IE33812B1 - Quinoline derivatives - Google Patents
Quinoline derivativesInfo
- Publication number
- IE33812B1 IE33812B1 IE904/69A IE90469A IE33812B1 IE 33812 B1 IE33812 B1 IE 33812B1 IE 904/69 A IE904/69 A IE 904/69A IE 90469 A IE90469 A IE 90469A IE 33812 B1 IE33812 B1 IE 33812B1
- Authority
- IE
- Ireland
- Prior art keywords
- vinyl
- piperidyl
- methoxy
- quinoline derivatives
- acid addition
- Prior art date
Links
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title abstract 5
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title 1
- 150000003248 quinolines Chemical class 0.000 abstract 7
- 239000002253 acid Substances 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- 229940111121 antirheumatic drug quinolines Drugs 0.000 abstract 3
- 229920002554 vinyl polymer Polymers 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- -1 methylenedioxy Chemical group 0.000 abstract 2
- QSLVEBANMPJOKI-FPOVZHCZSA-N 1-[(3R,4S)-1-benzoyl-3-ethenylpiperidin-4-yl]-3-(6-methoxyquinolin-4-yl)propan-2-one Chemical compound COC=1C=C2C(=CC=NC2=CC1)CC(C[C@H]1[C@H](CN(CC1)C(C1=CC=CC=C1)=O)C=C)=O QSLVEBANMPJOKI-FPOVZHCZSA-N 0.000 abstract 1
- 101000653791 Bos taurus Protein S100-A12 Proteins 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 230000000078 anti-malarial effect Effects 0.000 abstract 1
- 239000003430 antimalarial agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000000640 hydroxylating effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/94—Oxygen atom, e.g. piperidine N-oxide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
-
- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
- H02J50/00—Circuit arrangements or systems for wireless supply or distribution of electric power
- H02J50/30—Circuit arrangements or systems for wireless supply or distribution of electric power using light, e.g. lasers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Computer Networks & Wireless Communication (AREA)
- Power Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
1280201 Quinoline derivatives F HOFFMANN-LA ROCHE & CO AG 2 July 1969 [2 July 1968] 33312/69 Heading C2C The invention comprises processes for the preparation of racemic or optically active quinoline derivatives of the Formula A wherein R 1 is H, OH, halogen, C 1-7 alkyl, C 1-7 alkoxy, or methylenedioxy, R 2 is vinyl or C 1-7 alkyl and m is 1 or 2, with the proviso that when R 1 is methylenedioxy, m is 1, and of acid addition salts thereof and the novel quinoline derivatives of the Formulµ Ib and IIb provided that when (R 1 )m is OCH 3 in position 6<SP>1</SP>, R 2 is other than ethyl, their antipodes and racemates and acid addition salts thereof. The said processes consisting of hydroxylating the corresponding racemic or optically active 4-(5- R 2 - 4 - quinuclidin - 2 - yl)methylquinolines or by cyclizing racemic or optically active compounds of the Formula E and if desired, converting the so-obtained bases into acid addition salts. Diastereometric 6 - methoxy - 4 - {3 - [ - 3(R)- vinyl - 4(S) - piperidyl] - 1,2 - epoxypropyl}. quinolines are obtained by deacylating diastereomeric 6 - methoxy - 4 - {3 - [1 - benzoyl - 3- (R) - vinyl - 4(S) - piperidyl] - 1,2 - epoxypropyl}. quinolines resulting from cyclization of epimeric 6 - methoxy - 4 - { - 3 - [1 - benzoyl - 3(R) - vinyl- 4(S) - piperidyl] - 1 - bromo - 2 - oxopropyl}. quinolines, which are made by brominating 6- methoxy - 4 - {3 - [1 - benzoyl - 3(R) -vinyl - 4(S) -piperidyl]-2-oxopropyl}-quinoline. Pharmaceutical compositions, suitable for oral, parenteral or rectal administration, contain the above novel quinoline derivatives of Formulµ Ib and IIb or antipodes or racemates or acid addition salts thereof in association with compatible pharmaceutical carriers. The compounds possess antimalarial and antiarrhythmic properties.
[GB1280201A]
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE830/72A IE33814B1 (en) | 1968-07-02 | 1969-07-02 | Quinoline derivatives |
| IE829/72A IE33813B1 (en) | 1968-07-02 | 1969-07-02 | Quinoline derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74191468A | 1968-07-02 | 1968-07-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE33812L IE33812L (en) | 1970-01-02 |
| IE33812B1 true IE33812B1 (en) | 1974-11-13 |
Family
ID=24982733
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE904/69A IE33812B1 (en) | 1968-07-02 | 1969-07-02 | Quinoline derivatives |
| IE829/72A IE33813B1 (en) | 1968-07-02 | 1969-07-02 | Quinoline derivatives |
| IE830/72A IE33814B1 (en) | 1968-07-02 | 1969-07-02 | Quinoline derivatives |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE829/72A IE33813B1 (en) | 1968-07-02 | 1969-07-02 | Quinoline derivatives |
| IE830/72A IE33814B1 (en) | 1968-07-02 | 1969-07-02 | Quinoline derivatives |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS497160B1 (en) |
| AT (4) | AT319482B (en) |
| BE (1) | BE735451A (en) |
| CA (3) | CA954516A (en) |
| CH (4) | CH559183A5 (en) |
| DE (1) | DE1933600A1 (en) |
| DK (1) | DK129235B (en) |
| FR (2) | FR2012152B1 (en) |
| GB (2) | GB1280203A (en) |
| IE (3) | IE33812B1 (en) |
| IL (4) | IL32535A (en) |
| NL (1) | NL162384C (en) |
| PH (3) | PH11413A (en) |
| SE (3) | SE364044B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3857837A (en) * | 1968-07-02 | 1974-12-31 | Hoffmann La Roche | Processes and intermediated for quinine, quinidine, isomers and derivatives thereof |
| JPS5147064U (en) * | 1974-10-04 | 1976-04-07 | ||
| US4400512A (en) * | 1976-12-17 | 1983-08-23 | Rohm And Haas Company | Azaspiro compounds |
| US4357471A (en) | 1976-12-17 | 1982-11-02 | Rohm And Haas Company | Azaspiro compounds |
| US4374991A (en) | 1976-12-17 | 1983-02-22 | Rohm And Haas Company | 2,6-Dimethylpiperidinyl-N-carbobutoxymethyl urea |
| NL7908031A (en) * | 1979-11-01 | 1981-06-01 | Acf Chemiefarma Nv | NEW QUINOLINE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING SUCH A COMPOUND AND METHOD FOR PREPARING THESE COMPOUNDS. |
| US4405630A (en) * | 1980-12-29 | 1983-09-20 | Rohm And Haas Company | Arthropod repellent compositions and methods |
-
1969
- 1969-06-27 CH CH1452471A patent/CH559183A5/xx not_active IP Right Cessation
- 1969-06-27 CH CH986169A patent/CH533622A/en not_active IP Right Cessation
- 1969-06-27 CH CH1452371A patent/CH559181A5/xx not_active IP Right Cessation
- 1969-06-27 CH CH1452571A patent/CH559184A5/xx not_active IP Right Cessation
- 1969-07-01 AT AT627069A patent/AT319482B/en active
- 1969-07-01 AT AT49371A patent/AT323338B/en not_active IP Right Cessation
- 1969-07-01 BE BE735451D patent/BE735451A/xx unknown
- 1969-07-01 AT AT00494/71A patent/AT300813B/en not_active IP Right Cessation
- 1969-07-01 PH PH10495A patent/PH11413A/en unknown
- 1969-07-01 FR FR696922136A patent/FR2012152B1/fr not_active Expired
- 1969-07-01 AT AT49271A patent/AT323337B/en not_active IP Right Cessation
- 1969-07-02 IE IE904/69A patent/IE33812B1/en unknown
- 1969-07-02 IL IL32535A patent/IL32535A/en unknown
- 1969-07-02 SE SE09413/69A patent/SE364044B/xx unknown
- 1969-07-02 DK DK359069AA patent/DK129235B/en unknown
- 1969-07-02 IE IE829/72A patent/IE33813B1/en unknown
- 1969-07-02 GB GB57018/71A patent/GB1280203A/en not_active Expired
- 1969-07-02 SE SE7212266A patent/SE376612B/xx unknown
- 1969-07-02 IE IE830/72A patent/IE33814B1/en unknown
- 1969-07-02 GB GB33312/69A patent/GB1280201A/en not_active Expired
- 1969-07-02 DE DE19691933600 patent/DE1933600A1/en not_active Ceased
- 1969-07-02 NL NL6910136.A patent/NL162384C/en not_active IP Right Cessation
- 1969-07-02 SE SE7212265A patent/SE375776B/xx unknown
- 1969-07-02 CA CA055,886A patent/CA954516A/en not_active Expired
-
1971
- 1971-07-28 JP JP46056691A patent/JPS497160B1/ja active Pending
- 1971-10-01 FR FR7135510A patent/FR2108178B1/fr not_active Expired
- 1971-11-01 CA CA126,549A patent/CA974994A/en not_active Expired
- 1971-11-01 CA CA126,550A patent/CA954517A/en not_active Expired
-
1973
- 1973-06-15 PH PH14731A patent/PH10708A/en unknown
- 1973-06-15 PH PH14732A patent/PH10255A/en unknown
- 1973-12-21 IL IL43884A patent/IL43884A0/en unknown
- 1973-12-21 IL IL43886A patent/IL43886A0/en unknown
- 1973-12-21 IL IL43885A patent/IL43885A0/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES482087A1 (en) | Octahydro pyrazolo (3,4-g)quinolines, process for their preparation and pharmaceutical compositions containing them. | |
| FI940951A0 (en) | Method of Preparation of Parenteral Antibacterial Composition | |
| IE38679L (en) | Piperazine derivatives | |
| EP0150937A3 (en) | Dihydropyridazinones | |
| IE33812B1 (en) | Quinoline derivatives | |
| IE821243L (en) | Quinoline derivatives | |
| JPS5692884A (en) | Novel piperidine derivative and its preparation | |
| DK535484A (en) | CYCLOHEXANDERIVATIVES, PROCEDURES FOR PREPARING IT, AND PHARMACEUTICAL PRODUCTS WITH CONTENTS | |
| IE33474L (en) | Quinoline derivatives | |
| JPS52282A (en) | Process for preparation of carbostyril derivatives | |
| IE35284L (en) | Quinoline derivatives | |
| JPS5726670A (en) | Acrylonitrile derivative | |
| GB1280202A (en) | Quinoline derivatives | |
| ES8604912A1 (en) | 4-(Arylpiperazinylethylaminoethoxy) phenol derivatives, process for their preparation and their therapeutical application. | |
| EP0260605A3 (en) | Dihydropyridine-5-phosphonic acid cyclic ester | |
| AU560656B2 (en) | N-acyl-3-amino-1,2,3,4-tetrahydroquinolines | |
| IE35953L (en) | Quinoline derivatives | |
| JPS572289A (en) | Production of penem-3-carboxylic derivative | |
| JPS5716856A (en) | 4-guanidinomethylcyclohexanecarboxylic acid ester and its preparation | |
| SE8006598L (en) | PROCEDURE FOR PREPARING 1,3-DIHYDROSPIRO / ISOBENSOFURAN-1,4'-PIPERIDINES | |
| JPS52116482A (en) | Carbostyril derivatives and its preparation | |
| JPS51133277A (en) | A process for preparing novel carbostyril derivatives | |
| ATE126190T1 (en) | 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-5- | |
| JPS53111078A (en) | Carbostyril derivative | |
| GB1260530A (en) | Benzylimidazolidinones and a process for the manufacture thereof |