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GB1305644A - - Google Patents

Info

Publication number
GB1305644A
GB1305644A GB1824370A GB1824370A GB1305644A GB 1305644 A GB1305644 A GB 1305644A GB 1824370 A GB1824370 A GB 1824370A GB 1824370 A GB1824370 A GB 1824370A GB 1305644 A GB1305644 A GB 1305644A
Authority
GB
United Kingdom
Prior art keywords
alkyl
hydroxy
hydroxyalkyl
those
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1824370A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1305644A publication Critical patent/GB1305644A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1305644 #-Adrenolytic medicines BOEHRINGER INGELHEIM GmbH 16 April 1970 [16 April 1969] 18243/70 Heading A5B Pharmaceutical compositions having improved #-adrenolytic activity comprise a #- receptor blocking agent of the 1-aryloxy-2- hydroxy-3-aminopropane or 1-aryl-1-hydroxy- 2-amino-methane type and a "minor tranquilizer". The #-adrenolyties are those of the general formula: Ar-OCH 2 -CHOH-CH 2 - NHR wherein Ar is an iso-, homo- or heterocyclic group which contains at least one 6- membered aromatic ring linked directly to the remainder of the molecule and which may optionally be substituted by one or more C 1-4 alkyl, alkoxy, alkenyl, alkenyloxy, alkynyl, alkylnyloxy, alkylthio, alkylsuphonyl, hydroxyalkyl, aminoalkyl, alkylamino, dialkylamino, acyl, acyloxy, acylamino, phenyl, phenoxy, phenylamino, phenylthio, phenylsulphonyl, phenylsulphonylamino, benzoylamino, phenalkoxy, haloalkyl, alkoxyalkyl, monoalkylaminoalkyl or dialkylaminoalkyl, nitro, hydroxy, amino, cyano or halogeno groups and R is a C 1-8 alkyl or hydroxyalkyl groups and those of the general formula: Ar 1 -CHOHCHR 1 ,-NHR wherein Ar 1 is a phenyl, naphthyl, tetralyl or indanyl group optionally substituted by halo, nitro, alkyl or alkoxy groups, R is a C 1-8 alkyl or hydroxyalkyl group and R 1 is hydrogen or a C 1-4 alkyl group. Suitable tranquilizers are those which are non-hypnotic and show no antipsychotic effect and include Hydroxyzine, Methylpentynol, Mephenesin, Mephenesin carbamate, Guiaphenesin, Meprobamate, Prenderol, Carisoprodol, Mebutamate, Chlordiazepoxide, Diazepam. Nitrazepam, Medazepam and Oxazepam. The compositions may be in conventional forms for oral, rectal and parenteral administration.
GB1824370A 1969-04-16 1970-04-16 Expired GB1305644A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19691919342 DE1919342A1 (en) 1969-04-16 1969-04-16 Cardiac active combination preparations

Publications (1)

Publication Number Publication Date
GB1305644A true GB1305644A (en) 1973-02-07

Family

ID=5731393

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1824370A Expired GB1305644A (en) 1969-04-16 1970-04-16

Country Status (8)

Country Link
BE (1) BE748820A (en)
CA (1) CA940048A (en)
DE (1) DE1919342A1 (en)
FR (1) FR2042334B1 (en)
GB (1) GB1305644A (en)
IE (1) IE34187B1 (en)
NL (1) NL7005435A (en)
ZA (1) ZA702530B (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000282A (en) 1974-12-16 1976-12-28 Merck & Co., Inc. 2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines
US4125618A (en) 1976-06-15 1978-11-14 Merck & Co., Inc. Novel substituted pyridines, their preparation and pharmaceutical use
US4234590A (en) 1979-02-05 1980-11-18 Merck & Co., Inc. Thiosubstituted pyridines
FR2460671A1 (en) * 1979-07-02 1981-01-30 Sandoz Sa NOVEL PHARMACEUTICAL COMPOSITIONS BASED ON AN INDOLE DERIVATIVE AND BENZODIAZEPINE
US4279913A (en) * 1978-01-04 1981-07-21 Merck & Co., Inc. Polysubstituted-2-(3-loweralkylamino-2-R1 O-propoxy)pyridines
US4294969A (en) * 1979-01-29 1981-10-13 Merck & Co., Inc. Process for producing 2-bromo-3,5-disubstituted pyridines
US4416735A (en) 1982-06-17 1983-11-22 Eastman Kodak Company Diluent and method for potentiometric assay of liquids
EP0098113A1 (en) * 1982-06-25 1984-01-11 Ayerst, Mckenna And Harrison Inc. A combination of beta-adrenoceptor antagonists and anxiolytic agents

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU76150A1 (en) * 1976-11-08 1978-07-10
FR2401661A1 (en) * 1977-08-29 1979-03-30 Italiana Med Sint Compsns. for treating anxiety and neurodystonic states - contain a synergistic mixt. of benzodiazepine anxiolytic and beta adrenergic receptor inhibitor

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000282A (en) 1974-12-16 1976-12-28 Merck & Co., Inc. 2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines
US4125618A (en) 1976-06-15 1978-11-14 Merck & Co., Inc. Novel substituted pyridines, their preparation and pharmaceutical use
US4279913A (en) * 1978-01-04 1981-07-21 Merck & Co., Inc. Polysubstituted-2-(3-loweralkylamino-2-R1 O-propoxy)pyridines
US4294969A (en) * 1979-01-29 1981-10-13 Merck & Co., Inc. Process for producing 2-bromo-3,5-disubstituted pyridines
US4234590A (en) 1979-02-05 1980-11-18 Merck & Co., Inc. Thiosubstituted pyridines
FR2460671A1 (en) * 1979-07-02 1981-01-30 Sandoz Sa NOVEL PHARMACEUTICAL COMPOSITIONS BASED ON AN INDOLE DERIVATIVE AND BENZODIAZEPINE
US4416735A (en) 1982-06-17 1983-11-22 Eastman Kodak Company Diluent and method for potentiometric assay of liquids
EP0098113A1 (en) * 1982-06-25 1984-01-11 Ayerst, Mckenna And Harrison Inc. A combination of beta-adrenoceptor antagonists and anxiolytic agents
US4468391A (en) * 1982-06-25 1984-08-28 Ayerst, Mckenna & Harrison, Inc. Combination of β-adrenoceptor antagonists and anxiolytic agents

Also Published As

Publication number Publication date
CA940048A (en) 1974-01-15
ZA702530B (en) 1971-01-27
DE1919342A1 (en) 1970-12-03
FR2042334A1 (en) 1971-02-12
IE34187L (en) 1970-10-16
NL7005435A (en) 1970-10-20
IE34187B1 (en) 1975-03-05
FR2042334B1 (en) 1974-08-30
BE748820A (en) 1970-10-12

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee