IE34187B1 - Improvements in compositions having beta-adrenolytic activity - Google Patents
Improvements in compositions having beta-adrenolytic activityInfo
- Publication number
- IE34187B1 IE34187B1 IE439/70A IE43970A IE34187B1 IE 34187 B1 IE34187 B1 IE 34187B1 IE 439/70 A IE439/70 A IE 439/70A IE 43970 A IE43970 A IE 43970A IE 34187 B1 IE34187 B1 IE 34187B1
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- hydroxy
- hydroxyalkyl
- those
- group
- Prior art date
Links
- 230000000694 effects Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- -1 alkylnyloxy Chemical group 0.000 abstract 6
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- JWDYCNIAQWPBHD-UHFFFAOYSA-N 1-(2-methylphenyl)glycerol Chemical compound CC1=CC=CC=C1OCC(O)CO JWDYCNIAQWPBHD-UHFFFAOYSA-N 0.000 abstract 1
- HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- LEROTMJVBFSIMP-UHFFFAOYSA-N Mebutamate Chemical compound NC(=O)OCC(C)(C(C)CC)COC(N)=O LEROTMJVBFSIMP-UHFFFAOYSA-N 0.000 abstract 1
- YLCXGBZIZBEVPZ-UHFFFAOYSA-N Medazepam Chemical compound C12=CC(Cl)=CC=C2N(C)CCN=C1C1=CC=CC=C1 YLCXGBZIZBEVPZ-UHFFFAOYSA-N 0.000 abstract 1
- NPPQSCRMBWNHMW-UHFFFAOYSA-N Meprobamate Chemical compound NC(=O)OCC(C)(CCC)COC(N)=O NPPQSCRMBWNHMW-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 230000000561 anti-psychotic effect Effects 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- OFZCIYFFPZCNJE-UHFFFAOYSA-N carisoprodol Chemical compound NC(=O)OCC(C)(CCC)COC(=O)NC(C)C OFZCIYFFPZCNJE-UHFFFAOYSA-N 0.000 abstract 1
- 229960004587 carisoprodol Drugs 0.000 abstract 1
- 229960004782 chlordiazepoxide Drugs 0.000 abstract 1
- ANTSCNMPPGJYLG-UHFFFAOYSA-N chlordiazepoxide Chemical compound O=N=1CC(NC)=NC2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 ANTSCNMPPGJYLG-UHFFFAOYSA-N 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 abstract 1
- 229960003529 diazepam Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- ZQDWXGKKHFNSQK-UHFFFAOYSA-N hydroxyzine Chemical compound C1CN(CCOCCO)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZQDWXGKKHFNSQK-UHFFFAOYSA-N 0.000 abstract 1
- 229960000930 hydroxyzine Drugs 0.000 abstract 1
- 230000000147 hypnotic effect Effects 0.000 abstract 1
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 229960004119 mebutamate Drugs 0.000 abstract 1
- 229960002225 medazepam Drugs 0.000 abstract 1
- 229960003861 mephenesin Drugs 0.000 abstract 1
- KRPAJLYSLFNDOA-UHFFFAOYSA-N mephenesin carbamate Chemical compound CC1=CC=CC=C1OCC(O)COC(N)=O KRPAJLYSLFNDOA-UHFFFAOYSA-N 0.000 abstract 1
- 229950006838 mephenesin carbamate Drugs 0.000 abstract 1
- 229960004815 meprobamate Drugs 0.000 abstract 1
- QXLPXWSKPNOQLE-UHFFFAOYSA-N methylpentynol Chemical compound CCC(C)(O)C#C QXLPXWSKPNOQLE-UHFFFAOYSA-N 0.000 abstract 1
- 229960002238 methylpentynol Drugs 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- KJONHKAYOJNZEC-UHFFFAOYSA-N nitrazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1 KJONHKAYOJNZEC-UHFFFAOYSA-N 0.000 abstract 1
- 229960001454 nitrazepam Drugs 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229960004535 oxazepam Drugs 0.000 abstract 1
- ADIMAYPTOBDMTL-UHFFFAOYSA-N oxazepam Chemical compound C12=CC(Cl)=CC=C2NC(=O)C(O)N=C1C1=CC=CC=C1 ADIMAYPTOBDMTL-UHFFFAOYSA-N 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- XRVCFZPJAHWYTB-UHFFFAOYSA-N prenderol Chemical compound CCC(CC)(CO)CO XRVCFZPJAHWYTB-UHFFFAOYSA-N 0.000 abstract 1
- 229950006800 prenderol Drugs 0.000 abstract 1
- 239000003087 receptor blocking agent Substances 0.000 abstract 1
- 239000003204 tranquilizing agent Substances 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1305644 #-Adrenolytic medicines BOEHRINGER INGELHEIM GmbH 16 April 1970 [16 April 1969] 18243/70 Heading A5B Pharmaceutical compositions having improved #-adrenolytic activity comprise a #- receptor blocking agent of the 1-aryloxy-2- hydroxy-3-aminopropane or 1-aryl-1-hydroxy- 2-amino-methane type and a "minor tranquilizer". The #-adrenolyties are those of the general formula: Ar-OCH 2 -CHOH-CH 2 - NHR wherein Ar is an iso-, homo- or heterocyclic group which contains at least one 6- membered aromatic ring linked directly to the remainder of the molecule and which may optionally be substituted by one or more C 1-4 alkyl, alkoxy, alkenyl, alkenyloxy, alkynyl, alkylnyloxy, alkylthio, alkylsuphonyl, hydroxyalkyl, aminoalkyl, alkylamino, dialkylamino, acyl, acyloxy, acylamino, phenyl, phenoxy, phenylamino, phenylthio, phenylsulphonyl, phenylsulphonylamino, benzoylamino, phenalkoxy, haloalkyl, alkoxyalkyl, monoalkylaminoalkyl or dialkylaminoalkyl, nitro, hydroxy, amino, cyano or halogeno groups and R is a C 1-8 alkyl or hydroxyalkyl groups and those of the general formula: Ar 1 -CHOHCHR 1 ,-NHR wherein Ar 1 is a phenyl, naphthyl, tetralyl or indanyl group optionally substituted by halo, nitro, alkyl or alkoxy groups, R is a C 1-8 alkyl or hydroxyalkyl group and R 1 is hydrogen or a C 1-4 alkyl group. Suitable tranquilizers are those which are non-hypnotic and show no antipsychotic effect and include Hydroxyzine, Methylpentynol, Mephenesin, Mephenesin carbamate, Guiaphenesin, Meprobamate, Prenderol, Carisoprodol, Mebutamate, Chlordiazepoxide, Diazepam. Nitrazepam, Medazepam and Oxazepam. The compositions may be in conventional forms for oral, rectal and parenteral administration.
[GB1305644A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19691919342 DE1919342A1 (en) | 1969-04-16 | 1969-04-16 | Cardiac active combination preparations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE34187L IE34187L (en) | 1970-10-16 |
| IE34187B1 true IE34187B1 (en) | 1975-03-05 |
Family
ID=5731393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE439/70A IE34187B1 (en) | 1969-04-16 | 1970-04-07 | Improvements in compositions having beta-adrenolytic activity |
Country Status (8)
| Country | Link |
|---|---|
| BE (1) | BE748820A (en) |
| CA (1) | CA940048A (en) |
| DE (1) | DE1919342A1 (en) |
| FR (1) | FR2042334B1 (en) |
| GB (1) | GB1305644A (en) |
| IE (1) | IE34187B1 (en) |
| NL (1) | NL7005435A (en) |
| ZA (1) | ZA702530B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4000282A (en) | 1974-12-16 | 1976-12-28 | Merck & Co., Inc. | 2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines |
| US4060601A (en) | 1976-06-15 | 1977-11-29 | Merck & Co., Inc. | Certain lower-alkyl amino-2'-hydroxy-propoxy pyridines |
| LU76150A1 (en) * | 1976-11-08 | 1978-07-10 | ||
| FR2401661A1 (en) * | 1977-08-29 | 1979-03-30 | Italiana Med Sint | Compsns. for treating anxiety and neurodystonic states - contain a synergistic mixt. of benzodiazepine anxiolytic and beta adrenergic receptor inhibitor |
| US4279913A (en) * | 1978-01-04 | 1981-07-21 | Merck & Co., Inc. | Polysubstituted-2-(3-loweralkylamino-2-R1 O-propoxy)pyridines |
| US4294969A (en) * | 1979-01-29 | 1981-10-13 | Merck & Co., Inc. | Process for producing 2-bromo-3,5-disubstituted pyridines |
| US4234590A (en) | 1979-02-05 | 1980-11-18 | Merck & Co., Inc. | Thiosubstituted pyridines |
| DE2926653A1 (en) * | 1979-07-02 | 1981-01-22 | Sandoz Ag | NEW THERAPEUTIC USE OF ORGANIC COMPOUNDS |
| US4416735A (en) | 1982-06-17 | 1983-11-22 | Eastman Kodak Company | Diluent and method for potentiometric assay of liquids |
| US4468391A (en) * | 1982-06-25 | 1984-08-28 | Ayerst, Mckenna & Harrison, Inc. | Combination of β-adrenoceptor antagonists and anxiolytic agents |
-
1969
- 1969-04-16 DE DE19691919342 patent/DE1919342A1/en active Pending
-
1970
- 1970-04-07 IE IE439/70A patent/IE34187B1/en unknown
- 1970-04-08 CA CA079,531A patent/CA940048A/en not_active Expired
- 1970-04-10 BE BE748820D patent/BE748820A/en unknown
- 1970-04-15 ZA ZA702530A patent/ZA702530B/en unknown
- 1970-04-15 NL NL7005435A patent/NL7005435A/xx unknown
- 1970-04-16 GB GB1824370A patent/GB1305644A/en not_active Expired
- 1970-04-16 FR FR7013780A patent/FR2042334B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CA940048A (en) | 1974-01-15 |
| ZA702530B (en) | 1971-01-27 |
| DE1919342A1 (en) | 1970-12-03 |
| FR2042334A1 (en) | 1971-02-12 |
| IE34187L (en) | 1970-10-16 |
| NL7005435A (en) | 1970-10-20 |
| GB1305644A (en) | 1973-02-07 |
| FR2042334B1 (en) | 1974-08-30 |
| BE748820A (en) | 1970-10-12 |
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