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HUP0100601A3 - Bicyclic compounds containing nitrogen, processes for their preparation and pharmaceutical compositions thereof - Google Patents

Bicyclic compounds containing nitrogen, processes for their preparation and pharmaceutical compositions thereof

Info

Publication number
HUP0100601A3
HUP0100601A3 HU0100601A HUP0100601A HUP0100601A3 HU P0100601 A3 HUP0100601 A3 HU P0100601A3 HU 0100601 A HU0100601 A HU 0100601A HU P0100601 A HUP0100601 A HU P0100601A HU P0100601 A3 HUP0100601 A3 HU P0100601A3
Authority
HU
Hungary
Prior art keywords
processes
preparation
pharmaceutical compositions
compounds containing
containing nitrogen
Prior art date
Application number
HU0100601A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of HUP0100601A2 publication Critical patent/HUP0100601A2/hu
Publication of HUP0100601A3 publication Critical patent/HUP0100601A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU0100601A 1997-11-28 1998-11-18 Bicyclic compounds containing nitrogen, processes for their preparation and pharmaceutical compositions thereof HUP0100601A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9704404A SE9704404D0 (sv) 1997-11-28 1997-11-28 New compounds
PCT/SE1998/002091 WO1999028322A1 (en) 1997-11-28 1998-11-18 Heterocyclic compounds for inhibition of gastric acid secretion, processes for their preparation and pharmaceutical compositions thereof

Publications (2)

Publication Number Publication Date
HUP0100601A2 HUP0100601A2 (hu) 2001-09-28
HUP0100601A3 true HUP0100601A3 (en) 2002-10-28

Family

ID=20409181

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0100601A HUP0100601A3 (en) 1997-11-28 1998-11-18 Bicyclic compounds containing nitrogen, processes for their preparation and pharmaceutical compositions thereof

Country Status (32)

Country Link
US (1) US6518270B1 (hu)
EP (1) EP1042324B1 (hu)
JP (1) JP2001525322A (hu)
KR (1) KR20010032559A (hu)
CN (1) CN1142933C (hu)
AR (1) AR016972A1 (hu)
AT (1) ATE233263T1 (hu)
AU (1) AU752187C (hu)
BR (1) BR9814755A (hu)
CA (1) CA2311798A1 (hu)
CZ (1) CZ292349B6 (hu)
DE (1) DE69811735T2 (hu)
DK (1) DK1042324T3 (hu)
EE (1) EE04060B1 (hu)
ES (1) ES2191356T3 (hu)
HU (1) HUP0100601A3 (hu)
ID (1) ID24730A (hu)
IL (1) IL136145A0 (hu)
IS (1) IS5486A (hu)
MY (1) MY121032A (hu)
NO (1) NO315704B1 (hu)
NZ (1) NZ504355A (hu)
PL (1) PL340920A1 (hu)
PT (1) PT1042324E (hu)
RU (1) RU2241000C2 (hu)
SE (1) SE9704404D0 (hu)
SK (1) SK283904B6 (hu)
TR (1) TR200001530T2 (hu)
TW (1) TW515798B (hu)
UA (1) UA70932C2 (hu)
WO (1) WO1999028322A1 (hu)
ZA (1) ZA9810468B (hu)

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SE9704404D0 (sv) 1997-11-28 1997-11-28 Astra Ab New compounds
NZ517706A (en) * 1999-10-08 2004-01-30 Affinium Pharm Inc Fab I inhibitors
DE60230934D1 (de) * 2001-04-06 2009-03-05 Affinium Pharm Inc Fab-i-inhibitoren
JP2003119140A (ja) * 2001-08-08 2003-04-23 Sankyo Co Ltd ピロロピリダジン化合物を含有する医薬
BR0309398A (pt) * 2002-04-19 2005-02-01 Cellular Genomics Inc Composto ou um seu sal, hidrato, solvato, forma cristalina, diastereÈmero, prodroga farmaceuticamente aceitável, ou misturas deles, composição farmacêutica, e, métodos para tratar uma condição envolvida com a cinase em um mamìfero, para tratar câncer, e para identificar uma cinase
AU2003270489A1 (en) 2002-09-09 2004-03-29 Cellular Genomics, Inc. 6-ARYL-IMIDAZO(1,2-a)PYRAZIN-8-YLAMINES, METHOD OF MAKING, AND METHOD OF USE THEREOF
TW200420293A (en) * 2002-09-25 2004-10-16 Sankyo Co Pharmaceutical compositions for the reduction of gastric acid concentration in blood
AU2003266621A1 (en) * 2002-09-25 2004-04-19 Sankyo Company, Limited Medicinal composition for treatment for or prevention of visceral pain
ES2518316T3 (es) * 2002-12-06 2014-11-05 Debiopharm International Sa Compuestos heterocíclicos, métodos de fabricación de los mismos y su uso en terapia
US7189723B2 (en) 2003-02-10 2007-03-13 Cgi Pharmaceuticals, Inc. Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of kinase activity
AR043002A1 (es) * 2003-02-18 2005-07-13 Altana Pharma Ag Imidazopirazinas 6-substituidos
ATE409485T1 (de) * 2003-03-17 2008-10-15 Affinium Pharm Inc Pharmazeutische zusammensetzungen inhibitoren von fab i und weitere antibiotika enthaltend
US7405295B2 (en) 2003-06-04 2008-07-29 Cgi Pharmaceuticals, Inc. Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
US7393848B2 (en) 2003-06-30 2008-07-01 Cgi Pharmaceuticals, Inc. Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds
US7259164B2 (en) 2003-08-11 2007-08-21 Cgi Pharmaceuticals, Inc. Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity
US20080280944A1 (en) 2003-11-03 2008-11-13 Paula Fernstrom Imidazo[1,2-A]Pyridine Derivatives For The Treatment Of Silent Gastro-Esophageal Reflux
SI1828167T1 (sl) * 2004-06-04 2014-12-31 Debiopharm International Sa Forum "Apres-Demain" Akrilamidni derivati kot anitibiotična sredstva
KR20220084426A (ko) * 2004-07-28 2022-06-21 다케다 야쿠힌 고교 가부시키가이샤 피롤로〔2,3-ｃ〕피리딘 화합물, 그 제조 방법 및 용도
AU2005268767A1 (en) * 2004-08-02 2006-02-09 Altana Pharma Ag 5-substituted 1H-pyrrolo[3,2-B]pyridines
BRPI0514695A (pt) * 2004-09-03 2008-06-17 Yuhan Corp derivados de pirrol[3, 2-b]piridina e processos para a preparação destes
ES2342478T3 (es) * 2004-09-03 2010-07-07 Yuhan Corporation Derivados de pirrolo(3,2-c)piridina y procedimiento para la preparacion de los mismos.
MX2007002214A (es) * 2004-09-03 2007-05-07 Yuhan Corp Derivados de pirrolo[3,2-c]piridina y procesos para su preparacion.
PL1784404T3 (pl) 2004-09-03 2012-04-30 Yuhan Corp Pochodne pirolo[2,3-c]pirydyny i sposoby ich wytwarzania
WO2007024294A2 (en) 2005-05-03 2007-03-01 Cgi Pharmaceuticals, Inc. Certain substituted ureas, as modulators of kinase activity
US7709468B2 (en) 2005-09-02 2010-05-04 Abbott Laboratories Imidazo based heterocycles
EP1973902A2 (en) * 2005-12-05 2008-10-01 Affinium Pharmaceuticals, Inc. 3-heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents
JP2009539840A (ja) * 2006-06-06 2009-11-19 シェーリング コーポレイション プロテインキナーゼ阻害剤としてのイミダゾピラジン
EP2687533B1 (en) 2006-07-20 2017-07-19 Debiopharm International SA Acrylamide derivatives as FAB I inhibitors
US8263613B2 (en) * 2007-02-16 2012-09-11 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab I inhibitors
CA2714414A1 (en) 2008-02-13 2009-08-20 Cgi Pharmaceuticals, Inc. Certain substituted amides, method of making, and method of use thereof
NZ593460A (en) 2008-12-08 2013-11-29 Gilead Connecticut Inc Imidazopyrazine syk inhibitors
US8450321B2 (en) 2008-12-08 2013-05-28 Gilead Connecticut, Inc. 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
TWI529172B (zh) 2008-12-08 2016-04-11 吉李德康乃狄克公司 作爲脾臟酪胺酸激酶（Ｓｙｋ）抑制劑之咪唑並吡化合物
CN103168039B (zh) 2010-03-11 2016-08-03 吉利德康涅狄格公司 咪唑并吡啶类syk抑制剂
RS58898B1 (sr) 2012-06-19 2019-08-30 Debiopharm Int Sa Prolek derivati (e)-n-metil-n-((3-metilbenzofuran-2-il)metil)-3-(7-okso-5,6,7,8-tetrahidro-1,8-naftiridin-3-il)akrilamida
ES2822285T3 (es) 2013-07-30 2021-04-30 Kronos Bio Inc Polimorfo de inhibidores de SYK
KR20160036590A (ko) 2013-07-30 2016-04-04 질레드 코네티컷 인코포레이티드 Ｓｙｋ 억제제의 제제
MX2016007311A (es) 2013-12-04 2016-09-07 Gilead Sciences Inc Metodos para tratar canceres.
GB201321738D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
TWI735853B (zh) 2013-12-23 2021-08-11 美商克洛諾斯生技有限公司 脾酪胺酸激酶抑制劑
CN106687139A (zh) 2014-07-14 2017-05-17 吉利德科学公司 用于治疗癌症的组合
PT3419628T (pt) 2016-02-26 2021-01-05 Debiopharm Int Sa Medicamento para o tratamento de infeções do pé diabético
US11384082B2 (en) 2017-08-25 2022-07-12 Kronos Bio, Inc. Hydrates of polymorphs of 6-(1H-indazol-6-YL)-N-(4-morpholinophenyl)-2,3-dihydroimidazo[1,2-A]pyrazin-8-amine bisemsylate as Syk inhibitors
CA3129508A1 (en) 2019-02-14 2020-08-20 Debiopharm International S.A. Solid formulations of afabicin with histidine
CA3130848A1 (en) 2019-02-22 2020-08-27 Kronos Bio, Inc. Solid forms of condensed pyrazines as syk inhibitors
CN113939306B (zh) 2019-06-14 2024-07-19 德彪药业国际股份公司 用于治疗涉及生物膜的细菌感染的药物及其用途

Family Cites Families (11)

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US4507294A (en) * 1982-03-08 1985-03-26 Schering Corp. Imidazo[1,2-a]pyrazines
DE3269604D1 (en) * 1981-06-26 1986-04-10 Schering Corp Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
US4725601A (en) * 1985-06-04 1988-02-16 Fujisawa Pharmaceutical Co., Ltd. Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers
IL97931A0 (en) * 1990-04-27 1992-06-21 Byk Gulden Lomberg Chem Fab Pyridazine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
US5041442A (en) * 1990-07-31 1991-08-20 Syntex (U.S.A.) Inc. Pyrrolo(1,2-a)pyrazines as inhibitors of gastric acid secretion
WO1992006979A1 (de) * 1990-10-15 1992-04-30 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue diazine
DE59209687D1 (de) * 1991-10-25 1999-06-02 Byk Gulden Lomberg Chem Fab Pyrrolo-pyridazine mit magen- und darmschutzwirkungen
AU680998B2 (en) * 1994-01-19 1997-08-14 Sankyo Company Limited Pyrrolopyridazine derivative
SE9602286D0 (sv) 1996-06-10 1996-06-10 Astra Ab New compounds
SE9700661D0 (sv) 1997-02-25 1997-02-25 Astra Ab New compounds
SE9704404D0 (sv) 1997-11-28 1997-11-28 Astra Ab New compounds

Also Published As

Publication number Publication date
CZ20001947A3 (cs) 2000-11-15
US6518270B1 (en) 2003-02-11
MY121032A (en) 2005-12-30
CN1284078A (zh) 2001-02-14
HUP0100601A2 (hu) 2001-09-28
SE9704404D0 (sv) 1997-11-28
NZ504355A (en) 2001-12-21
IL136145A0 (en) 2001-05-20
SK6742000A3 (en) 2001-03-12
HK1030216A1 (en) 2001-04-27
DE69811735T2 (de) 2003-12-18
BR9814755A (pt) 2000-10-03
EE200000315A (et) 2001-10-15
ATE233263T1 (de) 2003-03-15
PL340920A1 (en) 2001-03-12
AR016972A1 (es) 2001-08-01
PT1042324E (pt) 2003-06-30
JP2001525322A (ja) 2001-12-11
EP1042324B1 (en) 2003-02-26
TW515798B (en) 2003-01-01
NO20002721L (no) 2000-07-28
ZA9810468B (en) 1999-05-21
AU752187C (en) 2003-09-18
DE69811735D1 (de) 2003-04-03
CZ292349B6 (cs) 2003-09-17
DK1042324T3 (da) 2003-05-05
CA2311798A1 (en) 1999-06-10
IS5486A (is) 2000-05-10
ID24730A (id) 2000-08-03
AU752187B2 (en) 2002-09-12
AU1356599A (en) 1999-06-16
EP1042324A1 (en) 2000-10-11
WO1999028322A1 (en) 1999-06-10
TR200001530T2 (tr) 2000-11-21
NO315704B1 (no) 2003-10-13
NO20002721D0 (no) 2000-05-26
ES2191356T3 (es) 2003-09-01
RU2241000C2 (ru) 2004-11-27
UA70932C2 (uk) 2004-11-15
CN1142933C (zh) 2004-03-24
KR20010032559A (ko) 2001-04-25
EE04060B1 (et) 2003-06-16
SK283904B6 (sk) 2004-04-06

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