ID21956A - Asam n-(aril dan atau heteroarilasetil) amino ester, komposisi farmasi yang mengandungnya, dan metoda untuk menghambat pelepasan betha-amiloid peptida dan atau sintesanya dengan menggunakan senyawa tersebut - Google Patents

Asam n-(aril dan atau heteroarilasetil) amino ester, komposisi farmasi yang mengandungnya, dan metoda untuk menghambat pelepasan betha-amiloid peptida dan atau sintesanya dengan menggunakan senyawa tersebut

Info

Publication number: ID21956A
Authority: ID; Indonesia
Prior art keywords: methods; amiloid; betha; sprit; peptides
Prior art date: 1996-11-22

Application number

IDW990269A

Other languages

English (en)

Indonesian (id)

Inventor

Jing Wu

Eugene D Thorsett

Jeffrey S Nissen

Thomas E Mabry

Lee H Latimer

Varghese John

Lawrence F Yang

James E Audia

Original Assignee

Elan Pharm Inc

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-22

Filing date

1997-11-20

Publication date

1999-08-19

1997-11-20 Application filed by Elan Pharm Inc, Lilly Co Eli filed Critical Elan Pharm Inc

1999-08-19 Publication of ID21956A publication Critical patent/ID21956A/id

Links

238000000034 method Methods 0.000 title abstract 4
150000001875 compounds Chemical class 0.000 title abstract 3
102000004196 processed proteins & peptides Human genes 0.000 title 3
108090000765 processed proteins & peptides Proteins 0.000 title 3
-1 AMINO ESTER Chemical class 0.000 title 1
239000002253 acid Substances 0.000 title 1
208000024827 Alzheimer disease Diseases 0.000 abstract 2
DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 abstract 2
230000015572 biosynthetic process Effects 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
238000003786 synthesis reaction Methods 0.000 abstract 2

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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
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- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Furan Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IDW990269A 1996-11-22 1997-11-20 Asam n-(aril dan atau heteroarilasetil) amino ester, komposisi farmasi yang mengandungnya, dan metoda untuk menghambat pelepasan betha-amiloid peptida dan atau sintesanya dengan menggunakan senyawa tersebut ID21956A (id)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US75489596A	1996-11-22	1996-11-22

Publications (1)

Publication Number	Publication Date
ID21956A true ID21956A (id)	1999-08-19

Family

ID=25036849

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IDW990269A ID21956A (id)	1996-11-22	1997-11-20	Asam n-(aril dan atau heteroarilasetil) amino ester, komposisi farmasi yang mengandungnya, dan metoda untuk menghambat pelepasan betha-amiloid peptida dan atau sintesanya dengan menggunakan senyawa tersebut

Country Status (16)

Country	Link
EP (1)	EP0951464B1 (hu)
JP (1)	JP2001505204A (hu)
KR (1)	KR20000069074A (hu)
CN (1)	CN1237960A (hu)
AT (1)	ATE295346T1 (hu)
AU (1)	AU739035B2 (hu)
BR (1)	BR9713404A (hu)
CA (1)	CA2267065A1 (hu)
DE (1)	DE69733272T2 (hu)
HU (1)	HUP0000492A3 (hu)
ID (1)	ID21956A (hu)
IL (1)	IL129238A0 (hu)
NO (1)	NO992463L (hu)
NZ (1)	NZ334950A (hu)
TR (1)	TR199901128T2 (hu)
WO (1)	WO1998022430A1 (hu)

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JP2002518451A (ja) *	1998-06-22	2002-06-25	エランファーマシューティカルズ，インコーポレイテッド	環状アミノ酸化合物およびその医薬組成物、並びにそれら化合物を用いたβ−アミロイドペプチドの放出および／またはその合成を阻害する方法
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HRP990246A2 (en)	1998-08-07	2000-06-30	Du Pont Pharm Co	Succinoylamino benzodiazepines as inhibitors of a beta protein production
EP1131634A2 (en)	1998-09-30	2001-09-12	Elan Pharmaceuticals, Inc.	Determining the mechanism of beta-amyloid peptide generation
AU778005B2 (en)	1998-12-24	2004-11-11	Bristol-Myers Squibb Pharma Company	Succinoylamino benzodiazepines as inhibitors of Abeta protein production
BR0007663A (pt)	1999-01-22	2002-05-07	Elan Pharm Inc	Derivados de acila para uso no tratamento de doenças relacionadas com o vla-4
US6503902B2 (en)	1999-09-13	2003-01-07	Bristol-Myers Squibb Pharma Company	Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production
US6960576B2 (en)	1999-09-13	2005-11-01	Bristol-Myers Squibb Pharma Company	Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
EP1222176A1 (en)	1999-10-08	2002-07-17	Bristol-Myers Squibb Pharma Company	AMINO LACTAM SULFONAMIDES AS INHIBITORS OF A$g(b) PROTEIN PRODUCTION
CA2395314A1 (en)	1999-12-23	2001-11-15	Neurochem, Inc.	Compounds and methods for modulating cerebral amyloid angiopathy
JP2003523345A (ja)	2000-02-17	2003-08-05	ブリストル−マイヤーズスクイブファーマカンパニー	Ａβタンパク質産生の阻害剤としてのスクシノイルアミノ炭素環および複素環
MXPA02009755A (es)	2000-04-03	2003-03-27	Bristol Myers Squibb Pharma Co	Lactamas ciclicas como inhibidores de la produccion de proteina a-beta.
JP2004508289A (ja)	2000-04-03	2004-03-18	デュポン　ファーマシューティカルズ　カンパニー	Ａβタンパク質産生の阻害剤としての環状ラクタム
CA2404273A1 (en)	2000-04-11	2001-10-18	Bristol-Myers Squibb Pharma Company	Substituted lactams as inhibitors of a.beta. protein production
US6878363B2 (en)	2000-05-17	2005-04-12	Bristol-Myers Squibb Pharma Company	Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
WO2001092235A1 (en)	2000-06-01	2001-12-06	Bristol-Myers Squibb Pharma Company	LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
US6432944B1 (en)	2000-07-06	2002-08-13	Bristol-Myers Squibb Company	Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives
RU2290403C2 (ru) *	2000-12-28	2006-12-27	Дайити Фармасьютикал Ко., Лтд.	Ингибиторы vla-4
ZA200304059B (en) *	2000-12-28	2004-07-06	Daiichi Seiyaku Co	VLA-4 inhibitors.
EP1450795A1 (en) *	2001-12-04	2004-09-01	Elan Pharmaceuticals, Inc.	Peptide isosteres containing a heterocycle useful in the treatment of alzheimer's disease
TW200307671A (en)	2002-05-24	2003-12-16	Elan Pharm Inc	Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins
TWI281470B (en)	2002-05-24	2007-05-21	Elan Pharm Inc	Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
AU2003247758A1 (en)	2002-06-27	2004-01-19	Elan Pharmaceuticals, Inc.	Methods for treating alzheimer's disease using hydroxyethylene compounds containing a heterocyclic amide bond isostere
FR2842523A1 (fr) *	2002-07-17	2004-01-23	Sanofi Synthelabo	Derives d'acylaminothiazole, leur preparation et leur application en therapeutique
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1997
- 1997-11-20 ID IDW990269A patent/ID21956A/id unknown
- 1997-11-20 CA CA002267065A patent/CA2267065A1/en not_active Abandoned
- 1997-11-20 AU AU52498/98A patent/AU739035B2/en not_active Ceased
- 1997-11-20 AT AT97947410T patent/ATE295346T1/de not_active IP Right Cessation
- 1997-11-20 BR BR9713404-0A patent/BR9713404A/pt unknown
- 1997-11-20 CN CN97199775A patent/CN1237960A/zh active Pending
- 1997-11-20 DE DE69733272T patent/DE69733272T2/de not_active Expired - Fee Related
- 1997-11-20 IL IL12923897A patent/IL129238A0/xx unknown
- 1997-11-20 HU HU0000492A patent/HUP0000492A3/hu unknown
- 1997-11-20 EP EP97947410A patent/EP0951464B1/en not_active Expired - Lifetime
- 1997-11-20 WO PCT/US1997/020355 patent/WO1998022430A1/en not_active Ceased
- 1997-11-20 JP JP52369998A patent/JP2001505204A/ja not_active Ceased
- 1997-11-20 NZ NZ334950A patent/NZ334950A/en unknown
- 1997-11-20 KR KR1019997004507A patent/KR20000069074A/ko not_active Withdrawn
- 1997-11-20 TR TR1999/01128T patent/TR199901128T2/xx unknown
1999
- 1999-05-21 NO NO992463A patent/NO992463L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
KR20000069074A (ko)	2000-11-25
AU5249898A (en)	1998-06-10
DE69733272D1 (de)	2005-06-16
EP0951464B1 (en)	2005-05-11
NO992463D0 (no)	1999-05-21
TR199901128T2 (xx)	1999-07-21
ATE295346T1 (de)	2005-05-15
CN1237960A (zh)	1999-12-08
CA2267065A1 (en)	1998-05-28
HUP0000492A3 (en)	2000-06-28
WO1998022430A1 (en)	1998-05-28
EP0951464A1 (en)	1999-10-27
NZ334950A (en)	2001-03-30
AU739035B2 (en)	2001-10-04
NO992463L (no)	1999-07-19
IL129238A0 (en)	2000-02-17
DE69733272T2 (de)	2006-01-26
BR9713404A (pt)	2000-01-25
HUP0000492A1 (hu)	2000-05-28
JP2001505204A (ja)	2001-04-17

Publication	Publication Date	Title
ID21956A (id)	1999-08-19	Asam n-(aril dan atau heteroarilasetil) amino ester, komposisi farmasi yang mengandungnya, dan metoda untuk menghambat pelepasan betha-amiloid peptida dan atau sintesanya dengan menggunakan senyawa tersebut
WO1998022493A3 (en)	1998-07-23	N-(ARYL/HETEROARYL) AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS
EA199900778A1 (ru)	2000-04-24	ГЕТЕРОЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ И ИХ ИСПОЛЬЗОВАНИЕ ДЛЯ ИНГИБИРОВАНИЯ β-АМИЛОИДНОГО ПЕПТИДА
BR9713400A (pt)	2000-01-25	Processos e compostos para inibir liberação de peptìdeo beta-amilóide e/ou sua sìntese.
EA199900593A1 (ru)	2000-02-28	ЦИКЛОАЛКИЛЬНЫЕ СОЕДИНЕНИЯ, ЛАКТАМЫ, ЛАКТОНЫ И РОДСТВЕННЫЕ СОЕДИНЕНИЯ, СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И СПОСОБЫ ИНГИБИРОВАНИЯ ВЫСВОБОЖДЕНИЯ И/ИЛИ СИНТЕЗА β-АМИЛОИДНОГО ПЕПТИДА С ПОМОЩЬЮ УКАЗАННЫХ СОЕДИНЕНИЙ
ATE249422T1 (de)	2003-09-15	Verbindungen und zusammensetzungen zur verabreichung aktiver stoffe
ATE245449T1 (de)	2003-08-15	Pharmazeutische zusammensetzungen, die alkylamide von di- und tricarbonsäuren als gelierungsmittel enthalten
BR9808928A (pt)	2001-12-04	Complexo molecular e liberação controlada dealfa hidroxiácidos
BR0115427A (pt)	2003-10-07	Composto, composição farmacêutica, métodos para inibir a liberação de peptìdeo beta-amilóide e/ou sua sìntese, para tratar a doença de alzheimer, e para prevenir a doença e o progresso da doença de alzheimer, e, uso de um composto
WO2002048183A3 (en)	2003-06-05	Compositions of peptide crystals
WO1998022441A3 (en)	1998-08-27	N-(aryl/heteroaryl) amino acid esters, pharmaceutical compositions, and methods for inhibiting beta-amyloid peptide and/or its synthesis
EP1093372A4 (en)	2004-09-29	CYCLIC AMINO ACID COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS OF INHIBITING PEPTIDE RELEASE $ g (b) -AMYLOID AND / OR ITS SYNTHESIS USING THE SAME
ATE260658T1 (de)	2004-03-15	Pharmazeutische zubereitungen zur verminderung von atmungsdepressionen
MX9703642A (es)	1998-11-29	Metodos para el tratamiento de esclerosis multiple utilizando analogos de peptido en la posicion 91 de la proteina basica de mielina humana.
WO1996028470A3 (en)	1996-11-14	Peptide analogues of human myelin basic protein useful in treating multiple sclerosis
ES2170144T3 (es)	2002-08-01	Variantes que no se empalman de gp350/220.
ATE203665T1 (de)	2001-08-15	Stabilisierte pharmazeutische zusammensetzungen und verfahren zu ihrer herstellung
WO2001034639A3 (en)	2002-07-11	β-AMINOACID COMPOUNDS USEFUL FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS
DE69420574D1 (de)	1999-10-14	Derivate von therapeutisch in der blutgerinnungskaskade wirksamen peptiden, verfahren zur herstellung und sie enthaltende pharmazeutische zubereitungen
ECSP972320A (es)	1999-05-17	METODOS Y COMPOSICIONES PARA INHIBIR LA LIBERACION DE PEPTIDO ß- AMILOIDE Y/O SU SINTESIS
AU5662996A (en)	1996-10-16	Compounds and compositions for delivering active agents
ECSP972350A (es)	1999-08-12	CICLOALQUILO, LACTAMA, LACTONA Y COMPUESTOS CONEXOS, COMPOSICIONES FARMACEUTICAS QUE COMPRENDEN LOS MISMOS, Y METODOS PARA INHIBIR LA LIBERACION DEL PEPTIDO ß-AMILOIDE Y/O SU SINTESIS MEDIANTE EL USO DE TALES COMPUESTOS
TH27915B (th)	1998-02-16	การปรับปรุงความสามารถที่จะทนทานได้ของกรด(สูตร)- อะมิโนที่ออกฤทธิ์ทางเภสัชกรรม