HRP20041209A2 - Novel adenosine analogues and their use as pharmaceutical agents - Google Patents

Novel adenosine analogues and their use as pharmaceutical agents Download PDF

Info

Publication number: HRP20041209A2
Authority: HR; Croatia
Prior art keywords: alkyl; alkylene; group; pharmaceutically acceptable; hydroxy
Prior art date: 2002-06-27

Application number

HR20041209A

Other languages

English (en)

Croatian (hr)

Inventor

Bigot Antony

Stengelin Siegfried

Jaehne Gerhard

Herling Andreas

M�ller G�nter

Jakob Hock Franz

R. Myers Michael

Original Assignee

Aventis Pharma Deutschland Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-06-27

Filing date

2003-06-26

Publication date

2005-08-31

2003-06-26 Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh

2005-08-31 Publication of HRP20041209A2 publication Critical patent/HRP20041209A2/hr

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Molecular Biology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Vascular Medicine (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

HR20041209A 2002-06-27 2003-06-26 Novel adenosine analogues and their use as pharmaceutical agents HRP20041209A2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02014324A EP1375508A1 (en)	2002-06-27	2002-06-27	N6-substituted adenosine analogues and their use as pharmaceutical agents
PCT/EP2003/006749 WO2004003002A1 (en)	2002-06-27	2003-06-26	Novel adenosine analogues and their use as pharmaceutical agents

Publications (1)

Publication Number	Publication Date
HRP20041209A2 true HRP20041209A2 (en)	2005-08-31

Family

ID=29716849

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20041209A HRP20041209A2 (en)	2002-06-27	2003-06-26	Novel adenosine analogues and their use as pharmaceutical agents

Country Status (19)

Country	Link
EP (2)	EP1375508A1 (es)
JP (1)	JP2006501178A (es)
KR (1)	KR20050014888A (es)
CN (1)	CN1671728A (es)
AR (1)	AR039697A1 (es)
AU (1)	AU2003280141A1 (es)
BR (1)	BR0312428A (es)
CA (1)	CA2490253A1 (es)
HR (1)	HRP20041209A2 (es)
IL (1)	IL165934A0 (es)
MA (1)	MA27465A1 (es)
MX (1)	MXPA04012815A (es)
NO (1)	NO20050398L (es)
PE (1)	PE20040584A1 (es)
PL (1)	PL375197A1 (es)
RU (1)	RU2005101872A (es)
TW (1)	TW200500376A (es)
WO (1)	WO2004003002A1 (es)
ZA (1)	ZA200410062B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GEP20104880B (en)	2005-09-21	2010-01-11	Pfizer Ltd	Carboxamide derivatives as muscarinic receptor antagonists
JP2007153789A (ja) *	2005-12-05	2007-06-21	Mitsui Chemicals Inc	光学活性３−アミノピロリジン誘導体の製造方法
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2011157827A1 (de)	2010-06-18	2011-12-22	Sanofi	Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
EP2567959B1 (en)	2011-09-12	2014-04-16	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CN119039201A (zh) *	2024-07-19	2024-11-29	苏州汉德创宏生化科技有限公司	一种(s)-1-叔丁氧羰基-3-氨基吡咯烷的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1545645A1 (de) *	1965-12-06	1969-08-21	Boehringer Mannheim Gmbh	Verfahren zur Herstellung von disubstituierten Adenosin-Derivaten
AU575438B2 (en) *	1984-10-26	1988-07-28	Warner-Lambert Company	N6 - substituted deoxyribose analogues of adenosines
US4755594A (en) *	1986-01-31	1988-07-05	Warner-Lambert Company	N6 -substituted adenosines
AU8276187A (en) *	1986-10-31	1988-05-25	Warner-Lambert Company	Selected n6-substituted adenosines having selective a2 binding activity
WO1997033591A1 (en) *	1996-03-13	1997-09-18	Novo Nordisk A/S	A method of treating disorders related to cytokines in mammals
US6376472B1 (en) *	1996-07-08	2002-04-23	Aventis Pharmaceuticals, Inc.	Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
UA51716C2 (uk) *	1996-07-08	2002-12-16	Авентіс Фармасьютікалз Продактс Інк.	Сполуки, що мають гіпотензивну, кардіопротекторну, анти-ішемічну та антиліполітичну властивості, фармацевтична композиція та способи лікування
EP0983768A1 (en) *	1997-05-23	2000-03-08	Nippon Shinyaku Co., Ltd.	Medicinal composition for prevention or treatment of hepatopathy
GB9723566D0 (en) *	1997-11-08	1998-01-07	Glaxo Group Ltd	Chemical compounds
GB9723589D0 (en) *	1997-11-08	1998-01-07	Glaxo Group Ltd	Chemical compounds

2002
- 2002-06-27 EP EP02014324A patent/EP1375508A1/en not_active Withdrawn
2003
- 2003-06-18 AR ARP030102151A patent/AR039697A1/es unknown
- 2003-06-25 PE PE2003000640A patent/PE20040584A1/es not_active Application Discontinuation
- 2003-06-26 CA CA002490253A patent/CA2490253A1/en not_active Abandoned
- 2003-06-26 AU AU2003280141A patent/AU2003280141A1/en not_active Abandoned
- 2003-06-26 WO PCT/EP2003/006749 patent/WO2004003002A1/en not_active Ceased
- 2003-06-26 PL PL03375197A patent/PL375197A1/xx not_active Application Discontinuation
- 2003-06-26 IL IL16593403A patent/IL165934A0/xx unknown
- 2003-06-26 CN CNA038179660A patent/CN1671728A/zh active Pending
- 2003-06-26 MX MXPA04012815A patent/MXPA04012815A/es not_active Application Discontinuation
- 2003-06-26 RU RU2005101872/04A patent/RU2005101872A/ru not_active Application Discontinuation
- 2003-06-26 KR KR10-2004-7021262A patent/KR20050014888A/ko not_active Withdrawn
- 2003-06-26 HR HR20041209A patent/HRP20041209A2/hr not_active Application Discontinuation
- 2003-06-26 JP JP2004516688A patent/JP2006501178A/ja active Pending
- 2003-06-26 EP EP03740352A patent/EP1527083A1/en not_active Withdrawn
- 2003-06-26 TW TW092117351A patent/TW200500376A/zh unknown
- 2003-06-26 BR BR0312428-2A patent/BR0312428A/pt not_active IP Right Cessation
2004
- 2004-12-13 ZA ZA200410062A patent/ZA200410062B/xx unknown
- 2004-12-24 MA MA28022A patent/MA27465A1/fr unknown
2005
- 2005-01-25 NO NO20050398A patent/NO20050398L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO20050398L (no)	2005-01-25
BR0312428A (pt)	2005-04-26
EP1375508A1 (en)	2004-01-02
JP2006501178A (ja)	2006-01-12
EP1527083A1 (en)	2005-05-04
WO2004003002A1 (en)	2004-01-08
MXPA04012815A (es)	2005-02-24
CN1671728A (zh)	2005-09-21
AU2003280141A1 (en)	2004-01-19
RU2005101872A (ru)	2005-08-10
MA27465A1 (fr)	2005-08-01
PE20040584A1 (es)	2004-11-03
CA2490253A1 (en)	2004-01-08
IL165934A0 (en)	2006-01-15
PL375197A1 (en)	2005-11-28
KR20050014888A (ko)	2005-02-07
TW200500376A (en)	2005-01-01
ZA200410062B (en)	2008-08-27
AR039697A1 (es)	2005-03-09

Publication	Publication Date	Title
US7265111B2 (en)	2007-09-04	Adenosine analogues and their use as pharmaceutical agents
DE60002356T2 (de)	2004-02-19	Purin-derivate
US7393851B2 (en)	2008-07-01	Azaindole derivatives as inhibitors of p38 kinase
US6294522B1 (en)	2001-09-25	N6 heterocyclic 8-modified adenosine derivatives
DE602004001676T2 (de)	2007-08-30	Triazolo-Pyridine als entzündungshemmende Verbindungen
RU2269527C2 (ru)	2006-02-10	Производные пиридопиримидинов, способы их получения и фармацевтическая композиция на их основе
JP5519513B2 (ja)	2014-06-11	糖尿病などの疾患を処置するためのイミダゾ［１，２−ａ］ピリミジン誘導体
JP2021073302A (ja)	2021-05-13	メチル／フルオロ−ピリジニル−メトキシ置換ピリジノン−ピリジニル化合物及びフルオロ−ピリミジニル−メトキシ置換ピリジノン−ピリジニル化合物
MX2008000355A (es)	2008-03-07	Nuevo derivado de 1,-dioxido de 1,4-benzotiazepina con mejores propiedades, metodo para su produccion, medicamentos que contienen este compuesto y su uso.
CN1378550A (zh)	2002-11-06	部分或完全a1激动剂－n6杂环5′硫代腺苷衍生物
MX2008000426A (es)	2008-03-10	Derivados de 1,1-dioxido de 1,4-benzotiazepina, procedimiento para su preparacion, medicamentos que comprende este compuesto y su uso como un hipolipidemico.
CA2375385C (en)	2006-02-14	Propargyl phenyl ether a2a receptor agonists
Yoshimura et al.	1997	A facile, alternative synthesis of 4 ‘-thioarabinonucleosides and their biological activities
KR20070046868A (ko)	2007-05-03	아릴-치환된 폴리사이클릭 아민, 이의 제조방법 및약제로서의 이의 용도
SK4742002A3 (en)	2003-05-02	Purine derivatives
JP2008517983A (ja)	2008-05-29	プロテインキナーゼ阻害剤としてのオルト縮合ピリジンおよびピリミジン誘導体（例えば、プリン類）
KR20080104341A (ko)	2008-12-02	내피 리파제의 억제제로서의 이미다조피리딘-2-온 유도체
JP2009526855A (ja)	2009-07-23	アルファカルボリンおよびその使用
US20070004684A1 (en)	2007-01-04	Alpha-Carbolines as CDK-1 inhibitors
HRP20041209A2 (en)	2005-08-31	Novel adenosine analogues and their use as pharmaceutical agents
CN1910181A (zh)	2007-02-07	杂环基取代的7－氨基－4－喹诺酮－3－甲酸衍生物、其生产方法及其作为药物的用途
WO1998035977A1 (en)	1998-08-20	Benzimidazole derivatives
HK1083508A (en)	2006-07-07	Novel adenosine analogues and their use as pharmaceutical agents
MXPA06008403A (es)	2006-12-13	Derivados de acido 7-fenilamino-4-quinolona-3-carboxilico, metodos para su produccion y su uso como medicamentos

Legal Events

Date	Code	Title	Description
2005-08-31	A1OB	Publication of a patent application
2006-02-22	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
2006-02-28	PNAN	Change of the applicant name, address/residence	Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, DE
2006-04-12	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20060412 Year of fee payment: 4
2008-11-06	OBST	Application withdrawn