ID16660A - Senyawa-senyawa b-laktam monosiklik baru - Google Patents

Senyawa-senyawa b-laktam monosiklik baru

Info

Publication number: ID16660A
Authority: ID; Indonesia
Prior art keywords: monosiclic; laktam; compounds; new; new monosiclic
Prior art date: 1996-04-26

Application number

IDP971394A

Other languages

English (en)

Inventor

Colin Andrew Leach

Deirdre Mary Bernadette Hickey

Robert John Ife

Dashyant Dhanak

Colin Theobald

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-26

Filing date

1997-04-25

Publication date

1997-10-30

1996-04-26 Priority claimed from GBGB9608646.7A external-priority patent/GB9608646D0/en

1996-11-15 Priority claimed from GBGB9623756.5A external-priority patent/GB9623756D0/en

1996-12-03 Priority claimed from GBGB9625121.0A external-priority patent/GB9625121D0/en

1997-04-25 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

1997-10-30 Publication of ID16660A publication Critical patent/ID16660A/id

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Obesity (AREA)
Dermatology (AREA)
Physical Education & Sports Medicine (AREA)
Toxicology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IDP971394A 1996-04-26 1997-04-25 Senyawa-senyawa b-laktam monosiklik baru ID16660A (id)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9608646.7A GB9608646D0 (en)	1996-04-26	1996-04-26	Novel compounds
GBGB9623756.5A GB9623756D0 (en)	1996-11-15	1996-11-15	Novel compounds
GBGB9625121.0A GB9625121D0 (en)	1996-12-03	1996-12-03	Novel compounds

Publications (1)

Publication Number	Publication Date
ID16660A true ID16660A (id)	1997-10-30

Family

ID=27268259

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IDP971394A ID16660A (id)	1996-04-26	1997-04-25	Senyawa-senyawa b-laktam monosiklik baru

Country Status (17)

Country	Link
EP (1)	EP0915843A1 (id)
JP (1)	JP2000509049A (id)
AR (1)	AR006833A1 (id)
AU (1)	AU2698697A (id)
BR (1)	BR9709196A (id)
CA (1)	CA2252696A1 (id)
CZ (1)	CZ341098A3 (id)
HU (1)	HUP9901359A3 (id)
ID (1)	ID16660A (id)
IL (1)	IL126696A0 (id)
MA (1)	MA26426A1 (id)
NO (1)	NO984939L (id)
NZ (1)	NZ332476A (id)
PE (1)	PE64398A1 (id)
PL (1)	PL329530A1 (id)
TR (1)	TR199802160T2 (id)
WO (1)	WO1997041098A1 (id)

Families Citing this family (30)

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AU2001235466B2 (en)	2000-02-16	2004-04-22	Glaxo Group Limited	Pyrimidine-4-one derivatives as LDL-PLA2 inhibitors
US6982251B2 (en)	2000-12-20	2006-01-03	Schering Corporation	Substituted 2-azetidinones useful as hypocholesterolemic agents
SI1413331T1 (sl)	2001-01-26	2008-02-29	Schering Corp	Kombinacije fenofibrata peroksisomskega proliferator aktivirajocega receptorja (PPAR) z ezetimib zaviralcem absorpcije sterola za vaskularne indikacije
RS50406B (sr)	2001-01-26	2009-12-31	Schering Corporation,	Upotreba supstituisanih jedinjenja azetidinona za lečenje sitosterolemije
US7071181B2 (en)	2001-01-26	2006-07-04	Schering Corporation	Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
UA75644C2 (en)	2001-03-28	2006-05-15	Schering Corp	Enantioselective synthesis of azetidinone intermediate compounds
EP1392287B8 (en) *	2001-05-25	2007-01-10	Schering Corporation	Use of substituted azetidinone derivatives in the treatment of Alzheimer's disease
MXPA04002573A (es)	2001-09-21	2004-06-18	Schering Corp	Tratamiento de xantoma con derivados de azetidinona como inhibidores de la absorcion de esterol.
US7053080B2 (en)	2001-09-21	2006-05-30	Schering Corporation	Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7056906B2 (en)	2001-09-21	2006-06-06	Schering Corporation	Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
EP1562582A1 (en)	2002-11-06	2005-08-17	Schering Corporation	Cholesterol absorption inhibitors for the treatment of demyelination
US7459442B2 (en)	2003-03-07	2008-12-02	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
ES2311806T3 (es)	2003-03-07	2009-02-16	Schering Corporation	Compuesto de azetidinona sustituidos, fornulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
US7192944B2 (en)	2003-03-07	2007-03-20	Schering Corp.	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP4589919B2 (ja)	2003-03-07	2010-12-01	シェーリングコーポレイション	高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用
US8962633B2 (en)	2007-05-11	2015-02-24	Thomas Jefferson University	Methods of treatment and prevention of metabolic bone diseases and disorders
KR101730290B1 (ko)	2007-05-11	2017-04-25	토마스 제퍼슨 유니버시티	신경변성 질환 및 장애의 치료 및 예방 방법
BRPI0810336A2 (pt)	2007-05-11	2019-03-19	The Trustees Of The University Of Pennsylvania	"método para tratar e/ou prevenir úlceras de pele em um indivíduo"
CA2820408C (en)	2010-12-06	2018-03-06	Glaxo Group Limited	Pyrimidinone compounds for use in the treatment of diseases or conditions mediated by lp-pla2
WO2012080497A2 (en)	2010-12-17	2012-06-21	Glaxo Group Limited	Methods of treatment and prevention of eye diseases
WO2013000267A1 (zh)	2011-06-27	2013-01-03	中国科学院上海药物研究所	唑类杂环化合物、其制备方法、药物组合物和用途
JP2014521611A (ja)	2011-07-27	2014-08-28	グラクソグループリミテッド	Ｌｐ−ＰＬＡ２阻害剤としての２，３−ジヒドロイミダゾ［１，２−ｃ］ピリミジン−５（１Ｈ）−オン化合物の使用
JP2014521625A (ja)	2011-07-27	2014-08-28	グラクソグループリミテッド	二環式ピリミドン化合物
WO2014114694A1 (en)	2013-01-25	2014-07-31	Glaxosmithkline Intellectual Property Development Limited	2,3-dihydroimidazol[1,2-c]pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (lp-pla2) inhibitors
CA2899124A1 (en)	2013-01-25	2014-07-31	Glaxosmithkline Intellectual Property Development Limited	Compounds
JP2016505053A (ja)	2013-01-25	2016-02-18	グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅＩｎｔｅｌｌｅｃｔｕａｌＰｒｏｐｅｒｔｙＤｅｖｅｌｏｐｍｅｎｔＬｉｍｉｔｅｄ	Ｌｐ‐ＰＬＡ２の阻害剤としての二環式ピリミドン化合物
WO2016012916A1 (en)	2014-07-22	2016-01-28	Glaxosmithkline Intellectual Property Development Limited	1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2016012917A1 (en)	2014-07-22	2016-01-28	Glaxosmithkline Intellectual Property Development Limited	1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2021089032A1 (zh)	2019-11-09	2021-05-14	上海赛默罗生物科技有限公司	三环二氢咪唑并嘧啶酮衍生物、其制备方法、药物组合物和用途
CN115304620A (zh)	2021-05-07	2022-11-08	上海赛默罗生物科技有限公司	嘧啶酮衍生物、其制备方法、药物组合物和用途

Family Cites Families (14)

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US4680391A (en) *	1983-12-01	1987-07-14	Merck & Co., Inc.	Substituted azetidinones as anti-inflammatory and antidegenerative agents
IL89835A0 (en) *	1988-04-11	1989-12-15	Merck & Co Inc	Substituted azetidinones,their preparation and pharmaceutical compositions containing them
IL99658A0 (en) *	1990-10-15	1992-08-18	Merck & Co Inc	Substituted azetidinones and pharmaceutical compositions containing them
WO1993000332A1 (en) *	1991-06-25	1993-01-07	Merck & Co., Inc.	Substituted azetidinones as anti-inflammatory and antidegenerative agents
EP0596015B1 (en) *	1991-07-23	1997-10-01	Schering Corporation	Substituted beta-lactam compounds useful as hypocholesterolemic agents and processes for the preparation thereof
TW275621B (id) *	1992-10-27	1996-05-11	Merck & Co Inc
WO1994013636A1 (en) *	1992-12-17	1994-06-23	Merck & Co., Inc.	New substituted azetidinones as anti-inflammatory and antidegenerative agents
DE69423436T2 (de) *	1993-06-25	2000-09-07	Smithkline Beecham P.L.C., Brentford	An lipoprotein gebundene phospholipase a2, inhibitoren davon und deren verwendung für diagnose und therapie
EP1634953A3 (en) *	1993-10-06	2006-06-28	ICOS Corporation	Platelet-activating factor acethylhydrolase
GB9421816D0 (en) *	1994-10-29	1994-12-14	Smithkline Beecham Plc	Novel compounds
SK80397A3 (en) *	1994-12-22	1998-01-14	Smithkline Beecham Plc	Substituted azetidin-2-ones, preparation method thereof, farmaceutical compositions and their use
AU5014496A (en) *	1995-03-23	1996-10-08	Japan Tobacco Inc.	Diphenylmethyl-azetidinone compounds and elastase inhibitor
CN1197452A (zh) *	1995-07-01	1998-10-28	史密丝克莱恩比彻姆有限公司	用于治疗动脉粥样硬化的氮杂环丁烷酮衍生物
JP2000505063A (ja) *	1995-12-08	2000-04-25	スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー	アテローム性動脈硬化症の治療のためのアゼチジノン化合物

1997
- 1997-04-15 CA CA002252696A patent/CA2252696A1/en not_active Abandoned
- 1997-04-15 IL IL12669697A patent/IL126696A0/xx unknown
- 1997-04-15 PL PL97329530A patent/PL329530A1/xx unknown
- 1997-04-15 NZ NZ332476A patent/NZ332476A/en unknown
- 1997-04-15 EP EP97920699A patent/EP0915843A1/en not_active Withdrawn
- 1997-04-15 HU HU9901359A patent/HUP9901359A3/hu unknown
- 1997-04-15 BR BR9709196A patent/BR9709196A/pt not_active Application Discontinuation
- 1997-04-15 JP JP9538507A patent/JP2000509049A/ja active Pending
- 1997-04-15 AU AU26986/97A patent/AU2698697A/en not_active Abandoned
- 1997-04-15 WO PCT/EP1997/001898 patent/WO1997041098A1/en not_active Ceased
- 1997-04-15 CZ CZ983410A patent/CZ341098A3/cs unknown
- 1997-04-15 TR TR1998/02160T patent/TR199802160T2/xx unknown
- 1997-04-24 PE PE1997000311A patent/PE64398A1/es not_active Application Discontinuation
- 1997-04-24 AR ARP970101682A patent/AR006833A1/es unknown
- 1997-04-24 MA MA24565A patent/MA26426A1/fr unknown
- 1997-04-25 ID IDP971394A patent/ID16660A/id unknown
1998
- 1998-10-23 NO NO984939A patent/NO984939L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO984939L (no)	1998-12-23
HUP9901359A3 (en)	2000-03-28
AR006833A1 (es)	1999-09-29
TR199802160T2 (xx)	1999-04-21
HUP9901359A2 (hu)	1999-08-30
IL126696A0 (en)	1999-08-17
CA2252696A1 (en)	1997-11-06
NO984939D0 (no)	1998-10-23
NZ332476A (en)	2000-06-23
PE64398A1 (es)	1999-01-06
CZ341098A3 (cs)	1999-03-17
WO1997041098A1 (en)	1997-11-06
AU2698697A (en)	1997-11-19
BR9709196A (pt)	1999-05-25
EP0915843A1 (en)	1999-05-19
MA26426A1 (fr)	2004-12-20
JP2000509049A (ja)	2000-07-18
PL329530A1 (en)	1999-03-29

Publication	Publication Date	Title
ID21881A (id)	1999-08-05	Turunan-turunan baru pirazol tersubstitusi
ID17686A (id)	1998-01-22	Fotoinisiator alpha-aminoasetofenon baru
ID16660A (id)	1997-10-30	Senyawa-senyawa b-laktam monosiklik baru
ID15881A (id)	1997-08-14	Oksazolidinan tersubstitusi yang baru
ID15840A (id)	1997-08-14	Turunan-turunan 19-nor-pregnena baru
ID18759A (id)	1998-05-07	Imidazole tersubstitusi sikloalkil baru
ID19403A (id)	1998-07-09	Senyawa-senyawa heterosiklik
ID19609A (id)	1998-07-23	Senyawa-senyawa heterosiklik
ID16152A (id)	1997-09-04	Senyawa-senyawa triaril
ID21850A (id)	1999-08-05	Formula senyawa baru
ID27263A (id)	2001-03-22	Dihidropirimidina baru
ID15904A (id)	1997-08-14	Senyawa-senyawa tiofenopirimidina
ID19476A (id)	1998-07-16	Senyawa piridilpirol
ID18685A (id)	1998-04-30	Senyawa trisiklik tersubstitusi
ID18431A (id)	1998-04-09	Senyawa-senyawa baru
DE69716924D1 (de)	2002-12-12	Phosphonat-nukleotid-verbindungen
BR9705635A (pt)	1999-05-18	Compostos
ID17421A (id)	1997-12-24	Senyawa senyawa baru
ID26299A (id)	2000-12-14	Herbisida baru
DK0923594T3 (da)	2003-02-10	Bromotiacumicinforbindelser
ID18262A (id)	1998-03-19	Turunan-turunan baru piranosida
ID16247A (id)	1997-09-11	Metode baru
ID19433A (id)	1998-07-09	Senyaw-senyawa baru
ID16684A (id)	1997-10-30	Senyawa-senyawa sulfonilurea baru
ID24191A (id)	2000-07-13	Komposisi baru