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HUP0500028A2 - Triaza-spiro[5.5]undekán-azármazék citokróm P450 izozim 3A4 inhibitorral és/vagy P-glikoprotein inhibitorral való kombinációját tartalmazó gyógyszer - Google Patents

Triaza-spiro[5.5]undekán-azármazék citokróm P450 izozim 3A4 inhibitorral és/vagy P-glikoprotein inhibitorral való kombinációját tartalmazó gyógyszer

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Publication number
HUP0500028A2
HUP0500028A2 HU0500028A HUP0500028A HUP0500028A2 HU P0500028 A2 HUP0500028 A2 HU P0500028A2 HU 0500028 A HU0500028 A HU 0500028A HU P0500028 A HUP0500028 A HU P0500028A HU P0500028 A2 HUP0500028 A2 HU P0500028A2
Authority
HU
Hungary
Prior art keywords
group
inhibitor
optionally substituted
hydrogen atom
substituted alkyl
Prior art date
Application number
HU0500028A
Other languages
English (en)
Inventor
Haruo Imawaka
Shiro Shibayama
Yoshikazu Takaoka
Original Assignee
Ono Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co., Ltd. filed Critical Ono Pharmaceutical Co., Ltd.
Publication of HUP0500028A2 publication Critical patent/HUP0500028A2/hu

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/499—Spiro-condensed pyrazines or piperazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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Abstract

A találmány tárgya gyógyszerkészítmény, amely egy általános képletűtriaza-spiro[5.5]undekán-származék - ahol R1 hidrogénatom, adottesetben szubsztituált alkil-, alkenil-, alkinilcsoport, -COR6, -CONR7R8, -COOR9, -SO2R10, -COCOOR11, -CONR12 COR13 általános képletűvagy Cyc1 csoport; R2 hidrogénatom, adott esetben szubsztituáltalkil-, alkenil-, alkinilcsoport, -OR90 általános képletű vagy Cyc3 csoport; R3 és R4hidrogénatom, adott esetben szubsztituált alkil-, alkenil-,alkinilcsoport, -COOR120, -CONR121R122 általános képletű vagy Cyc4csoport: vagy együtt egy általános képletű csoportot képeznek; és R5hidrogénatom, adott esetben szubsztituált alkilcsoport vagy Cyc5 vagykvaterner ammóniumsója, N-oxidja vagy nem toxikus sója és legalább egycitokróm P 450 izozim inhibitor és/vagy legalább egy P-glikoproteininhibitor kombinációját tartalmazza. A fenti gyógyszerkészítménykülönböző gyulladásos megbetegedések gyógyítására alkalmazható. Ó
HU0500028A 2001-10-23 2002-03-18 Triaza-spiro[5.5]undekán-azármazék citokróm P450 izozim 3A4 inhibitorral és/vagy P-glikoprotein inhibitorral való kombinációját tartalmazó gyógyszer HUP0500028A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001324435 2001-10-23
PCT/JP2002/002552 WO2003035074A1 (en) 2001-10-23 2002-03-18 Drugs comprising combination of triazaspiro[5,5]undecane derivative with cytochrome p450 isozyme 3a4 inhibitor and/or p-glycoprotein inhibitor

Publications (1)

Publication Number Publication Date
HUP0500028A2 true HUP0500028A2 (hu) 2005-04-28

Family

ID=19141164

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0500028A HUP0500028A2 (hu) 2001-10-23 2002-03-18 Triaza-spiro[5.5]undekán-azármazék citokróm P450 izozim 3A4 inhibitorral és/vagy P-glikoprotein inhibitorral való kombinációját tartalmazó gyógyszer

Country Status (15)

Country Link
EP (1) EP1438962A4 (hu)
JP (1) JPWO2003035074A1 (hu)
KR (1) KR20040045882A (hu)
CN (1) CN1571671A (hu)
BR (1) BR0213372A (hu)
CA (1) CA2461545A1 (hu)
CZ (1) CZ2004500A3 (hu)
HU (1) HUP0500028A2 (hu)
IL (1) IL161053A0 (hu)
MX (1) MXPA04003816A (hu)
NO (1) NO20041618L (hu)
PL (1) PL370280A1 (hu)
RU (1) RU2004115621A (hu)
WO (1) WO2003035074A1 (hu)
ZA (1) ZA200403086B (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050057408A (ko) * 2002-09-18 2005-06-16 오노 야꾸힝 고교 가부시키가이샤 트리아자스피로[5.5]운데칸 유도체 및 이를 유효 성분으로하는 약제
TW200413371A (en) 2002-09-18 2004-08-01 Ono Pharmaceutical Co Novel crystal of triazaspiro [5.5]undecane derivatives
EP1621540A4 (en) * 2003-04-21 2008-07-23 Ono Pharmaceutical Co HETEROCYCLIC COMPOUNDS CONTAINING NITROGEN AND USE THEREOF
US20070003608A1 (en) * 2005-04-08 2007-01-04 Almond Merrick R Compounds, compositions and methods for the treatment of viral infections and other medical disorders
US8642577B2 (en) 2005-04-08 2014-02-04 Chimerix, Inc. Compounds, compositions and methods for the treatment of poxvirus infections
WO2006129679A1 (ja) * 2005-05-31 2006-12-07 Ono Pharmaceutical Co., Ltd. スピロピペリジン化合物およびその医薬用途
KR100709555B1 (ko) * 2005-09-29 2007-04-20 한국과학기술연구원 고성능 액체크로마토그래피-질량분석기를 이용한 혈장 중의에이즈 치료제 검출 방법
JP5562255B2 (ja) 2008-01-25 2014-07-30 キメリクス，インコーポレイテッド ウイルス感染を治療する方法
US8614200B2 (en) 2009-07-21 2013-12-24 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
ES2629165T3 (es) 2010-02-12 2017-08-07 Chimerix, Inc. Métodos de tratamiento de una infección vírica
WO2011139709A2 (en) 2010-04-26 2011-11-10 Chimerix, Inc. Methods of treating retroviral infections and related dosage regimes
CN104535774B (zh) * 2015-01-16 2017-04-19 中国药科大学 一种炎性肠病状态下药物敏感性的新检测指标及其在药物治疗方案设计中的应用
KR102203334B1 (ko) 2019-04-12 2021-01-15 성균관대학교산학협력단 피모자이드의 항암제 병용요법
WO2024223797A1 (en) 2023-04-28 2024-10-31 Institut National de la Santé et de la Recherche Médicale Use of cyp3a4 inhibitors for the treatment of hepatitis d virus (hdv) infections

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5567592A (en) * 1994-02-02 1996-10-22 Regents Of The University Of California Screening method for the identification of bioenhancers through the inhibition of P-glycoprotein transport in the gut of a mammal
MXPA02005465A (es) * 1999-12-03 2003-10-15 Ono Pharmaceutical Co Derivados de triazaspiro(5.5)undecano y composiciones farmaceuticas que los comprenden, como un ingrediente activo.

Also Published As

Publication number Publication date
NO20041618L (no) 2004-07-22
CZ2004500A3 (cs) 2005-03-16
CN1571671A (zh) 2005-01-26
PL370280A1 (en) 2005-05-16
KR20040045882A (ko) 2004-06-02
RU2004115621A (ru) 2005-03-27
ZA200403086B (en) 2005-05-11
BR0213372A (pt) 2005-02-01
WO2003035074A1 (en) 2003-05-01
JPWO2003035074A1 (ja) 2005-02-10
CA2461545A1 (en) 2003-05-01
MXPA04003816A (es) 2004-07-30
EP1438962A4 (en) 2005-11-09
IL161053A0 (en) 2004-08-31
EP1438962A1 (en) 2004-07-21

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