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IE35123B1 - Phenylalkane derivatives and processes for the preparation thereof - Google Patents

Phenylalkane derivatives and processes for the preparation thereof

Info

Publication number
IE35123B1
IE35123B1 IE430/71A IE43071A IE35123B1 IE 35123 B1 IE35123 B1 IE 35123B1 IE 430/71 A IE430/71 A IE 430/71A IE 43071 A IE43071 A IE 43071A IE 35123 B1 IE35123 B1 IE 35123B1
Authority
IE
Ireland
Prior art keywords
general formula
chlorine
atom
group
chlorine atom
Prior art date
Application number
IE430/71A
Other versions
IE35123L (en
Inventor
K Godfrey
Original Assignee
Reckitt & Colmann Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reckitt & Colmann Prod Ltd filed Critical Reckitt & Colmann Prod Ltd
Publication of IE35123L publication Critical patent/IE35123L/en
Publication of IE35123B1 publication Critical patent/IE35123B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/807—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen all halogen atoms bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1308327 o - Phenoxyphenylacetic acids RECKITT & COLMAN PRODUCTS Ltd 19 April 1971 [14 April 1970] 17832/70 Heading C2C [Also in Division A5] Novel o-phenoxyphenylacetic acids of the general formula wherein R<SP>1</SP> is a hydrogen atom or methyl group, R<SP>2</SP> is a chlorine atom, R<SP>3</SP> is a C 1-6 alkyl group at position 4, a trifluoromethyl group at position 5, a methyl group at position 6 or a chlorine atom at position 4 or 5, and additionally compounds as defined above but wherein R<SP>2</SP> maybe a methoxy group when R<SP>3</SP> is a chlorine atom at position 4; and wherein one or more of the chlorine substituents is/are replaced by a bromine substituent are prepared by hydrolysis of a thioketone of the general formula They may be purified by conversion to the corresponding amide with thionyl chloride and ammonia, followed by alkaline hydrolysis. Thioketones of the second general formula above are prepared by reaction of an alkali metal phenolate and an o-haloacetophenone of the respective general formulµ wherein Y is ONa or OK and X is a chlorine, bromine or iodine atom, at a temperature of at least 120‹ C. in the presence of a copper catalyst and treatment of the resulting o-phenoxyacetophenone of the general formula with sulphur and morpholine. [GB1308327A]
IE430/71A 1970-04-14 1971-04-05 Phenylalkane derivatives and processes for the preparation thereof IE35123B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1783270 1970-04-14

Publications (2)

Publication Number Publication Date
IE35123L IE35123L (en) 1971-10-14
IE35123B1 true IE35123B1 (en) 1975-11-12

Family

ID=10101999

Family Applications (1)

Application Number Title Priority Date Filing Date
IE430/71A IE35123B1 (en) 1970-04-14 1971-04-05 Phenylalkane derivatives and processes for the preparation thereof

Country Status (13)

Country Link
US (1) US3766263A (en)
JP (1) JPS536143B1 (en)
BE (1) BE842952Q (en)
CA (1) CA935438A (en)
FR (1) FR2092044B1 (en)
GB (1) GB1308327A (en)
HK (1) HK51576A (en)
IE (1) IE35123B1 (en)
KE (1) KE2633A (en)
MY (1) MY7600176A (en)
NL (1) NL157006B (en)
SE (1) SE372254B (en)
ZA (1) ZA712345B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2451140A1 (en) * 1973-10-29 1975-04-30 Eisai Co Ltd M-PHENOXYPHENYLPROPIONIC ACID DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND COMPOUNDS CONTAINING THESE COMPOUNDS
CS181686B2 (en) * 1974-01-14 1978-03-31 Isf Spa Process for preparing 4-cyclopropylmethylenoxy-3-chlorphenylacetic acid
US4065503A (en) * 1974-09-30 1977-12-27 Sandoz, Inc. P-Phenoxy-alkylphenones and corresponding alcohols
GB2093021B (en) * 1981-01-24 1985-10-02 Reckitt & Colman Product Ltd 2-(2,4-dichlorophenoxy) phenylacetic acid
US4430510A (en) 1981-06-18 1984-02-07 Schering Corporation Process for the preparation of 2-(2,4-dichlorophenoxy)-phenylacetic acid
US4468469A (en) * 1981-11-04 1984-08-28 Miles Laboratories, Inc. Substituted phenylacetic acids and salts as TBP blocking agents in iodothyronine immunoassays
JPS60103906U (en) * 1983-12-20 1985-07-16 株式会社ヨコオ antenna connection device
GB8715242D0 (en) * 1987-06-29 1987-08-05 Wood E M Fenclofenac as immunosuppressant drug
US5145790A (en) * 1990-05-04 1992-09-08 Abbott Laboratories Reagents and method for detecting polychlorinated biphenyls
AU659106B2 (en) * 1990-11-06 1995-05-11 Fgn, Inc. Method for treating colonic polyps by the use of esters and amides of substituted phenyl and pyridyl amino carboxylates
US5538852A (en) * 1992-10-02 1996-07-23 Ecochem Research, Inc. Immunoassay for polychlorinated biphenyls
US6544556B1 (en) 2000-09-11 2003-04-08 Andrx Corporation Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
ITMI20012434A1 (en) * 2001-11-20 2003-05-20 Dompe Spa 2-ARYL-PROPIONIC ACIDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
ES2418153T3 (en) 2006-03-08 2013-08-12 Cortria Corporation Combination therapy with non-selective COX inhibitors to prevent gastric lesions related to COX

Also Published As

Publication number Publication date
HK51576A (en) 1976-08-20
ZA712345B (en) 1972-05-31
KE2633A (en) 1976-06-11
US3766263A (en) 1973-10-16
DE2117826B2 (en) 1975-11-20
CA935438A (en) 1973-10-16
GB1308327A (en) 1973-02-21
MY7600176A (en) 1976-12-31
JPS536143B1 (en) 1978-03-04
NL157006B (en) 1978-06-15
BE842952Q (en) 1976-10-01
SE372254B (en) 1974-12-16
NL7104884A (en) 1971-10-18
IE35123L (en) 1971-10-14
FR2092044A1 (en) 1972-01-21
DE2117826A1 (en) 1971-10-28
FR2092044B1 (en) 1975-08-01

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