en) |
| CA (1) | CA1030539A (en) |
| CH (1) | CH601243A5 (en) |
| DD (1) | DD112126A5 (en) |
| DE (1) | DE2424076A1 (en) |
| DK (1) | DK137043B (en) |
| ES (1) | ES426427A1 (en) |
| FI (1) | FI153174A7 (en) |
| FR (1) | FR2229414B1 (en) |
| GB (1) | GB1453863A (en) |
| HU (1) | HU168001B (en) |
| IE (1) | IE39269B1 (en) |
| IL (1) | IL44849A (en) |
| IN (1) | IN139603B (en) |
| NL (1) | NL7406711A (en) |
| PH (1) | PH10621A (en) |
| SE (1) | SE7406631L (en) |
| SU (1) | SU578869A3 (en) |
| ZM (1) | ZM7974A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4065457A (en) * | 1973-05-19 | 1977-12-27 | Beecham Group Limited | 4-Hydroxy-3-nitro-carbostyril compounds |
| US4192876A (en) * | 1975-07-23 | 1980-03-11 | Sandoz, Inc. | 4-Hydroxy-3-nitro-quinoline-2(1H)-ones |
| DE2631317A1 (en) * | 1975-07-23 | 1977-02-17 | Sandoz Ag | ORGANIC COMPOUNDS, THEIR USE AND MANUFACTURING |
| JPS5919095B2 (en) * | 1977-06-22 | 1984-05-02 | 大塚製薬株式会社 | Quinoline derivatives and their production method |
| JPH0681744B2 (en) * | 1986-10-06 | 1994-10-19 | 三菱化成株式会社 | Method for producing 2,4-dioxyquinoline derivative |
| US5622965A (en) * | 1993-03-12 | 1997-04-22 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | 4-hydroxy-3-nitro-1,2-dihydroquinolin-2-ones and the use thereof as excitatory amino acid and glycine receptor antagonists |
-
1973
- 1973-05-19 GB GB2400073A patent/GB1453863A/en not_active Expired
-
1974
- 1974-05-15 IE IE1039/74A patent/IE39269B1/en unknown
- 1974-05-17 HU HUBE1198A patent/HU168001B/hu unknown
- 1974-05-17 CA CA200,335A patent/CA1030539A/en not_active Expired
- 1974-05-17 SE SE7406631A patent/SE7406631L/xx unknown
- 1974-05-17 CH CH683674A patent/CH601243A5/xx not_active IP Right Cessation
- 1974-05-17 FR FR7417170A patent/FR2229414B1/fr not_active Expired
- 1974-05-17 AT AT409674A patent/AT334373B/en not_active IP Right Cessation
- 1974-05-17 IL IL44849A patent/IL44849A/en unknown
- 1974-05-17 NL NL7406711A patent/NL7406711A/xx not_active Application Discontinuation
- 1974-05-17 FI FI1531/74A patent/FI153174A7/fi unknown
- 1974-05-17 ES ES426427A patent/ES426427A1/en not_active Expired
- 1974-05-17 DE DE2424076A patent/DE2424076A1/en active Pending
- 1974-05-17 SU SU7402031653A patent/SU578869A3/en active
- 1974-05-17 DK DK273074AA patent/DK137043B/en unknown
- 1974-05-20 AR AR253837A patent/AR201506A1/en active
- 1974-05-20 JP JP49056448A patent/JPS5030884A/ja active Pending
- 1974-05-20 ZM ZM79/74A patent/ZM7974A1/en unknown
- 1974-05-20 DD DD178631A patent/DD112126A5/xx unknown
- 1974-05-20 PH PH15854A patent/PH10621A/en unknown
- 1974-06-18 IN IN1344/CAL/74A patent/IN139603B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH601243A5 (en) | 1978-06-30 |
| ES426427A1 (en) | 1976-09-16 |
| FR2229414A1 (en) | 1974-12-13 |
| IE39269B1 (en) | 1978-08-30 |
| DK137043C (en) | 1978-06-05 |
| GB1453863A (en) | 1976-10-27 |
| IN139603B (en) | 1976-07-10 |
| IL44849A (en) | 1978-04-30 |
| CA1030539A (en) | 1978-05-02 |
| DK137043B (en) | 1978-01-09 |
| SU578869A3 (en) | 1977-10-30 |
| AU6915874A (en) | 1975-11-20 |
| DE2424076A1 (en) | 1974-12-05 |
| ZM7974A1 (en) | 1974-12-20 |
| FR2229414B1 (en) | 1977-11-10 |
| SE7406631L (en) | 1974-11-20 |
| NL7406711A (en) | 1974-11-21 |
| HU168001B (en) | 1976-02-28 |
| AT334373B (en) | 1976-01-10 |
| JPS5030884A (en) | 1975-03-27 |
| IL44849A0 (en) | 1974-07-31 |
| ATA409674A (en) | 1976-05-15 |
| PH10621A (en) | 1977-07-19 |
| FI153174A7 (en) | 1974-11-20 |
| DD112126A5 (en) | 1975-03-20 |
| AR201506A1 (en) | 1975-03-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1454778A (en) | Therapeutic compositions comprising dioxamates | |
| GB1292601A (en) | Bis-(2-carboxy-chromone) compounds, their preparation and pharmaceutical compositions containing them | |
| GB1432809A (en) | Coumarin derivatives | |
| IE39269L (en) | Nitrocarbostyrils; pharmaceutical compositions. | |
| GB1290818A (en) | ||
| GB1528723A (en) | 1-nitro-9-n-substituted aminoalkylamino-acridines their salts and a method of preparing same | |
| GB1439724A (en) | Berbine derivatives and pharmaceutical compositions containing them | |
| GB1174051A (en) | Aminophenol Derivatives and Analgesic and Antipyretic Compositions | |
| GB1409648A (en) | Substituted pyrrolidinemethanol compounds and pharmaceutical compositions thereof | |
| GB1347433A (en) | Acetophenone oxime derivatives and pharmaceutical preparations which contain the same | |
| GB1225462A (en) | ||
| GB1433270A (en) | Benzopyrano-2,3-c-pyrazolecarboxylic acids their preparation and compositions containing them | |
| IE40893L (en) | PYRIMIDO [1,2-a] QUINOLINES | |
| GB1114660A (en) | Tetrahydro-lsoquinolines | |
| MY102090A (en) | Compounds with antiinflammatory activity, process for preparation thereof and pharmaceutical compositions therefrom | |
| GB1320453A (en) | Aromatic diethers | |
| GB1276359A (en) | Anthranilic acid derivatives | |
| GB1291571A (en) | Aza chromone-2-carboxylic acids | |
| IE37932L (en) | Xylidides | |
| GB1489333A (en) | Pharmaceutical compositions comprising reduced quinoline derivatives | |
| IE37186B1 (en) | Improvements in and relating to the production of benzyl-pyrimidines | |
| GB1445766A (en) | Phenoxysubstituted malonic acid derivatives their preparation and pharmaceutical compositions containing them | |
| GB1313274A (en) | Bicycloalkanecarboxymides and the preparation thereof | |
| IE43972L (en) | Piperidinoalkylindole derivatives | |
| GB1164058A (en) | Novel Sulphanilamides and a process for the manufacture thereof |