[go: up one dir, main page]

HRP20020344B1 - Način priprave citaloprama - Google Patents

Način priprave citaloprama

Info

Publication number
HRP20020344B1
HRP20020344B1 HR20020344A HRP20020344A HRP20020344B1 HR P20020344 B1 HRP20020344 B1 HR P20020344B1 HR 20020344 A HR20020344 A HR 20020344A HR P20020344 A HRP20020344 A HR P20020344A HR P20020344 B1 HRP20020344 B1 HR P20020344B1
Authority
HR
Croatia
Prior art keywords
citalopram
preparation
dimethylamino
acyl
reacting
Prior art date
Application number
HR20020344A
Other languages
English (en)
Croatian (hr)
Inventor
Harold Rock Michael
Petersen Hans
Ellegaard Peter
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Priority claimed from PCT/DK1999/000581 external-priority patent/WO2000012044A2/en
Publication of HRP20020344A2 publication Critical patent/HRP20020344A2/hr
Publication of HRP20020344B1 publication Critical patent/HRP20020344B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
HR20020344A 1999-10-25 1999-10-25 Način priprave citaloprama HRP20020344B1 (hr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/DK1999/000581 WO2000012044A2 (en) 1999-10-25 1999-10-25 Method for the preparation of citalopram

Publications (2)

Publication Number Publication Date
HRP20020344A2 HRP20020344A2 (en) 2004-02-29
HRP20020344B1 true HRP20020344B1 (hr) 2010-10-31

Family

ID=8157164

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020344A HRP20020344B1 (hr) 1999-10-25 1999-10-25 Način priprave citaloprama

Country Status (25)

Country Link
US (1) US6566540B2 (is)
EP (1) EP1298124B1 (is)
KR (1) KR100505820B1 (is)
AR (1) AR024518A1 (is)
AT (2) ATE277032T1 (is)
CA (1) CA2291133C (is)
CY (1) CY1107635T1 (is)
CZ (1) CZ292894B6 (is)
DE (3) DE69920526T2 (is)
DK (2) DK1228056T3 (is)
EA (1) EA002801B1 (is)
ES (1) ES2282365T3 (is)
HK (1) HK1043129B (is)
HR (1) HRP20020344B1 (is)
HU (1) HUP0200169A3 (is)
IL (3) IL143875A0 (is)
IS (1) IS2260B (is)
NO (1) NO20071311L (is)
NZ (1) NZ512406A (is)
PL (1) PL201056B1 (is)
PT (2) PT1298124E (is)
SI (2) SI1228056T1 (is)
SK (1) SK287140B6 (is)
TR (1) TR200401456T1 (is)
UA (1) UA72238C2 (is)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR034612A1 (es) * 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
PE20040991A1 (es) * 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
US20050137255A1 (en) * 2002-12-23 2005-06-23 H. Lundbeck A/S Crystalline escitalopram hydrobromide and methods for preparing the same
BR0317623A (pt) * 2002-12-23 2005-11-29 Lundbeck & Co As H Escitalopram, composição farmacêutica, e, uso de hidrobrometo de escitalopram
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US20050196453A1 (en) * 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
AU2006304889A1 (en) * 2005-10-14 2007-04-26 H. Lundbeck A/S Stable pharmaceutical formulations containing escitalopram and bupropion
AU2006308635A1 (en) * 2005-10-14 2007-05-10 H. Lundbeck A/S Methods of treating central nervous system disorders with a low dose combination of escitalopram and bupropion
HRP20171908T1 (hr) * 2007-08-03 2018-01-26 Richter Gedeon Nyrt. Farmaceutski pripravak koji sadrži ligande dopamin receptora i metode liječenja koje koriste ligande dopamin receptora

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650884A (en) * 1984-08-06 1987-03-17 H. Lundbeck A/S Novel intermediate and method for its preparation
US4943590A (en) * 1988-06-14 1990-07-24 H. Lundbeck A/S Pharmaceutically useful (+)-1-(3-dimethylaminopropyl)-1-(4'-fluorophenyl)-1,3-dihydrosobenzofuran-5-carbonitrile and non-toxic acid addition salts thereof
WO1998019511A2 (en) * 1997-11-10 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (is) 1965-03-18
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
DE3926765A1 (de) 1989-08-12 1991-02-14 Hoechst Ag Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
EA001728B1 (ru) 1997-07-08 2001-08-27 Х.Лундбекк А/С Способ получения циталопрама
CZ292911B6 (cs) * 1997-11-11 2004-01-14 H. Lundbeck A/S Způsob výroby citalopramu
NZ510858A (en) 1998-10-20 2003-11-28 H Method for the preparation of citalopram
TR200101796T2 (tr) 1998-12-23 2001-11-21 H. Lundbeck A/S 5-Siyanofitalitin preparasyonuna yönelik metot
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
AU759716B2 (en) * 1999-04-14 2003-04-17 H. Lundbeck A/S Method for the preparation of citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
IL144816A (en) 2000-08-18 2005-09-25 Lundbeck & Co As H Method for the preparation of citalopram
PL353369A1 (en) 2000-12-28 2003-11-17 H.Lundbeck A/S Process for the preparation of pure citalopram

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650884A (en) * 1984-08-06 1987-03-17 H. Lundbeck A/S Novel intermediate and method for its preparation
US4943590A (en) * 1988-06-14 1990-07-24 H. Lundbeck A/S Pharmaceutically useful (+)-1-(3-dimethylaminopropyl)-1-(4'-fluorophenyl)-1,3-dihydrosobenzofuran-5-carbonitrile and non-toxic acid addition salts thereof
WO1998019511A2 (en) * 1997-11-10 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram

Also Published As

Publication number Publication date
SK287140B6 (sk) 2010-01-07
IS2260B (is) 2007-06-15
HUP0200169A2 (en) 2002-06-29
US6566540B2 (en) 2003-05-20
PL201056B1 (pl) 2009-03-31
KR100505820B1 (ko) 2005-08-03
EP1298124B1 (en) 2007-02-28
DK1298124T3 (da) 2007-07-09
EA200100593A1 (ru) 2001-10-22
IL143875A (en) 2008-03-20
EP1298124A1 (en) 2003-04-02
IL176943A0 (en) 2006-12-10
CA2291133C (en) 2003-06-17
HK1043129B (zh) 2004-10-21
IL143875A0 (en) 2002-04-21
ATE355268T1 (de) 2006-03-15
HRP20020344A2 (en) 2004-02-29
PT1228056E (pt) 2005-02-28
PL349440A1 (en) 2002-07-29
ATE277032T1 (de) 2004-10-15
CZ292894B6 (cs) 2003-12-17
DE69920526D1 (de) 2004-10-28
PT1298124E (pt) 2007-05-31
CY1107635T1 (el) 2013-04-18
NO20071311L (no) 2001-08-24
HK1043129A1 (en) 2002-09-06
UA72238C2 (en) 2005-02-15
ES2282365T3 (es) 2007-10-16
SI1298124T1 (sl) 2007-08-31
SI1228056T1 (en) 2005-02-28
TR200401456T1 (tr) 2005-04-21
KR20010092799A (ko) 2001-10-27
IS5970A (is) 2001-06-15
NZ512406A (en) 2004-01-30
CA2291133A1 (en) 2001-04-25
DE69935355D1 (de) 2007-04-12
DK1228056T3 (da) 2005-01-24
DE19983836C1 (de) 2003-10-23
EA002801B1 (ru) 2002-10-31
DE69935355T2 (de) 2007-11-08
HUP0200169A3 (en) 2002-11-28
AR024518A1 (es) 2002-10-16
DE69920526T2 (de) 2006-02-23
US20020177722A1 (en) 2002-11-28

Similar Documents

Publication Publication Date Title
DE69830504D1 (de) Antithrombotische mitteln
ES2018111A6 (es) Procedimiento de preparacion de derivados de 4h-1-benzopiran-4-ona o sus sales.
DE69831868D1 (en) Antithrombosemittel
CA2334775A1 (en) Benzo(b)thiepine-1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
DK0889875T3 (da) Cycloproylalkansyrederivater
RU93049997A (ru) Производные метилен-бис-фосфоновой кислоты, способ их получения, фармацевтическая композиция
WO2000012044A3 (en) Method for the preparation of citalopram
HRP20020344B1 (hr) Način priprave citaloprama
EA200000431A3 (ru) Новые замещенные димерные соединения, способ их получения и фармацевтические композиции, содержащие их
KR930016436A (ko) 4, 13-디옥사바이사이클로[8.2.1]트리데세논유도체와 그의 제조방법, 그의 제조를 위한 중간체 및 이화합물이 함유된 약학조성물
HUP0300856A2 (hu) Eljárás szubsztituált fenil-acetonitrilek elżállítására
BG107050A (en) Method for the preparation of citalopram
PT1204658E (pt) Agonistas benzofurilpiperazina de serotonina
YU5893A (sh) Sulfonilkarbamid i postupak za njegovo dobijanje
EA199800354A1 (ru) Способ получения производных камптотецина
YU31995A (sh) Benzotiofeni glikopiranozida, postupak za njihovo dobijanje i njihova farmaceutska formulacija
RU92004388A (ru) Способ получения 2-замещенных 4,6-диалкоксипиримидинов
CA2092919A1 (en) Epoxysuccinamic acid derivatives
BG105646A (en) Benzofuran derivatives, their preparation and use
JPH10245390A5 (is)
FR2431497A1 (fr) Nouveaux derives de l'acide clavulanique, utilisables comme medicament
HK118093A (en) 3-(n-methyl-n-alkylamino)-2-methoxymethyl-propanol derivatives
CA2335394A1 (en) Aerothricin analogs, their preparation and use
ATE259800T1 (de) Substituierte 5-(2,2difluor-1,3-benzodioxol-5-yl) cyclopentenopyridinderivate
BG104964A (bg) Подобрен метод за получаване на фармацевтично ценни норбензоморфанови производни

Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20111022

Year of fee payment: 13

PBON Lapse due to non-payment of renewal fee

Effective date: 20121026