HUP0101498A1 - Dexmedetomidin alkalmazása nyugtató hatású gyógyszerkészítmények előállítására - Google Patents
Dexmedetomidin alkalmazása nyugtató hatású gyógyszerkészítmények előállításáraInfo
- Publication number
- HUP0101498A1 HUP0101498A1 HU0101498A HUP0101498A HUP0101498A1 HU P0101498 A1 HUP0101498 A1 HU P0101498A1 HU 0101498 A HU0101498 A HU 0101498A HU P0101498 A HUP0101498 A HU P0101498A HU P0101498 A1 HUP0101498 A1 HU P0101498A1
- Authority
- HU
- Hungary
- Prior art keywords
- dexmedetomidine
- pharmaceutical compositions
- sedative effect
- producing pharmaceutical
- producing
- Prior art date
Links
- HRLIOXLXPOHXTA-NSHDSACASA-N dexmedetomidine Chemical compound C1([C@@H](C)C=2C(=C(C)C=CC=2)C)=CN=C[N]1 HRLIOXLXPOHXTA-NSHDSACASA-N 0.000 title abstract 2
- 229960004253 dexmedetomidine Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000001624 sedative effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A találmány tárgya (I) képletű dexmedetomidin vagy ennekfarmakológiailag alkalmazható sója alkalmazása intenzív osztályonnyugtatószerként alkalmazható gyógyszerkészítmények előállítására. Ó
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8028798P | 1998-04-01 | 1998-04-01 | |
| US11094498P | 1998-12-04 | 1998-12-04 | |
| PCT/FI1999/000266 WO1999049854A2 (en) | 1998-04-01 | 1999-03-31 | Use of dexmedetomidine for icu sedation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0101498A1 true HUP0101498A1 (hu) | 2002-03-28 |
| HUP0101498A3 HUP0101498A3 (en) | 2002-06-28 |
| HU229162B1 HU229162B1 (hu) | 2013-09-30 |
Family
ID=26763325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0101498A HU229162B1 (hu) | 1998-04-01 | 1999-03-31 | Dexmedetomidin nyugtatószerként történõ alkalmazása intenzív osztályon |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP1069893B1 (hu) |
| JP (1) | JP4606581B2 (hu) |
| KR (1) | KR20010034728A (hu) |
| CN (1) | CN1168441C (hu) |
| AR (1) | AR015744A1 (hu) |
| AT (1) | ATE347359T1 (hu) |
| AU (1) | AU754484B2 (hu) |
| BG (1) | BG64540B1 (hu) |
| BR (1) | BR9909872A (hu) |
| CA (1) | CA2326339C (hu) |
| CZ (1) | CZ301013B6 (hu) |
| DE (1) | DE69934305T2 (hu) |
| DK (1) | DK1069893T3 (hu) |
| EA (1) | EA005524B1 (hu) |
| ES (1) | ES2278441T3 (hu) |
| GB (1) | GB2352972B (hu) |
| HU (1) | HU229162B1 (hu) |
| IL (1) | IL138416A (hu) |
| NO (1) | NO329194B1 (hu) |
| NZ (1) | NZ507203A (hu) |
| PL (1) | PL192517B1 (hu) |
| PT (1) | PT1069893E (hu) |
| SI (1) | SI1069893T1 (hu) |
| SK (1) | SK286160B6 (hu) |
| TR (1) | TR200002837T2 (hu) |
| TW (1) | TW552136B (hu) |
| WO (1) | WO1999049854A2 (hu) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2259827C2 (ru) | 1999-10-29 | 2005-09-10 | Орион Корпорейшн | Лечение или предупреждение гипотензии и шока |
| CA2480881C (en) * | 2002-04-08 | 2012-09-11 | Guilford Pharmaceuticals, Inc. | Pharmaceutical compositions containing water-soluble prodrugs of propofol and methods of administering same |
| US7141597B2 (en) * | 2003-09-12 | 2006-11-28 | Allergan, Inc. | Nonsedating α-2 agonists |
| US20060058700A1 (en) * | 2004-08-26 | 2006-03-16 | Marro Dominic P | Patient sedation monitor |
| US20080119820A1 (en) | 2006-09-20 | 2008-05-22 | Phan Phillip C | Methods for Delivering Volatile Anesthetics for Regional Anesthesia and/or Pain Relief |
| CA2712731C (en) | 2008-01-22 | 2016-05-03 | The Board Of Regents Of The University Of Texas System | Volatile anesthetic compositions comprising extractive solvents for regional anesthesia and/or pain relief |
| JP6172938B2 (ja) * | 2009-05-15 | 2017-08-02 | レクロ・ファーマ,インコーポレーテッド | デクスメデトミジンの舌下組成物およびその使用方法 |
| DE102009050016A1 (de) | 2009-05-27 | 2011-05-05 | Modine Manufacturing Co., Racine | Wärmeübertragereinheit |
| US20130096170A1 (en) * | 2011-10-14 | 2013-04-18 | Hospira, Inc. | Methods of treating pediatric patients using dexmedetomidine |
| PE20142314A1 (es) | 2011-12-11 | 2015-01-23 | Recro Pharma Inc | Composiciones intranasales de dexmedetomidina y metodos de uso de ellas |
| US8242158B1 (en) * | 2012-01-04 | 2012-08-14 | Hospira, Inc. | Dexmedetomidine premix formulation |
| JP5921928B2 (ja) * | 2012-03-28 | 2016-05-24 | テルモ株式会社 | 既希釈デクスメデトミジン製剤 |
| KR102146690B1 (ko) * | 2012-10-15 | 2020-08-24 | 오리온 코포레이션 | 수의학적 소음 혐오증 완화 방법 |
| CN105473669A (zh) | 2013-07-24 | 2016-04-06 | I-技术有限公司 | 作为抑制剂的对映异构体左旋美托咪啶在海洋生物污损表面附着的应用 |
| JP6310070B2 (ja) | 2013-10-07 | 2018-04-11 | テイコク ファーマ ユーエスエー インコーポレーテッド | デクスメデトミジン経皮組成物を用いる、注意欠陥多動性障害、不安症及び不眠症の治療法及び組成物 |
| US10987342B2 (en) * | 2013-10-07 | 2021-04-27 | Teikoku Pharma Usa, Inc. | Methods and compositions for transdermal delivery of a non-sedative amount of dexmedetomidine |
| KR101827980B1 (ko) | 2013-10-07 | 2018-02-13 | 테이코쿠 팔마 유에스에이, 인코포레이티드 | 덱스메데토미딘 경피 전달 장치 및 이의 사용 방법 |
| RU2723761C1 (ru) | 2016-10-31 | 2020-06-17 | ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. | Способы устранения боли с использованием устройств для трансдермальной доставки дексмедетомидина |
| CN113975273B (zh) * | 2020-07-27 | 2023-07-11 | 宜昌人福药业有限责任公司 | 一种抗焦虑用纳米混悬鼻腔喷雾剂及其制备方法 |
| CN115197149B (zh) * | 2021-04-02 | 2023-09-22 | 四川大学华西医院 | 一种5-苄基咪唑类化合物及其制备方法和用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2101114B (en) * | 1981-07-10 | 1985-05-22 | Farmos Group Ltd | Substituted imidazole derivatives and their preparation and use |
| FI844786A0 (fi) * | 1984-12-04 | 1984-12-04 | Farmos Oy | Terapeutiskt utnyttjbar foerening. |
| GB2206880B (en) * | 1987-07-16 | 1991-04-24 | Farmos Oy | Optical isomers of an imidazole derivative |
| GB2215206B (en) * | 1988-02-29 | 1991-07-03 | Farmos Oy | 4-substituted imidazole derivatives useful in perioperative care |
| US5344840A (en) * | 1988-02-29 | 1994-09-06 | Orion-Yhtyma Oy | 4-substituted imidazole derivatives useful in perioperative care |
| US5217718A (en) * | 1989-08-18 | 1993-06-08 | Cygnus Therapeutic Systems | Method and device for administering dexmedetomidine transdermally |
| US5124157A (en) * | 1989-08-18 | 1992-06-23 | Cygnus Therapeutic Systems | Method and device for administering dexmedetomidine transdermally |
| FI894911A0 (fi) * | 1989-10-17 | 1989-10-17 | Farmos Oy | En terapeutiskt vaerdefull foerening. |
| GB2281206A (en) * | 1993-08-25 | 1995-03-01 | Orion Yhtymae Oy | Use of dexmedetomidine |
-
1999
- 1999-03-30 AR ARP990101414A patent/AR015744A1/es unknown
- 1999-03-31 EP EP99913332A patent/EP1069893B1/en not_active Expired - Lifetime
- 1999-03-31 CN CNB998046272A patent/CN1168441C/zh not_active Ceased
- 1999-03-31 JP JP2000540820A patent/JP4606581B2/ja not_active Expired - Lifetime
- 1999-03-31 TR TR2000/02837T patent/TR200002837T2/xx unknown
- 1999-03-31 AT AT99913332T patent/ATE347359T1/de active
- 1999-03-31 HU HU0101498A patent/HU229162B1/hu unknown
- 1999-03-31 PL PL343553A patent/PL192517B1/pl unknown
- 1999-03-31 KR KR1020007010991A patent/KR20010034728A/ko not_active Ceased
- 1999-03-31 EA EA200001010A patent/EA005524B1/ru not_active IP Right Cessation
- 1999-03-31 BR BRPI9909872-5A patent/BR9909872A/pt not_active Application Discontinuation
- 1999-03-31 AU AU31494/99A patent/AU754484B2/en not_active Expired
- 1999-03-31 SI SI9930941T patent/SI1069893T1/sl unknown
- 1999-03-31 SK SK1436-2000A patent/SK286160B6/sk not_active IP Right Cessation
- 1999-03-31 DE DE69934305T patent/DE69934305T2/de not_active Expired - Lifetime
- 1999-03-31 CA CA002326339A patent/CA2326339C/en not_active Expired - Lifetime
- 1999-03-31 IL IL13841699A patent/IL138416A/xx not_active IP Right Cessation
- 1999-03-31 PT PT99913332T patent/PT1069893E/pt unknown
- 1999-03-31 NZ NZ507203A patent/NZ507203A/xx not_active IP Right Cessation
- 1999-03-31 GB GB0024932A patent/GB2352972B/en not_active Expired - Lifetime
- 1999-03-31 CZ CZ20003484A patent/CZ301013B6/cs not_active IP Right Cessation
- 1999-03-31 ES ES99913332T patent/ES2278441T3/es not_active Expired - Lifetime
- 1999-03-31 DK DK99913332T patent/DK1069893T3/da active
- 1999-03-31 WO PCT/FI1999/000266 patent/WO1999049854A2/en not_active Ceased
- 1999-04-01 TW TW088105188A patent/TW552136B/zh not_active IP Right Cessation
-
2000
- 2000-09-26 BG BG104797A patent/BG64540B1/bg unknown
- 2000-09-29 NO NO20004931A patent/NO329194B1/no not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB9A | Succession in title |
Owner name: ORION CORPORATION, FI Free format text: FORMER OWNER(S): ORION CORP., FI Owner name: ABBOTT LABORATORIES, US Free format text: FORMER OWNER(S): ORION CORP., FI |
|
| GB9A | Succession in title |
Owner name: ORION CORPORATION, FI Free format text: FORMER OWNER(S): ORION CORP., FI; ABBOTT LABORATORIES, US; ORION CORPORATION, FI |