[go: up one dir, main page]

HUP9801977A1 - Új indol- és indazolszármazékok, eljárás előállításukra és ilyen vegyületeket tartalmazó gyógyászati készítmények - Google Patents

Új indol- és indazolszármazékok, eljárás előállításukra és ilyen vegyületeket tartalmazó gyógyászati készítmények

Info

Publication number
HUP9801977A1
HUP9801977A1 HU9801977A HUP9801977A HUP9801977A1 HU P9801977 A1 HUP9801977 A1 HU P9801977A1 HU 9801977 A HU9801977 A HU 9801977A HU P9801977 A HUP9801977 A HU P9801977A HU P9801977 A1 HUP9801977 A1 HU P9801977A1
Authority
HU
Hungary
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
new indole
group
Prior art date
Application number
HU9801977A
Other languages
English (en)
Inventor
Jean-Jacques Descombes
Gilbert Lavielle
Olivier Muller
Christine Vayssettes-Courchay
Tony Verbeuren
Original Assignee
Adir Et Compagnie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir Et Compagnie filed Critical Adir Et Compagnie
Publication of HU9801977D0 publication Critical patent/HU9801977D0/hu
Publication of HUP9801977A1 publication Critical patent/HUP9801977A1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány új indol- és indazol-származékokra vonatkozik. A találmányszerinti vegyületek (I) általános képletében n értéke 0 vagy 1; A jelentése s-kötés vagy alkilén- vagy alkeniléncsoport; X jelentése nitrogénatom vagy C-R2 általános képletű csoport; R1 jelentése hidrogénatom vagy alkilcsoport; G1 jelentése adott esetben szubsztituált pirrolidinil-, piperidinil-,piperazinil- vagy aminocsoport. A találmány szerinti vegyületek nagyonszelektívek az 5-HT1B, 5-HT1D és 5-HT1-tetszőleges receptorokra. ═gypéldásul vénás elégtelenségek, migrén, magas vérnyomás kezelésérealkalmasak. Ó
HU9801977A 1997-09-03 1998-09-02 Új indol- és indazolszármazékok, eljárás előállításukra és ilyen vegyületeket tartalmazó gyógyászati készítmények HUP9801977A1 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9710939A FR2767827A1 (fr) 1997-09-03 1997-09-03 Nouveaux derives de l'indole et de l'indazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
HU9801977D0 HU9801977D0 (en) 1998-10-28
HUP9801977A1 true HUP9801977A1 (hu) 2000-11-28

Family

ID=9510710

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9801977A HUP9801977A1 (hu) 1997-09-03 1998-09-02 Új indol- és indazolszármazékok, eljárás előállításukra és ilyen vegyületeket tartalmazó gyógyászati készítmények

Country Status (19)

Country Link
US (2) US6020336A (hu)
EP (1) EP0902027B1 (hu)
JP (1) JPH11130773A (hu)
CN (2) CN1510034A (hu)
AT (1) ATE203531T1 (hu)
AU (1) AU736602B2 (hu)
BR (1) BR9803318A (hu)
CA (1) CA2246485C (hu)
DE (1) DE69801196T2 (hu)
DK (1) DK0902027T5 (hu)
ES (1) ES2162404T3 (hu)
FR (1) FR2767827A1 (hu)
GR (1) GR3036678T3 (hu)
HU (1) HUP9801977A1 (hu)
NO (1) NO316271B1 (hu)
NZ (1) NZ331683A (hu)
PL (1) PL328323A1 (hu)
PT (1) PT902027E (hu)
ZA (1) ZA988072B (hu)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000038677A1 (en) * 1998-12-23 2000-07-06 Allelix Biopharmaceuticals Inc. Indole and indolizidine derivatives for the treatment of migraine
YU54202A (sh) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
CA2398446A1 (en) 2000-04-18 2001-10-25 Agouron Pharmaceuticals, Inc. Pyrazoles for inhibiting protein kinases
ES2281434T3 (es) 2000-08-14 2007-10-01 Ortho-Mcneil Pharmaceutical, Inc. Pirazoles sustituidos.
US20070105841A1 (en) * 2000-08-14 2007-05-10 Breitenbucher J G Method for treating allergies using substituted pyrazoles
US7332494B2 (en) 2000-08-14 2008-02-19 Janssen Pharmaceutica, N.V. Method for treating allergies using substituted pyrazoles
FR2829134B1 (fr) 2001-08-28 2006-11-24 Atofina Procede de preparation de (meth) acrylates d'alkylimidazolidone
US20030073672A1 (en) * 2001-09-05 2003-04-17 Breitenbucher J. Guy Method for treating allergies using substituted pyrazoles
RU2295326C1 (ru) * 2005-10-05 2007-03-20 Елена Николаевна Лаптева Комплексный способ снижения избыточной массы тела
JPWO2012086735A1 (ja) * 2010-12-22 2014-06-05 大正製薬株式会社 縮合複素環化合物
CN102617548A (zh) * 2011-01-31 2012-08-01 北京赛林泰医药技术有限公司 作为gpr受体激动剂的双环杂芳基化合物及其组合物和应用
US9963458B2 (en) 2012-12-27 2018-05-08 Purdue Pharma L.P. Indole and indoline-type piperidine compounds and uses thereof
US9951038B2 (en) 2012-12-27 2018-04-24 Purdue Pharma L.P. Quinazolin-4(3H)-one-type piperidine compounds and uses thereof
WO2015138280A2 (en) * 2014-03-10 2015-09-17 Innov17 Llc Retinoic acid receptor-related orphan receptor modulators and uses thereof
US20150252022A1 (en) * 2014-03-10 2015-09-10 Innov17 Llc Retinoic acid receptor-related orphan receptor modulators and uses thereof
US11459308B2 (en) 2016-12-05 2022-10-04 Microbiotix, Inc. Broad spectrum inhibitors of filoviruses

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU198036B (en) * 1983-08-22 1989-07-28 Hoechst Roussel Pharma Process for production of derivatives of 3-piperidil-/1h/-indasole and medical preparatives containing them
TW203049B (hu) * 1990-04-13 1993-04-01 Yamanouchi Pharma Co Ltd
CA2109931A1 (en) * 1992-03-27 1993-10-14 Hiroshi Matsui Novel imidazole derivative, pharmaceutical use thereof, and intermediate therefor
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
GB9402016D0 (en) * 1994-02-02 1994-03-30 Merck Sharp & Dohme Therapeutic agents
EP0759918A1 (en) * 1994-05-19 1997-03-05 MERCK SHARP & DOHME LTD. Piperazine, piperidine and tetrahydropyridine derivatives of indol-3-ylalkyl as 5-ht1d-alpha agonists
GB2289465A (en) * 1994-05-19 1995-11-22 Merck Sharp & Dohme Five-membered heteroaromatic 5-HT receptor agonists
US5854268A (en) * 1994-08-02 1998-12-29 Merck Sharp & Dohme, Ltd. Azetidine, pyrrolidine and piperidine derivatives
ZA965837B (en) * 1995-07-11 1997-01-31 Merck & Co Inc A triazolylmethyl-indole ethylamine bisulfate salt
EP0844996A1 (en) * 1995-08-07 1998-06-03 MERCK SHARP & DOHME LTD. Substituted 1-indolylpropyl-4-phenethylpiperazine derivatives

Also Published As

Publication number Publication date
ATE203531T1 (de) 2001-08-15
FR2767827A1 (fr) 1999-02-26
NO984033L (no) 1999-03-04
US6020336A (en) 2000-02-01
NO316271B1 (no) 2004-01-05
CA2246485C (fr) 2004-04-20
PT902027E (pt) 2001-11-30
NZ331683A (en) 2000-01-28
NO984033D0 (no) 1998-09-02
DE69801196D1 (de) 2001-08-30
AU736602B2 (en) 2001-08-02
US6046205A (en) 2000-04-04
CA2246485A1 (fr) 1999-03-03
DE69801196T2 (de) 2002-03-14
PL328323A1 (en) 1999-03-15
DK0902027T3 (da) 2001-10-15
AU8306898A (en) 1999-03-18
EP0902027B1 (fr) 2001-07-25
DK0902027T5 (da) 2001-12-03
HU9801977D0 (en) 1998-10-28
EP0902027A1 (fr) 1999-03-17
HK1019738A1 (en) 2000-02-25
ZA988072B (en) 1999-03-09
CN1510034A (zh) 2004-07-07
ES2162404T3 (es) 2001-12-16
JPH11130773A (ja) 1999-05-18
BR9803318A (pt) 2000-02-08
CN1087741C (zh) 2002-07-17
GR3036678T3 (en) 2001-12-31
CN1218052A (zh) 1999-06-02

Similar Documents

Publication Publication Date Title
HUP9801977A1 (hu) Új indol- és indazolszármazékok, eljárás előállításukra és ilyen vegyületeket tartalmazó gyógyászati készítmények
ATE246190T1 (de) Heterozyklische verbindungen, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen die diese enthalten und ihre anwendung in der behandlung von diabetis und verwandten krankheiten
SE9902987D0 (sv) Novel compounds
SE9904738D0 (sv) Novel compounds
NO20023932D0 (no) Nye forbindelser
HUP0101999A2 (hu) 4-Hidroxi-kinolin-3-karboxamid- és -hidrazid-származékok, ezeket tartalmazó gyógyászati készítmények, valamint e vegyületek alkalmazása
DE69828445D1 (de) Heterozyklische verbindungen,und deren verwendung in arzneimittel,verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen
RU95110938A (ru) Производные 1-(2-оксоацетил)пиперидин-2-карбоновых кислот, фармацевтическая композиция, способ лечения, способ получения
TR200001973T2 (tr) 11 ß-halojen-7alfa-ile ikame edilmiş-estratrienler, bu 11ß-halojen-7alfa-ile ikame edilmiş-estratrienleri içeren farmasötik terkiplerin üretimi için yöntem ve ilaç üretiminde kullanımları.
MY127718A (en) Dolastatin 10 derivatives.
IS6658A (is) Ný efnasambönd
HUP0303283A2 (hu) Új piridinilcsoporttal szubsztituált pirazolopiridin-származékok, előállításuk és alkalmazásuk szív- és keringési betegségek kezelésére alkalmas gyógyszerkészítmény előállítására
TR199801594A2 (xx) CCR-3 resept�r antagonistleri.
YU21803A (sh) Farmaceutski aktivni derivati sulfonamida koji imaju i lipofilne i jonizujuće osobine kao inhibitori protein-junkinaza
ATE316083T1 (de) Adamantanderivate
TR199900920T2 (xx) Nafthiridin t�revleri.
MXPA02003199A (es) Derivados de sulfonamida farmaceuticamente activos.
NO20020282D0 (no) Nytt difenylpiperidinderivat
DK0748314T3 (da) Tetrasubstituerede imidazolderivater, fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler og farmaceutiske præparater med indhold deraf
HUP0402076A2 (hu) Szubsztituált indolok, eljárás az előállításukra és fájdalomcsillapítókénti alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
CA2153549A1 (fr) Nouveau derive de benzothiadiazine, son procede de preparation et les compositions pharmeceutiques qui le contiennent
ATE315563T1 (de) Piperidinylmorpholinylderivate als modulatoren der aktivität des chemokinrezeptors
MX9709451A (es) Derivados de benzisoxazol e indazol como agentes antipsicoticos.
MD1449F1 (en) 2-Amino-1,2,3,4-tetrahydronaphthalene derivatives active on the cardiovascular system, process for their preparation and pharmaceutical compositions containing them
DK0982305T3 (da) Indan-1-ol-derivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende derivaterne