HRP20041201A2 - Diphenyl azetidinones substituted by acidic groups, method for their production, medicaments containing said compounds and use thereof - Google Patents

Diphenyl azetidinones substituted by acidic groups, method for their production, medicaments containing said compounds and use thereof

Info

Publication number: HRP20041201A2
Authority: HR; Croatia
Prior art keywords: compounds; production; acidic groups; medicaments containing; substituted
Prior art date: 2002-06-19

Application number

HR20041201A

Inventor

Jaehne Gerhard

Frick Wendelin

Flohr Stefanie

Lindenschmidt Andreas

Glombik Heiner

Kramer Werner

Heuer Hubert

Schaefer Hans-Ludwig

Original Assignee

Aventis Pharma Deutschland Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-06-19

Filing date

2003-06-04

Publication date

2005-08-31

2003-06-04 Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh

2005-08-31 Publication of HRP20041201A2 publication Critical patent/HRP20041201A2/en

2006-12-31 Publication of HRPK20041201B3 publication Critical patent/HRPK20041201B3/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/568—Four-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Biochemistry (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Hematology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

HR20041201A 2002-06-19 2003-06-04 Diphenyl azetidinones substituted by acidic groups, method for their production, medicaments containing said compounds and use thereof HRPK20041201B3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10227508A DE10227508A1 (en)	2002-06-19	2002-06-19	Acid group-substituted diphenylazetidinones, processes for their preparation, pharmaceutical compositions containing them and their use
PCT/EP2003/005816 WO2004000805A1 (en)	2002-06-19	2003-06-04	Diphenyl azetidinones substituted by acidic groups, method for their production, medicaments containing said compounds and use thereof

Publications (2)

Publication Number	Publication Date
HRP20041201A2 true HRP20041201A2 (en)	2005-08-31
HRPK20041201B3 HRPK20041201B3 (en)	2006-12-31

Family

ID=29719283

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20041201A HRPK20041201B3 (en)	2002-06-19	2003-06-04	Diphenyl azetidinones substituted by acidic groups, method for their production, medicaments containing said compounds and use thereof

Country Status (28)

Country	Link
EP (1)	EP1517891B1 (en)
JP (1)	JP2005533073A (en)
KR (1)	KR20050008835A (en)
CN (1)	CN100467448C (en)
AR (1)	AR039690A1 (en)
AU (1)	AU2003238210B2 (en)
BR (1)	BR0311896A (en)
CA (1)	CA2490112A1 (en)
DE (1)	DE10227508A1 (en)
EC (1)	ECSP045497A (en)
HN (1)	HN2003000185A (en)
HR (1)	HRPK20041201B3 (en)
IL (1)	IL165789A0 (en)
MA (1)	MA27206A1 (en)
MX (1)	MXPA04012093A (en)
NO (1)	NO20050134L (en)
OA (1)	OA12869A (en)
PA (1)	PA8576101A1 (en)
PE (1)	PE20040564A1 (en)
PL (1)	PL372700A1 (en)
RS (1)	RS108404A (en)
RU (1)	RU2287522C2 (en)
SV (1)	SV2004001548A (en)
TN (1)	TNSN04250A1 (en)
TW (1)	TW200413311A (en)
UA (1)	UA78577C2 (en)
UY (1)	UY27853A1 (en)
WO (1)	WO2004000805A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0215579D0 (en)	2002-07-05	2002-08-14	Astrazeneca Ab	Chemical compounds
WO2005061452A1 (en)	2003-12-23	2005-07-07	Astrazeneca Ab	Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity
CA2589483C (en)	2004-12-03	2013-10-29	Schering Corporation	Substituted piperazines as cb1 antagonists
BRPI0609614A2 (en) *	2005-04-04	2010-04-20	Univ Pontificia Catolica Chile	use of ezetimibe in the prevention and treatment of biliary tree cholesterol lithiases
EP1902046B1 (en)	2005-06-20	2009-12-02	Schering Corporation	Piperidine derivatives useful as histamine h3 antagonists
SA06270191B1 (en)	2005-06-22	2010-03-29	استرازينيكا ايه بي	Novel 2-Azetidinone Derivatives as Cholesterol Absorption Inhibitors for the Treatment of Hyperlipidaemic Conditions
AR060623A1 (en)	2006-04-27	2008-07-02	Astrazeneca Ab	COMPOUNDS DERIVED FROM 2-AZETIDINONE AND A PREPARATION METHOD
NZ611323A (en) *	2006-06-23	2014-10-31	Abbvie Bahamas Ltd	Cyclopropyl amine derivatives as histamin h3 receptor modulators
JP2010500300A (en)	2006-08-08	2010-01-07	サノフィ−アベンティス	Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for their preparation, agents containing these compounds, and uses thereof
DE102007002260A1 (en)	2007-01-16	2008-07-31	Sanofi-Aventis	Use of substituted pyranonic acid derivatives for the preparation of medicaments for the treatment of the metabolic syndrome
EP2025674A1 (en)	2007-08-15	2009-02-18	sanofi-aventis	Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs
CN101200443B (en) *	2007-10-17	2011-06-29	中国药科大学	Azetidinone derivatives, processes for their preparation and pharmaceutical combinations containing them
DE102007063671A1 (en)	2007-11-13	2009-06-25	Sanofi-Aventis Deutschland Gmbh	New crystalline diphenylazetidinone hydrates, medicaments containing these compounds and their use
WO2010003624A2 (en)	2008-07-09	2010-01-14	Sanofi-Aventis	Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (en)	2008-12-08	2010-06-17	Sanofi-Aventis	A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
CA2754384A1 (en)	2009-03-06	2010-09-10	Lipideon Biotechnology Ag	Pharmaceutical hypocholesterolemic compositions
CN101993403B (en)	2009-08-11	2012-07-11	浙江海正药业股份有限公司	Azetidinone compound and medical applications thereof
KR20120060207A (en)	2009-08-26	2012-06-11	사노피	Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
WO2011157827A1 (en)	2010-06-18	2011-12-22	Sanofi	Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8828994B2 (en)	2011-03-08	2014-09-09	Sanofi	Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2766349B1 (en)	2011-03-08	2016-06-01	Sanofi	Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
WO2012120056A1 (en)	2011-03-08	2012-09-13	Sanofi	Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
US8828995B2 (en)	2011-03-08	2014-09-09	Sanofi	Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120055A1 (en)	2011-03-08	2012-09-13	Sanofi	Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2567959B1 (en)	2011-09-12	2014-04-16	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LT3300B (en) *	1992-12-23	1995-06-26	Schering Corp	Combination of a cholesterol biosynhtesis inhibitor and a beta- lactam cholesterol absorbtion inhibitor
US5631365A (en) *	1993-09-21	1997-05-20	Schering Corporation	Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US5756470A (en) *	1996-10-29	1998-05-26	Schering Corporation	Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
RU2181297C2 (en) *	2000-06-20	2002-04-20	Эпштейн Олег Ильич	Method of treatment of pathological syndrome and medicinal agent
DE10042447A1 (en) *	2000-08-29	2002-03-28	Aventis Pharma Gmbh	Vertebrate intestinal protein that absorbs cholesterol and use of this protein to identify inhibitors of intestinal cholesterol transport
IL156552A0 (en) *	2000-12-21	2004-01-04	Aventis Pharma Gmbh	Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use
IL156548A0 (en) *	2000-12-21	2004-01-04	Aventis Pharma Gmbh	Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use
DE50111751D1 (en) *	2000-12-21	2007-02-08	Sanofi Aventis Deutschland	NEW DIPHENZYLAZETIDINONE, PROCESS FOR THE PRODUCTION THEREOF, MEDICAMENT CONTAINING THESE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF LIPID METABOLISM DISORDER

2002
- 2002-06-19 DE DE10227508A patent/DE10227508A1/en not_active Withdrawn
2003
- 2003-04-06 UA UAA200500488A patent/UA78577C2/en unknown
- 2003-06-02 SV SV2003001548A patent/SV2004001548A/en not_active Application Discontinuation
- 2003-06-04 CA CA002490112A patent/CA2490112A1/en not_active Abandoned
- 2003-06-04 WO PCT/EP2003/005816 patent/WO2004000805A1/en not_active Ceased
- 2003-06-04 MX MXPA04012093A patent/MXPA04012093A/en active IP Right Grant
- 2003-06-04 EP EP03735535A patent/EP1517891B1/en not_active Expired - Lifetime
- 2003-06-04 HR HR20041201A patent/HRPK20041201B3/en not_active IP Right Cessation
- 2003-06-04 BR BR0311896-7A patent/BR0311896A/en not_active IP Right Cessation
- 2003-06-04 PL PL03372700A patent/PL372700A1/en not_active Application Discontinuation
- 2003-06-04 RS YUP-1084/04A patent/RS108404A/en unknown
- 2003-06-04 RU RU2005101093/04A patent/RU2287522C2/en not_active IP Right Cessation
- 2003-06-04 OA OA1200400331A patent/OA12869A/en unknown
- 2003-06-04 KR KR10-2004-7020643A patent/KR20050008835A/en not_active Ceased
- 2003-06-04 AU AU2003238210A patent/AU2003238210B2/en not_active Ceased
- 2003-06-04 CN CNB038143321A patent/CN100467448C/en not_active Expired - Fee Related
- 2003-06-04 JP JP2004514661A patent/JP2005533073A/en not_active Abandoned
- 2003-06-16 PE PE2003000596A patent/PE20040564A1/en not_active Application Discontinuation
- 2003-06-16 UY UY27853A patent/UY27853A1/en unknown
- 2003-06-17 AR ARP030102144A patent/AR039690A1/en unknown
- 2003-06-17 HN HN2003000185A patent/HN2003000185A/en unknown
- 2003-06-17 TW TW092116321A patent/TW200413311A/en unknown
- 2003-06-18 PA PA20038576101A patent/PA8576101A1/en unknown
2004
- 2004-11-16 MA MA27954A patent/MA27206A1/en unknown
- 2004-12-15 IL IL16578904A patent/IL165789A0/en unknown
- 2004-12-16 EC EC2004005497A patent/ECSP045497A/en unknown
- 2004-12-16 TN TNP2004000250A patent/TNSN04250A1/en unknown
2005
- 2005-01-11 NO NO20050134A patent/NO20050134L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
UA78577C2 (en)	2007-04-10
PL372700A1 (en)	2005-07-25
AU2003238210A1 (en)	2004-01-06
WO2004000805A1 (en)	2003-12-31
NO20050134D0 (en)	2005-01-11
RU2005101093A (en)	2005-07-20
HRPK20041201B3 (en)	2006-12-31
CN1662495A (en)	2005-08-31
EP1517891A1 (en)	2005-03-30
NO20050134L (en)	2005-03-18
JP2005533073A (en)	2005-11-04
DE10227508A1 (en)	2004-01-08
HN2003000185A (en)	2005-10-20
AR039690A1 (en)	2005-03-09
RS108404A (en)	2007-02-05
AU2003238210B2 (en)	2008-10-23
SV2004001548A (en)	2004-03-19
PA8576101A1 (en)	2004-02-07
PE20040564A1 (en)	2004-10-25
OA12869A (en)	2006-09-15
CA2490112A1 (en)	2003-12-31
MXPA04012093A (en)	2005-04-19
CN100467448C (en)	2009-03-11
KR20050008835A (en)	2005-01-21
IL165789A0 (en)	2006-01-15
UY27853A1 (en)	2003-12-31
TNSN04250A1 (en)	2007-03-12
TW200413311A (en)	2004-08-01
HK1079511A1 (en)	2006-04-07
ECSP045497A (en)	2005-03-10
EP1517891B1 (en)	2013-04-03
MA27206A1 (en)	2005-01-03
RU2287522C2 (en)	2006-11-20
BR0311896A (en)	2005-04-05

Publication	Publication Date	Title
HRP20041201A2 (en)	2005-08-31	Diphenyl azetidinones substituted by acidic groups, method for their production, medicaments containing said compounds and use thereof
PL378065A1 (en)	2006-02-20	Substituted n-arylheterocycles, method for production and use thereof as medicaments
HRP20041203A2 (en)	2005-06-30	Ring-substituted diphenyl azetidinones, method for the production thereof, medicaments containing said compounds, and use thereof
IL156552A0 (en)	2004-01-04	Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use
IL156548A0 (en)	2004-01-04	Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use
AU2003257465A1 (en)	2004-02-23	Substituted diaryl heterocycles, method for the production and use thereof as medicaments
IL191926A0 (en)	2008-12-29	Novel thiophenylglycoside derivatives, methods for production thereof, medicaments comprising said compounds and use thereof
ZA200500086B (en)	2006-07-26	Novel carboxamide compounds having an MCH-antagonistic effect, medicaments containing said compounds, and method for the production thereof
IL180874A0 (en)	2007-07-04	Substituted, bicyclic 8-pyrrolidinoxanthines, method for the production thereof and their use as medicaments
AU2002219173A1 (en)	2002-09-05	Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use
PL373329A1 (en)	2005-08-22	Heterocyclically substituted benzoylureas, method for their production and their use as medicaments
HUS1400056I1 (en)	2016-08-29	Glucopyranosyl-substituted benzol derivatives, drugs containing said compounds, the use thereof and method for the production thereof
PL376373A1 (en)	2005-12-27	Selected cgrp antagonists, method for production and use thereof as medicament
IL168056A0 (en)	2009-02-11	Selected cgrp antagonists, method for production and use thereof as medicament
IL191988A0 (en)	2008-12-29	Bicyclic heterocycles, medicaments containing said compounds, use thereof, and method for the production thereof
AU2003226806A1 (en)	2003-11-03	Bicyclic heterocycles, medicaments containing these compounds, their use, and method for the production thereof
PL376399A1 (en)	2005-12-27	Pyridopyrimidinone compounds, method for production thereof and medicaments comprising the same
ATE367152T1 (en)	2007-08-15	PRODUCTION METHOD FOR LOW DOSE PHARMACEUTICAL COMPOSITION
ZA200506422B (en)	2007-02-28	Substituted 4-phenyltetrahydroisoquinolines, method for the production thereof, the use of the same as medicaments, and medicament containing such compounds
HRP20041153A2 (en)	2005-06-30	Substituted thiophenes, method for the production thereof, their use as a medicament or diagnostic reagent, and a medicament containing the same
IL173918A0 (en)	2006-07-05	Substituted thienoimidazoles, method for production and use thereof as medicament or diagnostic and medicaments comprising the same
SI1560826T1 (en)	2006-08-31	Pyridopyrimidinone compounds, method for production thereof and medicaments comprising the same
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PL370271A1 (en)	2005-05-16	Dihydro-thia-phenanthrene-carbonyl-guanidines, method for the production thereof, use thereof as a medicament or diagnostic reagent
ZA200803619B (en)	2009-02-25	Bicyclic heterocycles, medicaments containing said compounds, use thereof, and method for the production thereof

Legal Events

Date	Code	Title	Description
2005-08-31	A1OB	Publication of a patent application
2006-02-09	PNAN	Change of the applicant name, address/residence	Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, DE
2006-03-31	AKOB	Publication of a request for the grant of a patent not including a substantive examination of a patent application (a consensual patent)
2006-12-31	PKB1	Consensual patent granted
2009-06-02	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20090602 Year of fee payment: 7
2010-12-05	PBKO	Lapse due to non-payment of renewal fee for consensual patent	Effective date: 20100605