HUP0402486A2 - Nitrogéntartalmú heterociklusos vegyületek, mint peroxiszóma proliferátorral aktivált receptor agonisták, az ezeket tartalmazó gyógyászati készítmények és alkalmazásuk - Google Patents
Nitrogéntartalmú heterociklusos vegyületek, mint peroxiszóma proliferátorral aktivált receptor agonisták, az ezeket tartalmazó gyógyászati készítmények és alkalmazásukInfo
- Publication number
- HUP0402486A2 HUP0402486A2 HU0402486A HUP0402486A HUP0402486A2 HU P0402486 A2 HUP0402486 A2 HU P0402486A2 HU 0402486 A HU0402486 A HU 0402486A HU P0402486 A HUP0402486 A HU P0402486A HU P0402486 A2 HUP0402486 A2 HU P0402486A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- group
- optionally substituted
- aryl
- heteroaryl
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
A találmány tárgyát képezik az (I) általános képletű peroxiszómaproliferátorral aktivált receptorok agonistái, az ezeket tartalmazógyógyászati készítmények, és alkalmazásuk például diabetes mellitus,szív- és érrendszeri betegségek, elhízottság, gyulladásos betegségekés hasonlók kezelésére szolgáló gyógyszerkészítmények előállítására.Az (I) általános képletben a szubsztituensek jelentése igen sokfélelehet, így például (a) R1 jelentése hidrogénatom, alkil-, aril-alkil-,heteroaril-alkil-, cikloalkil-aril-alkilcsoport, amely csoportok mindadott esetben szubsztituálva lehetnek; (b) R2 jelentése példáulalkil-, alkenil-, aril-alkil-, heteroaril-alkil-, alkil-szulfon-amid-;vagy 3-6 szénatomos cikloalkilcsoport, amely csoportok mind adottesetben szubsztituálva lehetnek; (c) W jelentése O vagy S; (d) Xjelentése adott esetben szubsztituált 1-5 szénatomos alkilén kapcsolócsoport, ahol a kapcsoló csoportban lévő egyik szénatom helyett adottesetben O, NH vagy S állhat, továbbá adott esetben két szénatom közöttkettős kötés van jelen; (e) Y jelentése C, O, S, NH és vegyértékkötésközül választott; és (f) E jelentése C(R3)(R4)A, A, és adott esetbenszubsztituált (CH2)nCOOR19 közül választott: és ahol (i) n értéke 0,1, 2 vagy 3,[ii] A jelentése például karboxil-, karboxamid-, adottesetben szubsztituált tetrazol vagy izoxazol; (iii) R3 jelentésealkil- vagy alkoxicsoport és R4 jelentése például adott esetbenszubsztituált alkil-, alkoxi-, cikloalkil-, aril-alkil- vagyfenilcsoport; R8 jelentése például alkil-, alkenil- vagy halogénatom;R9 jelentése például alkilcsoport, halogénatom, szubsztituált aril-,heteroarilcsoport és hasonlók; R21 jelentése például hidrogén- vagy =Ovagy adott esetben szubsztituált alkil-, aril- vagy heteroarilcsoport;R22 jelentése például adott esetben szubsztituált alkil-; aril- vagyheteroarilcsoport, továbbá a - - - - jelentése adott esetben jelenlévőkettős csoport. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33445301P | 2001-11-30 | 2001-11-30 | |
| PCT/US2002/036128 WO2003048130A2 (en) | 2001-11-30 | 2002-11-26 | Peroxisome proliferator activated receptor agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0402486A2 true HUP0402486A2 (hu) | 2005-03-29 |
| HUP0402486A3 HUP0402486A3 (en) | 2007-05-02 |
Family
ID=23307275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0402486A HUP0402486A3 (en) | 2001-11-30 | 2002-11-26 | Nitrogen containing heterocyclic compounds as peroxisome proliferator activated receptor agonists, their use and pharmaceutical compositions cointaining them |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7544812B2 (hu) |
| EP (1) | EP1453811A2 (hu) |
| JP (1) | JP2005517643A (hu) |
| KR (1) | KR20050044606A (hu) |
| CN (1) | CN1582279A (hu) |
| AU (1) | AU2002356927A1 (hu) |
| BR (1) | BR0214437A (hu) |
| CA (1) | CA2468846A1 (hu) |
| CO (1) | CO5640129A2 (hu) |
| EA (1) | EA007163B1 (hu) |
| HR (1) | HRP20040469A2 (hu) |
| HU (1) | HUP0402486A3 (hu) |
| IL (1) | IL161578A0 (hu) |
| MX (1) | MXPA04005123A (hu) |
| NO (1) | NO20042737L (hu) |
| NZ (1) | NZ532909A (hu) |
| PL (1) | PL370515A1 (hu) |
| WO (1) | WO2003048130A2 (hu) |
| ZA (1) | ZA200404173B (hu) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004000789A1 (en) | 2002-06-19 | 2003-12-31 | Eli Lilly And Company | Amide linker peroxisome proliferator activated receptor modulators |
| US7816385B2 (en) * | 2002-12-20 | 2010-10-19 | High Point Pharmaceuticals, Llc | Dimeric dicarboxylic acid derivatives, their preparation and use |
| DE10351859A1 (de) * | 2003-11-06 | 2005-06-09 | Beiersdorf Ag | Emulsionen mit zwei Verdickungsmitteln |
| EP1734963A4 (en) | 2004-04-02 | 2008-06-18 | Merck & Co Inc | METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER |
| US7456164B2 (en) | 2004-05-07 | 2008-11-25 | Pfizer, Inc | 3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands |
| BRPI0516217A (pt) * | 2004-09-28 | 2008-08-26 | Allergan Inc | compostos de 4-benzil-1,3-diidro-imidazol-2-tionas não-substituìdos e substituìdos que atuam como agonistas especìficos ou seletivos alfa2-adrenérgicos e métodos de utilização dos mesmos |
| US7504517B2 (en) | 2006-06-20 | 2009-03-17 | Wyeth | Kv1.5 potassium channel inhibitors |
| FR2903984B1 (fr) * | 2006-07-24 | 2008-10-03 | Genfit Sa | Derives d'imidazolones substitues, preparation et utilisations |
| US20100183696A1 (en) | 2007-01-30 | 2010-07-22 | Allergan, Inc | Treating Ocular Diseases Using Peroxisome Proliferator-Activated Receptor Delta Antagonists |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| US7879802B2 (en) | 2007-06-04 | 2011-02-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| AU2009256157B2 (en) | 2008-06-04 | 2014-12-18 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| JP2011528375A (ja) | 2008-07-16 | 2011-11-17 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
| CN101875636B (zh) * | 2010-05-18 | 2012-01-04 | 浙江大学 | 咪唑啉-2,4-二酮类衍生物及制备方法和用途 |
| US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
| JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
| AU2014274812B2 (en) | 2013-06-05 | 2018-09-27 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
| CN115894379B (zh) * | 2022-01-20 | 2025-06-27 | 哈尔滨三联药业股份有限公司 | 海因类化合物及其医药用途 |
| CN114835655A (zh) * | 2022-04-14 | 2022-08-02 | 河南师范大学 | 一种合成光学活性三氟甲基丙烯酸酯类化合物的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3452041A (en) * | 1965-05-19 | 1969-06-24 | American Home Prod | Hydantoin compounds and methods of preparation |
| NZ184281A (en) * | 1976-06-03 | 1980-04-28 | Wellcome Found | Hydantoin derivatives and pharmaceutical compositions |
| GB1601310A (en) * | 1978-05-23 | 1981-10-28 | Lilly Industries Ltd | Aryl hydantoins |
| JPS59159163A (ja) * | 1983-03-01 | 1984-09-08 | Fuji Photo Film Co Ltd | ハロゲン化銀カラ−感光材料 |
| GB9604242D0 (en) * | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| DE69811867T2 (de) | 1997-03-03 | 2003-11-20 | Boehringer Ingelheim Pharmaceuticals, Inc. | Kleine moleküle anwendbar in der behandlung von entzündgskrankheiten |
| ATE252091T1 (de) | 1999-08-27 | 2003-11-15 | Lilly Co Eli | Biaryl-oxa(thia)zolderivate und ihre verwendung als ppars modulatoren |
-
2002
- 2002-11-26 BR BR0214437-9A patent/BR0214437A/pt not_active IP Right Cessation
- 2002-11-26 NZ NZ532909A patent/NZ532909A/en unknown
- 2002-11-26 EP EP02804416A patent/EP1453811A2/en not_active Withdrawn
- 2002-11-26 US US10/496,770 patent/US7544812B2/en not_active Expired - Fee Related
- 2002-11-26 EA EA200400748A patent/EA007163B1/ru not_active IP Right Cessation
- 2002-11-26 WO PCT/US2002/036128 patent/WO2003048130A2/en not_active Ceased
- 2002-11-26 MX MXPA04005123A patent/MXPA04005123A/es unknown
- 2002-11-26 CN CNA028238001A patent/CN1582279A/zh active Pending
- 2002-11-26 AU AU2002356927A patent/AU2002356927A1/en not_active Abandoned
- 2002-11-26 IL IL16157802A patent/IL161578A0/xx unknown
- 2002-11-26 HU HU0402486A patent/HUP0402486A3/hu unknown
- 2002-11-26 KR KR1020047008021A patent/KR20050044606A/ko not_active Withdrawn
- 2002-11-26 HR HR20040469A patent/HRP20040469A2/hr not_active Application Discontinuation
- 2002-11-26 JP JP2003549322A patent/JP2005517643A/ja active Pending
- 2002-11-26 CA CA002468846A patent/CA2468846A1/en not_active Abandoned
- 2002-11-26 PL PL02370515A patent/PL370515A1/xx not_active Application Discontinuation
-
2004
- 2004-05-27 CO CO04049275A patent/CO5640129A2/es not_active Application Discontinuation
- 2004-05-27 ZA ZA200404173A patent/ZA200404173B/en unknown
- 2004-06-29 NO NO20042737A patent/NO20042737L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL161578A0 (en) | 2004-09-27 |
| NO20042737L (no) | 2004-08-17 |
| ZA200404173B (en) | 2005-08-23 |
| AU2002356927A1 (en) | 2003-06-17 |
| WO2003048130A3 (en) | 2003-11-20 |
| PL370515A1 (en) | 2005-05-30 |
| US20050020652A1 (en) | 2005-01-27 |
| MXPA04005123A (es) | 2005-02-17 |
| EA007163B1 (ru) | 2006-08-25 |
| US7544812B2 (en) | 2009-06-09 |
| WO2003048130A2 (en) | 2003-06-12 |
| EP1453811A2 (en) | 2004-09-08 |
| KR20050044606A (ko) | 2005-05-12 |
| EA200400748A1 (ru) | 2004-12-30 |
| JP2005517643A (ja) | 2005-06-16 |
| BR0214437A (pt) | 2004-10-13 |
| HRP20040469A2 (en) | 2004-10-31 |
| CA2468846A1 (en) | 2003-06-12 |
| CN1582279A (zh) | 2005-02-16 |
| NZ532909A (en) | 2006-08-31 |
| HUP0402486A3 (en) | 2007-05-02 |
| CO5640129A2 (es) | 2006-05-31 |
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