[go: up one dir, main page]

HUP9900884A2 - A Lawsonia intracellularis tenyésztése, anti-Lawsonia intracellularis vakcinák és diagnosztikumok - Google Patents

A Lawsonia intracellularis tenyésztése, anti-Lawsonia intracellularis vakcinák és diagnosztikumok

Info

Publication number
HUP9900884A2
HUP9900884A2 HU9900884A HUP9900884A HUP9900884A2 HU P9900884 A2 HUP9900884 A2 HU P9900884A2 HU 9900884 A HU9900884 A HU 9900884A HU P9900884 A HUP9900884 A HU P9900884A HU P9900884 A2 HUP9900884 A2 HU P9900884A2
Authority
HU
Hungary
Prior art keywords
intracellularis
lawsonia intracellularis
cultivation
vaccines
diagnostic agents
Prior art date
Application number
HU9900884A
Other languages
English (en)
Inventor
Jeffrey P. Knittel
Michael B. Roff
Original Assignee
Boehringer Ingelheim/Nobl Laboratories, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27041284&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP9900884(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/465,337 external-priority patent/US5714375A/en
Application filed by Boehringer Ingelheim/Nobl Laboratories, Inc. filed Critical Boehringer Ingelheim/Nobl Laboratories, Inc.
Publication of HUP9900884A2 publication Critical patent/HUP9900884A2/hu
Publication of HUP9900884A3 publication Critical patent/HUP9900884A3/hu
Publication of HU230199B1 publication Critical patent/HU230199B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/105—Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56922—Campylobacter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/825—Bacterial vaccine for porcine species, e.g. swine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)

Abstract

A találmány tárgya anti-Lawsőnia intracellűlaris vakcinák előállítása,valamint a Lawsőnia intracellűlaris által őkőzőtt fertőzés ellenivédekezésre és annak diagnősztizálására szőlgáló eljárásők. A L.intracellűlaris a sertések és más állatők prőliferatíventerőpathiájának kórőkőzója. A baktériűm tenyésztése őbligátsejtparazita vőlta miatt igen nehézkes. A találmány szerintitenyésztőeljárással (szűszpenzióban tartőtt sejttenyészetben,csökkentett őxigénkőncentrációban) a L. intracellűlaris gazdaságősantenyészthető üzemi méretekben is. Az eljárás lehetőséget adlegyengített törzsek létrehőzására és szelekciójára. ŕ
HU9900884A 1995-06-05 1996-06-05 A Lawsonia intracellularis tenyésztése, anti-Lawsonia intracellularis vakcinák és diagnosztikumok HU230199B1 (hu)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/465,337 1995-06-05
US08/465,337 US5714375A (en) 1995-06-05 1995-06-05 Ileal symbiont intracellularis propagation in suspended host cells
US08/658,194 US5885823A (en) 1995-06-05 1996-06-04 Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents
US08/658,194 1996-06-04
PCT/US1996/009576 WO1996039629A1 (en) 1995-06-05 1996-06-05 Lawsonia intracellularis cultivation, anti-lawsonia intracellularis vaccines and diagnostic agents

Publications (3)

Publication Number Publication Date
HUP9900884A2 true HUP9900884A2 (hu) 1999-07-28
HUP9900884A3 HUP9900884A3 (en) 2001-01-29
HU230199B1 HU230199B1 (hu) 2015-10-28

Family

ID=27041284

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900884A HU230199B1 (hu) 1995-06-05 1996-06-05 A Lawsonia intracellularis tenyésztése, anti-Lawsonia intracellularis vakcinák és diagnosztikumok

Country Status (23)

Country Link
US (1) US5885823A (hu)
EP (5) EP1655607B1 (hu)
JP (4) JP3765834B2 (hu)
KR (4) KR100544857B1 (hu)
AT (3) ATE441863T1 (hu)
AU (1) AU717045B2 (hu)
BG (1) BG64292B1 (hu)
BR (2) BR9608338B1 (hu)
CA (1) CA2222643C (hu)
CZ (1) CZ295933B6 (hu)
DE (5) DE843818T1 (hu)
DK (3) DK1403643T3 (hu)
ES (3) ES2173055T3 (hu)
FR (1) FR07C0071I2 (hu)
HU (1) HU230199B1 (hu)
LU (1) LU91405I2 (hu)
NL (1) NL300331I2 (hu)
NZ (1) NZ319994A (hu)
PL (6) PL189187B1 (hu)
PT (3) PT1645567E (hu)
RO (1) RO118885B1 (hu)
RU (2) RU2265849C2 (hu)
WO (1) WO1996039629A1 (hu)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE329031T1 (de) 1995-11-30 2006-06-15 Agriculture Victoria Serv Pty Therapeutische zusammensetzungen zur behandlung von lawsonia intracellularis infektionen
FR2772047B1 (fr) 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection
EP1181315A4 (en) * 1999-05-13 2002-08-14 Pfizer Prod Inc LAWSONIA DERIVATIVE GENE, FLGE POLYPEPTIDES, PEPTIDES AND PROTEINS AND USES THEREOF
JP2003521881A (ja) * 1999-05-13 2003-07-22 オーストラリアン ポーク リミティッド ローソニア由来の遺伝子及び関連ＯｍｐＨポリペプチド、ぺプチド及びタンパク質並びにそれらの使用
WO2000069906A1 (en) * 1999-05-13 2000-11-23 Pfizer Products Inc Lawsonia derived gene and related hemolysin polypeptides, peptides and proteins and their uses
EP1177212A4 (en) * 1999-05-13 2002-08-28 Pfizer Prod Inc LAWSONIA DERIVATIVE GENE AND RELATED POLYPEPTIDES, PEPTIDES AND SODC PROTEINS, AND USES THEREOF
US7029683B1 (en) 1999-05-13 2006-04-18 Pfizer Products, Inc. Lawsonia derived gene and related hemolysin polypeptides, peptides and proteins and their uses
US7052697B1 (en) * 1999-05-13 2006-05-30 Agriculture Victoria Services Pty Ltd Lawsonia derived gene and related OmpH polypeptides, peptides and proteins and their uses
US6605696B1 (en) * 1999-10-22 2003-08-12 Pfizer, Inc. Lawsonia intracellularis proteins, and related methods and materials
JP2004529854A (ja) * 2000-09-29 2004-09-30 アリゾナ・ボード・オブ・リージエンツ・オン・ビハーフ・オブ・ザ・ユニバーシテイー・オブ・アリゾナ 増殖性回腸炎のための改善されたワクチン及びその作製と使用の方法
WO2002038594A1 (en) * 2000-11-10 2002-05-16 Agriculture Victoria Services Pty. Ltd. Novel therapeutic compositions for treating infection by lawsonia spp
AUPR138100A0 (en) 2000-11-10 2000-12-07 Agriculture Victoria Services Pty Ltd Novel therapeutic compositions for treating infection by lawsonia spp
PT1219711E (pt) * 2000-12-20 2006-10-31 Intervet Int Bv Vacina de lawsonia intracellularis
US20030087421A1 (en) * 2001-07-11 2003-05-08 Gebhart Connie J Lawsonia intracellularis
WO2004033631A2 (en) * 2002-10-04 2004-04-22 Regents Of The University Of Minnesota Nucleic acid and polypeptide sequences from lawsonia intracellularis and methods of using
RU2420570C2 (ru) * 2003-07-25 2011-06-10 Бёрингер Ингельхайм Ветмедика, Инк. Lawsonia intracellularis ЕВРОПЕЙСКОГО ПРОИСХОЖДЕНИЯ И ВАКЦИНЫ, ДИАГНОСТИЧЕСКИЕ АГЕНТЫ НА ЕЕ ОСНОВЕ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
DK1664100T3 (da) * 2003-09-12 2010-04-06 Intervet Int Bv Vaccine med underenhed af Lawsonia intracellularis
EP1694698A1 (en) * 2003-12-09 2006-08-30 Intervet International BV Lawsonia intracellularis 26 kd subunit vaccine
DE602005021750D1 (de) * 2004-01-22 2010-07-22 Intervet Int Bv Impfstoffe mit lawsoniaintrazellularis-untereinheit
MY146476A (en) * 2004-06-24 2012-08-15 Boehringer Ingelheim Vetmed Method of diagnosing lawsonia intracellularis
EP1609870A1 (en) * 2004-06-24 2005-12-28 Boehringer Ingelheim Vetmedica Gmbh Method of diagnosing lawsonia intracellularis
US20060021536A1 (en) * 2004-07-30 2006-02-02 Limin Song Method for creating an absorbent article exhibiting a harmonic color scheme
KR100621882B1 (ko) * 2004-09-30 2006-09-19 건국대학교 산학협력단 돼지 증식성 회장염 감염돈에서 로소니아인트라셀룰라리스 균을 분리하는 방법
WO2006056853A1 (en) * 2004-11-24 2006-06-01 Pharmacia & Upjohn Company Llc Methods for cultivating lawsonia intracellularis
US20070212373A1 (en) * 2004-12-08 2007-09-13 Akzo Nobel N.V. Lawsonia Intracellularis 26 Kd Subunit Vaccine
US7700285B1 (en) 2005-12-29 2010-04-20 Boehringer Ingelheim Vetmedica, Inc. PCV2 immunogenic compositions and methods of producing such compositions
US7833707B2 (en) 2004-12-30 2010-11-16 Boehringer Ingelheim Vetmedica, Inc. Methods of overexpression and recovery of porcine circovirus type 2 ORF2
UA95602C2 (ru) 2004-12-30 2011-08-25 Берингер Ингельхейм Ветмедика, Инк. Иммуногенная композиция цвс2 и способы приготовления такой композиции
US8834891B2 (en) * 2005-03-14 2014-09-16 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions comprising Lawsonia intracellularis
US8398994B2 (en) 2005-07-15 2013-03-19 Boehringer Ingelheim Vetmedica, Inc. Lawsonia vaccine and methods of use thereof
ES2814473T3 (es) * 2005-12-29 2021-03-29 Boehringer Ingelheim Animal Health Usa Inc Composiciones inmunogénicas de PCV2 multivalentes y métodos para producir dichas composiciones
PL2371383T3 (pl) * 2005-12-29 2016-01-29 Boehringer Ingelheim Vetmedica Inc Zastosowanie kompozycji immunogennej do zmniejszania objawów klinicznych u świń
US8470336B2 (en) * 2006-05-25 2013-06-25 Boehringer Ingelheim Vetmedica, Inc. Vaccination of young animals against Lawsonia intracellularis infections
US20080241190A1 (en) * 2006-11-13 2008-10-02 Boehringer Ingelheim Vetmedica, Inc. Vaccination of horses against lawsonia intracellularis
US20100129397A1 (en) * 2006-12-11 2010-05-27 Boehringer Ingelheim Vetmedica, Inc. Effective method of treatment of porcine circovirus and lawsonia intracellularis infections
DK2094872T4 (da) * 2006-12-15 2020-05-18 Boehringer Ingelheim Animal Health Usa Inc Behandling af anti-PCV2-antistofseropositive svin med PCV2-antigen
EP1941903A1 (en) 2007-01-03 2008-07-09 Boehringer Ingelheim Vetmedica Gmbh Prophylaxis and treatment of PRDC
EP1958644A1 (en) * 2007-02-13 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Prevention and treatment of sub-clinical pcvd
US7829274B2 (en) * 2007-09-04 2010-11-09 Boehringer Ingelheim Vetmedica, Inc. Reduction of concomitant infections in pigs by the use of PCV2 antigen
WO2009037262A2 (en) 2007-09-17 2009-03-26 Boehringer Ingelheim Vetmedica, Inc. Method of preventing early lawsonia intracellularis infections
CN101874106A (zh) * 2007-10-12 2010-10-27 辉瑞大药厂 培养胞内劳森氏菌的方法
JP2011508595A (ja) * 2007-12-31 2011-03-17 ベーリンガー インゲルハイム フェトメディカ インコーポレイテッド 外来性アミノ酸の挿入を含むｐｃｖ２ｏｒｆ２ウイルス様粒子
US20090317423A1 (en) * 2008-01-23 2009-12-24 Boehringer Ingelheim Vetmedica, Inc. Pcv2 mycoplasma hyopneumoniae immunogenic compositions and methods of producing such compositions
WO2009103037A1 (en) * 2008-02-15 2009-08-20 Boehringer Ingelheim Vetmedica, Inc. Methods and compositions for reducing the impact of enteric diseases
TWI449533B (zh) 2008-04-18 2014-08-21 Intervet Int Bv 防備胞內勞森菌（Ｌａｗｓｏｎｉａ ｉｎｔｒａｃｅｌｌｕｌａｒｉｓ）、豬肺炎黴漿菌（Ｍｙｃｏｐｌａｓｍａ ｈｙｏｐｎｅｕｍｏｎｉａｅ）及豬環狀病毒（Ｐｏｒｃｉｎｅ ｃｉｒｃｏ ｖｉｒｕｓ）用疫苗
TWI551295B (zh) 2008-04-18 2016-10-01 英特威特國際股份有限公司 防備胞內勞森菌（Ｌａｗｓｏｎｉａ ｉｎｔｒａｃｅｌｌｕｌａｒｉｓ）用疫苗
WO2010010055A1 (en) * 2008-07-22 2010-01-28 Intervet International B.V. Lawsonia intracellularis bacterium of a novel serotype, vaccine based on that bacterium, antibodies suitable for diagnosing the novel lawsonia intracellularis serotype and hybridomas for producing the said antibodies
US8142760B2 (en) * 2008-09-05 2012-03-27 Nathan Len Winkelman Vaccination for Lawsonia intracellularis
WO2011006880A1 (en) * 2009-07-14 2011-01-20 Intervet International B.V. Lawsonia intracellularis propagation
TWI627281B (zh) * 2009-09-02 2018-06-21 百靈佳殷格翰家畜藥品公司 降低ｐｃｖ－２組合物殺病毒活性之方法及具有改良免疫原性之ｐｃｖ－２組合物
EP2499233B1 (en) 2009-11-09 2016-11-02 Intervet International B.V. Method to grow lawsonia intracellularis bacteria in persistently infected mccoy cells
EA032772B1 (ru) * 2012-12-28 2019-07-31 Бёрингер Ингельхайм Ветмедика Гмбх Способ получения иммуногенной композиции, предназначенной для лечения и/или профилактики вызываемых микоплазмами инфекций у субъекта
JP6821429B2 (ja) 2013-09-25 2021-01-27 ゾエティス・サービシーズ・エルエルシー Ｐｃｖ２ｂ分岐ワクチン組成物及び使用方法
CN105658660A (zh) 2013-10-02 2016-06-08 勃林格殷格翰动物保健公司 Pcv2 orf2蛋白变体和由其组成的病毒样颗粒
JP2018504424A (ja) 2015-02-04 2018-02-15 インターベット インターナショナル ベー． フェー． 豚における無症候性ローソニア感染症に対する使用のためのワクチン
EP3253410B1 (en) 2015-02-04 2020-05-06 Intervet International B.V. A vaccine for use against subclinical lawsonia infection in a pig
KR20180062468A (ko) * 2016-11-18 2018-06-11 녹십자수의약품(주) 신규한 로소니아 인트라셀룰라리스 균주 및 이의 용도
CN111757752B (zh) * 2018-02-28 2024-08-09 勃林格殷格翰动物保健有限公司 用于减少动物中的粪臭素和/或吲哚的方法
BR112023001324A2 (pt) 2020-07-24 2023-02-14 Boehringer Ingelheim Animal Health Usa Inc Combinação de vacina de suíno
WO2023073640A1 (en) 2021-11-01 2023-05-04 Boehringer Ingelheim Vetmedica Gmbh Immunogenic gel compositions
EP4594466A1 (en) * 2022-09-27 2025-08-06 Intervet International B.V. A method of culturing lawsonia intracellularis bacteria
WO2024260953A1 (en) * 2023-06-23 2024-12-26 Intervet International B.V. A method of culturing lawsonia intracellularis bacteria
CN119185351B (zh) * 2024-09-25 2025-09-16 武汉轻工大学 Li0004蛋白靶点在制备抑制劳森菌感染细胞增殖的药物中的应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4132597A (en) * 1976-06-09 1979-01-02 Ab Medipharm Method for cultivation of bacteria
US4237218A (en) * 1979-02-09 1980-12-02 Bio-Rad Laboratories, Inc. Micro-carrier cell culture
JPS5991879A (ja) * 1982-11-16 1984-05-26 Hideaki Yamada シユ−ドモナス属細菌の培養法
DK594084A (da) * 1984-12-12 1986-06-13 Novo Industri As Fremgangsmaade til stabilisering af extra-chromosomale elementer i bakterier under dyrkning
JPH0644865B2 (ja) * 1985-10-29 1994-06-15 三菱瓦斯化学株式会社 カンピロバクタ−属細菌の培養方法
US5338670A (en) * 1986-07-28 1994-08-16 The United States Of America As Represented By The Department Of Health And Human Services Production of bordetella pertussis toxin with a low concentration of iron
IT1227657B (it) * 1988-12-01 1991-04-23 Mini Ricerca Scient Tecnolog Antibiotici ab-021 e processo per la loro produzione
JPH0822221B2 (ja) * 1988-12-28 1996-03-06 日東化学工業株式会社 シュードモナス属細菌の培養法
JPH02308754A (ja) * 1989-05-24 1990-12-21 Yakult Honsha Co Ltd 乳発酵食品の製造法
US5296221A (en) * 1990-01-31 1994-03-22 Sani-Ei Sucrochemical Co., Ltd. Lactobacillus johnsonii ferm bp-2680 lactic acid bacteria preparations using the same and a process of manufacturing the preparations
DK0555366T3 (da) * 1990-11-01 2000-08-28 Univ Iowa State Res Found Inc Fremgangsmåde til bakteriel svækkelse og vaccine
SU1768637A1 (en) * 1990-12-04 1992-10-15 Inst Virusologii Im D I Ivanov Strain of human immunodeficient virus 1-type for preparation of diagnostic preparation
DE69232969T2 (de) * 1991-11-15 2004-08-05 Pfizer Inc. Methode zur herstellung von gram-negativen bakteriellen vakzinen
DE4208785A1 (de) * 1992-03-19 1993-09-23 Degussa Verfahren zum auffinden von insertionselementen (is-elemente) oder transposonen
US5610059A (en) * 1992-11-09 1997-03-11 University Of Arizona Etiological agent for porcine enteritis

Also Published As

Publication number Publication date
DE843818T1 (de) 2002-11-28
PL189287B1 (pl) 2005-07-29
NL300331I2 (nl) 2008-07-01
DE69634334T2 (de) 2006-04-13
JP2007151554A (ja) 2007-06-21
NL300331I1 (nl) 2008-03-03
EP0843818A1 (en) 1998-05-27
US5885823A (en) 1999-03-23
DE69637251T3 (de) 2016-06-02
ATE289069T1 (de) 2005-02-15
DE69634334D1 (de) 2005-03-17
PL189286B1 (pl) 2005-07-29
DE69637251T2 (de) 2008-06-12
KR20050048651A (ko) 2005-05-24
CA2222643A1 (en) 1996-12-12
KR100758614B1 (ko) 2007-09-13
JP4263212B2 (ja) 2009-05-13
DE69637251D1 (de) 2007-10-25
PT843818E (pt) 2005-04-29
EP0843818B1 (en) 2005-02-09
JPH11507225A (ja) 1999-06-29
JP3920300B2 (ja) 2007-05-30
ATE373015T1 (de) 2007-09-15
DK1403643T3 (da) 2010-01-04
RO118885B1 (ro) 2003-12-30
LU91405I2 (fr) 2008-02-21
ES2173055T1 (es) 2002-10-16
EP1403643B2 (en) 2018-10-03
BRPI9612938B8 (pt) 2017-09-12
DK1645567T3 (da) 2007-11-26
PL187849B1 (pl) 2004-10-29
CA2222643C (en) 2013-08-13
RU2265849C2 (ru) 2005-12-10
PL189250B1 (pl) 2005-07-29
PL189187B1 (pl) 2005-07-29
DK1645567T4 (en) 2016-04-11
BR9608338A (pt) 1999-01-05
BRPI9612938B1 (pt) 2010-07-27
KR100544857B1 (ko) 2006-01-24
DE69638016D1 (de) 2009-10-15
EP1403643A1 (en) 2004-03-31
KR20050046741A (ko) 2005-05-18
JP2006061165A (ja) 2006-03-09
AU717045B2 (en) 2000-03-16
EP0843818A4 (en) 2002-02-06
EP1655607B1 (en) 2015-05-13
PL325872A1 (en) 1998-08-17
FR07C0071I2 (fr) 2010-12-31
ES2294620T5 (es) 2016-03-23
DE122007000102I1 (de) 2008-04-17
EP1645567A1 (en) 2006-04-12
PT1645567E (pt) 2007-11-19
EP1655607A1 (en) 2006-05-10
BG102130A (bg) 1998-09-30
KR19990022509A (ko) 1999-03-25
HK1010911A1 (en) 1999-07-02
ES2173055T3 (es) 2005-07-01
FR07C0071I1 (hu) 2008-01-02
EP0843818B2 (en) 2018-12-19
HU230199B1 (hu) 2015-10-28
CZ295933B6 (cs) 2005-12-14
DK0843818T3 (da) 2005-05-09
EP2199795B1 (en) 2016-03-30
EP2199795A2 (en) 2010-06-23
RU2005114739A (ru) 2006-11-20
JP2008266340A (ja) 2008-11-06
PL187850B1 (pl) 2004-10-29
ATE441863T1 (de) 2009-09-15
CZ389997A3 (cs) 1998-07-15
EP1645567B2 (en) 2016-01-06
PT1403643E (pt) 2009-10-08
RU2305707C2 (ru) 2007-09-10
BG64292B1 (bg) 2004-08-31
JP3765834B2 (ja) 2006-04-12
HUP9900884A3 (en) 2001-01-29
JP5078740B2 (ja) 2012-11-21
WO1996039629A1 (en) 1996-12-12
BR9608338B1 (pt) 2009-05-05
ES2294620T3 (es) 2008-04-01
EP2199795A3 (en) 2010-11-03
EP1403643B1 (en) 2009-09-02
MX9709464A (es) 1998-06-30
KR20060129549A (ko) 2006-12-15
EP1645567B1 (en) 2007-09-12
KR100513481B1 (ko) 2006-01-27
ES2332587T3 (es) 2010-02-09
NZ319994A (en) 2000-01-28
AU6262796A (en) 1996-12-24

Similar Documents

Publication Publication Date Title
HUP9900884A2 (hu) A Lawsonia intracellularis tenyésztése, anti-Lawsonia intracellularis vakcinák és diagnosztikumok
Albritton Biology of Haemophilus ducreyi
Queiroz et al. A spiral microorganism in the stomach of pigs
Rosebury et al. A study of the isolation, cultivation and pathogenicity of Actinomyces israeli recovered from the human mouth and from actinomycosis in man
Gordon et al. Improved isolation of anaerobic bacteria from the gingival crevice area of man
Converse 3rd et al. Epidemiological studies of Streptococcus pneumoniae in infants: methods of isolating pneumococci
Ellner et al. Recovery and identification of anaerobes: a system suitable for the routine clinical laboratory
Fallon The rapid recognition of Lancefield group B haemolytic streptococci
Georg et al. Actinomyces viscosus as an agent of actinomycosis in the dog
Gunn et al. Comparison of methods for identifying Staphylococcus and Micrococcus spp
Kerr et al. Evaluation of the Mast ID and API 50CH systems for identification of Listeria spp
US3890200A (en) Selective medium for streptococcus mutans
Sneath et al. Bacteriology of Erysipeloid
Jones et al. Cultural diagnosis of chancroid
Beighton et al. The acquisition of Streptococcus mutans by infant monkeys (Macaca fascicularis) and its relationship to the initiation of dental caries
Carter Pasteurella and Francisella
Cary et al. Typing of Mima polymorpha by a precipitin technique
US3902969A (en) Method for the identification of {i streptococcus mutans
MY134726A (en) Lawsonia intracellularis cultivation, anti-lawsonia intracellularis vaccines and diagnostic agents
Skalka et al. Selective diagnostic medium for pathogenic Listeria spp
Ali et al. Factors influencing production of Salmonella enterotoxin (Stn)
CA1205029A (en) Selective agent for group a streptococci
Mickelsen et al. New differential medium for the isolation of Corynebacterium vaginale
Parikh et al. Streptococcal hyaluronidase and dentin caries
Smith et al. The serological identification of Streptococcus zymogenes with the Lancefield group D