HRP20120078T1 - Pirazolinski spojevi kao antagonisti mineralokortikoidnih receptora - Google Patents

Pirazolinski spojevi kao antagonisti mineralokortikoidnih receptora Download PDF

Info

Publication number: HRP20120078T1
Authority: HR; Croatia
Prior art keywords: group; alkyl; cyclopentyl; benzo; tetrahydro
Prior art date: 2006-10-31

Application number

HR20120078T

Other languages

English (en)

Croatian (hr)

Inventor

Jay Meyers Marvin

Barbieri Arhancet Graciela

Chen Xiangyang

Landis Hockerman Susan

Allen Long Scott

William Mahoney Matthew

Bruce Reitz David

Gerace Rico Joseph

Original Assignee

Pfizer Products Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-10-31

Filing date

2007-10-17

Publication date

2012-02-29

2007-10-17 Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.

2012-02-29 Publication of HRP20120078T1 publication Critical patent/HRP20120078T1/hr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Obesity (AREA)
Gastroenterology & Hepatology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Ophthalmology & Optometry (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

HR20120078T 2006-10-31 2007-10-17 Pirazolinski spojevi kao antagonisti mineralokortikoidnih receptora HRP20120078T1 (hr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US86360606P	2006-10-31	2006-10-31
PCT/IB2007/003207 WO2008053300A1 (en)	2006-10-31	2007-10-17	Pyrazoline compounds as mineralocorticoid receptor antagonists

Publications (1)

Publication Number	Publication Date
HRP20120078T1 true HRP20120078T1 (hr)	2012-02-29

Family

ID=39027523

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20120078T HRP20120078T1 (hr)	2006-10-31	2007-10-17	Pirazolinski spojevi kao antagonisti mineralokortikoidnih receptora

Country Status (40)

Country	Link
US (3)	US7781428B2 (es)
EP (1)	EP2089367B1 (es)
JP (1)	JP4977760B2 (es)
KR (1)	KR101107800B1 (es)
CN (1)	CN101541757A (es)
AP (1)	AP2527A (es)
AR (1)	AR063529A1 (es)
AT (1)	ATE537151T1 (es)
AU (1)	AU2007315884B2 (es)
BR (1)	BRPI0717937A2 (es)
CA (1)	CA2667966C (es)
CL (1)	CL2007003154A1 (es)
CO (1)	CO6160307A2 (es)
CR (1)	CR10725A (es)
CU (1)	CU23779B7 (es)
CY (1)	CY1112311T1 (es)
DK (1)	DK2089367T3 (es)
EA (1)	EA016370B1 (es)
ES (1)	ES2375877T3 (es)
GE (1)	GEP20115239B (es)
GT (1)	GT200700096A (es)
HN (1)	HN2007000437A (es)
HR (1)	HRP20120078T1 (es)
IL (1)	IL198241A0 (es)
MA (1)	MA30821B1 (es)
MX (1)	MX2009004662A (es)
MY (1)	MY145795A (es)
NI (1)	NI200900071A (es)
NO (1)	NO20091741L (es)
NZ (1)	NZ575923A (es)
PE (1)	PE20081472A1 (es)
PL (1)	PL2089367T3 (es)
PT (1)	PT2089367E (es)
RS (2)	RS20090208A (es)
SI (1)	SI2089367T1 (es)
TN (1)	TN2009000160A1 (es)
TW (1)	TWI357327B (es)
UA (1)	UA92670C2 (es)
UY (1)	UY30670A1 (es)
WO (1)	WO2008053300A1 (es)

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EP2568986B1 (en)	2010-05-10	2016-01-13	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and compositions for the treatment of fluid accumulation in and/ or under the retina
CA2798831A1 (en)	2010-05-11	2011-11-17	Pfizer Inc.	Morpholine compounds as mineralocorticoid receptor antagonists
JP6180930B2 (ja)	2010-06-16	2017-08-16	アンスティチュナショナルドゥラサンテエドゥラルシェルシュメディカル	創傷治癒過程における再上皮化を刺激するための方法及び組成物
CN102372710A (zh)	2010-08-18	2012-03-14	山东轩竹医药科技有限公司	作为盐皮质激素受体拮抗剂的并环类化合物
WO2012048022A2 (en) *	2010-10-05	2012-04-12	Nova Southeastern University	Methods and compositions for therapeutic modulation of aldosterone levels in heart disease
MX367404B (es)	2014-06-30	2019-08-20	Astrazeneca Ab	Amidas de benzoxazinona como moduladores del receptor de mineralocorticoides.
ES2846835T3 (es)	2015-10-13	2021-07-29	Inst Nat Sante Rech Med	Métodos y composiciones farmacéuticas para el tratamiento de la neovascularización coroidea
ES2973248T3 (es)	2016-07-26	2024-06-19	Inst Nat Sante Rech Med	Antagonista del receptor mineralocorticoide para el tratamiento de la osteoartritis
ES2859478T3 (es)	2016-09-02	2021-10-04	Bristol Myers Squibb Co	Compuestos heterocíclicos tricíclicos sustituidos
WO2019032631A1 (en)	2017-08-09	2019-02-14	Bristol-Myers Squibb Company	Oxime ether compounds
WO2019032632A1 (en)	2017-08-09	2019-02-14	Bristol-Myers Squibb Company	ALKYLPHENYL COMPOUNDS
WO2021180818A1 (en)	2020-03-11	2021-09-16	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods of determining whether a subject has or is at risk of having a central serous chorioretinopathy
US20240366632A1 (en)	2021-08-31	2024-11-07	Institut National de la Santé et de la Recherche Médicale	Methods for the treatment of ocular rosacea
CN113679716B (zh)	2021-10-13	2024-03-26	史大永	溴酚-吡唑啉化合物在治疗猫冠状病毒疾病中的应用
CN114230457B (zh) *	2022-01-04	2023-06-09	中山大学	一类2-亚苄基四氢萘酮衍生物及其制备方法和应用

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2007
- 2007-10-17 RS RSP-2009/0208A patent/RS20090208A/sr unknown
- 2007-10-17 MX MX2009004662A patent/MX2009004662A/es active IP Right Grant
- 2007-10-17 AP AP2009004822A patent/AP2527A/xx active
- 2007-10-17 NZ NZ575923A patent/NZ575923A/en not_active IP Right Cessation
- 2007-10-17 WO PCT/IB2007/003207 patent/WO2008053300A1/en not_active Ceased
- 2007-10-17 EP EP07825488A patent/EP2089367B1/en active Active
- 2007-10-17 AU AU2007315884A patent/AU2007315884B2/en not_active Ceased
- 2007-10-17 CA CA2667966A patent/CA2667966C/en not_active Expired - Fee Related
- 2007-10-17 PT PT07825488T patent/PT2089367E/pt unknown
- 2007-10-17 UA UAA200903302A patent/UA92670C2/ru unknown
- 2007-10-17 BR BRPI0717937-5A2A patent/BRPI0717937A2/pt not_active IP Right Cessation
- 2007-10-17 ES ES07825488T patent/ES2375877T3/es active Active
- 2007-10-17 KR KR1020097008836A patent/KR101107800B1/ko not_active Expired - Fee Related
- 2007-10-17 MY MYPI20091613A patent/MY145795A/en unknown
- 2007-10-17 CN CNA2007800433330A patent/CN101541757A/zh active Pending
- 2007-10-17 GE GEAP200711240A patent/GEP20115239B/en unknown
- 2007-10-17 SI SI200730830T patent/SI2089367T1/sl unknown
- 2007-10-17 RS RS20120051A patent/RS52203B/sr unknown
- 2007-10-17 DK DK07825488.5T patent/DK2089367T3/da active
- 2007-10-17 HR HR20120078T patent/HRP20120078T1/hr unknown
- 2007-10-17 PL PL07825488T patent/PL2089367T3/pl unknown
- 2007-10-17 JP JP2009533977A patent/JP4977760B2/ja not_active Expired - Fee Related
- 2007-10-17 AT AT07825488T patent/ATE537151T1/de active
- 2007-10-17 EA EA200970341A patent/EA016370B1/ru not_active IP Right Cessation
- 2007-10-24 US US11/923,248 patent/US7781428B2/en not_active Expired - Fee Related
- 2007-10-29 UY UY30670A patent/UY30670A1/es not_active Application Discontinuation
- 2007-10-29 AR ARP070104787A patent/AR063529A1/es not_active Application Discontinuation
- 2007-10-30 PE PE2007001482A patent/PE20081472A1/es not_active Application Discontinuation
- 2007-10-30 GT GT200700096A patent/GT200700096A/es unknown
- 2007-10-30 TW TW096140838A patent/TWI357327B/zh not_active IP Right Cessation
- 2007-10-31 CL CL200703154A patent/CL2007003154A1/es unknown
- 2007-10-31 HN HN2007000437A patent/HN2007000437A/es unknown
2009
- 2009-04-17 CU CU20090058A patent/CU23779B7/es not_active IP Right Cessation
- 2009-04-17 CR CR10725A patent/CR10725A/es not_active Application Discontinuation
- 2009-04-20 IL IL198241A patent/IL198241A0/en unknown
- 2009-04-21 CO CO09040130A patent/CO6160307A2/es unknown
- 2009-04-24 TN TNP2009000160A patent/TN2009000160A1/fr unknown
- 2009-04-29 NI NI200900071A patent/NI200900071A/es unknown
- 2009-04-30 MA MA31831A patent/MA30821B1/fr unknown
- 2009-05-04 NO NO20091741A patent/NO20091741L/no not_active Application Discontinuation
2010
- 2010-07-12 US US12/834,117 patent/US20100280016A1/en not_active Abandoned
2011
- 2011-10-20 US US13/277,270 patent/US20120035131A1/en not_active Abandoned
2012
- 2012-01-23 CY CY20121100076T patent/CY1112311T1/el unknown

Also Published As

Publication number	Publication date
RS52203B (sr)	2012-10-31
CO6160307A2 (es)	2010-05-20
US7781428B2 (en)	2010-08-24
EP2089367B1 (en)	2011-12-14
HN2007000437A (es)	2011-01-17
KR20090060371A (ko)	2009-06-11
WO2008053300A1 (en)	2008-05-08
JP2010508257A (ja)	2010-03-18
RS20090208A (sr)	2010-06-30
GT200700096A (es)	2010-07-15
AU2007315884B2 (en)	2012-10-04
US20100280016A1 (en)	2010-11-04
CA2667966A1 (en)	2008-05-08
CR10725A (es)	2009-05-12
TWI357327B (en)	2012-02-01
TN2009000160A1 (fr)	2010-10-18
MY145795A (en)	2012-04-30
DK2089367T3 (da)	2012-02-06
EA200970341A1 (ru)	2009-10-30
PE20081472A1 (es)	2008-10-18
AU2007315884A1 (en)	2008-05-08
CL2007003154A1 (es)	2008-05-09
EP2089367A1 (en)	2009-08-19
IL198241A0 (en)	2009-12-24
NZ575923A (en)	2011-01-28
AP2527A (en)	2012-12-06
GEP20115239B (en)	2011-06-10
BRPI0717937A2 (pt)	2013-12-03
US20080167294A1 (en)	2008-07-10
TW200822924A (en)	2008-06-01
CN101541757A (zh)	2009-09-23
UY30670A1 (es)	2008-05-31
UA92670C2 (ru)	2010-11-25
ATE537151T1 (de)	2011-12-15
ES2375877T3 (es)	2012-03-07
CU20090058A7 (es)	2011-07-11
CA2667966C (en)	2011-08-02
CU23779B7 (es)	2012-02-15
NI200900071A (es)	2010-03-08
US20120035131A1 (en)	2012-02-09
AP2009004822A0 (en)	2009-04-30
MA30821B1 (fr)	2009-10-01
SI2089367T1 (sl)	2012-02-29
NO20091741L (no)	2009-05-29
PL2089367T3 (pl)	2012-04-30
JP4977760B2 (ja)	2012-07-18
EA016370B1 (ru)	2012-04-30
CY1112311T1 (el)	2015-12-09
KR101107800B1 (ko)	2012-01-25
MX2009004662A (es)	2009-05-22
AR063529A1 (es)	2009-01-28
PT2089367E (pt)	2012-02-01

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