IE38120B1 - Pharmaceutically active derivatives of glycyrrhizinic acid and their preparation - Google Patents
Pharmaceutically active derivatives of glycyrrhizinic acid and their preparationInfo
- Publication number
- IE38120B1 IE38120B1 IE1330/73A IE133073A IE38120B1 IE 38120 B1 IE38120 B1 IE 38120B1 IE 1330/73 A IE1330/73 A IE 1330/73A IE 133073 A IE133073 A IE 133073A IE 38120 B1 IE38120 B1 IE 38120B1
- Authority
- IE
- Ireland
- Prior art keywords
- glycyrrhizinic
- aluminium
- acid
- iron
- solution
- Prior art date
Links
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical class O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 title abstract 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 10
- 229910052742 iron Inorganic materials 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 3
- 239000004411 aluminium Substances 0.000 abstract 3
- 229910052782 aluminium Inorganic materials 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- 150000001398 aluminium Chemical class 0.000 abstract 2
- 229960004949 glycyrrhizic acid Drugs 0.000 abstract 2
- 235000019410 glycyrrhizin Nutrition 0.000 abstract 2
- 229940074774 glycyrrhizinate Drugs 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/70—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of the iron group metals or copper
- B01J23/72—Copper
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/70—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of the iron group metals or copper
- B01J23/76—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of the iron group metals or copper combined with metals, oxides or hydroxides provided for in groups B01J23/02 - B01J23/36
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Seasonings (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
1445831 Iron and aluminium derivatives of glycyrrhizinic acid L R BOISSEVAIN 7 Aug 1973 [22 Aug 1972] 13455/72 Heading C2U [Also in Division A5] An iron or aluminium derivative of glycyrrhizinic acid, in which the amount of glycyrrhizinic moieties is at least 5% by weight and in which at least two thirds of the glycyrrhizinic moieties are insoluble in water, the glycyrrhizinic moiety weight being calculated as acid, which has been prepared by heating a product containing water soluble iron or aluminium glycyrrhizinate at a temperature of at least 70‹ C. for a sufficient time for the solubility to be reduced to the desired amount is novel. Preferably an aqueous soln. of iron or aluminium glycyrrhizinate is evaporated and optionally subsequently baked. The solution may be obtained by including active iron or aluminium in a solution of the free acid, digesting the solids therein with water for at least 12 hours and separating the solids from the solution. The solution of the acid may suitably be derived from liquorice. The product has anti-inflammatory and histiogenic properties and may be made up into pharmaceutical compositions.
[GB1445831A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1345572A GB1445831A (en) | 1972-08-22 | 1972-08-22 | Pharmaceutically active derivatives of glycyrrhizinic acid and their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE38120L IE38120L (en) | 1974-02-22 |
| IE38120B1 true IE38120B1 (en) | 1978-01-04 |
Family
ID=10023290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1330/73A IE38120B1 (en) | 1972-08-22 | 1973-08-03 | Pharmaceutically active derivatives of glycyrrhizinic acid and their preparation |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US3940381A (en) |
| JP (1) | JPS5821638B2 (en) |
| BE (1) | BE803830A (en) |
| CH (1) | CH587057A5 (en) |
| DE (1) | DE2342460A1 (en) |
| DK (1) | DK134508B (en) |
| FR (1) | FR2193619B1 (en) |
| GB (1) | GB1445831A (en) |
| IE (1) | IE38120B1 (en) |
| LU (1) | LU68268A1 (en) |
| NL (1) | NL175384C (en) |
| ZA (1) | ZA735623B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2019407B (en) * | 1978-04-14 | 1982-10-06 | Yamasa Shoyu Kk | Glycosides of compounds of the 3-hydroxy oleanane series and their extraction from plants of genus periandra |
| US4176228A (en) * | 1978-09-14 | 1979-11-27 | Macandrews And Forbes Company | Potassium-magnesium-calcium glycyrrhizin |
| DE3123211A1 (en) * | 1981-06-11 | 1983-01-05 | Unilever N.V., 3000 Rotterdam | ORAL CARE PRODUCTS |
| EP0093520B1 (en) * | 1982-04-27 | 1986-10-15 | Noristan Limited | Pharmaceutical compositions and preparation thereof |
| AU553789B2 (en) * | 1982-06-30 | 1986-07-24 | Biorex Laboratories Ltd. | Glycyrrhetinic acid derivatives in cream compositions |
| JPS5936619A (en) * | 1982-08-23 | 1984-02-28 | Tsumura Juntendo Inc | Carcinostatic adjuvant |
| JPS5936621A (en) * | 1982-08-25 | 1984-02-28 | Tsumura Juntendo Inc | Improving agent for cancerous symptom |
| US4423027A (en) * | 1982-12-22 | 1983-12-27 | Simon Lionel N | Pharmaceutical compositions of deglycyrrhizinated licorice (DGL) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL291778A (en) * | 1962-04-27 | |||
| US3332962A (en) * | 1963-06-04 | 1967-07-25 | American Cyanamid Co | Phosphonium salts and derivatives and their preparation |
| US3629231A (en) * | 1968-05-23 | 1971-12-21 | Biorex Laboratories Ltd | Derivatives of glycyrrhetinic acid |
| JPS5212775B2 (en) * | 1972-03-01 | 1977-04-09 |
-
1972
- 1972-08-22 GB GB1345572A patent/GB1445831A/en not_active Expired
-
1973
- 1973-08-03 IE IE1330/73A patent/IE38120B1/en unknown
- 1973-08-13 US US05/387,822 patent/US3940381A/en not_active Expired - Lifetime
- 1973-08-16 ZA ZA735623A patent/ZA735623B/en unknown
- 1973-08-16 NL NLAANVRAGE7311291,A patent/NL175384C/en not_active IP Right Cessation
- 1973-08-20 LU LU68268A patent/LU68268A1/xx unknown
- 1973-08-21 DK DK458673AA patent/DK134508B/en not_active IP Right Cessation
- 1973-08-21 CH CH1202673A patent/CH587057A5/xx not_active IP Right Cessation
- 1973-08-21 FR FR7330365A patent/FR2193619B1/fr not_active Expired
- 1973-08-21 BE BE134775A patent/BE803830A/en not_active IP Right Cessation
- 1973-08-22 JP JP48094225A patent/JPS5821638B2/en not_active Expired
- 1973-08-22 DE DE19732342460 patent/DE2342460A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| GB1445831A (en) | 1976-08-11 |
| JPS5821638B2 (en) | 1983-05-02 |
| IE38120L (en) | 1974-02-22 |
| US3940381A (en) | 1976-02-24 |
| NL175384C (en) | 1984-11-01 |
| NL7311291A (en) | 1974-02-26 |
| ZA735623B (en) | 1974-07-31 |
| DK134508C (en) | 1977-04-18 |
| NL175384B (en) | 1984-06-01 |
| DK134508B (en) | 1976-11-22 |
| BE803830A (en) | 1974-02-21 |
| DE2342460A1 (en) | 1974-03-07 |
| LU68268A1 (en) | 1973-10-24 |
| CH587057A5 (en) | 1977-04-29 |
| FR2193619A1 (en) | 1974-02-22 |
| FR2193619B1 (en) | 1977-07-15 |
| JPS4985226A (en) | 1974-08-15 |
| AU5944173A (en) | 1975-02-27 |
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