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HUP9900912A2 - Eljárás 2-aril-benzo[b]tiofén-származékok és intermedierjeik előállítására - Google Patents

Eljárás 2-aril-benzo[b]tiofén-származékok és intermedierjeik előállítására

Info

Publication number
HUP9900912A2
HUP9900912A2 HU9900912A HUP9900912A HUP9900912A2 HU P9900912 A2 HUP9900912 A2 HU P9900912A2 HU 9900912 A HU9900912 A HU 9900912A HU P9900912 A HUP9900912 A HU P9900912A HU P9900912 A2 HUP9900912 A2 HU P9900912A2
Authority
HU
Hungary
Prior art keywords
atom
thiophene derivatives
intermediates
aryl
benzo
Prior art date
Application number
HU9900912A
Other languages
English (en)
Inventor
James Abraham Aikins
Tony Y. Zhang
Original Assignee
Eli Lilly And Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Co. filed Critical Eli Lilly And Co.
Publication of HUP9900912A2 publication Critical patent/HUP9900912A2/hu
Publication of HUP9900912A3 publication Critical patent/HUP9900912A3/hu
Publication of HU219735B publication Critical patent/HU219735B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

A találmány szerinti eljárásők (XII) általánős képletű 2-aril-3-benzőil-banző[b]tiőfén-származékők és intermedierjeik (I) általánősképletű 2-aril-benző[b]tiőfén-származékők előállítására vőnatkőznak. Afenti képletekben R1 és R2 jelentése hidrőgén-, halőgénatőm-, alkőxi-,aril-őxi- vagy aminőcsőpőrt, R5 és R6 jelentése alkilcsőpőrt, vagy aközbezárt nitrőgénatőmmal együtt pirrőlidinő-, piperidinő-,hexametilén-iminő- vagy mőrfő- linőcsőpőrtőt alkőtnak, R8 és R9jelentése hidrőgén-, halőgéantőm, aminő- vagy hidrőxilcső- pőrt, és Xjelentése klór- vagy brómatőm. (I) (XII) ŕ
HU9900912A 1995-06-07 1996-06-04 Eljárás 2-aril-benzo[b]tiofén-származékok és intermedierjeik előállítására HU219735B (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/484,536 US5606076A (en) 1995-06-07 1995-06-07 Process for the synthesis of benzo[b]thiophenes
PCT/US1996/009167 WO1996040676A1 (en) 1995-06-07 1996-06-04 PROCESS FOR THE SYNTHESIS OF BENZO[b]THIOPHENES

Publications (3)

Publication Number Publication Date
HUP9900912A2 true HUP9900912A2 (hu) 1999-07-28
HUP9900912A3 HUP9900912A3 (en) 2000-03-28
HU219735B HU219735B (hu) 2001-07-30

Family

ID=23924560

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900912A HU219735B (hu) 1995-06-07 1996-06-04 Eljárás 2-aril-benzo[b]tiofén-származékok és intermedierjeik előállítására

Country Status (23)

Country Link
US (1) US5606076A (hu)
EP (1) EP0859770B1 (hu)
JP (1) JPH11506789A (hu)
KR (1) KR19990022502A (hu)
CN (1) CN1086699C (hu)
AT (1) ATE187450T1 (hu)
AU (1) AU702928B2 (hu)
BR (1) BR9609062A (hu)
CA (1) CA2223096A1 (hu)
CZ (1) CZ382797A3 (hu)
DE (1) DE69605573T2 (hu)
EA (1) EA000466B1 (hu)
ES (1) ES2140859T3 (hu)
GR (1) GR3032666T3 (hu)
HU (1) HU219735B (hu)
IL (1) IL122378A (hu)
NO (1) NO975582L (hu)
NZ (1) NZ310180A (hu)
PL (1) PL323909A1 (hu)
PT (1) PT859770E (hu)
TR (1) TR199701527T1 (hu)
UA (1) UA46027C2 (hu)
WO (1) WO1996040676A1 (hu)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY118009A (en) * 1996-09-25 2004-08-30 Lilly Co Eli Process for the synthesis of benzothiophenes
ZA9710262B (en) * 1996-11-19 1999-05-13 Lilly Co Eli Process for the synthesis of benzothiophenes
WO2004029046A2 (en) 2002-09-30 2004-04-08 A/S Gea Farmaceutisk Fabrik Novel raloxifene acid addition salts and/or solvates thereof, improved method for purification of said raloxifene acid addition salts and/or solvates thereof and pharmaceutical compositions comprising these
US8344149B2 (en) * 2006-10-17 2013-01-01 Cipla Limited Crystalline form of benzothiophene compound and process for preparation thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
IL65379A0 (en) * 1981-04-03 1982-05-31 Lilly Co Eli Process for preparing acylated benzothiophenes
JP2873898B2 (ja) * 1992-04-13 1999-03-24 富山化学工業株式会社 ベンゾ［ｂ］チオフェン−５−イル誘導体もしくはその光学活性体またはそれらの塩並びにそれらの製造法

Also Published As

Publication number Publication date
TR199701527T1 (xx) 1998-02-21
WO1996040676A1 (en) 1996-12-19
KR19990022502A (ko) 1999-03-25
NO975582D0 (no) 1997-12-03
IL122378A0 (en) 1998-06-15
NZ310180A (en) 1999-07-29
EA000466B1 (ru) 1999-08-26
CN1086699C (zh) 2002-06-26
CA2223096A1 (en) 1996-12-19
CN1192211A (zh) 1998-09-02
US5606076A (en) 1997-02-25
GR3032666T3 (en) 2000-06-30
PL323909A1 (en) 1998-04-27
UA46027C2 (uk) 2002-05-15
ATE187450T1 (de) 1999-12-15
DE69605573D1 (de) 2000-01-13
DE69605573T2 (de) 2000-05-25
PT859770E (pt) 2000-05-31
EP0859770A1 (en) 1998-08-26
HU219735B (hu) 2001-07-30
EP0859770B1 (en) 1999-12-08
AU6092196A (en) 1996-12-30
HUP9900912A3 (en) 2000-03-28
AU702928B2 (en) 1999-03-11
IL122378A (en) 2001-03-19
BR9609062A (pt) 1999-01-26
ES2140859T3 (es) 2000-03-01
EA199800040A1 (ru) 1998-08-27
NO975582L (no) 1997-12-03
JPH11506789A (ja) 1999-06-15
EP0859770A4 (hu) 1998-10-07
CZ382797A3 (cs) 1998-06-17

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Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee