ES370164A1 - Water-soluble corticoids - Google Patents
Water-soluble corticoidsInfo
- Publication number
- ES370164A1 ES370164A1 ES370164A ES370164A ES370164A1 ES 370164 A1 ES370164 A1 ES 370164A1 ES 370164 A ES370164 A ES 370164A ES 370164 A ES370164 A ES 370164A ES 370164 A1 ES370164 A1 ES 370164A1
- Authority
- ES
- Spain
- Prior art keywords
- stands
- see formula
- physiologically compatible
- water
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000003246 corticosteroid Substances 0.000 abstract 1
- 229960001334 corticosteroids Drugs 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedure for the preparation of water soluble corticosteroids of the general formula ** (see formula) ** (I) where R1 and R2 stand for hydrogen, fluorine or chlorine, and Y stands for SO3 M, PO3 M2, ** (see formula) ** or ** (see formula) **. HX where M stands for an alkali metal, preferably sodium, HX stands for an organic or inorganic acid, h stands for an integer between 1 and 3, and R3 and R4 they signify alcoholic groups, R3 and R4 being able to be also united to each other in the form of a ring, possibly with the inclusion of another heteroatom, characterized in that they are esterified in their own way the corresponding 21-hydroxy compounds are known, and the esters are then transformed, in a manner also known, with physiologically compatible bases or with physiologically compatible acids, into the salts. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19681793218 DE1793218C3 (en) | 1968-08-17 | 1968-08-17 | Water-soluble 21-hemisulfate alkali metal compounds of 6 a-fluoro-11 ß, 21-dihydroxy-16 a-methyl-3,20-dioxo-1,4-pregnadienes, processes for their preparation and pharmaceuticals containing them |
| DE1902651A DE1902651C3 (en) | 1969-01-15 | 1969-01-15 | New corticosteroid-21-monophosphates, processes for their preparation and medicinal products containing them |
| DE19691920634 DE1920634C3 (en) | 1969-04-19 | 1969-04-19 | Water-soluble corticosteroid-21-aminoacylates, processes for their preparation and pharmaceuticals containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES370164A1 true ES370164A1 (en) | 1971-04-01 |
Family
ID=27181456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES370164A Expired ES370164A1 (en) | 1968-08-17 | 1969-08-01 | Water-soluble corticoids |
Country Status (11)
| Country | Link |
|---|---|
| BE (1) | BE737501A (en) |
| BR (1) | BR6911575D0 (en) |
| CH (1) | CH527177A (en) |
| ES (1) | ES370164A1 (en) |
| FR (1) | FR2015858A1 (en) |
| GB (1) | GB1286093A (en) |
| IL (1) | IL32814A (en) |
| NL (1) | NL6912571A (en) |
| NO (1) | NO131427C (en) |
| SE (1) | SE352348B (en) |
| YU (1) | YU34304B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2715853A1 (en) * | 1977-04-06 | 1978-10-19 | Schering Ag | WATER-SOLUBLE CORTICOIDS |
| DE2920726A1 (en) * | 1979-05-18 | 1980-11-27 | Schering Ag | NEW CORTICOIDS, THEIR PRODUCTION AND USE |
| US4456602A (en) * | 1982-08-23 | 1984-06-26 | The Upjohn Company | Amine containing ester prodrugs of corticosteroids |
| US4443440A (en) * | 1982-08-30 | 1984-04-17 | The Upjohn Company | Amine containing ester prodrugs of corticosteroids |
| JP6090514B1 (en) * | 2016-05-18 | 2017-03-08 | 日本ゼオン株式会社 | Method for producing polymerizable compound |
| CN110800738A (en) * | 2019-11-11 | 2020-02-18 | 福州科理技术开发有限公司 | Deodorizing and pest killing spray liquid for kitchen garbage and its prepn |
-
1969
- 1969-07-21 YU YU1889/69A patent/YU34304B/en unknown
- 1969-07-23 CH CH1128069A patent/CH527177A/en not_active IP Right Cessation
- 1969-08-01 ES ES370164A patent/ES370164A1/en not_active Expired
- 1969-08-11 IL IL32814A patent/IL32814A/en unknown
- 1969-08-14 BE BE737501D patent/BE737501A/xx unknown
- 1969-08-15 NO NO3303/69A patent/NO131427C/no unknown
- 1969-08-15 BR BR211575/69A patent/BR6911575D0/en unknown
- 1969-08-15 SE SE11408/69A patent/SE352348B/xx unknown
- 1969-08-18 NL NL6912571A patent/NL6912571A/xx not_active Application Discontinuation
- 1969-08-18 GB GB41152/69A patent/GB1286093A/en not_active Expired
- 1969-08-18 FR FR6928228A patent/FR2015858A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| NO131427B (en) | 1975-02-17 |
| GB1286093A (en) | 1972-08-16 |
| NO131427C (en) | 1975-05-28 |
| BE737501A (en) | 1970-02-16 |
| FR2015858A1 (en) | 1970-04-30 |
| IL32814A0 (en) | 1969-11-12 |
| YU188969A (en) | 1978-10-31 |
| CH527177A (en) | 1972-08-31 |
| BR6911575D0 (en) | 1973-02-13 |
| YU34304B (en) | 1979-04-30 |
| SE352348B (en) | 1972-12-27 |
| NL6912571A (en) | 1970-02-19 |
| IL32814A (en) | 1973-06-29 |
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