HUP0401301A3 - Pyrrolo pyrimidines, process for their preparation, their use and pharmaceutical compositions containing them - Google Patents

Pyrrolo pyrimidines, process for their preparation, their use and pharmaceutical compositions containing them

Info

Publication number: HUP0401301A3
Authority: HU; Hungary
Prior art keywords: preparation; pharmaceutical compositions; compositions containing; pyrimidines; pyrrolo
Prior art date: 2001-08-30

Application number

HU0401301A

Other languages

English (en)

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-30

Filing date

2002-08-29

Publication date

2008-03-28

2002-08-29 Application filed by Novartis Ag filed Critical Novartis Ag

2004-10-28 Publication of HUP0401301A2 publication Critical patent/HUP0401301A2/hu

2008-03-28 Publication of HUP0401301A3 publication Critical patent/HUP0401301A3/hu

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Oncology (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Transplantation (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Vascular Medicine (AREA)
Communicable Diseases (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

HU0401301A 2001-08-30 2002-08-29 Pyrrolo pyrimidines, process for their preparation, their use and pharmaceutical compositions containing them HUP0401301A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0121033.5A GB0121033D0 (en)	2001-08-30	2001-08-30	Organic compounds
PCT/EP2002/009663 WO2003020721A1 (en)	2001-08-30	2002-08-29	Pyrrolo pyrimidines as agents for the inhibition of cystein proteases

Publications (2)

Publication Number	Publication Date
HUP0401301A2 HUP0401301A2 (hu)	2004-10-28
HUP0401301A3 true HUP0401301A3 (en)	2008-03-28

Family

ID=9921234

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0401301A HUP0401301A3 (en)	2001-08-30	2002-08-29	Pyrrolo pyrimidines, process for their preparation, their use and pharmaceutical compositions containing them

Country Status (29)

Country	Link
US (2)	US7452886B2 (hu)
EP (1)	EP1423391B8 (hu)
JP (1)	JP4629334B2 (hu)
KR (1)	KR100695845B1 (hu)
CN (1)	CN100372849C (hu)
AR (1)	AR036374A1 (hu)
AT (1)	ATE326469T1 (hu)
AU (1)	AU2002333760B2 (hu)
BR (1)	BR0212226A (hu)
CA (1)	CA2458684C (hu)
CY (1)	CY1105573T1 (hu)
DE (1)	DE60211530T2 (hu)
DK (1)	DK1423391T3 (hu)
EC (1)	ECSP044998A (hu)
ES (1)	ES2262888T3 (hu)
GB (1)	GB0121033D0 (hu)
HU (1)	HUP0401301A3 (hu)
IL (3)	IL160367A0 (hu)
MX (1)	MXPA04001935A (hu)
MY (1)	MY157368A (hu)
NO (1)	NO328890B1 (hu)
NZ (1)	NZ531343A (hu)
PE (1)	PE20030418A1 (hu)
PL (1)	PL368280A1 (hu)
PT (1)	PT1423391E (hu)
RU (1)	RU2331644C2 (hu)
TW (1)	TWI297690B (hu)
WO (1)	WO2003020721A1 (hu)
ZA (1)	ZA200401042B (hu)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030144234A1 (en) *	2001-08-30	2003-07-31	Buxton Francis Paul	Methods for the treatment of chronic pain and compositions therefor
SE0201980D0 (sv) *	2002-06-24	2002-06-24	Astrazeneca Ab	Novel compounds
GB0220187D0 (en)	2002-08-30	2002-10-09	Novartis Ag	Organic compounds
KR101095807B1 (ko)	2002-09-24	2011-12-21	노파르티스 아게	탈수초성 장애의 치료에 있어서의 스핑고신-1-포스페이트 수용체 아고니스트
AR043692A1 (es) *	2003-02-06	2005-08-10	Novartis Ag	2-cianopirrolopirimidinas y sus usos farmaceuticos
GB0304640D0 (en) *	2003-02-28	2003-04-02	Novartis Ag	Organic compounds
JP4710606B2 (ja) *	2003-04-18	2011-06-29	小野薬品工業株式会社	スピロピペリジン化合物およびその医薬用途
MXPA05011593A (es) *	2003-04-28	2005-12-15	Novartis Ag	Composicion farmaceutica que comprende un inhibidor de catepsina s y un opioide.
EP1797883A3 (en) *	2003-04-28	2007-08-01	Novartis AG	Pharmaceutical composition comprising a cathepsin S inhibitor and an opioid
CA2523085A1 (en) *	2003-04-30	2004-11-18	Fmc Corporation	Insecticidal (dihalopropenyl) phenylalkyl substituted dihydrobenzofuran and dihydrobenzopyran derivatives
WO2005011703A1 (en) *	2003-08-04	2005-02-10	Akzo Nobel N.V.	2-cyano-1,3,5-triazine-4,6-diamine derivatives
EP1786816A4 (en) *	2003-09-10	2009-11-04	Virochem Pharma Inc	SPIROHYDANTOIN COMPOUNDS AND METHODS FOR MODULATING CHEMOKINE RECEPTOR ACTIVITY
MXPA06009019A (es)	2004-02-18	2007-03-08	Astrazeneca Ab	Compuestos de tetrazol y su uso como antagonistas del receptor de glutamato metabotropico.
US20070197510A1 (en) *	2004-03-10	2007-08-23	Kazuyuki Ohmoto	Nitriles and medicinal compositions containing the same as the active ingredient
ES2251292B1 (es)	2004-04-20	2007-07-01	Inke, S.A.	Procedimiento para la obtencion de un compuesto farmaceuticamente activo y de sus intermedios de sintesis.
CN1980934B (zh)	2004-05-03	2011-10-26	詹森药业有限公司	作为选择性雄激素受体调节剂（sarms）的新的吲哚衍生物
TW200614993A (en)	2004-06-11	2006-05-16	Akzo Nobel Nv	4-phenyl-pyrimidine-2-carbonitrile derivatives
US7951816B2 (en)	2004-08-27	2011-05-31	Ono Pharmaceutical Co., Ltd.	Compound containing basic group and use thereof
KR100651849B1 (ko) *	2005-02-01	2006-12-01	엘지전자 주식회사	세탁기
RU2424234C2 (ru) *	2005-08-05	2011-07-20	Ибриженикс Са	Новые ингибиторы цистеиновых протеаз и их терапевтическое применение
AU2006286489B2 (en)	2005-09-01	2012-08-09	Ares Trading S.A.	Treatment of optic neuritis
TW200745055A (en) *	2005-09-23	2007-12-16	Organon Nv	4-Phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives
US7326715B2 (en)	2005-09-23	2008-02-05	N.V. Organon	4-Phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives
AR056720A1 (es) *	2005-10-26	2007-10-17	Smithkline Beecham Corp	Compuesto de tiazol substtuido composicion farmaceuticamente que lo comprende y su uso para preparar un medicamento
WO2007058322A1 (ja)	2005-11-18	2007-05-24	Ono Pharmaceutical Co., Ltd.	塩基性基を含有する化合物およびその用途
EP1957494A2 (en) *	2005-12-05	2008-08-20	Incyte Corporation	Lactam compounds and methods of using the same
US7687515B2 (en)	2006-01-17	2010-03-30	N.V. Organon	6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives
US8618122B2 (en)	2006-05-16	2013-12-31	Ono Pharmaceutical Co., Ltd.	Compound having acidic group which may be protected, and use thereof
WO2008032191A2 (en)	2006-09-13	2008-03-20	Astrazeneca Ab	Spiro-oxazolidinone compounds and their use as metabotropic glutamate receptor potentiators
TW200911803A (en) *	2007-07-16	2009-03-16	Organon Nv	6-phenyl-1H-imidazo [4,5-c] pyridine-4-carbonitrile derivatives
US7932251B2 (en)	2007-07-16	2011-04-26	N.V. Organon	6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives
AU2008312055A1 (en)	2007-10-19	2009-04-23	Astrazeneca Ab	Tetrazole derivatives as modulators of metabotropic glutamate receptors (mGluRs)
JP2011525189A (ja)	2008-06-20	2011-09-15	ノバルティスアーゲー	多発性硬化症を治療するための小児科の組成物
TW201035094A (en)	2009-01-16	2010-10-01	Organon Nv	6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives
US8026236B2 (en)	2009-01-16	2011-09-27	N.V. Organon	6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives
CA2766100C (en)	2009-06-29	2018-05-22	Incyte Corporation	Pyrimidinones as pi3k inhibitors
WO2011075643A1 (en)	2009-12-18	2011-06-23	Incyte Corporation	Substituted heteroaryl fused derivatives as pi3k inhibitors
CN102892768A (zh)	2009-12-30	2013-01-23	艾科尔公司	被取代的吡咯并氨基嘧啶化合物
EP2523954B1 (en)	2010-01-15	2014-04-16	Merck Sharp & Dohme B.V.	1h-[1,2,3]triazolo[4,5-c]pyridine-4- carbonitrile derivatives as cathepsin s inhibitors
WO2011130342A1 (en)	2010-04-14	2011-10-20	Incyte Corporation	FUSED DERIVATIVES AS ΡI3Κδ INHIBITORS
WO2011163195A1 (en)	2010-06-21	2011-12-29	Incyte Corporation	Fused pyrrole derivatives as pi3k inhibitors
WO2012027495A1 (en)	2010-08-27	2012-03-01	University Of The Pacific	Piperazinylpyrimidine analogues as protein kinase inhibitors
EP2626431B1 (en)	2010-10-06	2015-09-16	Fundació Institut de Recerca Biomèdica (IRB Barcelona)	Method for the diagnosis, prognosis and treatment of breast cancer metastasis
ES2764848T3 (es)	2010-12-20	2020-06-04	Incyte Holdings Corp	N-(1-(fenilo sustituido)etilo)-9H-purina-6-aminas como inhibidores de PI3K
WO2012125629A1 (en)	2011-03-14	2012-09-20	Incyte Corporation	Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors
US9126948B2 (en)	2011-03-25	2015-09-08	Incyte Holdings Corporation	Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
KR102131612B1 (ko)	2011-09-02	2020-07-08	인사이트 홀딩스 코포레이션	Ｐｉ３ｋ 억제제로서 헤테로시클릴아민
AR090548A1 (es)	2012-04-02	2014-11-19	Incyte Corp	Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
EP2650682A1 (en)	2012-04-09	2013-10-16	Fundació Privada Institut de Recerca Biomèdica	Method for the prognosis and treatment of cancer metastasis
MX355055B (es) *	2012-04-17	2018-04-03	Astellas Pharma Inc	Compuesto heterociclico aromatico biciclico nitrogenado.
CN104603288B (zh)	2012-06-06	2018-12-14	生物医学研究机构基金会	用于肺癌转移的诊断、预后和治疗的方法
US10119171B2 (en)	2012-10-12	2018-11-06	Inbiomotion S.L.	Method for the diagnosis, prognosis and treatment of prostate cancer metastasis
HK1213946A1 (zh)	2012-10-12	2016-07-15	Inbiomotion S.L.	用於使用c-maf对前列腺癌转移进行诊断、预後和治疗的方法
US20160032399A1 (en)	2013-03-15	2016-02-04	Inbiomotion S.L.	Method for the Prognosis and Treatment of Renal Cell Carcinoma Metastasis
US20160032400A1 (en)	2013-03-15	2016-02-04	Fundació Institut De Recerca Biomèdica (Irb Barcelona)	Method for the prognosis and treatment of cancer metastasis
EP3055429B1 (en)	2013-10-09	2019-03-27	Fundació Institut de Recerca Biomèdica (IRB Barcelona)	Method for the prognosis and treatment of metastasizing cancer of the bone originating from breast cancer
WO2015191677A1 (en)	2014-06-11	2015-12-17	Incyte Corporation	Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
EP3229909B1 (en)	2014-12-11	2020-10-14	Inbiomotion S.L.	Binding members for human c-maf
SI3831833T1 (sl)	2015-02-27	2023-03-31	Incyte Holdings Corporation	Postopki za pripravo inhibitorja PI3K
WO2016183063A1 (en)	2015-05-11	2016-11-17	Incyte Corporation	Crystalline forms of a pi3k inhibitor
WO2016183060A1 (en)	2015-05-11	2016-11-17	Incyte Corporation	Process for the synthesis of a phosphoinositide 3-kinase inhibitor
KR102867720B1 (ko)	2016-05-25	2025-10-01	인바이오모션 에스.엘.	c-MAF 상태에 기초한 유방암의 치료
AU2018372762B2 (en)	2017-11-22	2025-08-21	Inbiomotion S.L.	Therapeutic treatment of breast cancer based on c-maf status
KR102054910B1 (ko) *	2017-12-19	2019-12-12	한림제약(주)	피롤로[2,3-d]피리미딘 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
EP3781156A4 (en)	2018-04-16	2022-05-18	C4 Therapeutics, Inc.	SPIROCYCLIC COMPOUNDS
EP3556760A1 (en) *	2018-04-19	2019-10-23	F. Hoffmann-La Roche AG	Spiro compounds
IL278889B2 (en)	2018-06-01	2025-11-01	Incyte Corp	Dosing regimen for the treatment of pi3k related disorders
WO2020201572A1 (en)	2019-04-05	2020-10-08	Université De Bretagne Occidentale	Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning
WO2022226166A1 (en) *	2021-04-22	2022-10-27	Protego Biopharma, Inc.	Spirocyclic imidazolidinones and imidazolidinediones for treatment of light chain amyloidosis
CA3239086A1 (en) *	2021-12-01	2023-06-08	St Pharm Co., Ltd.	Method for preparing triazolopyrimidinone derivative

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1251074B (de)	1960-11-02	1967-09-28	J R Geigy A -G , Basel (Schweiz)	Selektives Herbizid
CH627919A5 (de)	1977-04-14	1982-02-15	Ciba Geigy Ag	Herbizide mittel.
US5958930A (en) *	1991-04-08	1999-09-28	Duquesne University Of The Holy Ghost	Pyrrolo pyrimidine and furo pyrimidine derivatives
DK0682027T3 (da) *	1994-05-03	1998-05-04	Ciba Geigy Ag	Pyrrolopyrimidinderivater med antiproliferativ virkning
US5683999A (en) *	1995-03-17	1997-11-04	The Dupont Merck Pharmaceutical Company	Cyclic urea HIV protease inhibitors
DK0831829T3 (da) *	1995-06-07	2003-12-15	Pfizer	Heterocykliske, ringkondenserede pyrimidinderivater
CA2283961A1 (en) *	1997-03-19	1998-09-24	Basf Aktiengesellschaft	Pyrrolo[2,3d]pyrimidines and their use as tyrosine kinase inhibitors
JP2002519325A (ja) *	1998-06-30	2002-07-02	イーライ・リリー・アンド・カンパニー	二環性ｓＰＬＡ２インヒビター
CA2344249A1 (en) *	1998-09-18	2000-03-30	Basf Aktiengesellschaft	Pyrrolopyrimidines as protein kinase inhibitors
JP4078074B2 (ja) *	1999-12-10	2008-04-23	ファイザー・プロダクツ・インク	ピロロ［２，３−ｄ］ピリミジン化合物
EP1265897A1 (en) *	2000-03-20	2002-12-18	Axys Pharmaceuticals, Inc.	Non-amidine containing protease inhibitors
WO2001083460A1 (en)	2000-04-28	2001-11-08	Tanabe Seiyaku Co., Ltd.	Cyclic compounds

2001
- 2001-08-30 GB GBGB0121033.5A patent/GB0121033D0/en not_active Ceased
2002
- 2002-08-27 MY MYPI20023181A patent/MY157368A/en unknown
- 2002-08-28 AR ARP020103229A patent/AR036374A1/es unknown
- 2002-08-28 TW TW091119570A patent/TWI297690B/zh not_active IP Right Cessation
- 2002-08-29 WO PCT/EP2002/009663 patent/WO2003020721A1/en not_active Ceased
- 2002-08-29 HU HU0401301A patent/HUP0401301A3/hu unknown
- 2002-08-29 AT AT02797553T patent/ATE326469T1/de active
- 2002-08-29 KR KR1020047003048A patent/KR100695845B1/ko not_active Expired - Fee Related
- 2002-08-29 PE PE2002000833A patent/PE20030418A1/es not_active Application Discontinuation
- 2002-08-29 ES ES02797553T patent/ES2262888T3/es not_active Expired - Lifetime
- 2002-08-29 PL PL02368280A patent/PL368280A1/xx not_active Application Discontinuation
- 2002-08-29 RU RU2004109815/04A patent/RU2331644C2/ru not_active IP Right Cessation
- 2002-08-29 CA CA002458684A patent/CA2458684C/en not_active Expired - Fee Related
- 2002-08-29 JP JP2003524991A patent/JP4629334B2/ja not_active Expired - Fee Related
- 2002-08-29 MX MXPA04001935A patent/MXPA04001935A/es active IP Right Grant
- 2002-08-29 NZ NZ531343A patent/NZ531343A/en not_active IP Right Cessation
- 2002-08-29 AU AU2002333760A patent/AU2002333760B2/en not_active Ceased
- 2002-08-29 CN CNB028168402A patent/CN100372849C/zh not_active Expired - Fee Related
- 2002-08-29 IL IL16036702A patent/IL160367A0/xx unknown
- 2002-08-29 PT PT02797553T patent/PT1423391E/pt unknown
- 2002-08-29 DE DE60211530T patent/DE60211530T2/de not_active Expired - Lifetime
- 2002-08-29 BR BR0212226-0A patent/BR0212226A/pt not_active Application Discontinuation
- 2002-08-29 DK DK02797553T patent/DK1423391T3/da active
- 2002-08-29 US US10/487,760 patent/US7452886B2/en not_active Expired - Fee Related
- 2002-08-29 EP EP02797553A patent/EP1423391B8/en not_active Expired - Lifetime
2004
- 2004-02-09 ZA ZA200401042A patent/ZA200401042B/en unknown
- 2004-02-12 IL IL160367A patent/IL160367A/en not_active IP Right Cessation
- 2004-03-01 EC EC2004004998A patent/ECSP044998A/es unknown
- 2004-03-19 NO NO20041180A patent/NO328890B1/no not_active IP Right Cessation
2006
- 2006-08-03 CY CY20061101095T patent/CY1105573T1/el unknown
2008
- 2008-09-25 US US12/237,896 patent/US20090054467A1/en not_active Abandoned
2009
- 2009-05-07 IL IL198643A patent/IL198643A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
TWI297690B (en)	2008-06-11
RU2331644C2 (ru)	2008-08-20
DE60211530D1 (de)	2006-06-22
CA2458684A1 (en)	2003-03-13
EP1423391B1 (en)	2006-05-17
ZA200401042B (en)	2004-10-25
MY157368A (en)	2016-06-15
US7452886B2 (en)	2008-11-18
IL198643A (en)	2010-12-30
NZ531343A (en)	2006-01-27
KR100695845B1 (ko)	2007-03-20
ECSP044998A (es)	2004-04-28
AU2002333760B2 (en)	2007-01-04
PE20030418A1 (es)	2003-06-12
US20050054851A1 (en)	2005-03-10
IL160367A (en)	2009-12-24
MXPA04001935A (es)	2004-06-15
CA2458684C (en)	2009-04-07
DK1423391T3 (da)	2006-09-25
NO20041180L (no)	2004-03-19
GB0121033D0 (en)	2001-10-24
EP1423391B8 (en)	2007-12-12
IL160367A0 (en)	2004-07-25
CN1549817A (zh)	2004-11-24
KR20040029123A (ko)	2004-04-03
JP2005502683A (ja)	2005-01-27
DE60211530T2 (de)	2006-12-21
PL368280A1 (en)	2005-03-21
CN100372849C (zh)	2008-03-05
AR036374A1 (es)	2004-09-01
ES2262888T3 (es)	2006-12-01
WO2003020721A1 (en)	2003-03-13
ATE326469T1 (de)	2006-06-15
US20090054467A1 (en)	2009-02-26
NO328890B1 (no)	2010-06-07
BR0212226A (pt)	2004-08-17
PT1423391E (pt)	2006-09-29
HK1072254A1 (zh)	2005-08-19
RU2004109815A (ru)	2005-10-20
CY1105573T1 (el)	2010-07-28
EP1423391A1 (en)	2004-06-02
JP4629334B2 (ja)	2011-02-09
HUP0401301A2 (hu)	2004-10-28

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HUP0201122A3 (en)	2003-11-28	Pyrimidinone compounds, process for their preparation and pharmaceutical compositions containing them
HUP0402063A3 (en)	2008-03-28	Indole-2-carboxamides process for producing them, pharmaceutical compositions containing them and use thereof
HUP0400989A3 (en)	2011-08-29	Substituted 2-pyridine-cyclohexane-1,4-diamine derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0400784A3 (en)	2007-09-28	Bicyclic heterocondensated pyrrolcarboxamide derivatives, their use and pharmaceutical compositions containing them
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IL169500A0 (en)	2007-07-04	Pyrrolopyridazine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
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HUP0203385A3 (en)	2003-07-28	Pyrimidine derivatives, process for their preparation, pharmaceutical compositions containing them and their use
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HUP0201730A3 (en)	2004-12-28	Thienopyrimidines as phosphodiesterase inhibitors, their use, pharmaceutical compositions containing them and process for the preparation thereof
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HUP0401350A3 (en)	2009-03-02	Novel imidazopyridine compounds with therapeutic effect, process for their preparation and pharmaceutical compositions containing them
HUP0303045A3 (en)	2004-03-29	Pyrimidine derivatives, process for their preparation, pharmaceutical compositions containing them and their use
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HUP0401082A3 (en)	2011-07-28	Substituted 4-aminocyclohexanols, process for their preparation and pharmaceutical compositions containing them

Legal Events

Date	Code	Title	Description
2012-05-29	FD9A	Lapse of provisional protection due to non-payment of fees