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HRP20000162B1 - Amorphous torasemide modification - Google Patents

Amorphous torasemide modification

Info

Publication number
HRP20000162B1
HRP20000162B1 HR20000162A HRP20000162A HRP20000162B1 HR P20000162 B1 HRP20000162 B1 HR P20000162B1 HR 20000162 A HR20000162 A HR 20000162A HR P20000162 A HRP20000162 A HR P20000162A HR P20000162 B1 HRP20000162 B1 HR P20000162B1
Authority
HR
Croatia
Prior art keywords
torasemide modification
amorphous torasemide
amorphous
modification
torasemide
Prior art date
Application number
HR20000162A
Other languages
English (en)
Inventor
Filic Darko
Dumic Miljenko
Klepic Božena
Danilovski Aleksandar
Tu­A Marijan
Original Assignee
Pliva D D
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva D D filed Critical Pliva D D
Priority to HR20000162A priority Critical patent/HRP20000162B1/xx
Priority to ARP000102019A priority patent/AR023788A1/es
Priority to BR0017175-1A priority patent/BR0017175A/pt
Priority to SK1509-2002A priority patent/SK15092002A3/sk
Priority to AU2000241348A priority patent/AU2000241348A1/en
Priority to EA200201003A priority patent/EA004950B1/ru
Priority to GE4937A priority patent/GEP20043300B/en
Priority to YU70502A priority patent/YU70502A/sh
Priority to MXPA02009210A priority patent/MXPA02009210A/es
Priority to DE60007360T priority patent/DE60007360T2/de
Priority to CZ20023436A priority patent/CZ20023436A3/cs
Priority to PT00920938T priority patent/PT1272470E/pt
Priority to CNB008194319A priority patent/CN1211368C/zh
Priority to US10/239,024 priority patent/US6767917B1/en
Priority to AT00920938T priority patent/ATE256662T1/de
Priority to CA002401908A priority patent/CA2401908A1/en
Priority to EP00920938A priority patent/EP1272470B1/en
Priority to IL15180100A priority patent/IL151801A0/xx
Priority to ES00920938T priority patent/ES2213006T3/es
Priority to HU0300596A priority patent/HUP0300596A3/hu
Priority to KR1020027012411A priority patent/KR20020093847A/ko
Priority to PCT/HR2000/000011 priority patent/WO2001070694A1/en
Priority to SI200030301T priority patent/SI1272470T1/xx
Priority to JP2001568906A priority patent/JP2003528083A/ja
Priority to EEP200200534A priority patent/EE200200534A/xx
Priority to PL00357154A priority patent/PL357154A1/xx
Publication of HRP20000162A2 publication Critical patent/HRP20000162A2/hr
Priority to IS6551A priority patent/IS6551A/is
Priority to NO20024464A priority patent/NO20024464L/no
Priority to ZA200208309A priority patent/ZA200208309B/en
Priority to BG107208A priority patent/BG107208A/xx
Publication of HRP20000162B1 publication Critical patent/HRP20000162B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C07D213/71—Sulfur atoms to which a second hetero atom is attached

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
HR20000162A 2000-03-20 2000-03-20 Amorphous torasemide modification HRP20000162B1 (en)

Priority Applications (30)

Application Number Priority Date Filing Date Title
HR20000162A HRP20000162B1 (en) 2000-03-20 2000-03-20 Amorphous torasemide modification
ARP000102019A AR023788A1 (es) 2000-03-20 2000-04-28 Modificacion amorfa de torasemida
CA002401908A CA2401908A1 (en) 2000-03-20 2000-05-02 Amorphous torasemide modification
EP00920938A EP1272470B1 (en) 2000-03-20 2000-05-02 Amorphous torasemide modification
AU2000241348A AU2000241348A1 (en) 2000-03-20 2000-05-02 Amorphous torasemide modification
EA200201003A EA004950B1 (ru) 2000-03-20 2000-05-02 Аморфная модификация торасемида
GE4937A GEP20043300B (en) 2000-03-20 2000-05-02 Amorphous Torasemide Modification
YU70502A YU70502A (sh) 2000-03-20 2000-05-02 Amorfna modifikacija torasemida
MXPA02009210A MXPA02009210A (es) 2000-03-20 2000-05-02 Modificacion amorfa de torasemida.
DE60007360T DE60007360T2 (de) 2000-03-20 2000-05-02 Amorphe modifikation von torasemid
CZ20023436A CZ20023436A3 (cs) 2000-03-20 2000-05-02 Amorfní modifikace torasemidu, způsob její přípravy a přípravy farmaceutického prostředku obsahujícího tuto modifikaci
PT00920938T PT1272470E (pt) 2000-03-20 2000-05-02 Forma modificada da torasemida amorfa
CNB008194319A CN1211368C (zh) 2000-03-20 2000-05-02 无定形的托拉塞米变体
US10/239,024 US6767917B1 (en) 2000-03-20 2000-05-02 Amorphous torasemide modification
AT00920938T ATE256662T1 (de) 2000-03-20 2000-05-02 Amorphe modifikation von torasemid
BR0017175-1A BR0017175A (pt) 2000-03-20 2000-05-02 Modificação da torasemida amorfa
IL15180100A IL151801A0 (en) 2000-03-20 2000-05-02 Amorphous torasemide modification
SI200030301T SI1272470T1 (en) 2000-03-20 2000-05-02 Amorphous torasemide modification
EEP200200534A EE200200534A (et) 2000-03-20 2000-05-02 Torasemiidi amorfne modifikatsioon, selle valmistamine ja kasutamine soolade saamiseks ning seda sisaldav farmatseutiline preparaat
HU0300596A HUP0300596A3 (en) 2000-03-20 2000-05-02 Amorphous torasemide modification, process for its preparation its use and pharmaceutical compositions containing it
KR1020027012411A KR20020093847A (ko) 2000-03-20 2000-05-02 무정형 토라세미드 변형물
PCT/HR2000/000011 WO2001070694A1 (en) 2000-03-20 2000-05-02 Amorphous torasemide modification
SK1509-2002A SK15092002A3 (sk) 2000-03-20 2000-05-02 Amorfná modifikácia torasemidu, spôsob jej prípravy a farmaceutický prostriedok obsahujúci túto modifikáciu
JP2001568906A JP2003528083A (ja) 2000-03-20 2000-05-02 非晶質トラセミド変態
ES00920938T ES2213006T3 (es) 2000-03-20 2000-05-02 Forma modificada de torasemida amorfa.
PL00357154A PL357154A1 (en) 2000-03-20 2000-05-02 Amorphous torasemide modification
IS6551A IS6551A (is) 2000-03-20 2002-09-17 Formlaus torasemíð umbreyting
NO20024464A NO20024464L (no) 2000-03-20 2002-09-18 Amorf Torasemide-modifikasjon
ZA200208309A ZA200208309B (en) 2000-03-20 2002-10-15 Amorphous torasemide modification.
BG107208A BG107208A (bg) 2000-03-20 2002-10-21 Аморфна тораземидна модификация

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HR20000162A HRP20000162B1 (en) 2000-03-20 2000-03-20 Amorphous torasemide modification

Publications (2)

Publication Number Publication Date
HRP20000162A2 HRP20000162A2 (en) 2001-12-31
HRP20000162B1 true HRP20000162B1 (en) 2004-06-30

Family

ID=10947070

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20000162A HRP20000162B1 (en) 2000-03-20 2000-03-20 Amorphous torasemide modification

Country Status (29)

Country Link
US (1) US6767917B1 (is)
EP (1) EP1272470B1 (is)
JP (1) JP2003528083A (is)
KR (1) KR20020093847A (is)
CN (1) CN1211368C (is)
AR (1) AR023788A1 (is)
AT (1) ATE256662T1 (is)
AU (1) AU2000241348A1 (is)
BG (1) BG107208A (is)
BR (1) BR0017175A (is)
CA (1) CA2401908A1 (is)
CZ (1) CZ20023436A3 (is)
DE (1) DE60007360T2 (is)
EA (1) EA004950B1 (is)
EE (1) EE200200534A (is)
ES (1) ES2213006T3 (is)
GE (1) GEP20043300B (is)
HR (1) HRP20000162B1 (is)
HU (1) HUP0300596A3 (is)
IL (1) IL151801A0 (is)
IS (1) IS6551A (is)
MX (1) MXPA02009210A (is)
NO (1) NO20024464L (is)
PL (1) PL357154A1 (is)
PT (1) PT1272470E (is)
SK (1) SK15092002A3 (is)
WO (1) WO2001070694A1 (is)
YU (1) YU70502A (is)
ZA (1) ZA200208309B (is)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI20816A (sl) * 1999-08-11 2002-08-31 Teva Pharmaceutical Industries Ltd. Polimorfi torsemid-a
IN192178B (is) * 2001-08-03 2004-03-06 Ranbaxy Lab
EP1668008A4 (en) 2003-08-28 2009-02-25 Nitromed Inc NITROSED AND NITROSYLATED DIETETIC COMPOUNDS, COMPOSITIONS AND APPLICATION METHODS
AU2006216665A1 (en) 2005-02-24 2006-08-31 Nicox S.A. Nitric oxide enhancing diuretic compounds, compositions and methods of use
CN100421662C (zh) * 2005-11-08 2008-10-01 周卓和 托拉塞米分散片及其制备方法和应用
CN104370805B (zh) * 2013-08-13 2016-09-07 天津汉瑞药业有限公司 托拉塞米化合物
CN105949115A (zh) * 2016-05-26 2016-09-21 南京正科医药股份有限公司 一种新晶型托拉塞米
CN115417810B (zh) * 2022-09-22 2023-10-10 南京正科医药股份有限公司 一种托拉塞米晶型ⅰ的精制方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1477664A (en) 1974-04-17 1977-06-22 Christiaens Sa A Pyridine derivatives
DE3529529A1 (de) * 1985-08-17 1987-02-19 Boehringer Mannheim Gmbh Verfahren zur herstellung einer stabilen modifikation von torasemid
GB8816620D0 (en) 1988-07-13 1988-08-17 Lepetit Spa Rifapentine hydrohalides
ES2150105T3 (es) 1995-02-22 2000-11-16 Aventis Pharma Ltd Piretanida amorfa, polimorfos de piretanida, proceso para su preparacion y su uso.
IN182496B (is) 1996-02-20 1999-04-17 Reddy Research Foundation
HRP980532B1 (en) 1998-10-02 2005-06-30 Pliva Novel crystalline torasemide modification
US5914336A (en) * 1998-06-02 1999-06-22 Boehringer Mannheim Gmbh Method of controlling the serum solubility of orally administered torasemide and composition relating thereto
SI20816A (sl) 1999-08-11 2002-08-31 Teva Pharmaceutical Industries Ltd. Polimorfi torsemid-a

Also Published As

Publication number Publication date
AR023788A1 (es) 2002-09-04
PL357154A1 (en) 2004-07-12
CZ20023436A3 (cs) 2003-03-12
CA2401908A1 (en) 2001-09-27
GEP20043300B (en) 2004-02-10
MXPA02009210A (es) 2004-09-06
NO20024464L (no) 2002-09-20
JP2003528083A (ja) 2003-09-24
US6767917B1 (en) 2004-07-27
EE200200534A (et) 2004-04-15
CN1452613A (zh) 2003-10-29
IL151801A0 (en) 2003-04-10
AU2000241348A1 (en) 2001-10-03
WO2001070694A1 (en) 2001-09-27
YU70502A (sh) 2006-01-16
HRP20000162A2 (en) 2001-12-31
DE60007360D1 (de) 2004-01-29
ATE256662T1 (de) 2004-01-15
DE60007360T2 (de) 2004-10-07
EP1272470A1 (en) 2003-01-08
EP1272470B1 (en) 2003-12-17
BR0017175A (pt) 2002-12-10
NO20024464D0 (no) 2002-09-18
EA004950B1 (ru) 2004-10-28
BG107208A (bg) 2003-07-31
SK15092002A3 (sk) 2003-05-02
ZA200208309B (en) 2003-10-15
EA200201003A1 (ru) 2003-02-27
HUP0300596A2 (hu) 2003-07-28
WO2001070694A8 (en) 2002-03-21
ES2213006T3 (es) 2004-08-16
IS6551A (is) 2002-09-17
KR20020093847A (ko) 2002-12-16
CN1211368C (zh) 2005-07-20
HUP0300596A3 (en) 2005-08-29
PT1272470E (pt) 2004-05-31

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