HUP0200917A3 - C7 ester substituted taxanes as antitumor agents and pharmaceutical compositions containing them - Google Patents

C7 ester substituted taxanes as antitumor agents and pharmaceutical compositions containing them

Info

Publication number: HUP0200917A3
Authority: HU; Hungary
Prior art keywords: pharmaceutical compositions; compositions containing; antitumor agents; ester substituted; substituted taxanes
Prior art date: 2000-02-02

Application number

HU0200917A

Other languages

English (en)

Original Assignee

Univ Florida State Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-02

Filing date

2001-02-02

Publication date

2004-07-28

2001-02-02 Application filed by Univ Florida State Res Found filed Critical Univ Florida State Res Found

2002-04-29 Publication of HU0200917D0 publication Critical patent/HU0200917D0/hu

2002-08-28 Publication of HUP0200917A2 publication Critical patent/HUP0200917A2/hu

2004-07-28 Publication of HUP0200917A3 publication Critical patent/HUP0200917A3/hu

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Epoxy Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

HU0200917A 2000-02-02 2001-02-02 C7 ester substituted taxanes as antitumor agents and pharmaceutical compositions containing them HUP0200917A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US17979400P	2000-02-02	2000-02-02
PCT/US2001/003385 WO2001057027A1 (en)	2000-02-02	2001-02-02	C7 ester substituted taxanes as antitumor agents

Publications (3)

Publication Number	Publication Date
HU0200917D0 HU0200917D0 (en)	2002-04-29
HUP0200917A2 HUP0200917A2 (en)	2002-08-28
HUP0200917A3 true HUP0200917A3 (en)	2004-07-28

Family

ID=22658029

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0200917A HUP0200917A3 (en)	2000-02-02	2001-02-02	C7 ester substituted taxanes as antitumor agents and pharmaceutical compositions containing them

Country Status (35)

Country	Link
US (3)	US6610860B2 (hu)
EP (1)	EP1183253B8 (hu)
JP (1)	JP2003522167A (hu)
KR (1)	KR100784161B1 (hu)
CN (1)	CN1362955A (hu)
AR (1)	AR030188A1 (hu)
AT (1)	ATE396188T1 (hu)
AU (1)	AU776051B2 (hu)
BG (1)	BG65279B1 (hu)
BR (1)	BR0104749A (hu)
CA (1)	CA2368993C (hu)
CO (1)	CO5280224A1 (hu)
CZ (1)	CZ298484B6 (hu)
DE (1)	DE60134094D1 (hu)
DK (1)	DK1183253T3 (hu)
ES (1)	ES2307588T3 (hu)
GE (1)	GEP20043322B (hu)
HK (1)	HK1047938A1 (hu)
HU (1)	HUP0200917A3 (hu)
IL (1)	IL145641A0 (hu)
MX (1)	MXPA01009901A (hu)
MY (1)	MY137637A (hu)
NO (1)	NO327982B1 (hu)
NZ (1)	NZ514409A (hu)
PL (1)	PL202668B1 (hu)
PT (1)	PT1183253E (hu)
RO (1)	RO121777B1 (hu)
RU (1)	RU2265017C2 (hu)
SA (1)	SA01220045B1 (hu)
SK (1)	SK13712001A3 (hu)
TR (1)	TR200102856T1 (hu)
TW (1)	TWI291873B (hu)
UA (1)	UA75573C2 (hu)
WO (1)	WO2001057027A1 (hu)
ZA (1)	ZA200108060B (hu)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CO5280224A1 (es)	2000-02-02	2003-05-30	Univ Florida State Res Found	Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
JP2003521545A (ja) *	2000-02-02	2003-07-15	フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド	改良された溶解性を有するタキサン製剤
CA2354486A1 (en) *	2001-07-31	2003-01-31	Florida State University Research Foundation, Inc.	C7 ester substituted taxanes
SG125889A1 (en) *	2001-08-01	2006-10-30	Univ Florida State Res Found	C7 ester subsituted taxanes
KR100819578B1 (ko) *	2001-08-01	2008-04-04	플로리다 스테이트 유니버시티 리서치 파운데이션, 인크	Ｃ７ 에스테르 치환된 탁산
US20030082229A1 (en) *	2001-11-01	2003-05-01	Board Of Regents, The University Of Texas Systems	Parenteral chlorambucil for treatment of malignant and autoimmune disease and methods of use
US8012950B2 (en) *	2003-08-29	2011-09-06	Wisconsin Alumni Research Foundation	Method to diagnose and treat degenerative joint disease
EP1785416A3 (en) *	2003-09-25	2007-05-30	Tapestry Pharmaceuticals, Inc.	9, 10-alpha, alpha-OH-Taxane Analogs and methods for production thereof
EP1894921A3 (en) *	2003-09-25	2008-03-12	Tapestry Pharmaceuticals, Inc.	9, 10-Alpha, Alpha-Oh-Taxane analogs and methods for production thereof
JP2007527432A (ja) *	2004-03-05	2007-09-27	フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド	Ｃ７ラクチルオキシ置換タキサン
TW200533339A (en) *	2004-03-16	2005-10-16	Bristol Myers Squibb Co	Therapeutic synergy of anti-cancer compounds
EP1812864A2 (en) *	2004-10-07	2007-08-01	Emory University	Multifunctional nanoparticles conjugates and their use
CN103172662A (zh)	2004-10-25	2013-06-26	德克技术公司	作为抗肿瘤剂的异磷酰胺氮芥及其类似物的盐
US20060216767A1 (en) *	2005-03-22	2006-09-28	Saladax Biomedical Inc.	Docetaxel immunoassay
PL217731B1 (pl)	2006-06-01	2014-08-29	Tomasz Byrski	Sposób wykrywania genetycznie uwarunkowanej obniżonej odpowiedzi na chemioterapię cytostatykiem taksanowym, zastosowanie mutacji założycielskiej oraz zestawu do wykrywania takiej odpowiedzi
EP1913958B1 (en) *	2006-08-03	2009-12-23	Sanofi-Aventis	Antitumor compositions containing acetylcyclopropyl docetaxel and trastuzumab
WO2008106621A1 (en)	2007-02-28	2008-09-04	Tapestry Pharmaceuticals, Inc	Taxane analogs for the treatment of brain cancer
US11786504B2 (en)	2006-09-28	2023-10-17	Tapestry Pharmaceuticals, Inc.	Taxane analogs for the treatment of brain cancer
WO2008121476A1 (en)	2007-03-28	2008-10-09	Tapestry Pharmaceuticals, Inc.	Biologically active taxane analogs and methods of treatment by oral administration
US11873308B2 (en)	2006-11-06	2024-01-16	Tapestry Pharmaceuticals, Inc.	Biologically active taxane analogs and methods of treatment by oral administration
EP2118079A1 (en)	2007-02-07	2009-11-18	The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services	Synthetic macrocyclic compounds for treating cancer
KR101505415B1 (ko)	2007-04-06	2015-03-25	지오팜 온콜로지 인코포레이티드	이소포스포르아미드 머스타드의 염 및 이의 동족체
WO2010014841A1 (en)	2008-07-31	2010-02-04	Ziopharm Oncology, Inc.	Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof
CA2753041A1 (en)	2009-02-24	2010-09-02	Dekk-Tec, Inc.	Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents
WO2010138686A1 (en)	2009-05-29	2010-12-02	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Mdri-inverse agents
WO2011112867A1 (en)	2010-03-10	2011-09-15	The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services	The use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas
WO2013009475A1 (en)	2011-07-11	2013-01-17	The United States Of America, As Represented By The Secretary, Department Of Health & Human Services	Photosensitizing antibody-phuorophore conjugates
WO2012033601A1 (en)	2010-08-20	2012-03-15	The United States Of America, As Represented By The Secretary, Department Of Health & Human Services	Thiosemicarbazones with mdr1 - inverse activity
CA2874655C (en)	2012-05-25	2020-11-03	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Methods of regulating cannabinoid receptor activity-related disorders and diseases
EP3054987B1 (en)	2013-10-11	2019-10-09	The United States of America, represented by the Secretary, Department of Health and Human Services	Tem8 antibodies and their use
JP6796058B2 (ja)	2014-08-08	2020-12-02	ザユナイテッドステイツオブアメリカ，アズリプレゼンテッドバイザセクレタリー，デパートメントオブヘルスアンドヒューマンサービシーズ	インビトロおよびインビボにおける標的の光制御除去
JP7551496B2 (ja)	2017-10-31	2024-09-17	カリヴィルイムノセラピューティクス，インコーポレイテッド	全身送達のためのプラットフォーム腫瘍溶解性ベクター
WO2019099615A1 (en)	2017-11-17	2019-05-23	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Use of copeptin to modulate the immune response and hematopoiesis, and stimulate bone growth
CA3096305A1 (en)	2018-04-10	2019-10-17	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Combination of near infrared photoimmunotherapy targeting cancer cells and host-immune activation
US20220380474A1 (en)	2019-07-02	2022-12-01	The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic	Monoclonal antibodies that bind egfrviii and their use
US12503695B2 (en)	2020-01-27	2025-12-23	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	RAB13 and NET1 antisense oligonucleotides to treat metastatic cancer
JP2023552289A (ja)	2020-11-19	2023-12-15	カリヴィルイムノセラピューティクス，インコーポレイテッド	腫瘍微小環境リモデリングによる腫瘍溶解性免疫療法
JP2024505519A (ja)	2021-01-29	2024-02-06	ザユナイテッドステイツオブアメリカアズリプリゼンテッドバイザセクレタリー、デパートメントオブヘルスアンドヒューマンサービシーズ	がんを処置するための近赤外光免疫療法（ｎｉｒ－ｐｉｔ）併用療法
TW202305125A (zh)	2021-04-30	2023-02-01	美商凱立凡爾免疫治療股份有限公司	用於經修飾mhc表現之溶瘤病毒
WO2024006965A1 (en)	2022-06-30	2024-01-04	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Cd25-specific antibodies and uses thereof
AU2024296940A1 (en)	2023-07-07	2026-01-29	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Humanized 40h3 antibody

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2601675B1 (fr) *	1986-07-17	1988-09-23	Rhone Poulenc Sante	Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5321128A (en) *	1988-09-06	1994-06-14	Kabi Pharmacia Ab	Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US4960790A (en)	1989-03-09	1990-10-02	University Of Kansas	Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
SE463189B (sv)	1989-03-13	1990-10-22	Eston Joensson	Preparat avsett att tillfoeras amalgamfyllningar i taender foer att daerigenom hindra eller minska avgaang av kvicksilver eller kvicksilveraanga
US5175315A (en)	1989-05-31	1992-12-29	Florida State University	Method for preparation of taxol using β-lactam
FR2679230B1 (fr)	1991-07-16	1993-11-19	Rhone Poulenc Rorer Sa	Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent.
US5227400A (en)	1991-09-23	1993-07-13	Florida State University	Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5489601A (en) *	1991-09-23	1996-02-06	Florida State University	Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5721268A (en)	1991-09-23	1998-02-24	Florida State University	C7 taxane derivatives and pharmaceutical compositions containing them
US5350866A (en)	1991-09-23	1994-09-27	Bristol-Myers Squibb Company	10-desacetoxytaxol derivatives
US5243045A (en)	1991-09-23	1993-09-07	Florida State University	Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5430160A (en)	1991-09-23	1995-07-04	Florida State University	Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5714513A (en)	1991-09-23	1998-02-03	Florida State University	C10 taxane derivatives and pharmaceutical compositions
US5283253A (en)	1991-09-23	1994-02-01	Florida State University	Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
RU2059631C1 (ru) *	1991-11-29	1996-05-10	Дзе Юниверсити оф Канзас	Производные таксола и фармацевтическая композиция, обладающая противоопухолевой активностью
ATE195973T1 (de)	1992-01-15	2000-09-15	Squibb & Sons Inc	Enzymatische verfahren zur resolution von enantiomeren-mischungen nützlich wie zwischenprodukte zur herstellung von taxanen
US5272171A (en)	1992-02-13	1993-12-21	Bristol-Myers Squibb Company	Phosphonooxy and carbonate derivatives of taxol
US5200534A (en)	1992-03-13	1993-04-06	University Of Florida	Process for the preparation of taxol and 10-deacetyltaxol
AU672006B2 (en)	1992-04-17	1996-09-19	Abbott Laboratories	Taxol derivatives
US5248796A (en)	1992-06-18	1993-09-28	Bristol-Myers Squibb Company	Taxol derivatives
US5319112A (en)	1992-08-18	1994-06-07	Virgnia Tech Intellectual Properties, Inc.	Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
WO1994005282A1 (en)	1992-09-04	1994-03-17	The Scripps Research Institute	Water soluble taxol derivatives
CA2100808A1 (en)	1992-10-01	1994-04-02	Vittorio Farina	Deoxy paclitaxels
CZ292993B6 (cs)	1992-12-23	2004-01-14	Bristol-Myers Squibb Company	Způsob přípravy taxanu nesoucího oxazolinový postranní řetězec a taxan tímto způsobem připravený
IL108443A0 (en) *	1993-01-29	1994-04-12	Univ Florida State	C7 taxane derivatives and pharmaceutical compositions containing them
US5703247A (en)	1993-03-11	1997-12-30	Virginia Tech Intellectual Properties, Inc.	2-Debenzoyl-2-acyl taxol derivatives and methods for making same
ES2164100T3 (es) *	1993-03-22	2002-02-16	Univ Florida State	Taxanos con una cadena lateral de piridina sustituida.
AU691804B2 (en) *	1993-03-22	1998-05-28	Florida State University	Taxanes having furyl or thienyl substituted side-chain
DE69425563T2 (de) *	1993-03-22	2001-01-25	Florida State University, Tallahassee	Taxane mit amino-substituierter seitenkette
AU7138894A (en)	1993-06-11	1995-01-03	Pharmacia & Upjohn Company	Delta 6,7--taxols antineoplastic use and pharmaceutical compositions containing them
IL109926A (en)	1993-06-15	2000-02-29	Bristol Myers Squibb Co	Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
TW397866B (en)	1993-07-14	2000-07-11	Bristol Myers Squibb Co	Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
FR2711369B1 (fr)	1993-10-20	1995-11-17	Rhone Poulenc Rorer Sa	Nouveaux taxoïdes, leur préparation et les compositions qui les contiennent.
US5415869A (en) *	1993-11-12	1995-05-16	The Research Foundation Of State University Of New York	Taxol formulation
US5414869A (en) *	1993-11-26	1995-05-16	Thomson; Margaret I.	Knotless scarf and method of making same
FR2721024B1 (fr) *	1994-06-09	1996-07-12	Rhone Poulenc Rorer Sa	Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
WO1996013495A1 (en) *	1994-10-28	1996-05-09	The Research Foundation Of State University Of New York	Taxoid derivatives, their preparation and their use as antitumor agents
TW354293B (en)	1995-06-06	1999-03-11	Bristol Myers Squibb Co	Prodrugs of paclitaxel derivatives
US5780653A (en)	1995-06-07	1998-07-14	Vivorx Pharmaceuticals, Inc.	Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
CA2231837A1 (en)	1995-09-13	1997-03-20	Florida State University	Radiosensitizing taxanes and their pharmaceutical preparations
US5767297A (en)	1997-02-05	1998-06-16	Ensuiko Sugar Refining Co., Ltd.	Taxoid derivative and method of producing thereof
FR2745814B1 (fr) *	1996-03-06	1998-04-03	Rhone Poulenc Rorer Sa	Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US6545168B1 (en)	1996-05-06	2003-04-08	Florida State University	1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
WO1997044027A1 (en) *	1996-05-17	1997-11-27	Merck & Co., Inc.	Compositions for a once a day treatment of cyclooxygenase-2 mediated diseases
US5795909A (en)	1996-05-22	1998-08-18	Neuromedica, Inc.	DHA-pharmaceutical agent conjugates of taxanes
JP4172726B2 (ja) *	1996-05-22	2008-10-29	ルイトポルド・ファーマシューティカルズ・インコーポレーテッド	シス―ドコサヘキサエン酸とドセタキセルとの共有複合体を含有する製剤
US6576636B2 (en)	1996-05-22	2003-06-10	Protarga, Inc.	Method of treating a liver disorder with fatty acid-antiviral agent conjugates
US5811452A (en)	1997-01-08	1998-09-22	The Research Foundation Of State University Of New York	Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US5912264A (en)	1997-03-03	1999-06-15	Bristol-Myers Squibb Company	6-halo-or nitrate-substituted paclitaxels
US7288665B1 (en)	1997-08-18	2007-10-30	Florida State University	Process for selective derivatization of taxanes
CA2305399A1 (en) *	1997-10-08	1999-04-15	Bio Research Corporation Of Yokohama	Taxoid derivatives and process for producing the same
US6136988A (en)	1998-04-10	2000-10-24	Hauser, Inc.	7-hexanoyltaxol and methods for preparing the same
US5964739A (en) *	1998-06-18	1999-10-12	Champ; Raynido A.	Safety disposable needle structure
US6146659A (en)	1998-07-01	2000-11-14	Neopharm, Inc.	Method of administering liposomal encapsulated taxane
EP1192126A1 (en)	1999-06-21	2002-04-03	Napro Biotherapeutics, Inc.	C-2 hydroxyl protected-n-acyl(2r,3s)-3-phenylisoserine activated esters and methods for production thereof
WO2001025223A1 (en) *	1999-10-06	2001-04-12	The Research Foundation Of State University Of New York	Stabilization of taxane-containing dispersed systems
JP2003521545A (ja) *	2000-02-02	2003-07-15	フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド	改良された溶解性を有するタキサン製剤
CO5280224A1 (es) *	2000-02-02	2003-05-30	Univ Florida State Res Found	Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
IL145635A0 (en)	2000-02-02	2002-06-30	Univ Florida State Res Found	Taxane formulations having improved solubility
IT1319168B1 (it)	2000-03-17	2003-09-26	Indena Spa	Derivati di condensazione ad attivita' antitumorale, loro metodo dipreparazione e formulazioni che li contengono.

2001
- 2001-01-31 CO CO01007075A patent/CO5280224A1/es not_active Application Discontinuation
- 2001-01-31 AR ARP010100463A patent/AR030188A1/es not_active Application Discontinuation
- 2001-02-02 DK DK01905349T patent/DK1183253T3/da active
- 2001-02-02 RO ROA200101085A patent/RO121777B1/ro unknown
- 2001-02-02 ES ES01905349T patent/ES2307588T3/es not_active Expired - Lifetime
- 2001-02-02 CZ CZ20013503A patent/CZ298484B6/cs not_active IP Right Cessation
- 2001-02-02 HU HU0200917A patent/HUP0200917A3/hu unknown
- 2001-02-02 GE GE4514A patent/GEP20043322B/en unknown
- 2001-02-02 HK HK03100173.6A patent/HK1047938A1/zh unknown
- 2001-02-02 MY MYPI20010481A patent/MY137637A/en unknown
- 2001-02-02 TR TR2001/02856T patent/TR200102856T1/xx unknown
- 2001-02-02 KR KR1020017012600A patent/KR100784161B1/ko not_active Expired - Fee Related
- 2001-02-02 PT PT01905349T patent/PT1183253E/pt unknown
- 2001-02-02 MX MXPA01009901A patent/MXPA01009901A/es active IP Right Grant
- 2001-02-02 UA UA2001106734A patent/UA75573C2/uk unknown
- 2001-02-02 CA CA002368993A patent/CA2368993C/en not_active Expired - Fee Related
- 2001-02-02 US US09/775,851 patent/US6610860B2/en not_active Expired - Fee Related
- 2001-02-02 CN CN01800306A patent/CN1362955A/zh active Pending
- 2001-02-02 DE DE60134094T patent/DE60134094D1/de not_active Expired - Fee Related
- 2001-02-02 WO PCT/US2001/003385 patent/WO2001057027A1/en not_active Ceased
- 2001-02-02 JP JP2001557859A patent/JP2003522167A/ja active Pending
- 2001-02-02 AT AT01905349T patent/ATE396188T1/de not_active IP Right Cessation
- 2001-02-02 SK SK1371-2001A patent/SK13712001A3/sk unknown
- 2001-02-02 AU AU33239/01A patent/AU776051B2/en not_active Ceased
- 2001-02-02 RU RU2001129507/04A patent/RU2265017C2/ru not_active IP Right Cessation
- 2001-02-02 NZ NZ514409A patent/NZ514409A/xx unknown
- 2001-02-02 EP EP01905349A patent/EP1183253B8/en not_active Expired - Lifetime
- 2001-02-02 PL PL350026A patent/PL202668B1/pl not_active IP Right Cessation
- 2001-02-02 IL IL14564101A patent/IL145641A0/xx unknown
- 2001-02-02 BR BR0104749-3A patent/BR0104749A/pt not_active IP Right Cessation
- 2001-03-06 TW TW090102237A patent/TWI291873B/zh active
- 2001-04-11 SA SA1220045A patent/SA01220045B1/ar unknown
- 2001-10-01 ZA ZA200108060A patent/ZA200108060B/en unknown
- 2001-10-01 NO NO20014759A patent/NO327982B1/no not_active IP Right Cessation
- 2001-10-01 BG BG105967A patent/BG65279B1/bg unknown
2003
- 2003-06-25 US US10/606,027 patent/US7186849B2/en not_active Expired - Fee Related
2007
- 2007-01-09 US US11/621,321 patent/US20070249708A1/en not_active Abandoned

Also Published As

Publication number	Publication date
NZ514409A (en)	2004-03-26
SK13712001A3 (sk)	2002-05-09
KR20010111583A (ko)	2001-12-19
CZ298484B6 (cs)	2007-10-17
RU2265017C2 (ru)	2005-11-27
AU776051B2 (en)	2004-08-26
ES2307588T3 (es)	2008-12-01
DE60134094D1 (de)	2008-07-03
US6610860B2 (en)	2003-08-26
NO20014759D0 (no)	2001-10-01
US20020013346A1 (en)	2002-01-31
EP1183253A1 (en)	2002-03-06
EP1183253B8 (en)	2009-01-07
CO5280224A1 (es)	2003-05-30
PL202668B1 (pl)	2009-07-31
BR0104749A (pt)	2001-12-26
SA01220045B1 (ar)	2008-06-07
DK1183253T3 (da)	2008-09-22
HK1047938A1 (zh)	2003-03-14
CA2368993C (en)	2009-10-20
AU3323901A (en)	2001-08-14
AR030188A1 (es)	2003-08-13
HUP0200917A2 (en)	2002-08-28
BG65279B1 (bg)	2007-11-30
HU0200917D0 (en)	2002-04-29
EP1183253B1 (en)	2008-05-21
ATE396188T1 (de)	2008-06-15
NO20014759L (no)	2001-11-29
TWI291873B (en)	2008-01-01
TR200102856T1 (tr)	2002-06-21
JP2003522167A (ja)	2003-07-22
MY137637A (en)	2009-02-27
RO121777B1 (ro)	2008-04-30
GEP20043322B (en)	2003-12-10
WO2001057027A1 (en)	2001-08-09
KR100784161B1 (ko)	2007-12-12
MXPA01009901A (es)	2003-07-28
US20070249708A1 (en)	2007-10-25
CA2368993A1 (en)	2001-08-09
PL350026A1 (en)	2002-10-21
PT1183253E (pt)	2008-08-04
UA75573C2 (en)	2006-05-15
US20040014979A1 (en)	2004-01-22
US7186849B2 (en)	2007-03-06
NO327982B1 (no)	2009-11-02
IL145641A0 (en)	2002-06-30
CZ20013503A3 (cs)	2002-03-13
BG105967A (en)	2002-08-30
CN1362955A (zh)	2002-08-07
ZA200108060B (en)	2003-12-01

Publication	Publication Date	Title
HUP0200917A3 (en)	2004-07-28	C7 ester substituted taxanes as antitumor agents and pharmaceutical compositions containing them
HUP0400114A3 (en)	2007-05-02	N-benzoyl-benzenesulfonamid derivatives as antitumor agents and pharmaceutical compositions containing them
HUP0300798A3 (en)	2006-02-28	Substituted-triazolopyrimidines and their use as anticancer agents and pharmaceutical compositions containing them
GB2358582B (en)	2004-09-29	Pharmaceutical compositions
AU6219601A (en)	2001-10-30	Pharmaceutical compositions
HUP0200750A3 (en)	2005-02-28	C10 heterosubstituted acetate taxanes as antitumor agents and pharmaceutical compositions containing them and their use
GB0009584D0 (en)	2000-06-07	Pharmaceutical compositions
HUP0203311A3 (en)	2004-06-28	New pharmaceutical compositions of prolonged effect
IL137363A (en)	2005-12-18	Pharmaceutical compositions containing mupirocin
AU8576801A (en)	2002-01-02	Pharmaceutical compositions
HUP0303184A3 (en)	2008-03-28	Substituted c-cyclohexylmethylamine derivatives and pharmaceutical compositions containing them
AU1390002A (en)	2002-03-22	Pharmaceutical compositions
GB0008485D0 (en)	2000-05-24	Pharmaceutical compositions
HUP0303204A3 (en)	2010-04-28	1-methylcarbapenem derivatives and pharmaceutical compositions containing them
HUP0200759A3 (en)	2002-10-28	C10 carbonate substituted taxanes as antitumor agents and pharmaceutical compositions containing them and their use
HUP0200651A3 (en)	2002-10-28	C7 heterosubstituted acetate taxanes as antitumor agents and pharmaceutical compositions containing them
HUP0200756A3 (en)	2005-02-28	C7 carbonate substituted taxanes as antitumor agents and pharmaceutical compositions containing them
GB0009613D0 (en)	2000-06-07	Pharmaceutical compositions
AU4834101A (en)	2001-09-24	N-deacetylthiocolchicine derivatives and pharmaceutical compositions containing them
HUP0200721A3 (en)	2005-02-28	C10 carbamoyloxy substituted taxanes as antitumor agents and pharmaceutical compositions containing them and their use
IL159614A0 (en)	2004-06-01	Benzofuran derivatives and pharmaceutical compositions containing the same
HUP0200752A2 (en)	2002-10-28	C7 carbamoyloxy substituted taxanes as antitumor agents
GB0013503D0 (en)	2000-07-26	Pharmaceutical compositions and their uses
HUP0500956A3 (en)	2013-01-28	Oxapenem-3-carboxylic acids and pharmaceutical compositions containing them
PT1326607E (pt)	2008-09-11	Composições farmacêuticas contendo ácidos oxapenemo-3- carboxílicos

Legal Events

Date	Code	Title	Description
2010-10-28	FD9A	Lapse of provisional protection due to non-payment of fees